Biochemistry: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

Science

Volumn 310, Issue 5755, 2005, Pages 1821-1824

  Bienko, Marzena ^a   Green, Catherine M ^b   Crosetto, Nicola ^a   Rudolf, Fabian ^c   Zapart, Grzegorz ^a   Coull, Barry ^b,e   Kannouche, Patricia ^b,f   Wider, Gerhard ^c   Peter, Matthias ^c   Lehmann, Alan R ^b   Hofmann, Kay ^d   Dikic, Ivan ^a  

^a GOETHE UNIVERSITY MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

^c ETH ZURICH   (Switzerland)

^d MILTENYI BIOTEC GMBH   (Germany)

^e UNILEVER RESEARCH   (United Kingdom)

^f INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOSYNTHESIS; CELLS; DNA; RNA;

PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA); REPLICATION MACHINERY; TRANSLESION SYNTHESIS (TLS);

ENZYMES;

CYCLINE; DNA POLYMERASE; UBIQUITIN; UNCLASSIFIED DRUG; Y POLYMERASE; DNA; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE ETA; DNA POLYMERASE IOTA; HYBRID PROTEIN; ZINC FINGER PROTEIN;

PROTEIN;

ARTICLE; CELL DIVISION; CELL STRAIN HEK293; DNA DAMAGE; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TRANSLESION SYNTHESIS; UBIQUITINATION; ULTRAVIOLET IRRADIATION; XERODERMA PIGMENTOSUM; AMINO ACID SEQUENCE; ANIMAL; BIOLOGY; BIOSYNTHESIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DNA REPAIR; DNA REPLICATION; GENETIC TRANSFECTION; GENETICS; HYDROPHOBICITY; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEAR MAGNETIC RESONANCE; POINT MUTATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE;

MAMMALIA;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CELL LINE; COMPUTATIONAL BIOLOGY; DNA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA-DIRECTED DNA POLYMERASE; HUMANS; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POINT MUTATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; TRANSFECTION; UBIQUITIN; XERODERMA PIGMENTOSUM; ZINC FINGERS;

EID: 29144499065     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1120615     Document Type: Article

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19. We thank E. Friedberg and S. Tateishi for help with reagents and W. Mueller-Esterl, A. Carr, K. Caldecott, and members of the Dikic laboratory for critical reading of the manuscript. We also thank J. Wing and I. Konrad for technical assistance. This work was supported by a scholarship from the Ernst Schering Foundation (to M.B.), an MRC Programme Grant and EC Contract MRTN-CT-2003-503618 (to A.R.L), grants from the Swiss National Science Foundation and Eidgenössische Technische Hochschule Zürich (to M.P. and G.W.), and grants from the Deutsche Forschungsgemeinschaft (DI 931/1-1) and Boehringer Ingelheim Fonds (to I.D.).