메뉴 건너뛰기




Volumn 173, Issue 2, 2006, Pages 195-206

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BRCA1 PROTEIN; BRCA2 PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CHECKPOINT KINASE RAD3; DNA; FANDCD 2 PROTEIN; MDC 1 PROTEIN; MRE11 PROTEIN; NIBRIN; PROTEIN; PROTEIN A; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; RAD50 PROTEIN; RAD51 PROTEIN; RAD52 PROTEIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

EID: 33646117239     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200510130     Document Type: Article
Times cited : (519)

References (47)
  • 1
    • 3242882820 scopus 로고    scopus 로고
    • PI 3-kinase related kinases: 'Big' players in stress-induced signaling pathways
    • Abraham, R.T. 2004. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst.). 3:883-887.
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 883-887
    • Abraham, R.T.1
  • 2
    • 0347988236 scopus 로고    scopus 로고
    • Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains
    • Aten, J.A., J. Stap, P.M. Krawczyk, C.H. van Oven, R.A. Hoebe, J. Essers, and R. Kanaar. 2004. Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science. 303:92-95.
    • (2004) Science , vol.303 , pp. 92-95
    • Aten, J.A.1    Stap, J.2    Krawczyk, P.M.3    Van Oven, C.H.4    Hoebe, R.A.5    Essers, J.6    Kanaar, R.7
  • 3
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C.J., and M.B. Kastan. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:499-506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 4
    • 22944462083 scopus 로고    scopus 로고
    • Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1
    • Bekker-Jensen, S., C. Lukas, F. Melander, J. Bartek, and J. Lukas. 2005. Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1. J. Cell Biol. 170:201-211.
    • (2005) J. Cell Biol. , vol.170 , pp. 201-211
    • Bekker-Jensen, S.1    Lukas, C.2    Melander, F.3    Bartek, J.4    Lukas, J.5
  • 6
    • 3242879828 scopus 로고    scopus 로고
    • Chk1 in the DNA damage response: Conserved roles from yeasts to mammals
    • Chen, Y., and Y. Sanchez. 2004. Chk1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair (Amst.). 3:1025-1032.
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 1025-1032
    • Chen, Y.1    Sanchez, Y.2
  • 7
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: Partners in checkpoint signaling
    • Cortez, D., S. Guntuku, J. Qin, and S.J. Elledge. 2001. ATR and ATRIP: partners in checkpoint signaling. Science. 294:1713-1716.
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 10
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • Falck, J., J. Coates, and S.P. Jackson. 2005. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature. 434:605-611.
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 11
    • 29944434644 scopus 로고    scopus 로고
    • Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
    • Greenberg, R.A., B. Sobhian, S. Pathania, S.B. Cantor, Y. Nakatani, and D.M. Livingston. 2006. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev. 20:34-46.
    • (2006) Genes Dev. , vol.20 , pp. 34-46
    • Greenberg, R.A.1    Sobhian, B.2    Pathania, S.3    Cantor, S.B.4    Nakatani, Y.5    Livingston, D.M.6
  • 13
    • 0036153467 scopus 로고    scopus 로고
    • Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: Colocalization with proteins involved in DNA repair
    • Jakob, B., M. Scholz, and G. Taucher-Scholz. 2002. Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: colocalization with proteins involved in DNA repair. Int. J. Radiat. Biol. 78:75-88.
    • (2002) Int. J. Radiat. Biol. , vol.78 , pp. 75-88
    • Jakob, B.1    Scholz, M.2    Taucher-Scholz, G.3
  • 15
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan, M.B., and J. Bartek. 2004. Cell-cycle checkpoints and cancer. Nature. 432:316-323.
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 16
    • 0346668366 scopus 로고    scopus 로고
    • Specific recruitment of human cohesin to laser-induced DNA damage
    • Kim, J.S., T.B. Krasieva, V. LaMorte, A.M. Taylor, and K. Yokomori. 2002. Specific recruitment of human cohesin to laser-induced DNA damage. J. Biol. Chem. 277:45149-45153.
    • (2002) J. Biol. Chem. , vol.277 , pp. 45149-45153
    • Kim, J.S.1    Krasieva, T.B.2    LaMorte, V.3    Taylor, A.M.4    Yokomori, K.5
  • 17
    • 23744447715 scopus 로고    scopus 로고
    • Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells
    • Kim, J.S., T.B. Krasieva, H. Kurumizaka, D.J. Chen, A.M. Taylor, and K. Yokomori. 2005. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J. Cell Biol. 170:341-347.
    • (2005) J. Cell Biol. , vol.170 , pp. 341-347
    • Kim, J.S.1    Krasieva, T.B.2    Kurumizaka, H.3    Chen, D.J.4    Taylor, A.M.5    Yokomori, K.6
  • 18
    • 0036500555 scopus 로고    scopus 로고
    • Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
    • Kim, S.T., B. Xu, and M.B. Kastan. 2002. Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage. Genes Dev. 16:560-570.
    • (2002) Genes Dev. , vol.16 , pp. 560-570
    • Kim, S.T.1    Xu, B.2    Kastan, M.B.3
  • 19
    • 2942687831 scopus 로고    scopus 로고
    • Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway
    • Kitagawa, R., C.J. Bakkenist, P.J. McKinnon, and M.B. Kastan. 2004. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 18:1423-1438.
    • (2004) Genes Dev. , vol.18 , pp. 1423-1438
    • Kitagawa, R.1    Bakkenist, C.J.2    McKinnon, P.J.3    Kastan, M.B.4
  • 21
    • 3242889155 scopus 로고    scopus 로고
    • Interplay between chromatin and cell cycle checkpoints in the context of ATR/ATM-dependent checkpoints
    • Koundrioukoff, S., S. Polo, and G. Almouzni. 2004. Interplay between chromatin and cell cycle checkpoints in the context of ATR/ATM-dependent checkpoints. DNA Repair (Amst.). 3:969-978.
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 969-978
    • Koundrioukoff, S.1    Polo, S.2    Almouzni, G.3
  • 22
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human non-homologous DNA end-joining
    • Lieber, M.R., Y. Ma, U. Pannicke, and K. Schwarz. 2003. Mechanism and regulation of human non-homologous DNA end-joining. Nat. Rev. Mol. Cell Biol. 4:712-720.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 23
    • 0038141976 scopus 로고    scopus 로고
    • Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre
    • Lisby, M., U.H. Mortensen, and R. Rothstein. 2003. Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre. Nat. Cell Biol. 5:572-577.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 572-577
    • Lisby, M.1    Mortensen, U.H.2    Rothstein, R.3
  • 24
    • 4544281398 scopus 로고    scopus 로고
    • Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
    • Lisby, M., J.H. Barlow, R.C. Burgess, and R. Rothstein. 2004. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell. 118:699-713.
    • (2004) Cell , vol.118 , pp. 699-713
    • Lisby, M.1    Barlow, J.H.2    Burgess, R.C.3    Rothstein, R.4
  • 25
    • 0038496703 scopus 로고    scopus 로고
    • Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control
    • Lou, Z., C.C. Chini, K. Minter-Dykhouse, and J. Chen. 2003. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J. Biol. Chem. 278:13599-13602.
    • (2003) J. Biol. Chem. , vol.278 , pp. 13599-13602
    • Lou, Z.1    Chini, C.C.2    Minter-Dykhouse, K.3    Chen, J.4
  • 26
    • 0037341599 scopus 로고    scopus 로고
    • Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
    • Lukas, C., J. Falck, J. Bartkova, J. Bartek, and J. Lukas. 2003. Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5:255-260.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 255-260
    • Lukas, C.1    Falck, J.2    Bartkova, J.3    Bartek, J.4    Lukas, J.5
  • 28
    • 25144514003 scopus 로고    scopus 로고
    • Imaging of protein movement induced by chromosomal breakage: Tiny 'local' lesions pose great 'global' challenges
    • Lukas, C., J. Bartek, and J. Lukas. 2005. Imaging of protein movement induced by chromosomal breakage: tiny 'local' lesions pose great 'global' challenges. Chromosoma. 114:146-154.
    • (2005) Chromosoma , vol.114 , pp. 146-154
    • Lukas, C.1    Bartek, J.2    Lukas, J.3
  • 29
    • 3242890575 scopus 로고    scopus 로고
    • Mammalian cell cycle checkpoints: Signalling pathways and their organization in space and time
    • Lukas, J., C. Lukas, and J. Bartek. 2004. Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair (Amst.). 3:997-1007.
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 997-1007
    • Lukas, J.1    Lukas, C.2    Bartek, J.3
  • 30
    • 30344444484 scopus 로고    scopus 로고
    • Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
    • Murr, R., J.I. Loizou, Y.G. Yang, C. Cuenin, H. Li, Z.Q. Wang, and Z. Herceg. 2006. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat. Cell Biol. 8:91-99.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 91-99
    • Murr, R.1    Loizou, J.I.2    Yang, Y.G.3    Cuenin, C.4    Li, H.5    Wang, Z.Q.6    Herceg, Z.7
  • 31
    • 0142011461 scopus 로고    scopus 로고
    • The cellular response to DNA double-strand breaks: Defining the sensors and mediators
    • Petrini, J.H., and T.H. Stracker. 2003. The cellular response to DNA double-strand breaks: defining the sensors and mediators. Trends Cell Biol. 13:458-462.
    • (2003) Trends Cell Biol. , vol.13 , pp. 458-462
    • Petrini, J.H.1    Stracker, T.H.2
  • 32
    • 0033514993 scopus 로고    scopus 로고
    • Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage
    • Raderschall, E., E.I. Golub, and T. Haaf. 1999. Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage. Proc. Natl. Acad. Sci. USA. 96:1921-1926.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1921-1926
    • Raderschall, E.1    Golub, E.I.2    Haaf, T.3
  • 33
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh, Y. 2003. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer. 3:155-168.
    • (2003) Nat. Rev. Cancer. , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 34
    • 30944435598 scopus 로고    scopus 로고
    • Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response
    • Smits, V.A., P.M. Reaper, and S.P. Jackson. 2006. Rapid PIKK-dependent release of Chk1 from chromatin promotes the DNA-damage checkpoint response. Curr. Biol. 16:150-159.
    • (2006) Curr. Biol. , vol.16 , pp. 150-159
    • Smits, V.A.1    Reaper, P.M.2    Jackson, S.P.3
  • 35
  • 36
    • 10944232673 scopus 로고    scopus 로고
    • Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair
    • Strom, L., H.B. Lindroos, K. Shirahige, and C. Sjogren. 2004. Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair. Mol. Cell. 16:1003-1015.
    • (2004) Mol. Cell , vol.16 , pp. 1003-1015
    • Strom, L.1    Lindroos, H.B.2    Shirahige, K.3    Sjogren, C.4
  • 37
    • 29244434544 scopus 로고    scopus 로고
    • MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
    • Stucki, M., J.A. Clapperton, D. Mohammad, M.B. Yaffe, S.J. Smerdon, and S.P. Jackson. 2005. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell. 123:1213-1226.
    • (2005) Cell , vol.123 , pp. 1213-1226
    • Stucki, M.1    Clapperton, J.A.2    Mohammad, D.3    Yaffe, M.B.4    Smerdon, S.J.5    Jackson, S.P.6
  • 38
    • 10844237358 scopus 로고    scopus 로고
    • Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing radiation
    • Syljuasen, R.G., C.S. Sorensen, J. Nylandsted, C. Lukas, J. Lukas, and J. Bartek. 2004. Inhibition of Chk1 by CEP-3891 accelerates mitotic nuclear fragmentation in response to ionizing radiation. Cancer Res. 64:9035-9040.
    • (2004) Cancer Res. , vol.64 , pp. 9035-9040
    • Syljuasen, R.G.1    Sorensen, C.S.2    Nylandsted, J.3    Lukas, C.4    Lukas, J.5    Bartek, J.6
  • 39
    • 5444220661 scopus 로고    scopus 로고
    • Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex
    • Takahashi, T.S., P. Yiu, M.F. Chou, S. Gygi, and J.C. Walter. 2004. Recruitment of Xenopus Scc2 and cohesin to chromatin requires the pre-replication complex. Nat. Cell Biol. 6:991-996.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 991-996
    • Takahashi, T.S.1    Yiu, P.2    Chou, M.F.3    Gygi, S.4    Walter, J.C.5
  • 40
    • 0034710152 scopus 로고    scopus 로고
    • Rad51 accumulation at sites of DNA damage and in postreplicative chromatin
    • Tashiro, S., J. Walter, A. Shinohara, N. Kamada, and T. Cremer. 2000. Rad51 accumulation at sites of DNA damage and in postreplicative chromatin. J. Cell Biol. 150:283-291.
    • (2000) J. Cell Biol. , vol.150 , pp. 283-291
    • Tashiro, S.1    Walter, J.2    Shinohara, A.3    Kamada, N.4    Cremer, T.5
  • 41
    • 10944262393 scopus 로고    scopus 로고
    • DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain
    • Unal, E., A. Arbel-Eden, U. Sattler, R. Shroff, M. Lichten, J.E. Haber, and D. Koshland. 2004. DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol. Cell. 16:991-1002.
    • (2004) Mol. Cell , vol.16 , pp. 991-1002
    • Unal, E.1    Arbel-Eden, A.2    Sattler, U.3    Shroff, R.4    Lichten, M.5    Haber, J.E.6    Koshland, D.7
  • 42
    • 28444456705 scopus 로고    scopus 로고
    • The histone code at DNA breaks: A guide to repair?
    • van Attikum, H., and S.M. Gasser. 2005. The histone code at DNA breaks: a guide to repair? Nat. Rev. Mol. Cell Biol. 6:757-765.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 757-765
    • Van Attikum, H.1    Gasser, S.M.2
  • 43
    • 1642280957 scopus 로고    scopus 로고
    • UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress
    • Ward, I.M., K. Minn, and J. Chen. 2004. UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J. Biol. Chem. 279:9677-9680.
    • (2004) J. Biol. Chem. , vol.279 , pp. 9677-9680
    • Ward, I.M.1    Minn, K.2    Chen, J.3
  • 44
    • 0036500690 scopus 로고    scopus 로고
    • SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
    • Yazdi, P.T., Y. Wang, S. Zhao, N. Patel, E.Y. Lee, and J. Qin. 2002. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 16:571-582.
    • (2002) Genes Dev. , vol.16 , pp. 571-582
    • Yazdi, P.T.1    Wang, Y.2    Zhao, S.3    Patel, N.4    Lee, E.Y.5    Qin, J.6
  • 45
    • 20744436198 scopus 로고    scopus 로고
    • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • You, Z., C. Chahwan, J. Bailis, T. Hunter, and P. Russell. 2005. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol. Cell. Biol. 25:5363-5379.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5
  • 46
    • 0034967556 scopus 로고    scopus 로고
    • ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
    • Zhao, H., and H. Piwnica-Worms. 2001. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol. 21:4129-4139.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 4129-4139
    • Zhao, H.1    Piwnica-Worms, H.2
  • 47
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B.B., and S.J. Elledge. 2000. The DNA damage response: putting checkpoints in perspective. Nature. 408:433-439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.