Ubiquitin-binding domains

Biochemical Journal

Volumn 399, Issue 3, 2006, Pages 361-372

  Hurley, James H ^a   Lee, Sangho ^a   Prag, Gali ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Endocytosis; Proteasome; Protein structure; Ubiquitin binding domain; Ubiquitination; Vesicle trafficking

Indexed keywords

CELL CULTURE; CHEMICAL MODIFICATION; COMPLEXATION; DEGRADATION; MOLECULAR STRUCTURE; POLYMERIZATION; QUALITY CONTROL;

ENDOCYTOSIS; PROTEASOME; PROTEIN STRUCTURES; UBIQUITIN-BINDING DOMAINS; UBIQUITINATION; VESICLE TRAFFICKING;

PROTEINS;

LYSINE; PROTEIN DUIM; PROTEIN MIU; PROTEIN NZF; PROTEIN PFU; PROTEIN UBA; PROTEIN UIM; PROTEIN ZNF; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

BINDING AFFINITY; CELL CYCLE REGULATION; DNA REPAIR; ENDOCYTOSIS; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; MEMBRANE BINDING; NONHUMAN; OLIGOMERIZATION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; STRESS; SURFACE PLASMON RESONANCE; UBIQUITINATION;

ANIMALS; HUMANS; KINETICS; MODELS, MOLECULAR; POLYUBIQUITIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; STRUCTURE-ACTIVITY RELATIONSHIP; UBIQUITIN; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

EID: 33750555919     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20061138     Document Type: Review

References (110)

1. Hershko, A., Ciechanover, A. and Varshavsky, A. (2000) The ubiquitin system. Nat. Med. 6, 1073-1081
2. Pickart, C. M. (2001) Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533
3. Weissman, A. M. (2001) Themes and variations on ubiquitylation. Nat. Rev. Mol. Cell Biol. 2, 169-178
4. Hochstrasser, M. (2000) Evolution and function of ubiquitin-like protein-conjugation systems. Nat. Cell Biol. 2, E153-E157
5. Miller, J. and Gordon, C. (2005) The regulation of proteasome degradation by multi-ubiquitin chain binding proteins. FEBS Lett. 579, 3224-3230
6. Elsasser, S. and Finley, D. (2005) Delivery of ubiquitinated substrates to protein-unfolding macbines. Nat. Cell Biol. 7, 742-710
7. Hicke, L. (2001) A new ticket for entry into budding vesicles - ubiquitin. Cell 106, 527-530
8. Raiborg, C., Rusten, T. E. and Stenmark, H. (2003) Protein sorting into multivesicular endosomes. Curr. Opin. Cell Biol. 15, 446-455
9. Staub, O. and Rotin, D. (2006) Roie of ubiquitylation in cellular membrane transport. Physiol. Rev. 86, 669-707
10. Huang, T. T. and D'Andrea, A. D. (2006) Regulation of DNA repair by ubiquitylation. Nat. Rev. Mol. Cell Biol. 7, 323-334
11. Di Fiore, P. P., Polo, S. and Hofmann, K. (2003) When ubiquitin meets ubiquitin receptors: a signalling connection. Nat. Rev. Mol. Cell Biol. 4, 491-497
12. Haglund, K. and Dikic, I. (2005) Ubiquitylation and cell signaling. EMBO J. 24, 3353-3359
13. Hicke, L., Schubert, H. L. and Hill, C. P. (2005) Ubiquitin-binding domains. Nat. Rev. Mol. Cell Biol. 6, 610-621
14. Harper, J. W. and Schulman, B. A. (2006) Structural complexity in ubiquitin recognition. Cell 124, 1133-1136
15. Mizuno, E., Kawahata, K., Kato, M., Kitamura, N. and Komada, M. (2003) STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. Mol. Biol. Cell 14, 3675-3689
16. Hofmann, K. and Falquet, L. (2001) A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem. Sci. 26, 347-350
17. Polo, S., Sigismund, S., Faretta, M., Guidi, M., Capua, M. R., Bossi, G., Chen, H., De Camilli, P. and Di Fiore, P. P. (2002) A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature 416, 451-455
18. Shih, S. C., Katzmann, D. J., Schnell, J. D., Sutanto, M., Emr, S. D. and Hicke, L. (2002) Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat. Cell Biol. 4, 389-393
19. Bilodeau, P. S., Urbanowski, J. L., Winistorfer, S. C. and Piper, R. C. (2002) The Vps27p-Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Nat. Cell Biol. 4, 534-539
20. Raiborg, C., Bache, K. G., Gillooly, D. J., Madshush, I. H., Stang, E. and Stenmark, H. (2002) Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat. Cell Biol. 4, 394-398
21. Klapisz, E., Sorokina, I., Lemeer, S., Pijnenburg, M., Verkleij, A. J. and Henegouwen, P. (2002) A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination. J. Biol. Chem. 277, 30746-30753
22. Oldham, C. E., Mohney, R. P., Miller, S. L. H., Hanes, R. N. and O'Bryan, J. P. (2002) The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination. Curr. Biol. 12, 1112-1116
23. Katz, M., Shtiegman, K., Tal-Or, P., Yakir, L., Mosesson, Y., Harari, D., Machluf, Y., Asao, H., Jovin, T., Sugamura, K. and Yarden, Y. (2002) Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4. Traffic 3, 740-751
24. Miller, S. L. H., Malotky, E. and O'Bryan, J. P. (2004) Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding and ubiquitylation. J. Biol. Chem. 279, 33528-33537
25. Shekhtman, A. and Cowburn, D. (2002) A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins. Biochem. Biophys. Res. Commun. 296, 1222-1227
26. Fisher, R. D., Wang, B., Alam, S. L., Higginson, D. S., Robinson, H., Sundquist, W. I. and Hill, C. P. (2003) Structure and ubiquitin binding of the ubiquitin-interacting motif. J. Biol. Chem. 278, 28976-28984
27. Swanson, K. A., Kang, R. S., Stamenova, S. D., Hicke, L. and Radhakrishnan, I. (2003) Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation. EMBO J. 22, 4597-4606
28. Ryu, K. S., Lee, K. J., Bae, S. H., Kim, B. K., Kim, K. A. and Choi, B. S. (2003) Binding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5a. J. Biol. Chem. 278, 36621-36627
29. Wang, Q. H., Young, P. and Walters, K. J. (2005) Structure of S5a bound to monoubiquitin provides a model for polyubiquitin recognition. J. Mol. Biol. 348, 727-739
30. Lee, S., Tsai, Y. C., Mattera, R., Smith, W. J., Kostelansky, M. S., Weissman, A. M., Bonifacino, J. S. and Hurley, J. H. (2006) Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5. Nat. Struct. Mol. Biol. 13, 264-271
31. Penengo, L., Mapelli, M., Murachelli, A. G., Confalonieri, S., Magri, L., Musacchio, A., Di Fiore, P. P., Polo, S. and Schneider, T. R. (2006) Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell 124, 1183-1195
32. Hirano, S., Kawasaki, M., Ura, H., Kato, R., Raiborg, C., Stenmark, H. and Wakatsuki, S. (2006) Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting. Nat. Struct. Mol. Biol. 13, 272-277
33. Hofmann, K. and Bucher, P. (1996) The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. Trends Biochem. Sci. 21, 172-173
34. Dieckmann, T., Withers-Ward, E. S., Jarosinski, M. A., Liu, C. F., Chen, I. S. Y. and Feigon, J. (1998) Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr. Nat. Struct. Biol. 5, 1042-1047
35. Withers-Ward, E. S., Mueller, T. D., Chen, I. S. Y. and Feigon, J. (2000) Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr. Biochemistry 39, 14103-14112
36. Mueller, T. D. and Feigon, J. (2002) Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions. J. Mol. Biol. 319, 1243-1255
37. Wilkinson, C. R. M., Seeger, M., Hartmann-Petersen, R., Stone, M., Wallace, M., Semple, C. and Gordon, C. (2001) Proteins containing the UBA domain are able to bind to multi-ubiquitin chains. Nat. Cell Biol. 3, 939-943
38. Funakoshi, M., Sasaki, T., Nishimoto, T. and Kobayashi, H. (2002) Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome. Proc. Natl. Acad. Sci. U.S.A. 99, 745-750
39. Raasi, S. and Pickart, C. M. (2003) Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains. J. Biol. Chem. 278, 8951-8959
40. Vadlamudi, R. K., Joung, I., Strominger, J. L. and Shin, J. (1996) p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding protiens. J. Biol. Chem. 271, 20235-20237
41. Bertolaet, B. L., Clarke, D. J., Wolff, M., Watson, M. H., Henze, M., Divita, G. and Reed, S. I. (2001) UBA domains of DNA damage-inducible proteins interact with ubiquitin. Nat. Struct. Biol. 8, 417-422
42. Chen, L., Shinde, U., Ortolan, T. G. and Madura, K. (2001) Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly. EMBO Rep. 2, 933-938
43. Bertolaet, B. L., Clarke, D. J., Wolff, M., Watson, M. H., Henze, M., Divita, G. and Reed, S. I. (2001) UBA domains mediate protein-protein interactions between two DNA damage-inducible proteins. J. Mol. Biol. 313, 955-963
44. Wang, Q. H., Goh, A. M., Howley, P. M. and Walters, K. J. (2003) Ubiquitin recognition by the DNA repair protein hHR23a. Biochemistry 42, 13529-13535
45. Mueller, T. D., Kamionka, M. and Feigon, J. (2004) Specificity of the interaction between ubiquitin-associated domains and ubiquitin. J. Biol. Chem. 279, 11926-11936
46. Yuan, X. M., Simpson, P., McKeown, C., Kondo, H., Uchiyama, K., Wallis, R., Dreveny, I., Keetch, C., Zhang, X. D., Robinson, C. et al. (2004) Structure, dynamics and interactions of p47, a major adaptor of the AAA ATPase, p97. EMBO J. 23, 1463-1473
47. Ohno, A., Jee, J., Fujiwara, K., Tenno, T., Goda, N., Tochio, H., Kobayashi, H., Hiroaki, H. and Shirakawa, M. (2005) Structure of the UBA domain of Dsk2p in complex with ubiquitin: molecular determinants for ubiquitin recognition. Structure 13, 521-532
48. Varadan, R., Assfalg, M., Raasi, S., Pickart, C. and Fushman, D. (2005) Structural determinants for selective recognition of a lys48-linked polyubiquitin chain by a UBA domain. Mol. Cell 18, 687-698
49. Swanson, K. A., Hicke, L. and Radhakrishnan, I. (2006) Structural basis for monoubiquitin recognition by the Ede1 UBA domain. J. Mol. Biol. 358, 713-724
50. Chang, Y. G., Song, A. X., Gao, Y. G., Shi, Y. H., Lin, X. J., Cao, X. T., Lin, D. H. and Hu, H. Y. (2006) Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin. Prot. Sci. 15, 1248-1259
51. Lowe, E. D., Hasan, N., Trempe, J. F., Fonso, L., Noble, M. E. M., Endicott, J. A., Johnson, L. N. and Brown, N. R. (2006) Structures of the Dsk2 UBL and UBA domains and their complex. Acta Crystallogr, Sect. D: Biol. Crystallogr. 62, 177-188
52. Prag, G., Misra, S., Jones, E. A., Ghirlando, R., Davies, B. A., Horazdovsky, B. F. and Hurley, J. H. (2003) Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell 113, 609-620
53. Kang, R. S., Daniels, C. M., Francis, S. A., Shih, S. C., Salerno, W. J., Hicke, L. and Radhakrishnan, I. (2003) Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Cell 113, 621-630
54. Raasi, S., Varadan, R., Fushman, D. and Pickart, C. M. (2005) Diverse polyubiquitin interaction properties of ubiquitin-associated domains. Nat. Struct. Mol. Biol. 12, 708-714
55. Trempe, J. F., Brown, N. R., Lowe, E. D., Gordon, C., Campbell, I. D., Noble, M. E. M. and Endicott, J. A. (2005) Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain. EMBO J. 24, 3178-3189
56. Varadan, R., Walker, O., Pickart, C. and Fushman, D. (2002) Structural properties of polyubiquitin chains in solution. J. Mol. Biol. 324, 637-647
57. 63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling. J. Biol. Chem. 279, 7055-7063
58. Ponting, C. P. (2000) Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction. Biochem. J. 351, 527-535
59. Donaldson, K. M., Yin, H. W., Gekakis, N., Supek, F. and Joazeiro, C. A. P. (2003) Ubiquitin signals protein trafficking via interaction with a novel ubiquitin binding domain in the membrane fusion regulator, Vps9p. Curr. Biol. 13, 258-262
60. Shih, S. C., Prag, G., Francis, S. A., Sutanto, M. A., Hurley, J. H. and Hicke, L. (2003) A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. EMBO J. 22, 1273-1281
61. Davies, B. A., Topp, J. D., Sfeir, A. J., Katzmann, D. J., Carney, D. S., Tall, G. G., Friedberg, A. S., Deng, L., Chen, Z. J. and Horazdovsky, B. F. (2003) Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic. J. Biol. Chem. 278, 19826-19833
62. Puertollano, R. and Bonifacino, J. S. (2004) Interactions of GGA3 with the ubiquitin sorting machinery. Nat. Cell Biol. 6, 244-251
63. Scott, P. M., Bilodeau, P. S., Zhdankina, O., Winistorfer, S. C., Hauglund, M. J., Allaman, M. M., Kearney, W. R., Robertson, A. D., Boman, A. L. and Piper, R. C. (2004) GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network. Nat. Cell Biol. 6, 252-259
64. Collins, B. M., Watson, P. J. and Owen, D. J. (2003) The structure of the GGA1-GAT domain reveals the molecular basis for ARF binding and membrane association of GGAs. Dev. Cell 4, 321-332
65. Suer, S., Misra, S., Saidi, L. F. and Hurley, J. H. (2003) Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor. Proc. Natl. Acad. Sci. U.S.A. 100, 4451-4456
66. Zhu, G. Y., Zhai, P., He, X. Y., Terzyan, S., Zhang, R. G., Joachimiak, A., Tang, J. and Zhang, X. J. C. (2003) Crystal structure of the human GGA1 GAT domain. Biochemistry 42, 6392-6399
67. Shiba, T., Kawasaki, M., Takatsu, H., Nogi, T., Matsugaki, N., Igarashi, N., Suzuki, M., Kato, R., Nakayama, K. and Wakatsuki, S. (2003) Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport. Nat. Struct. Biol. 10, 386-393
68. Shiba, Y., Katoh, Y., Shiba, T., Wakatsuki, S. and Nakayama, K. (2004) GAT (GGA and Tom1) domain responsible for ubiquitin binding and ubiquitination. Mol. Biol. Cell 15, 314A-314A
69. Mattera, R., Puertollano, R., Smith, W. J. and Bonifacino, J. S. (2004) The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites. J. Biol. Chem. 279, 31409-31418
70. Bilodeau, P. S., Winistorfer, S. C., Allaman, M. M., Surendhran, K., Kearney, W. R., Robertson, A. D. and Piper, R. C. (2004) The GAT domains of clathrin-associated GGA proteins have two ubiquitin binding motifs. J. Biol. Chem. 279, 54808-54816
71. Katoh, Y., Shiba, Y., Mitsuhashi, H., Yanagida, Y., Takatsu, H. and Nakayama, K. (2004) Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes. J. Biol. Chem. 279, 24435-24443
72. Prag, G., Lee, S. H., Mattera, R., Arighi, C. N., Beach, B. M., Bonifacino, J. S. and Hurley, J. H. (2005) Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins. Proc. Natl. Acad. Sci. U.S.A. 102, 2334-2339
73. Kawasaki, M., Shiba, T., Shiba, Y., Yamaguchi, Y., Matsugaki, N., Igarashi, N., Suzuki, M., Kato, R., Kato, K., Nakayama, K. and Wakatsuki, S. (2005) Molecular mechanism of ubiquitin recognition by GGA3 GAT domain. Genes Cells 10, 639-654
74. Akutsu, M., Kawasaki, M., Katoh, Y., Shiba, T., Yamaguchi, Y., Kato, R., Kato, K., Nakayama, K. and Wakatsuki, S. (2005) Structural basis for recognition of ubiquitinated cargo by Tom1-GAT domain. FEBS Lett. 579, 5385-5391
75. Meyer, H. H., Wang, Y. Z. and Warren, G. (2002) Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4. EMBO J. 21, 5645-5652
76. Wertz, I. E., O'Rourke, K. M., Zhou, H. L., Eby, M., Aravind, L., Seshagiri, S., Wu, P., Wiesmann, C., Baker, R., Boone, D. L. et al. (2004) De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappa B signalling. Nature 430, 694-699
77. Hook, S. S., Orian, A., Cowley, S. M. and Eisenman, R. N. (2002) Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc. Natl. Acad. Sci. U.S.A. 99, 13425-13430
78. Seigneurin-Berny, D., Verdel, A., Curtet, S., Lemercier, C., Garin, J., Rousseaux, S. and Khochbin, S. (2001) Identification of components of the murine histone deacetylase 6 complex: Link between acetylation and ubiquitination signaling pathways. Mol. Cell. Biol. 21, 8035-8044
79. Alam, S. L., Sun, J., Payne, M., Welch, B. D., Black, B. K., Davis, D. R., Meyer, H. H., Emr, S. D. and Sundquist, W. I. (2004) Ubiquitin interactions of NZF zinc fingers. EMBO J. 23, 1411-1421
80. Wang, B., Alam, S. L., Meyer, H. H., Payne, M., Stemmler, T. L. Davis, D. R. and Sundquist, W. I. (2003) Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J. Biol. Chem. 278, 20225-20234
81. Mattera, R., Tsai, Y. C., Weissman, A. M. and Bonifacino, J. S. (2006) The Rab5 guanine nucleotide exchange factor Rabex-5 binds ubiquitin (Ub) and functions as a Ub ligase through an atypical Ub-interacting motif and a zinc finger domain. J. Biol. Chem. 281, 6874-6883
82. Reyes-Turcu, F. E., Horton, J. R., Mullally, J. E., Heroux, A., Cheng, X. D. and Wilkinson, K. D. (2006) The ubiquitin binding domain ZnFUBP recognizes the C-terminal diglycine motif of unanchored ubiquitin. Cell 124, 1197-1208
83. Bienko, M., Green, C. M., Crosetto, N., Rudolf, F., Zapart, G., Coull, B., Kannouche, P., Wider, G., Peter, M., Lehmann, A. R., Hofmann, K. and Dikic, I. (2005) Ubiquitin-binding domains in Y-family polymerases regulate transtesion synthesis. Science 310, 1821-1824
84. McKenna, S., Hu, J., Moraes, T., Xiao, W., Ellison, M. J. and Spyracopoulos, L. (2003) Energetics and specificity of interactions within Ub · Uev · Ubc13 human ubiquitin conjugation complexes. Biochemistry 42, 7922-7930
85. McKenna, S., Spyracopoulos, L., Moraes, T., Pastushok, L., Ptak, C., Xiao, W. and Ellison, M. J. (2001) Noncovalent interaction between ubiquitin and the human DNA repair protein mms2 is required for ubc13-mediated polyubiquitination, J. Biol. Chem. 276, 40120-40126
86. McKenna, S., Moraes, T., Pastushok, L., Ptak, C., Xiao, W., Spyracopoulos, L. and Ellison, M. J. (2003) An NMR-based model of the ubiquitin-bound human ubiquitin conjugation complex Mms2-Ubc13 - the structural basis for lysine 63 chain catalysis. J. Biol. Chem. 278, 13151-13158
87. Garrus, J. E., von Schwedler, U. K., Pornillos, O. W., Morham, S. G., Zavitz, K. H., Wang, H. E., Wettstein, D. A., Stray, K. M., Cote, M., Rich, R. L. et al. (2001) Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell 107, 55-65
88. Teo, H., Veprintsev, D. B. and Williams, R. L. (2004) Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins. J. Biol. Chem. 279, 28689-28696
89. Sundquist, W. I., Schubert, H. L., Kelly, B. N., Hill, G. C., Holton, J. M. and Hill, C. P. (2004) Ubiquitin recognition by the human TSG101 protein. Mol. Cell 13, 783-789
90. Brzovic, P. S., Lissounov, A., Christensen, D. E., Hoyt, D. W. and Klevit, R. E. (2006) A UbcH5/ubiquitin noncovalent complex is required for processive BRCA1-directed ubiquitination. Mol. Cell 21, 873-880
91. Slagsvold, T., Aasland, R., Hirano, S., Bache, K. G., Raiborg, C., Trambaiano, D., Wakatsuki, S. and Stenmark, H. (2005) Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. J. Biol. Chem. 280, 19600-19606
92. Teo, H., Gill, D. J., Sun, J., Perisic, O., Veprintsev, D. B., Vallis, Y., Emr, S. D. and Williams, R. L. (2006) ESCRT-I core and ESCRT-II GLUE domain structure reveal role for GLUE in linking to ESCRT-I and membranes. Cell 125, 99-111
93. Cope, G. A., Suh, G. S. B., Aravind, L., Schwarz, S. E., Zipursky, S. L., Koonin, E. V. and Deshaies, R. J. (2002) Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science 298, 608-611
94. Verma, R., Aravind, L., Oania, R., McDonald, W. H., Yates, J. R., Koonin, E. V. and Deshaies, R. J. (2002) Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26 S proteasome, Science 298, 611-615
95. Yao, T. T. and Cohen, R. E. (2002) A cryptic protease couples deubiquitination and degradation by the proteasome. Nature 419, 403-407
96. Bellare, P., Kutach, A. K., Rines, A. K., Guthrie, C. and Sontheimer, E. J. (2006) Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA 12, 292-302
97. Mullally, J. E., Chernova, T. and Wilkinson, K. D. (2006) Doa1 is a Cdc48 adapter that possesses a novel ubiquitin binding domain. Mol. Cell. Biol. 26, 822-830
98. Hicke, L. (2001) Protein regulation by monoubiquitin. Nat. Rev. Mol. Cell Biol. 2, 195-201
99. Haglund, K., Sigismund, S., Polo, S., Szymkiewicz, I., Di Fiore, P. P. and Dikic, I. (2003) Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat. Cell Biol. 5, 461-466
100. Mosesson, Y., Shtiegman, K., Katz, M., Zwang, Y., Vereb, G., Szollosi, J. and Yarden, Y. (2003) Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation. J. Biol. Chem. 278, 21323-21326
101. Huang, F. T., Kirkpatrick, D., Jiang, X. J., Gygi, S. and Sorkin, A. (2006) Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. Mol. Cell 21, 737-748
102. Barriere, H., Nemes, C., Lechardeur, D., Khan-Mohammad, M., Fruh, K. and Lukacs, G. L. (2006) Molecular basis of oligoubiquitin-dependent internalization of membrane proteins in mammalian cells. Traffic 7, 282-297
103. Hawryluk, M. J., Keyel, P. A., Mishra, S. K., Watkins, S. C., Heuser, J. E. and Traub, L. M. (2006) Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic 7, 262-281
104. Alam, S. L. and Sundquist, W. I. (2006) Two new structures of Ub-receptor complexes. U2. Nat. Struct. Mol. Biol. 13, 186-188
105. Hurley, J. H. and Emr, S. D. (2006) The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Ann. Rev. Biophys. Biomol. Struct. 35, 277-298
106. Bonifacino, J. S. and Traub, L. M. (2003) Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu. Rev. Biochem. 72, 395-447
107. Hoeller, D., Crosetto, N., Blagoev, B., Raiborg, C., Tikkanen, R., Wagner, S., Kowanetz, K., Breitling, R., Mann, M., Stenmark, H. and Dikic, I. (2006) Regulation of ubiquitin-binding proteins by monoubiquitination. Nat. Cell Biol. 8, 163-U145
108. Panneerselvam, S., Marx, A., Mandelkow, E. M. and Mandelkow, E. (2006) Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1. Structure 14, 173-183
109. Reverter, D. and Lima, C. D. (2005) Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex. Nature 435, 687-692
110. Haglund, K., Di Fiore, P. P. and Dikic, I. (2003) Distinct monoubiquitin signals in receptor endocytosis. Trends Biochem. Sci. 28, 598-603