Linear ubiquitination: A newly discovered regulator of cell signalling

Trends in Biochemical Sciences

Volumn 38, Issue 2, 2013, Pages 94-102

  Rieser, Eva ^a,b   Cordier, Stefanie M ^b   Walczak, Henning ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

HOIL 1; HOIP; Linear ubiquitination; LUBAC; RBR E3 ligases; SHARPIN; TNFsignalling

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYSTEINE; IRON REGULATORY FACTOR; LYSINE; METHIONINE; RING FINGER PROTEIN; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; ENZYME SPECIFICITY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN TARGETING; REVIEW; UBIQUITINATION;

ANIMALS; HUMANS; LYSINE; METHIONINE; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITINATION;

EID: 84872820481     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2012.11.007     Document Type: Review

References (64)

1. Haglund K., Dikic I. Ubiquitylation and cell signaling. EMBO J. 2005, 24:3353-3359.
2. Hershko A., Ciechanover A. The ubiquitin system. Annu. Rev. Biochem. 1998, 67:425-479.
3. Hershko A., et al. Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J. Biol. Chem. 1983, 258:8206-8214.
4. Pickart C.M., Eddins M.J. Ubiquitin: structures, functions, mechanisms. Biochim. Biophys. Acta 2004, 1695:55-72.
5. Komander D., Rape M. The ubiquitin code. Annu. Rev. Biochem. 2012, 81:203-229.
6. Cook W.J., et al. Structure of tetraubiquitin shows how multiubiquitin chains can be formed. J. Mol. Biol. 1994, 236:601-609.
7. Varadan R., et al. Structural properties of polyubiquitin chains in solution. J. Mol. Biol. 2002, 324:637-647.
8. Husnjak K., et al. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 2008, 453:481-488.
9. Meierhofer D., et al. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. J. Proteome Res. 2008, 7:4566-4576.
10. Xu P., et al. Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell 2009, 137:133-145.
11. Chau V., et al. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 1989, 243:1576-1583.
12. Komander D., et al. Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep. 2009, 10:466-473.
13. Ye Y., Rape M. Building ubiquitin chains: E2 enzymes at work. Nat. Rev. Mol. Cell Biol. 2009, 10:755-764.
14. Kim H.T., et al. Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J. Biol. Chem. 2007, 282:17375-17386.
15. Ardley H.C., Robinson P.A. E3 ubiquitin ligases. Essays Biochem. 2005, 41:15-30.
16. Christensen D.E., Klevit R.E. Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination. FEBS J. 2009, 276:5381-5389.
17. Plechanovova A., et al. Mechanism of ubiquitylation by dimeric RING ligase RNF4. Nat. Struct. Mol. Biol. 2011, 18:1052-1059.
18. Wenzel D.M., Klevit R.E. Following Ariadne's thread: a new perspective on RBR ubiquitin ligases. BMC Biol. 2012, 10:24.
19. Wenzel D.M., et al. UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. Nature 2011, 474:105-108.
20. Kirisako T., et al. A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J. 2006, 25:4877-4887.
21. Gerlach B., et al. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 2011, 471:591-596.
22. Ikeda F., et al. SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Nature 2011, 471:637-641.
23. Tokunaga F., et al. SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. Nature 2011, 471:633-636.
24. Haas T.L., et al. Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol. Cell 2009, 36:831-844.
25. Tokunaga F., et al. Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat. Cell Biol. 2009, 11:123-132.
26. Stieglitz B., et al. Structural analysis of SHARPIN, a subunit of a large multi-protein E3 ubiquitin ligase, reveals a novel dimerization function for the pleckstrin homology superfold. J. Biol. Chem. 2012, 287:20823-20829.
27. Chaugule V.K., et al. Autoregulation of Parkin activity through its ubiquitin-like domain. EMBO J. 2011, 30:2853-2867.
28. Stieglitz B., et al. LUBAC synthesizes linear ubiquitin chains via a thioester intermediate. EMBO Rep. 2012, 13:840-846.
29. Inn K.S., et al. Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction. Mol. Cell 2011, 41:354-365.
30. Zak D.E., et al. Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:11536-11541.
31. Damgaard R.B., et al. The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. Mol. Cell 2012, 46:746-758.
32. Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003, 114:181-190.
33. Hsu H., et al. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 1996, 4:387-396.
34. Hsu H., et al. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996, 84:299-308.
35. Hsu H., et al. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 1995, 81:495-504.
36. Tsao D.H., et al. Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway. Mol. Cell 2000, 5:1051-1057.
37. Vince J.E., et al. TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis. J. Biol. Chem. 2009, 284:35906-35915.
38. Rothe M., et al. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995, 83:1243-1252.
39. Shu H.B., et al. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:13973-13978.
40. Ea C.K., et al. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 2006, 22:245-257.
41. Wu C.J., et al. Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat. Cell Biol. 2006, 8:398-406.
42. Xu M., et al. A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol. Cell 2009, 36:302-314.
43. Dynek J.N., et al. c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J. 2010, 29:4198-4209.
44. Walczak H. TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer. Immunol. Rev. 2011, 244:9-28.
45. Ivins F.J., et al. NEMO oligomerization and its ubiquitin-binding properties. Biochem. J. 2009, 421:243-251.
46. Lo Y.C., et al. Structural basis for recognition of diubiquitins by NEMO. Mol. Cell 2009, 33:602-615.
47. Rahighi S., et al. Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell 2009, 136:1098-1109.
48. Kensche T., et al. Analysis of NF-kappaB essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-kappaB. J. Biol. Chem. 2012, 287:23626-23634.
49. Micheau O., et al. NF-kappaB signals induce the expression of c-FLIP. Mol. Cell. Biol. 2001, 21:5299-5305.
50. Wang C.Y., et al. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998, 281:1680-1683.
51. Van Herreweghe F., et al. Tumor necrosis factor-mediated cell death: to break or to burst, that's the question. Cell. Mol. Life Sci. 2010, 67:1567-1579.
52. Vandenabeele P., et al. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 2010, 11:700-714.
53. Seymour R.E., et al. Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis. Genes Immun. 2007, 8:416-421.
54. Gijbels M.J., et al. Maintenance of donor phenotype after full-thickness skin transplantation from mice with chronic proliferative dermatitis (cpdm/cpdm) to C57BL/Ka and nude mice and vice versa. J. Invest. Dermatol. 1995, 105:769-773.
55. HogenEsch H., et al. A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice. Am. J. Pathol. 1993, 143:972-982.
56. Brennan F.M., Feldmann M. Cytokines in autoimmunity. Curr. Opin. Immunol. 1996, 8:872-877.
57. Feldmann M., et al. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 1996, 14:397-440.
58. Mazza J., et al. Innovative uses of tumor necrosis factor alpha inhibitors. Dermatol. Clin. 2010, 28:559-575.
59. Taylor P.C., Feldmann M. Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat. Rev. Rheumatol. 2009, 5:578-582.
60. Prakash S., et al. Substrate selection by the proteasome during degradation of protein complexes. Nat. Chem. Biol. 2009, 5:29-36.
61. Thrower J.S., et al. Recognition of the polyubiquitin proteolytic signal. EMBO J. 2000, 19:94-102.
62. Zhao S., Ulrich H.D. Distinct consequences of posttranslational modification by linear versus K63-linked polyubiquitin chains. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:7704-7709.
63. Niu J., et al. LUBAC regulates NF-kappaB activation upon genotoxic stress by promoting linear ubiquitination of NEMO. EMBO J. 2011, 30:3741-3753.
64. van Wijk S.J., et al. Fluorescence-based sensors to monitor localization and functions of linear and k63-linked ubiquitin chains in cells. Mol. Cell 2012, 47:797-809.