The NEDD8 conjugation pathway regulates p53 transcriptional activity and head and neck cancer cell sensitivity to ionizing radiation

International Journal of Oncology

Volumn 41, Issue 4, 2012, Pages 1531-1540

  Guihard, Sébastien ^a   Ramolu, Ludivine ^a   Macabre, Christine ^a   Wasylyk, Bohdan ^b   Noël, Georges ^a   Abecassis, Joseph ^a   Jung, Alain C ^a  

^a CENTRE PAUL STRAUSS   (France)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Head and neck cancer; Human papillomavirus; NEDDylation; p53; Radiosensitivity

Indexed keywords

NEDD8 PROTEIN; PROTEIN P53;

ARTICLE; CANCER CELL; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIVITY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING; WILD TYPE; X RAY;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMAN PAPILLOMAVIRUS 16; HUMANS; RADIATION TOLERANCE; RADIATION, IONIZING; RADIATION-SENSITIZING AGENTS; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINS;

EID: 84866493830     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1584     Document Type: Article

References (29)

1. Leemans CR, Braakhuis BJ and Brakenhoff RH: The molecular biology of head and neck cancer. Nat Rev Cancer 11: 9-22, 2011.
2. Butz K, Whitaker N, Denk C, Ullmann A, Geisen C and Hoppe-Seyler F: Induction of the p53-target gene GADD45 in HPV-positive cancer cells. Oncogene 18: 2381-2386, 1999.
3. Jung AC, Briolat J, Millon R, et al: Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. Int J Cancer 126: 1882-1894, 2010.
4. Klussmann JP, Mooren JJ, Lehnen M, et al: Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications. Clin Cancer Res 15: 1779-1786, 2009.
5. Gong L and Yeh ET: Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. J Biol Chem 274: 12036-12042, 1999.
6. Osaka F, Kawasaki H, Aida N, et al: A new NEDD8-ligating system for cullin-4A. Genes Dev 12: 2263-2268, 1998.
7. Petroski MD and Deshaies RJ: Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 6: 9-20, 2005.
8. Xirodimas DP, Saville MK, Bourdon JC, Hay RT and Lane DP: Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 118: 83-97, 2004.
9. Ragin CC, Reshmi SC and Gollin SM: Mapping and analysis of HPV16 integration sites in a head and neck cancer cell line. Int J Cancer 110: 701-709, 2004.
10. Maalouf M, Alphonse G, Colliaux A, et al: Different mechanisms of cell death in radiosensitive and radioresistant p53 mutated head and neck squamous cell carcinoma cell lines exposed to carbon ions and x-rays. Int J Radiat Oncol Biol Phys 74: 200-209, 2009.
11. Gupta AK, Lee JH, Wilke WW, et al: Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT. Int J Radiat Oncol Biol Phys 74: 928-933, 2009.
12. Chen Y, McPhie DL, Hirschberg J and Neve RL: The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. J Biol Chem 275: 8929-8935, 2000.
13. de Boer MA, Jordanova ES, Kenter GG, et al: High human papillomavirus oncogene mRNA expression and not viral DNA load is associated with poor prognosis in cervical cancer patients. Clin Cancer Res 13: 132-138, 2007.
14. Garrison SP, Jeffers JR, Yang C, et al: Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis. Mol Cell Biol 28: 5391-5402, 2008.
15. Franken NA, Rodermond HM, Stap J, Haveman J and van Bree C: Clonogenic assay of cells in vitro. Nat Protoc 1: 2315-2319, 2006.
16. Abramoff MD, Magelhaes PJ and Ram SJ: Image processing with ImageJ. Biophotonics Int 11: 36-42, 2004.
17. Rasband WS: ImageJ. National Institutes of Health, Bethesda, MA. http://rsb.info.nih.gov/ij/, 1997-2008.
18. Kozarsky KF, McKinley DR, Austin LL, Raper SE, Stratford-Perricaudet LD and Wilson JM: In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J Biol Chem 269: 13695-13702, 1994.
19. Lassen P: The role of Human papillomavirus in head and neck cancer and the impact on radiotherapy outcome. Radiother Oncol 95: 371-380, 2010.
20. Abida WM, Nikolaev A, Zhao W, Zhang W and Gu W: FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity. J Biol Chem 282: 1797-1804, 2007.
21. Kim HJ, Kim SH, Shim SO, et al: Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development. Cell Death Differ 14: 103-115, 2007.
22. Nakayama KI and Nakayama K: Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 6: 369-381, 2006.
23. Jia L, Yang J, Hao X, et al: Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing target. Clin Cancer Res 16: 814-824, 2010.
24. Watson IR, Blanch A, Lin DC, Ohh M and Irwin MS: Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function. J Biol Chem 281: 34096-34103, 2006.
25. Quiet CA, Weichselbaum RR and Grdina DJ: Variation in radiation sensitivity during the cell cycle of two human squamous cell carcinomas. Int J Radiat Oncol Biol Phys 20: 733-738, 1991.
26. Tell R, Heiden T, Granath F, Borg AL, Skog S and Lewensohn R: Comparison between radiation-induced cell cycle delay in lymphocytes and radiotherapy response in head and neck cancer. Br J Cancer 77: 643-649, 1998.
27. Milhollen MA, Traore T, Adams-Duffy J, et al: MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κBdependent lymphoma. Blood 116: 1515-1523, 2010.
28. Soucy TA, Smith PG, Milhollen MA, et al: An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature 458: 732-736, 2009.
29. Ang KK, Harris J, Wheeler R, et al: Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 363: 24-35, 2010.