Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

Science

Volumn 300, Issue 5625, 2003, Pages 1542-1548

  Zou, Lee ^a   Elledge, Stephen J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS; SIGNALING;

REPLICATION STRESS;

DNA;

ATM PROTEIN; BINDING PROTEIN; PROTEIN KINASE; PROTEIN KINASE ATRIP; PROTEIN RAD17; REPLICATION PROTEIN A; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

BIOCHEMISTRY; GENETICS;

ARTICLE; DNA DAMAGE; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

CELL CYCLE PROTEINS; CELL NUCLEUS; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DNA, FUNGAL; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; EXODEOXYRIBONUCLEASES; HELA CELLS; HUMANS; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION, IONIZING; RECOMBINATION, GENETIC; REPLICATION PROTEIN A; RNA, SMALL INTERFERING; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

ATAXIA; SACCHAROMYCETALES;

EID: 0037567268     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083430     Document Type: Article

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39. We thank P. Sung and S. Kowalczykowski for the purified human and yeast RPA used in some experiments; D. Toczyski, R. Kolodner, D. Cortez, S. Brill, J. Hurwitz, H. Rao, and E. Friedberg for reagents; D. Liu for technical assistance. L.Z. is a Fayez Sarofim fellow of the Damon Runyon Cancer Research Fund. S.J.E. is funded by NIH (grant no. GM44664) and is an investigator with the Howard Hughes Medical Institute and the Welch Professor of Biochemistry.