Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Nature

Volumn 434, Issue 7035, 2005, Pages 917-921

  Farmer, Hannah ^a   McCabe, Huala ^a   Lord, Christopher J ^a   Tutt, Andrew H J ^a,b   Johnson, Damian A ^a   Richardson, Tobias B ^a   Santarosa, Manuela ^a,e   Dillon, Krystyna J ^c   Hickson, Ian ^c   Knights, Charlotte ^c   Martin, Niall M B ^c   Jackson, Stephen P ^c,d   Smith, Graeme C M ^c   Ashworth, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b GUY S HOSPITAL   (United Kingdom)

^c KuDOS Pharmaceuticals Ltd   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CHROMOSOMES; ENZYME INHIBITION; ENZYMES; ONCOLOGY; PATIENT TREATMENT; TOXICITY; TUMORS;

CHROMOSOMAL INSTABILITY; DNA REPAIR; MUTANT CELLS; POLYMERASE;

DNA;

ANTINEOPLASTIC AGENT; BRCA1 PROTEIN; BRCA2 PROTEIN; DOUBLE STRANDED DNA; KU 0058684; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

BIOCHEMISTRY; BIOLOGY; MEDICINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER; CANCER MODEL; CELL CYCLE; CHROMOSOMAL INSTABILITY; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; DRUG EFFICACY; EMBRYONIC STEM CELL; ENZYME ACTIVITY; EXCISION REPAIR; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN DEFECT; TUMOR SUPPRESSOR GENE; ANIMAL; BIOLOGICAL MODEL; CELL SURVIVAL; DNA DAMAGE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION; NEOPLASM; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; GENES, BRCA1; GENES, BRCA2; MICE; MICE, NUDE; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; POLY(ADP-RIBOSE) POLYMERASES; SUBSTRATE SPECIFICITY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 17244373777     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03445     Document Type: Article

References (23)

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