Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress

Molecular Cell

Volumn 23, Issue 3, 2006, Pages 307-318

  Mailand, Niels ^a   Bekker Jensen, Simon ^a   Bartek, Jiri ^a   Lukas, Jiri ^a  

^a DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

Author keywords

CELLCYCLE; DNA; PROTEINS

Indexed keywords

ADAPTOR PROTEIN; CHECKPOINT KINASE 1; CLASPIN; MUTANT PROTEIN; POLO LIKE KINASE 1; PROTEIN SERINE THREONINE KINASE; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE SCF; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CLSPN PROTEIN, HUMAN; CYCLIN A; DOXORUBICIN; NUCLEAR PROTEIN; PROTEIN KINASE; PROTEIN TYROSINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; UBIQUITIN; WEE1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE REGULATION; CELL DIVISION; CONTROLLED STUDY; DNA DAMAGE; EMBRYO; ENZYME ACTIVITY; GENOTOXICITY; HUMAN; HUMAN CELL; MITOSIS; MOLECULAR RECOGNITION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; AMINO ACID SEQUENCE; BINDING SITE; BIOLOGICAL MODEL; CELL CULTURE; CELL CYCLE; CELL LINE; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BINDING SITES; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; CYCLIN A; DNA DAMAGE; DOXORUBICIN; FIBROBLASTS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-TYROSINE KINASES; RNA, SMALL INTERFERING; SEQUENCE HOMOLOGY, AMINO ACID; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSFECTION; UBIQUITIN;

EID: 33746429958     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2006.06.016     Document Type: Article

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