Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

Annual Review of Biochemistry

Volumn 73, Issue , 2004, Pages 39-85

  Sancar, Aziz ^a   Lindsey Boltz, Laura A ^a   Ünsal Kaçmaz, Keziban ^a   Linn, Stuart ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Damage recognition; Excision repair; PIKK family; Rad17 RFC 9 1 1 complex; Signal transduction

Indexed keywords

ATM PROTEIN; DNA; PROTEIN RAD1; PROTEIN RAD9;

APOPTOSIS; CANCER; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL REGENERATION; CHROMOSOME REPLICATION; DNA CROSS LINKING; DNA DAMAGE; DNA EXTRACTION; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; DNA STRUCTURE; EXCISION REPAIR; HOMOLOGOUS RECOMBINATION; HUMAN; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW;

ANIMALS; CELL CYCLE; CROSS-LINKING REAGENTS; DNA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; HUMANS; MODELS, BIOLOGICAL; PHOTOBIOLOGY; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 3943107573     PISSN: 00664154     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.biochem.73.011303.073723     Document Type: Review

References (275)

1. Zhou BB, Elledge SJ. 2000. Nature 408: 433-39
2. Kolodner RD, Putnam CD, Myung K. 2002. Science 297:552-57
3. Modrich P, Lahue R. 1996. Annu. Rev. Biochem. 65:101-33
4. Kolodner RD, Marsischky GT. 1999. Curr. Opin. Genet. Dev. 9:89-96
5. Cox MM, Goodman MF, Kreuzer KN, Sherratt DJ, Sandler SJ, Marians KJ. 2000. Nature 404:37-41
6. Cox MM. 2002. Mutat. Res. 510:107-20
7. Minko IG, Zou Y, Lloyd RS. 2002. Proc. Natl Acad. Sci. USA 99:1905-9
8. Sancar A. 1994. Biochemistry 33:2-9
9. Deisenhofer J. 2000. Mutat. Res. 460:143-49
10. Todo T. 1999. Mutat. Res. 434:89-97
11. Sancar A. 2003. Chem. Rev. 103:2203-38
12. Park H, Zhang KJ, Ren YJ, Nadji S, Sinha N, et al. 2002. Proc. Natl. Acad. Sci. USA 99:15965-70
13. Orren DK, Selby CP, Hearst JE, Sancar A. 1992. J. Biol. Chem. 267:780-88
14. Sancar A, Hearst JE. 1993. Science 259: 1415-20
15. Johnson PF, McKnight SL. 1989. Annu. Rev. Biochem. 58:799-839
16. Chen L. 1999. Curr. Opin. Struct. Biol. 9:48-55
17. Naar AM, Lemon BD, Tjian R. 2001. Annu. Rev. Biochem. 70:475-501
18. Sancar A, Franklin KA, Sancar GB. 1984. Proc. Natl. Acad. Sci. USA 81:7397-401
19. Tornaletti S, Hanawalt PC. 1999. Biochimie 81:139-46
20. Friedberg EC. 1996. Annu. Rev. Biochem. 65:15-42
21. Selby CP, Sancar A. 1993. Science 260: 53-58
22. Mellon I, Spivak G, Hanawalt PC. 1987. Cell 51:241-49
23. Mellon I, Hanawalt PC. 1989. Nature 342:95-98
24. Cox MM. 2001. Annu. Rev. Genet. 35:53-82
25. Zhou J, Ahn J, Wilson SH, Prives C. 2001. EMBO J. 20:914-23
26. Todo T, Takemori H, Ryo H, Ihara M, Matsunaga T, et al. 1993. Nature 361:371-74
27. Sancar A. 2000. Annu. Rev. Biochem. 69:31-67
28. Daniels DS, Tainer JA. 2000. Mutat. Res. 460:151-63
29. Lindahl T, Sedgwick B, Sekiguchi M, Nakabeppu Y. 1988. Annu. Rev. Biochem. 57:133-57
30. Kawate H, Sakumi K, Tsuzuki T, Nakatsuru Y, Ishikawa T, et al. 1998. Proc. Natl. Acad. Sci. USA 95:5116-20
31. Modrich P. 1997. J. Biol. Chem. 272: 24727-30
32. Fajardo-Cavazos P, Salazar C, Nicholson WL. 1993. J. Bacteriol. 175:1735-44
33. Koonin EV, Aravind L. 2001. J. Mol. Biol. 307:1271-92
34. Falnes PO, Johansen RF, Seeberg E. 2002. Nature 419:178-82
35. Trewick SC, Henshaw TF, Hausinger RP, Lindahl T, Sedgwick B. 2002. Nature 419:174-78
36. Aas PA, Otterlei M, Falnes PO, Vagbo CB, Skorpen F, et al. 2003. Nature 421:859-63
37. Wilson SH. 1998. Mutat. Res. 407:203-15
38. Memisoglu A, Samson L. 2000. Mutat. Res. 451:39-51
39. McCullough AK, Dodson ML, Lloyd RS. 1999. Annu. Rev. Biochem. 68:255-85
40. Mol CD, Parikh SS, Putnam CD, Lo TP, Tainer JA. 1999. Annu. Rev. Biophys. Biomol. Struct. 28:101-28
41. Matsumoto Y, Kim K. 1995. Science 269:699-702
42. Beard WA, Wilson SH. 2000. Mutat. Res. 460:231-44
43. Frosina G, Fortini P, Rossi O, Carrozzino F, Raspaglio G, et al. 1996. J. Biol. Chem. 271:9573-78
44. Klungland A, Lindahl T. 1997. EMBO J. 16:3341-48
45. Prasad R, Dianov GL, Bohr VA, Wilson SH. 2000. J. Biol. Chem. 275:4460-66
46. Roberts RJ, Cheng X. 1998. Annu. Rev. Biochem. 67:181-98
47. Berdal KG, Johansen RF, Seeberg E. 1998. EMBO J. 17:363-67
48. Sancar A. 1996. Annu. Rev. Biochem. 65:43-81
49. Petit C, Sancar A. 1999. Biochimie 81:15-25
50. Wood RD. 1997. J. Biol. Chem. 272: 23465-68
51. Wood RD. 1999. Biochimie 81:39-44
52. Travers AA. 1989. Annu. Rev. Biochem. 58:427-52
53. Mu D, Park CH, Matsunaga T, Hsu DS, Reardon JT, Sancar A. 1995. J. Biol. Chem. 270:2415-18
54. Mu D, Hsu DS, Sancar A. 1996. J. Biol. Chem. 271:8285-94
55. Evans E, Moggs JG, Hwang JR, Egly JM, Wood RD. 1997. EMBO J. 16:6559-73
56. Cleaver JE. 1968. Nature 218:652-56
57. Mu D, Wakasugi M, Hsu DS, Sancar A. 1997. J. Biol. Chem. 272:28971-79
58. Wakasugi M, Sancar A. 1998. Proc. Natl. Acad. Sci. USA 95:6669-74
59. Wakasugi M, Sancar A. 1999. J. Biol. Chem. 274:18759-68
60. He Z, Henricksen LA, Wold MS, Ingles CJ. 1995. Nature 374:566-69
61. Sugasawa K, Ng JM, Masutani C, Iwai S, van der Spek PJ, et al. 1998. Mol. Cell. 2:223-32
62. Sugasawa K, Okamoto T, Shimizu Y, Masutani C, Iwai S, Hanaoka F. 2001. Genes Dev. 15:507-21
63. Missura M, Buterin T, Hindges R, Hubscher U, Kasparkova J, et al. 2001. EMBO J. 20:3554-64
64. Reardon JT, Sancar A. 2003. Genes Dev. 17:2539-51
65. Ptashne M, Gann A. 2002. Genes and Signals. Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
66. Park CH, Mu D, Reardon JT, Sancar A. 1995. J. Biol. Chem. 270:4896-902
67. Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, et al. 1994. Nature 368:769-72
68. Egly JM. 2001. FEBS Lett. 498:124-28
69. Hopfield JJ. 1974. Proc. Natl. Acad. Sci. USA 71:4135-39
70. Hohl M, Thorel F, Clarkson SG, Scharer OD. 2003. J. Biol. Chem. 278:19500-8
71. Branum ME, Reardon JT, Sancar A. 2001. J. Biol. Chem. 276:25421-26
72. Bohr VA, Smith CA, Okumoto DS, Hanawalt PC. 1985. Cell 40:359-69
73. Venema J, Mullenders LH, Natarajan AT, van Zeeland AA, Mayne LV. 1990. Proc. Natl. Acad. Sci. USA 87:4707-11
74. Hanawalt PC. 2002. Oncogene 21: 8949-56
75. Selby CP, Witkin EM, Sancar A. 1991. Proc. Natl. Acad. Sci. USA 88:11574-78
76. Venema J, van Hoffen A, Natarajan AT, van Zeeland AA, Mullenders LH. 1990. Nucleic Acids Res. 18:443-48
77. Smerdon MJ, Conconi A. 1999. Prog. Nucleic Acid Res. Mol. Biol. 62:227-55
78. Thoma F. 1999. EMBO J. 18:6585-98
79. Hara R, Mo J, Sancar A. 2000. Mol. Cell. Biol. 20:9173-81
80. Green CM, Almouzni G. 2002. EMBO Rep. 3:28-33
81. Ura K, Araki M, Saeki H, Masutani C, Ito T, et al. 2001. EMBO J. 20:2004-14
82. Hara R, Sancar A. 2002. Mol. Cell. Biol. 22:6779-87
83. Hara R, Sancar A. 2003. Mol. Cell. Biol. 23:4121-25
84. Wang D, Hara R, Singh G, Sancar A, Lippard SJ. 2003. Biochemistry 42:6747-53
85. Chu G, Chang E. 1988. Science 242:564-67
86. Tang J, Chu G. 2002. DNA Repair 1:601-16
87. Reardon JT, Nichols AF, Keeney S, Smith CA, Taylor JS, et al. 1993. J. Biol. Chem. 268:21301-8
88. Keeney S, Chang GJ, Linn S. 1993. J. Biol. Chem. 268:21293-300
89. Nichols AF, Ong P, Linn S. 1996. J. Biol. Chem. 271:24317-20
90. Wakasugi M, Shimizu M, Morioka H, Linn S, Nikaido O, Matsunaga T. 2001. J. Biol. Chem. 276:15434-40
91. Hwang BJ, Toering S, Francke U, Chu G. 1998. Mol. Cell. Biol. 18:4391-99
92. Hwang BJ, Ford JM, Hanawalt PC, Chu G. 1999. Proc. Natl. Acad. Sci. USA 96:424-28
93. Itoh T, Nichols A, Linn S. 2001. Oncogene 20:7041-50
94. Kazantsev A, Mu D, Nichols AF, Zhao X, Linn S, Sancar A. 1996. Proc. Natl. Acad. Sci. USA 93:5014-18
95. Shiyanov P, Nag A, Raychaudhuri P. 1999. J. Biol. Chem. 274:35309-12
96. Itoh T, O'Shea CO, Linn S. 2003. Mol. Cell. Biol. 23:7540-53
97. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, et al. 2003. Cell 113:357-67
98. Alleva JL, Zuo S, Hurwitz J, Doetsch PW. 2000. Biochemistry 39:2659-66
99. McCready SJ, Osman F, Yasui A. 2000. Mutat. Res. 451:197-210
100. Ischenko AA, Saparbaev MK. 2002. Nature 415:183-87
101. Petrini JH. 1999. Am. J. Hum. Genet. 64:1264-69
102. Ferguson DO, Alt FW. 2001. Oncogene 20:5572-79
103. Khanna KK, Jackson SP. 2001. Nat. Genet. 27:247-54
104. D'Amours D, Jackson SP. 2002. Nat. Rev. Mol. Cell. Biol. 3:317-27
105. Rouse J, Jackson SP. 2002. Science 297:547-51
106. Sung P. 1994. Science 265:1241-43
107. Kowalczykowski SC. 2000. Trends Biochem. Sci. 25:156-65
108. Chen XB, Melchionna R, Denis CM, Gaillard PH, Blasina A, et al. 2001. Mol. Cell. 8:1117-27
109. Kaliraman V, Mullen JR, Fricke WM, Bastin-Shanower SA, Brill SJ. 2001. Genes Dev. 15:2730-40
110. Boddy MN, Russell P. 2001. Curr. Biol. 11:R953-56
111. Ogrunc M, Sancar A. 2003. J. Biol. Chem. 278:21715-20
112. Paull TT, Gellert M. 1998. Mol. Cell. 1:969-79
113. Trujillo KM, Yuan SSF, Lee EYHP, Sung P. 1998. J. Biol. Chem. 273:21447-50
114. Carney JP, Maser RS, Olivares H, Davis EM, Le Beau M, et al. 1998. Cell 93:477-86
115. Gottlieb TM, Jackson SP. 1993. Cell 72:131-42
116. Ramsden DA, Gellert M. 1998. EMBO J. 17:609-14
117. McElhinny SAN, Snowden CM, McCarville J, Ramsden DA. 2000. Mol. Cell. Biol. 20:2996-3003
118. Van Houten B, Gamper H, Holbrook SR, Hearst JE, Sancar A. 1986. Proc. Natl. Acad. Sci. USA 83:8077-81
119. Jachymczyk WJ, von Borstel RC, Mowat MR, Hastings PJ. 1981. Mol. Gen. Genet. 182:196-205
120. Hoy CA, Thompson LH, Mooney CL, Salazar EP. 1985. Cancer Res. 45:1737-43
121. Bessho T, Mu D, Sancar A. 1997. Mol. Cell. Biol. 17:6822-30
122. Mu D, Bessho T, Nechev LV, Chen DJ, Harris TM, et al. 2000. Mol. Cell. Biol. 20:2446-54
123. McHugh PJ, Sones WR, Hartley JA. 2000. Mol. Cell. Biol. 20:3425-33
124. Bessho T. 2003. J. Biol. Chem. 278:5250-54
125. Greenberg RB, Alberti M, Hearst JE, Chua MA, Saffron WA. 2001. J. Biol. Chem. 276:31551-60
126. Zheng H, Wang X, Warren AJ, Legerski RJ, Nairn RS, et al. 2003. Mol. Cell. Biol. 23:754-61
127. D'Andrea AD, Grompe M. 2003. Nat. Rev. Cancer 3:23-34
128. Nyberg KA, Michelson RJ, Putnam CW, Weinert TA. 2002. Annu. Rev. Genet. 36:617-56
129. Weinert TA, Hartwell LH. 1988. Science 241:317-22
130. Hartwell LH, Weinert TA. 1989. Science 246:629-34
131. Nasmyth K. 1996. Science 274:1643-45
132. Abraham RT. 2001. Genes Dev. 15:2177-96
133. Alcasabas AA, Osborn AJ, Bachant J, Hu F, Werler PJ, et al. 2001. Nat. Cell Biol. 3:958-65
134. Tanaka K, Russell P. 2001. Nat. Cell Biol. 3:966-72
135. Zou LZ, Elledge SJ. 2003. Science 300:1542-48
136. Durocher D, Jackson SP. 2001. Curr. Opin. Cell Biol. 13:225-31
137. Melo J, Toczyski D. 2002. Curr. Opin. Cell Biol. 14:237-45
138. Shiloh Y. 1997. Annu. Rev. Genet. 31:635-62
139. Perry J, Kleckner N. 2003. Cell 112:151-55
140. Bakkenist CJ, Kastan MB. 2003. Nature 421:499-506
141. Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, et al. 1995. Science 268:1749-53
142. Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, et al. 1998. Science 281:1674-77
143. Gately DP, Hittle JC, Chan GK, Yen TJ. 1998. Mol. Biol. Cell 9:2361-74
144. Chan DW, Son SC, Block W, Ye R, Khanna KK, et al. 2000. J. Biol. Chem. 275:7803-10
145. Smith GC, Cary RB, Lakin ND, Hann BC, Teo SH, et al. 1999. Proc. Natl. Acad. Sci. USA 96:11134-39
146. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, et al. 1998. Science 281:1677-79
147. Lim DS, Kim ST, Xu B, Maser RS, Lin J, et al. 2000. Nature 404:613-17
148. Cortez D, Wang Y, Qin J, Elledge SJ. 1999. Science 286:1162-66
149. Kim ST, Lim DS, Canman CE, Kastan MB. 1999. J. Biol. Chem. 274:37538-43
150. Cimprich KA, Shin TB, Keith CT, Schreiber SL. 1996. Proc. Natl. Acad. Sci. USA 93:2850-55
151. Brown EJ, Baltimore D. 2000. Genes Dev. 14:397-402
152. de Klein A, Muijtjens M, van Os R, Verhoeven Y, Smit B, et al. 2000. Curr. Biol. 10:479-82
153. O'Driscoll M, Ruiz-Perez VL, Woods CG, Jeggo PA, Goodship JA. 2003. Nat. Genet. 33:497-501
154. Ünsal-Kaçmaz K, Makhov AM, Griffith JD, Sancar A. 2002. Proc. Natl. Acad. Sci. USA 99:6673-78
155. Hall-Jackson CA, Cross DA, Morrice N, Smythe C. 1999. Oncogene 18:6707-13
156. Lakin ND, Hann BC, Jackson SP. 1999. Oncogene 18:3989-95
157. Cortez D, Guntuku S, Qin J, Elledge SJ. 2001. Science 294:1713-16
158. Griffiths DJ, Barbet NC, McCready S, Lehmann AR, Carr AM. 1995. EMBO J. 14:5812-23
159. Kondo T, Matsumoto K, Sugimoto K. 1999. Mol. Cell. Biol. 19:1136-43
160. Green CM, Erdjument-Bromage H, Tempst P, Lowndes NF. 2000. Curr. Biol. 10:39-42
161. Lindsey-Boltz LA, Bermudez VP, Hurwitz J, Sancar A. 2001. Proc. Natl Acad. Sci. USA 98:11236-41
162. Griffith JD, Lindsey-Boltz LA, Sancar A. 2002. J. Biol. Chem. 277:15233-36
163. Shiomi Y, Shinozaki A, Nakada D, Sugimoto K, Usukura J, et al. 2002. Genes Cells 7:861-68
164. Venclovas C, Thelen MP. 2000. Nucleic Acids Res. 28:2481-93
165. St Onge RP, Udell CM, Casselman R, Davey S. 1999. Mol. Biol. Cell 10:1985-95
166. Volkmer E, Karnitz LM. 1999. J. Biol. Chem. 274:567-70
167. Burtelow MA, Kaufmann SH, Karnitz LM. 2000. J. Biol. Chem. 275:26343-48
168. Burtelow MA, Roos-Mattjus PM, Rauen M, Babendure JR, Karnitz LM. 2001. J. Biol. Chem. 276:25903-9
169. Yuzhakov A, Kelman Z, Hurwitz J, O'Donnell M. 1999. EMBO J. 18:6189-99
170. Paulovich AG, Armour CD, Hartwell LH. 1998. Genetics 150:75-93
171. Longhese MP, Foiani M, Muzi-Falconi M, Lucchini G, Plevani P. 1998. EMBO J. 17:5525-28
172. Edwards RJ, Bentley NJ, Carr AM. 1999. Nat. Cell Biol. 1:393-98
173. Kondo T, Wakayama T, Naiki T, Matsumoto K, Sugimoto K. 2001. Science 294:867-70
174. Melo JA, Cohen J, Toczyski DP. 2001. Genes Dev. 15:2809-21
175. Zou L, Cortez D, Elledge SJ. 2002. Genes Dev. 16:198-208
176. Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, et al. 2003. Proc. Natl. Acad. Sci. USA 100:1633-38
177. Majka J, Burgers PM. 2003. Proc. Natl. Acad. Sci. USA 100:2249-54
178. Bao S, Tibbetts RS, Brumbaugh KM, Fang Y, Richardson DA, et al. 2001. Nature 411:969-74
179. Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EYHP. 2001. Proc. Natl. Acad. Sci. USA 98:13102-7
180. Vialard JE, Gilbert CS, Green CM, Lowndes NF. 1998. EMBO J. 17: 5679-88
181. Gilbert CS, Green CM, Lowndes NF. 2001. Mol. Cell 8:129-36
182. Schultz LB, Chehab NH, Malikzay A, Halazonetis TD. 2000. J. Cell Biol. 151:1381-90
183. Wang B, Matsuoka S, Carpenter PB, Elledge SJ. 2002. Science 298:1435-38
184. Yamane K, Wu XL, Chen JJ. 2002. Mol. Cell. Biol. 22:555-66
185. Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, et al. 2003. Nature 421:952-56
186. Lou ZK, Minter-Dykhouse K, Wu XL, Chen JJ. 2003. Nature 421:957-61
187. Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ. 2003. Nature 421:961-66
188. Kumagai A, Dunphy WG. 2000. Mol. Cell. 6:839-49
189. Kumagai A, Dunphy WG. 2003. Nat. Cell Biol. 5:161-65
190. Lee J, Kumagai A, Dunphy WG. 2003. Mol. Cell. 11:329-40
191. Rhind N, Russell P. 2000. J. Cell. Sci. 113:3889-96
192. McGowan CH. 2002. BioEssays 24:502-11
193. Walworth N, Davey S, Beach D. 1993. Nature 363:368-71
194. Rhind N, Russell P. 1998. Curr. Opin. Cell Biol. 10:749-58
195. Sanchez Y, Wong C, Thoma RS, Richman R, Wu RQ, et al. 1997. Science 277:1497-501
196. Brown AL, Lee CH, Schwarz JK, Mitiku N, Piwnica-Worms H, Chung JH. 1999. Proc. Natl. Acad. Sci. USA 96:3745-50
197. Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, et al. 2000. Science 287:1824-27
198. Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. 2000. Proc. Natl. Acad. Sci. USA 97:10389-94
199. Zhao H, Piwnica-Worms H. 2001. Mol. Cell. Biol. 21:4129-39
200. Takai H, Tominaga K, Motoyama N, Minamishima YA, Nagahama H, et al. 2000. Genes Dev. 14:1439-47
201. Liu QH, Guntuku S, Cui XS, Matsuoka S, Cortez D, et al. 2000. Genes Dev. 14:1448-59
202. Jack MT, Woo RA, Hirao A, Cheung A, Mak TW, Lee PW. 2002. Proc. Natl. Acad. Sci. USA 99:9825-29
203. Bell DW, Varley JM, Szydlo TE, Kang DH, Wahrer DCR, et al. 1999. Science 286:2528-31
204. Bartek J, Lukas J. 2001. Curr. Opin. Cell Biol. 13:738-47
205. Pardee AB. 2002. J. Biol. Chem. 277:26709-16
206. Molinari M, Mercurio C, Dominguez J, Goubin F, Draetta GF. 2000. EMBO Rep. 1:71-79
207. Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. 2001. Nature 410:842-47
208. Kastan MB, Lim DS. 2000. Nat. Rev. Mol. Cell. Biol. 1:179-86
209. Ryan KM, Phillips AC, Vousden KH. 2001. Curr. Opin. Cell Biol. 13:332-37
210. Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD. 1999. Proc. Natl. Acad. Sci. USA 96:13777-82
211. Zhang YP, Xiong Y. 2001. Science 292:1910-15
212. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. 1993. Cell 75:805-16
213. Lin WC, Lin FT, Nevins JR. 2001. Genes Dev. 15:1833-44
214. Siede W, Friedberg AS, Dianova I, Friedberg EC. 1994. Genetics 138: 271-81
215. Paulovich AG, Hartwell LH. 1995. Cell 82:841-47
216. Neecke H, Lucchini G, Longhese MP. 1999. EMBO J. 18:4485-97
217. Gerald JN, Benjamin JM, Kron SJ. 2002. J. Cell. Sci. 115:1749-57
218. Guo Z, Kumagai A, Wang SX, Dunphy WG. 2000. Genes Dev. 14:2745-56
219. Stokes MP, Van Hatten R, Lindsay HD, Michael WM. 2002. J. Cell Biol. 158863-72
220. Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA. 2002. Genes Dev. 16:2327-32
221. Nelson WG, Kastan MB. 1994. Mol. Cell. Biol. 14:1815-23
222. Zhang H, Taylor J, Siede W. 2003. J. Biol. Chem. 278:9382-87
223. Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S. 2002. Nature 419:135-41
224. Painter RB, Young BR. 1980. Proc. Natl. Acad. Sci. USA 77:7315-17
225. Santocanale C, Diffley JF. 1998. Nature 395:615-18
226. Tercero JA, Diffley JF. 2001. Nature 412:553-57
227. Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, et al. 2000. Mol. Cell. 6:649-59
228. Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, et al. 1992. Cell 71:587-97
229. Heffernan TP, Simpson DA, Frank AR, Heinloth AN, Paules RS, et al. 2002. Mol. Cell. Biol. 22:8552-61
230. Hewlett NG, Taniguchi T, Olson S, Cox B, Waisfisz Q, et al. 2002. Science 297:606-9
231. Osborn AJ, Elledge SJ, Zou L. 2002. Trends Cell Biol. 12:509-16
232. Connelly JC, Leach DR. 2002. Trends Biochem. Sci. 27:410-18
233. Venkitaraman AR. 2002. Cell 108:171-82
234. Yang HJ, Jeffrey PD, Miller J, Kinnucan E, Sun YT, et al. 2002. Science 297:1837-48
235. Kim ST, Xu B, Kastan MB. 2002. Genes Dev. 16:560-70
236. Yazdi PT, Wang Y, Zhao S, Patel N, Lee EYHP, Qin J. 2002. Genes Dev. 16:571-82
237. Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, et al. 1999. Cell 99:577-87
238. Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, et al. 1998. Cell 93:467-76
239. Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, et al. 2002. Cell 109:459-72
240. Hekmat-Nejad M, You ZS, Yee MC, Newport JW, Cimprich KA. 2000. Curr. Biol. 10:1565-73
241. Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. 2003. Mol. Cell. 11:203-13
242. Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, et al. 2000. Genes Dev. 14:2989-3002
243. Lee JS, Collins KM, Brown AL, Lee CH, Chung JH. 2000. Nature 404:201-4
244. Navas TA, Zhou Z, Elledge SJ. 1995. Cell 80:29-39
245. Feng W, D'Urso G. 2001. Mol. Cell. Biol. 21:4495-504
246. Waga S, Masuda T, Takisawa H, Sugino A. 2001. Proc. Natl. Acad. Sci. USA 98:4978-83
247. Zlotkin T, Kaufmann G, Jiang Y, Lee MY, Uitto L, et al. 1996. EMBO J. 15:2298-305
248. Pospiech H, Kursula I, Abdel-Aziz W, Malkas L, Uitto L, et al. 1999. Nucleic Acids Res. 27:3799-804
249. D'Urso G, Nurse P. 1997. Proc. Natl. Acad. Sci. USA 94:12491-96
250. Nichols AF, Sancar A. 1992. Nucleic Acids Res. 20:2441-46
251. Shivji MK, Podust VN, Hübscher U, Wood RD. 1995. Biochemistry 34:5011-17
252. Wang Z, Wu X, Friedberg EC. 1993. Mol. Cell. Biol. 13:1051-58
253. Jessberger R, Podust V, Hubscher U, Berg P. 1993. J. Biol. Chem. 268:15070-79
254. Li Y, Pursell ZF, Linn S. 2000. J. Biol. Chem. 275:23247-52
255. Dua R, Levy DL, Campbell JL. 1999. J. Biol. Chem. 274:22283-88
256. Kesti T, Flick K, Keranen S, Syvaoja JE, Wittenberg C. 1999. Mol. Cell. 3:679-85
257. Vlatkovic N, Guerrera S, Li Y, Linn S, Haines DS, Boyd MT. 2000. Nucleic Acids Res. 28:3581-86
258. Asahara H, Li Y, Fuss J, Haines DS, Vlatkovic N, et al. 2003. Nucleic Acids Res. 31:2451-59
259. Haber JE, Heyer WD. 2001. Cell 107:551-54
260. Kai M, Wang TS. 2003. Genes Dev. 17:64-76
261. Sogo JM, Lopes M, Foiani M. 2002. Science 297:599-602
262. Lopes M, Cotta-Ramusino C, Pellicioli A, Liberi G, Plevani P, et al. 2001. Nature 412:557-61
263. Cha RS, Kleckner N. 2002. Science 297:602-6
264. Casper AM, Nghiem P, Arlt MF, Glover TW. 2002. Cell 111:779-89
265. Xu B, Kim ST, Lim DS, Kastan MB. 2002. Mol. Cell. Biol. 22:1049-59
266. Brown EJ, Baltimore D. 2003. Genes Dev. 17:615-28
267. Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC. 2002. Nat. Genet. 30:285-89
268. Peng CY, Graves PR, Thoma RS, Wu ZQ, Shaw AS, Piwnica-Worms H. 1997. Science 277:1501-5
269. Chen MS, Hurov J, White LS, Woodford-Thomas T, Piwnica-Worms H. 2001. Mol. Cell. Biol. 21:3853-61
270. Zhao H, Watkins JL, Piwnica-Worms H. 2002. Proc. Natl. Acad. Sci. USA 99:14795-800
271. Furnari B, Rhind N, Russell P. 1997. Science 277:1495-97
272. Wang XF, McGowan CH, Zhao M, He LS, Downey JS, et al. 2000. Mol. Cell. Biol. 20:4543-52
273. Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, et al. 2001. Nature 411:102-07
274. Michael WM, Ott R, Fanning E, Newport J. 2000. Science 289:2133-37
275. You ZZ, Kong L, Newport J. 2002. J. Biol. Chem. 277:27088-93