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Volumn 22, Issue 24, 2003, Pages 6458-6470

Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7

Author keywords

BMP; Signal transduction; Smad; TGF ; Ubiquitination

Indexed keywords

BONE MORPHOGENETIC PROTEIN; GENE PRODUCT; PROTEIN ARKADIA; PROTEIN SMURF1; SMAD PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

EID: 10744228283     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg632     Document Type: Article
Times cited : (195)

References (41)
  • 1
    • 0034976149 scopus 로고    scopus 로고
    • TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
    • Bonni, S., Wang, H.R., Causing, C.G., Kavsak, P., Stroschein, S.L., Luo, K. and Wrana, J.L. (2001) TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat. Cell Biol., 3, 587-595.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 587-595
    • Bonni, S.1    Wang, H.R.2    Causing, C.G.3    Kavsak, P.4    Stroschein, S.L.5    Luo, K.6    Wrana, J.L.7
  • 2
    • 0033996038 scopus 로고    scopus 로고
    • STRAP and Smad7 synergize in the inhibition of transforming growth factor β signaling
    • Datta, P.K. and Moses, H.L. (2000) STRAP and Smad7 synergize in the inhibition of transforming growth factor β signaling. Mol. Cell. Biol., 20, 3157-3167.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3157-3167
    • Datta, P.K.1    Moses, H.L.2
  • 3
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • Derynck, R. and Zhang, Y.E. (2003) Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature, 425, 577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 4
    • 0035918274 scopus 로고    scopus 로고
    • Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation
    • Ebisawa, T., Fukuchi, M., Murakami, G., Chiba, T., Tanaka, K., Imamura, T. and Miyazono, K. (2001) Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem., 276, 12477-12480.
    • (2001) J. Biol. Chem. , vol.276 , pp. 12477-12480
    • Ebisawa, T.1    Fukuchi, M.2    Murakami, G.3    Chiba, T.4    Tanaka, K.5    Imamura, T.6    Miyazono, K.7
  • 5
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • Elbashir, S.M., Lendeckel, W. and Tuschl, T. (2001) RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev., 15, 188-200.
    • (2001) Genes Dev. , vol.15 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 6
    • 0035848835 scopus 로고    scopus 로고
    • Induction of the mammalian node requires Arkadia function in the extraembryonic lineages
    • Episkopou, V., Arkell, R., Timmons, P.M., Walsh, J.J., Andrew, R.L. and Swan, D. (2001) Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature, 410, 825-830.
    • (2001) Nature , vol.410 , pp. 825-830
    • Episkopou, V.1    Arkell, R.2    Timmons, P.M.3    Walsh, J.J.4    Andrew, R.L.5    Swan, D.6
  • 7
    • 0037173716 scopus 로고    scopus 로고
    • Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-β/Smad signaling
    • Ferrigno, O., Lallemand, F., Verrecchia, F., L'Hoste, S., Camonis, J., Atfi, A. and Mauviel, A. (2002) Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-β/Smad signaling. Oncogene, 21, 4879-4884.
    • (2002) Oncogene , vol.21 , pp. 4879-4884
    • Ferrigno, O.1    Lallemand, F.2    Verrecchia, F.3    L'Hoste, S.4    Camonis, J.5    Atfi, A.6    Mauviel, A.7
  • 8
    • 0034767430 scopus 로고    scopus 로고
    • Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins
    • Fukuchi, M., Imamura, T., Chiba, T., Ebisawa, T., Kawabata, M., Tanaka, K. and Miyazono, K. (2001) Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Mol. Biol. Cell, 12, 1431-1443.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1431-1443
    • Fukuchi, M.1    Imamura, T.2    Chiba, T.3    Ebisawa, T.4    Kawabata, M.5    Tanaka, K.6    Miyazono, K.7
  • 9
    • 0037115624 scopus 로고    scopus 로고
    • High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma
    • Fukuchi, M. et al. (2002) High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma. Cancer Res., 62, 7162-7165.
    • (2002) Cancer Res. , vol.62 , pp. 7162-7165
    • Fukuchi, M.1
  • 10
    • 0035842885 scopus 로고    scopus 로고
    • The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling
    • Hanyu, A., Ishidou, Y., Ebisawa, T., Shimanuki, T., Imamura, T. and Miyazono, K. (2001) The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling. J. Cell Biol., 155, 1017-1027.
    • (2001) J. Cell Biol. , vol.155 , pp. 1017-1027
    • Hanyu, A.1    Ishidou, Y.2    Ebisawa, T.3    Shimanuki, T.4    Imamura, T.5    Miyazono, K.6
  • 11
    • 0031964859 scopus 로고    scopus 로고
    • Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    • Hata, A., Lagna, G., Massagué, J. and Hemmati-Brivanlou, A. (1998) Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev., 12, 186-197.
    • (1998) Genes Dev. , vol.12 , pp. 186-197
    • Hata, A.1    Lagna, G.2    Massagué, J.3    Hemmati-Brivanlou, A.4
  • 12
    • 0031438047 scopus 로고    scopus 로고
    • TGF-β signalling from cell membrane to nucleus through SMAD proteins
    • Heldin, C.H., Miyazono, K. and ten Dijke, P. (1997) TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature, 390, 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    Ten Dijke, P.3
  • 15
    • 0034093738 scopus 로고    scopus 로고
    • Smad6 is a Smad1/5-induced Smad inhibitor: Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter
    • Ishida, W., Hamamoto, K., Kusanagi, K., Yagi, K., Kawabata, M., Takehara, K., Sampath, T.K., Kato, M. and Miyazono, K. (2000) Smad6 is a Smad1/5-induced Smad inhibitor: Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter. J. Biol. Chem., 275, 6075-6079.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6075-6079
    • Ishida, W.1    Hamamoto, K.2    Kusanagi, K.3    Yagi, K.4    Kawabata, M.5    Takehara, K.6    Sampath, T.K.7    Kato, M.8    Miyazono, K.9
  • 17
    • 0035422199 scopus 로고    scopus 로고
    • Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
    • Itoh, F., Asao, H., Sugamura, K., Heldin, C.H., ten Dijke, P. and Itoh, S. (2001) Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. EMBO J., 20, 4132-4142.
    • (2001) EMBO J. , vol.20 , pp. 4132-4142
    • Itoh, F.1    Asao, H.2    Sugamura, K.3    Heldin, C.H.4    Ten Dijke, P.5    Itoh, S.6
  • 18
    • 0032528041 scopus 로고    scopus 로고
    • Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors
    • Kawabata, M., Inoue, H., Hanyu, A., Imamura, T. and Miyazono, K. (1998) Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J., 17, 4056-4065.
    • (1998) EMBO J. , vol.17 , pp. 4056-4065
    • Kawabata, M.1    Inoue, H.2    Hanyu, A.3    Imamura, T.4    Miyazono, K.5
  • 19
    • 0034517389 scopus 로고    scopus 로고
    • Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation
    • Kavsak, P., Rasmussen, R.K., Causing, C.G., Bonni, S., Zhu, H., Thomsen, G.H. and Wrana, J.L. (2000) Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation. Mol. Cell, 6, 1365-1375.
    • (2000) Mol. Cell , vol.6 , pp. 1365-1375
    • Kavsak, P.1    Rasmussen, R.K.2    Causing, C.G.3    Bonni, S.4    Zhu, H.5    Thomsen, G.H.6    Wrana, J.L.7
  • 20
    • 0036534444 scopus 로고    scopus 로고
    • Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA
    • Kisielow, M., Kleiner, S., Nagasawa, M., Faisal, A. and Nagamine, Y. (2002) Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA. Biochem. J., 363, 1-5.
    • (2002) Biochem. J. , vol.363 , pp. 1-5
    • Kisielow, M.1    Kleiner, S.2    Nagasawa, M.3    Faisal, A.4    Nagamine, Y.5
  • 21
    • 0033553532 scopus 로고    scopus 로고
    • Substrate targeting in the ubiquitin system
    • Laney, J.D. and Hochstrasser, M. (1999) Substrate targeting in the ubiquitin system. Cell, 97, 427-430.
    • (1999) Cell , vol.97 , pp. 427-430
    • Laney, J.D.1    Hochstrasser, M.2
  • 22
    • 0034711290 scopus 로고    scopus 로고
    • Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-β signaling
    • Lin, X., Liang, M. and Feng, X.H. (2000) Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-β signaling. J. Biol. Chem., 275, 36818-36822.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36818-36822
    • Lin, X.1    Liang, M.2    Feng, X.H.3
  • 23
    • 0033257926 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of TGF-β-activated Smad2
    • Lo, R.S. and Massagué, J. (1999) Ubiquitin-dependent degradation of TGF-β-activated Smad2. Nat. Cell Biol., 1, 472-478.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 472-478
    • Lo, R.S.1    Massagué, J.2
  • 24
    • 0030671306 scopus 로고    scopus 로고
    • Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins
    • Marques, G., Musacchio, M., Shimell, M.J., Wunnenberg-Stapleton, K., Cho, K.W. and O'Connor, M.B. (1997) Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins. Cell, 91, 417-426.
    • (1997) Cell , vol.91 , pp. 417-426
    • Marques, G.1    Musacchio, M.2    Shimell, M.J.3    Wunnenberg-Stapleton, K.4    Cho, K.W.5    O'Connor, M.B.6
  • 25
    • 0034016101 scopus 로고    scopus 로고
    • Positive and negative regulation of TGF-β signaling
    • Miyazono, K. (2000) Positive and negative regulation of TGF-β signaling. J. Cell Sci., 113, 1101-1109.
    • (2000) J. Cell Sci. , vol.113 , pp. 1101-1109
    • Miyazono, K.1
  • 27
    • 0037621860 scopus 로고    scopus 로고
    • Regulation of TGF-β signaling and its roles in progression of tumors
    • Miyazono, K., Suzuki, H. and Imamura, T. (2003) Regulation of TGF-β signaling and its roles in progression of tumors. Cancer Sci., 94, 230-234.
    • (2003) Cancer Sci. , vol.94 , pp. 230-234
    • Miyazono, K.1    Suzuki, H.2    Imamura, T.3
  • 29
    • 0035848854 scopus 로고    scopus 로고
    • Arkadia enhances nodal-related signalling to induce mesendoderm
    • Niederlander, C., Walsh, J.J., Episkopou, V. and Jones, C.M. (2001) Arkadia enhances nodal-related signalling to induce mesendoderm. Nature, 410, 830-834.
    • (2001) Nature , vol.410 , pp. 830-834
    • Niederlander, C.1    Walsh, J.J.2    Episkopou, V.3    Jones, C.M.4
  • 30
    • 0036735752 scopus 로고    scopus 로고
    • Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension
    • Nishihara, N., Watabe, T., Imamura, T. and Miyazono, K. (2002) Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol. Biol. Cell, 13, 3055-3063.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 3055-3063
    • Nishihara, N.1    Watabe, T.2    Imamura, T.3    Miyazono, K.4
  • 31
    • 0030665807 scopus 로고    scopus 로고
    • Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity
    • Piccolo, S., Agius, E., Lu, B., Goodman, S., Dale, L. and De Robertis, E.M. (1997) Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. Cell, 91, 407-416.
    • (1997) Cell , vol.91 , pp. 407-416
    • Piccolo, S.1    Agius, E.2    Lu, B.3    Goodman, S.4    Dale, L.5    De Robertis, E.M.6
  • 32
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi, Y. and Massague, J. (2003) Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell, 113, 685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 33
    • 0036007119 scopus 로고    scopus 로고
    • Creation of a Sog morphogen gradient in the Drosophila embryo
    • Srinivasan, S., Rashka, K.E. and Bier, E. (2002) Creation of a Sog morphogen gradient in the Drosophila embryo. Dev. Cell, 2, 91-101.
    • (2002) Dev. Cell , vol.2 , pp. 91-101
    • Srinivasan, S.1    Rashka, K.E.2    Bier, E.3
  • 34
    • 0035498980 scopus 로고    scopus 로고
    • Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN
    • Stroschein, S.L., Bonni, S., Wrana, J.L. and Luo, K. (2001) Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev., 15, 2822-2836.
    • (2001) Genes Dev. , vol.15 , pp. 2822-2836
    • Stroschein, S.L.1    Bonni, S.2    Wrana, J.L.3    Luo, K.4
  • 36
    • 0038363366 scopus 로고    scopus 로고
    • Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7
    • Tajima, Y., Goto, K., Yoshida, M., Shinomiya, K., Sekimoto, T., Yoneda, Y., Miyazono, K. and Imamura, T. (2003) Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7. J. Biol. Chem., 278, 10716-10721.
    • (2003) J. Biol. Chem. , vol.278 , pp. 10716-10721
    • Tajima, Y.1    Goto, K.2    Yoshida, M.3    Shinomiya, K.4    Sekimoto, T.5    Yoneda, Y.6    Miyazono, K.7    Imamura, T.8
  • 37
    • 0035930333 scopus 로고    scopus 로고
    • The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction
    • Wan, Y., Liu, X. and Kirschner, M.W. (2001) The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction. Mol. Cell, 8, 1027-1039.
    • (2001) Mol. Cell , vol.8 , pp. 1027-1039
    • Wan, Y.1    Liu, X.2    Kirschner, M.W.3
  • 38
    • 0036198412 scopus 로고    scopus 로고
    • Jab1 antagonizes TGF-β signaling by inducing Smad4 degradation
    • Wan, M., Cao, X., Wu, Y., Bai, S., Wu, L., Shi, X., Wang, N. and Cao, X. (2002) Jab1 antagonizes TGF-β signaling by inducing Smad4 degradation. EMBO Rep., 3, 171-176.
    • (2002) EMBO Rep. , vol.3 , pp. 171-176
    • Wan, M.1    Cao, X.2    Wu, Y.3    Bai, S.4    Wu, L.5    Shi, X.6    Wang, N.7    Cao, X.8
  • 39
    • 0347475689 scopus 로고    scopus 로고
    • Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling
    • Yoshida, Y. et al. (2003) Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling. Mech. Dev., 120, 629-637.
    • (2003) Mech. Dev. , vol.120 , pp. 629-637
    • Yoshida, Y.1
  • 41
    • 0033549789 scopus 로고    scopus 로고
    • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    • Zhu, H., Kavsak, P., Abdollah, S., Wrana, J.L. and Thomsen, G.H. (1999) A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature, 400, 687-693.
    • (1999) Nature , vol.400 , pp. 687-693
    • Zhu, H.1    Kavsak, P.2    Abdollah, S.3    Wrana, J.L.4    Thomsen, G.H.5


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