Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Nature

Volumn 466, Issue 7309, 2010, Pages 941-946

  Nakada, Shinichiro ^a   Tai, Ikue ^a   Panier, Stephanie ^b,c   Al Hakim, Abdallah ^b   Iemura, Shun Ichiro ^d   Juang, Yu Chi ^b   O'Donnell, Lara ^b   Kumakubo, Ayako ^a   Munro, Meagan ^b   Sicheri, Frank ^b,c   Gingras, Anne Claude ^b,c   Natsume, Tohru ^d   Suda, Toshio ^a   Durocher, Daniel ^b,c  

^a KEIO UNIVERSITY   (Japan)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DNA; PROTEIN RNF 168; PROTEIN UBE2D; PROTEIN UBE2E; PROTEIN UBE2N; RING FINGER PROTEIN; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN CONJUGATING ENZYME 13; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN CONJUGATING ENZYME OTUB1; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG; ATM PROTEIN, HUMAN; CELL CYCLE PROTEIN; CHROMATIN; CYSTEINE PROTEINASE; DNA BINDING PROTEIN; OTUBAIN 1 PROTEIN, HUMAN; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; RNF168 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN; UBE2N PROTEIN, HUMAN; UBIQUITIN;

AMINO ACID; BIOCHEMISTRY; CANCER; CATALYSIS; CHEMICAL BINDING; DISEASE TREATMENT; DNA; ENZYME ACTIVITY; GENOMICS; INHIBITION;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS INHIBITION; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; UBIQUITINATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; DEFICIENCY; GENETICS; METABOLISM; PHYSIOLOGY; TUMOR CELL LINE;

CELL CYCLE PROTEINS; CELL LINE; CELL LINE, TUMOR; CHROMATIN; CYSTEINE ENDOPEPTIDASES; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; ATAXIA TELANGIECTASIA MUTATED PROTEINS;

EID: 77955867565     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09297     Document Type: Article

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