PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

Molecular Cell

Volumn 53, Issue 2, 2014, Pages 235-246

  Maréchal, Alexandre ^a   Li, Ju Mei ^c   Ji, Xiao Ye ^a   Wu, Ching Shyi ^a   Yazinski, Stephanie A ^a   Nguyen, Hai Dang ^a   Liu, Shizhou ^a,d   Jiménez, Amanda E ^a   Jin, Jianping ^c   Zou, Lee ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^d CHINA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; PRP19 ENZYME; SINGLE STRANDED DNA; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; ATAXIA TELANGIECTASIA; DNA BINDING; DNA DAMAGE; DNA REPLICATION; DNA SPLICING; ENZYME BINDING; ENZYME PHOSPHORYLATION; PROTEOMICS; UBIQUITINATION;

ATAXIA TELANGIECTASIA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ATAXIA TELANGIECTASIA MUTATED PROTEINS; DNA DAMAGE; DNA REPAIR; DNA REPAIR ENZYMES; DNA REPLICATION; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN KINASES; REPLICATION PROTEIN A; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 84892895021     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2013.11.002     Document Type: Article

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