PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

Science

Volumn 347, Issue 6218, 2015, Pages 185-188

  Ochi, Takashi ^a   Blackford, Andrew N ^b   Coates, Julia ^b   Jhujh, Satpal ^b   Mehmood, Shahid ^c   Tamura, Naoka ^a   Travers, Jon ^b   Wu, Qian ^a   Draviam, Viji M ^a   Robinson, Carol V ^c   Blundell, Tom L ^a   Jackson, Stephen P ^a,b,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CRISPR ASSOCIATED PROTEIN; DNA; KU ANTIGEN; NUCLEAR PROTEIN; NUCLEIC ACID BINDING PROTEIN; PAXX PROTEIN; PHLEOMYCIN; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; XLF PROTEIN; XRCC4 PROTEIN; CELL NUCLEUS ANTIGEN; DNA BINDING PROTEIN; NHEJ1 PROTEIN, HUMAN; PAXX PROTEIN, HUMAN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; XRCC4 PROTEIN, HUMAN;

CELLS AND CELL COMPONENTS; CRYSTAL STRUCTURE; DNA; PROTEIN;

ARTICLE; CELL DAMAGE; CELL SURVIVAL; CHROMATIN; CRYSTAL STRUCTURE; DNA DAMAGE; DNA END JOINING REPAIR; DNA STRUCTURE; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; IN VITRO STUDY; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; U2OS CELL LINE; CHEMISTRY; GENETICS; METABOLISM; PROTEIN SECONDARY STRUCTURE; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANTIGENS, NUCLEAR; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; HUMANS; PROTEIN STRUCTURE, SECONDARY; RNA INTERFERENCE;

EID: 84922384279     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1261971     Document Type: Article

References (13)

1. S. P. Jackson, J. Bartek, Nature 461, 1071-1078 (2009).
2. L. Woodbine, A. R. Gennery, P. A. Jeggo, DNA Repair (Amst.) 16, 84-96 (2014).
3. G. J. Williams et al., DNA Repair (Amst.) 17, 110-120 (2014).
4. T. Ochi, Q. Wu, T. L. Blundell, DNA Repair (Amst.) 17, 98-109 (2014).
5. S. Leidel, M. Delattre, L. Cerutti, K. Baumer, P. Gönczy, Nat. Cell Biol. 7, 115-125 (2005).
6. M. S. Junop et al., EMBO J. 19, 5962-5970 (2000).
7. B. L. Sibanda et al., Nat. Struct. Biol. 8, 1015-1019 (2001).
8. S. N. Andres, M. Modesti, C. J. Tsai, G. Chu, M. S. Junop, Mol. Cell 28, 1093-1101 (2007).
9. Y. Li et al., EMBO J. 27, 290-300 (2008).
10. M. van Breugel et al.; Science 331, 1196-1199 (2011).
11. D. Kitagawa et al., Cell 144, 364-375 (2011).
12. P. D. Hsu, E. S. Lander, F. Zhang, Cell 157, 1262-1278 (2014).
13. P. Ahnesorg, P. Smith, S. P. Jackson, Cell 124, 301-313 (2006).