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Volumn 12, Issue 12, 2012, Pages 801-817

DNA repair dysregulation from cancer driver to therapeutic target

Author keywords

[No Author keywords available]

Indexed keywords

6 O BENZYLGUANINE; ANTINEOPLASTIC AGENT; BMN 673; CAMPTOTHECIN; CARMUSTINE; CEP 9722; CETUXIMAB; CRT 0044876; CYCLOSPORIN; DACARBAZINE; DNA METHYLTRANSFERASE; EMBONIC ACID; IC 86621; IC 87361; ICOSAPENTAENOIC ACID; INO 1001; LOMEGUATRIB; LUCANTHONE; METHOXYAMINE; NIRAPARIB; NSC 281680; NU 7026; NU 7441; OLAPARIB; OLEANOLIC ACID; PEMETREXED; RUCAPARIB; TEMOZOLOMIDE; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84870218588     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3399     Document Type: Review
Times cited : (807)

References (197)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • An excellent review highlighting enabling characteristics, as well as emerging hallmarks, of cancer.
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011). An excellent review highlighting enabling characteristics, as well as emerging hallmarks, of cancer.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 34447323281 scopus 로고    scopus 로고
    • 6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy
    • DOI 10.1016/j.dnarep.2007.03.011, PII S1568786407001280
    • Tubbs, J. L., Pegg, A. E. & Tainer, J. A. DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6 alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair 6, 1100-1115 (2007 (Pubitemid 47058393)
    • (2007) DNA Repair , vol.6 , Issue.8 , pp. 1100-1115
    • Tubbs, J.L.1    Pegg, A.E.2    Tainer, J.A.3
  • 5
    • 0025801019 scopus 로고
    • Carcinogenic n nitrosamines in the diet: Occurrence, formation, mechanisms and carcinogenic potential
    • Tricker, A. R. & Preussmann, R. Carcinogenic N nitrosamines in the diet: occurrence, formation, mechanisms and carcinogenic potential. Mutat. Res. 259, 277-289 (1991
    • (1991) Mutat. Res. , vol.259 , pp. 277-289
    • Tricker, A.R.1    Preussmann, R.2
  • 7
    • 0029876088 scopus 로고    scopus 로고
    • 6-alkylguanine- DNA alkyltransferase expression in normal and malignant human colon
    • Zaidi, N. H., Liu, L. & Gerson, S. L. Quantitative immunohistochemical estimates of O6 alkylguanine-DNA alkyltransferase expression in normal and malignant human colon. Clin. Cancer Res. 2, 577-584 (1996 (Pubitemid 26099177)
    • (1996) Clinical Cancer Research , vol.2 , Issue.3 , pp. 577-584
    • Zaidi, N.H.1    Liu, L.2    Gerson, S.L.3
  • 8
    • 0025195404 scopus 로고
    • 6-alkylguanine-DNA alkyltransferase: Regulation and importance in response to alkylating carcinogenic and therapeutic agents
    • Pegg, A. E. Mammalian O6 alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenesis and therapeutic agents. Cancer Res. 50, 6119-6129 (1990 (Pubitemid 20323662)
    • (1990) Cancer Research , vol.50 , Issue.19 , pp. 6119-6129
    • Pegg, A.E.1
  • 9
    • 33746871832 scopus 로고    scopus 로고
    • 6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy
    • DOI 10.1016/j.ctrv.2006.03.004, PII S0305737206000569
    • Rabik, C. A., Njoku, M. C. & Dolan, M. E. Inactivation of O6 alkylguanine DNA alkyltransferase as a means to enhance chemotherapy. Cancer Treat. Rev. 32, 261-276 (2006 (Pubitemid 44522815)
    • (2006) Cancer Treatment Reviews , vol.32 , Issue.4 , pp. 261-276
    • Rabik, C.A.1    Njoku, M.C.2    Dolan, M.E.3
  • 11
    • 33645085569 scopus 로고    scopus 로고
    • Lomeguatrib, a potent inhibitor of o6 alkylguanine-dna-alkyltransferase: Phase i safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors
    • Ranson, M. et al. Lomeguatrib, a potent inhibitor of O6 alkylguanine-DNA-alkyltransferase: phase I safety, pharmacodynamic, and pharmacokinetic trial and evaluation in combination with temozolomide in patients with advanced solid tumors. Clin. Cancer Res. 12, 1577-1584 (2006
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1577-1584
    • Ranson, M.1
  • 12
    • 74549175856 scopus 로고    scopus 로고
    • Tumor o6-methylguanine-dna methyltransferase inactivation by oral lomeguatrib clin
    • Watson, A. J. et al. Tumor O6-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib Clin. Cancer Res. 16, 743-749 (2010
    • (2010) Cancer Res. , vol.16 , pp. 743-749
    • Watson, A.J.1
  • 13
    • 0033557903 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • Esteller, M., Hamilton, S. R., Burger, P. C., Baylin, S. B. & Herman, J. G. Inactivation of the DNA repair gene O6 methylguanine-DNAmethyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 59, 793-797 (1999 (Pubitemid 29086728)
    • (1999) Cancer Research , vol.59 , Issue.4 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5
  • 15
    • 0027278557 scopus 로고
    • Instability and decay of the primary structure of DNA
    • DOI 10.1038/362709a0
    • Lindahl, T. Instability and decay of the primary structure of DNA. Nature 362, 709-715 (1993). Review of the extent of endogenous and environmental damage to DNA, linking it to ageing and cancer. (Pubitemid 23125973)
    • (1993) Nature , vol.362 , Issue.6422 , pp. 709-715
    • Lindahl, T.1
  • 16
    • 77952571717 scopus 로고    scopus 로고
    • Oxygen as a friend and enemy: How to combat the mutational potential of 8 oxo-guanine
    • van Loon, B., Markkanen, E. & Hübscher, U. Oxygen as a friend and enemy: how to combat the mutational potential of 8 oxo-guanine. DNA Repair 9, 604-616 (2010
    • (2010) DNA Repair , vol.9 , pp. 604-616
    • Van Loon, B.1    Markkanen, E.2    Hübscher, U.3
  • 17
    • 0030049032 scopus 로고    scopus 로고
    • Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer
    • Wiseman, H. & Halliwell, B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem. J. 313, 17-29 (1996 (Pubitemid 26013419)
    • (1996) Biochemical Journal , vol.313 , Issue.1 , pp. 17-29
    • Wiseman, H.1    Halliwell, B.2
  • 18
    • 84861231399 scopus 로고    scopus 로고
    • The diverse roles and clinical relevance of parps in dna damage repair: Current state of the art
    • De Vos, M., Schreiber, V. & Dantzer, F. The diverse roles and clinical relevance of PARPs in DNA damage repair: current state of the art. Biochem. Pharmacol. 84, 137-146 (2012
    • (2012) Biochem. Pharmacol. , vol.84 , pp. 137-146
    • De Vos, M.1    Schreiber, V.2    Dantzer, F.3
  • 20
    • 0142009654 scopus 로고    scopus 로고
    • A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage
    • DOI 10.1093/nar/gkg761
    • El Khamisy, S. F., Masutani, M., Suzuki, H. & Caldecott, K. W. A requirement for PARP 1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage. Nucleic Acids Res. 31, 5526-5533 (2003). An elegant study demonstrating that ADP-ribose polymer formation at the site of the DNA break is necessary to recruit XRCC1, the scaffold protein of BER. (Pubitemid 37441922)
    • (2003) Nucleic Acids Research , vol.31 , Issue.19 , pp. 5526-5533
    • El-Khamisy, S.F.1    Masutani, M.2    Suzuki, H.3    Caldecott, K.W.4
  • 21
    • 0345061277 scopus 로고    scopus 로고
    • Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions
    • DOI 10.1016/S1568-7864(03)00116-2
    • Plo, I. et al. Association of XRCC1 and tyrosyl DNA phosphodiesterase Tdp 1 for the repair of topoisomerase I mediated DNA lesions. DNA Repair 2, 1087-1100 (2003 (Pubitemid 39662824)
    • (2003) DNA Repair , vol.2 , Issue.10 , pp. 1087-1100
    • Plo, I.1    Liao, Z.-Y.2    Barcelo, J.M.3    Kohlhagen, G.4    Caldecott, K.W.5    Weinfeld, M.6    Pommier, Y.7
  • 23
    • 32244435724 scopus 로고    scopus 로고
    • Is base excision repair a tumor suppressor mechanism?
    • Sweasy, J. B., Lang, T. & DiMaio, D. Is base excision repair a tumour suppressor mechanism? Cell Cycle 5, 250-259 (2006 (Pubitemid 43213493)
    • (2006) Cell Cycle , vol.5 , Issue.3 , pp. 250-259
    • Sweasy, J.B.1    Lang, T.2    DiMaio, D.3
  • 24
    • 77955095659 scopus 로고    scopus 로고
    • Human ap endonuclease 1 (ape1): From mechanistic insights to druggable target in cancer
    • Abbotts, R. & Madhusudan, S. Human AP endonuclease 1 (APE1): from mechanistic insights to druggable target in cancer. Cancer Treat. Rev. 36, 425-435 (2010
    • (2010) Cancer Treat. Rev. , vol.36 , pp. 425-435
    • Abbotts, R.1    Madhusudan, S.2
  • 25
    • 0020621890 scopus 로고
    • Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers
    • Hirai, K., Ueda, K. & Hayaishi, O. Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers. Cancer Res. 43, 3441-3446 (1983 (Pubitemid 13061611)
    • (1983) Cancer Research , vol.43 , Issue.7 , pp. 3441-3446
    • Hirai, K.1    Ueda, K.2    Hayaishi, O.3
  • 26
    • 67650576727 scopus 로고    scopus 로고
    • Poly(adp-ribose) polymerase 1 polymorphisms, expression and activity in selected human tumour cell lines
    • Zaremba, T. et al. Poly(ADP-ribose) polymerase 1 polymorphisms, expression and activity in selected human tumour cell lines. Br. J. Cancer 21, 256-262 (2009
    • (2009) Br. J. Cancer , vol.21 , pp. 256-262
    • Zaremba, T.1
  • 28
    • 0035837590 scopus 로고    scopus 로고
    • Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells
    • DOI 10.1016/S0921-8777(01)00076-3, PII S0921877701000763
    • Taverna, P. et al. Methoxyamine potentiates DNA single strand breaks and double strand breaks induced by temozolomide in colon cancer cells. Mutat. Res. 485, 269-281 (2001). The early identification that inhibition of APE1 endonuclease could increase TMZ cytotoxicity. (Pubitemid 32406283)
    • (2001) Mutation Research - DNA Repair , vol.485 , Issue.4 , pp. 269-281
    • Taverna, P.1    Liu, L.2    Hwang, H.-S.3    Hanson, A.J.4    Kinsella, T.J.5    Gerson, S.L.6
  • 29
    • 4444336712 scopus 로고    scopus 로고
    • Inhibition of the human apurinic/apyrimidinic endonuclease (Ape1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone
    • Luo, M. & Kelley, M. R. Inhibition of the human apurinic/apyrimidinic endonuclease (APE1) repair activity and sensitization of breast cancer cells to DNA alkylating agents with lucanthone. Anticancer Res. 24, 2127-2134 (2004 (Pubitemid 39166286)
    • (2004) Anticancer Research , vol.24 , Issue.4 , pp. 2127-2134
    • Luo, M.1    Kelley, M.R.2
  • 31
    • 79951675147 scopus 로고    scopus 로고
    • Development and evaluation of human ap endonuclease inhibitors in melanoma and glioma cell lines
    • Mohammed, M. Z. et al. Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines. Br. J. Cancer 104, 6536-6563 (2011
    • (2011) Br. J. Cancer , vol.104 , pp. 6536-6563
    • Mohammed, M.Z.1
  • 32
    • 33846976720 scopus 로고    scopus 로고
    • A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical dna-damaging agents
    • McNeill, D. R. & Wilson, D. M. A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. Mol. Cancer Res. 5, 61-70 (2007
    • (2007) Mol. Cancer Res. , vol.5 , pp. 61-70
    • McNeill, D.R.1    Wilson, D.M.2
  • 33
    • 0031762817 scopus 로고    scopus 로고
    • Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064
    • Bowman K. J., White, A., Golding, B. T., Griffin, R. J. & Curtin, N. J. Potentiation of anticancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors, NU1025 and NU1064. Br. J. Cancer 78, 1269-1277 (1998 (Pubitemid 28495236)
    • (1998) British Journal of Cancer , vol.78 , Issue.10 , pp. 1269-1277
    • Bowman, J.K.1    White, A.2    Golding, B.T.3    Griffin, R.J.4    Curtin, N.J.5
  • 34
    • 10744226451 scopus 로고    scopus 로고
    • Preclinical evaluation of a novel poly(adp-ribose) polymerase 1 (parp 1) inhibitor, ag14361, with significant anticancer chemo- and radio-sensitization activity
    • The first demonstration that a potent PARPi could enhance the antitumour activity of IR and topoisomerase I poisons in xenograft models, with complete durable regressions observed in combination with TMZ.
    • Calabrese, C. R. et al. Preclinical evaluation of a novel poly(ADP-ribose) polymerase 1 (PARP 1) inhibitor, AG14361, with significant anticancer chemo- and radio-sensitization activity. J. Natl Cancer Inst. 96, 56-67 (2004). The first demonstration that a potent PARPi could enhance the antitumour activity of IR and topoisomerase I poisons in xenograft models, with complete durable regressions observed in combination with TMZ.
    • (2004) J. Natl Cancer Inst. , vol.96 , pp. 56-67
    • Calabrese, C.R.1
  • 35
    • 59449085305 scopus 로고    scopus 로고
    • Phase i study of the poly(adp-ribose) polymerase inhibitor, ag014699, in combination with temozolomide in patients with advanced solid tumors
    • The first clinical trial of a PARPi in cancer patients.
    • Plummer, R. et al. Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors. Clin. Cancer Res. 14, 7917-7923 (2008). The first clinical trial of a PARPi in cancer patients.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7917-7923
    • Plummer, R.1
  • 36
    • 35148894301 scopus 로고    scopus 로고
    • First and final report of a phase ii study of the poly(adp-ribose) polymerase (parp) inhibitor, ag014699, in combination with temozolomide (tmz) in patients with metastatic malignant melanoma (mm)
    • Plummer, R. et al. First and final report of a phase II study of the poly(ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM). J. Clin. Oncol. Abstr. 24, 8013 (2006
    • (2006) J. Clin. Oncol. Abstr. , vol.24 , pp. 8013
    • Plummer, R.1
  • 37
    • 79956053314 scopus 로고    scopus 로고
    • Poly(adp-ribose) polymerase and xpf ercc1 participate in distinct pathways for the repair of topoisomerase i induced dna damage in mammalian cells
    • Zhang, Y. W. et al. Poly(ADP-ribose) polymerase and XPF ERCC1 participate in distinct pathways for the repair of topoisomerase I induced DNA damage in mammalian cells. Nucleic Acids Res. 39, 3128-3140 (2011
    • (2011) Nucleic Acids Res. , vol.39 , pp. 3128-3140
    • Zhang, Y.W.1
  • 38
    • 79951887369 scopus 로고    scopus 로고
    • Therapeutic potential of poly(adp-ribose) polymerase inhibitor ag014699 in human cancers with mutated or methylated brca1 or brca2
    • Drew, Y. et al. Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. J. Natl Cancer Inst. 103, 334-346 (2011
    • (2011) J. Natl Cancer Inst. , vol.103 , pp. 334-346
    • Drew, Y.1
  • 40
    • 84871352245 scopus 로고    scopus 로고
    • Phase i safety and pharmacokinetic (pk) study of veliparib in combination with whole brain radiation therapy (wbrt) in patients (pts) with brain metastases
    • Mehta, M. P. et al. Phase I safety and pharmacokinetic (PK) study of veliparib in combination with whole brain radiation therapy (WBRT) in patients (pts) with brain metastases. J. Clin. Oncol. Abstr. 30, 2013 (2012
    • (2012) J. Clin. Oncol. Abstr. , vol.30 , pp. 2013
    • Mehta, M.P.1
  • 41
    • 79960350167 scopus 로고    scopus 로고
    • The xeroderma pigmentosum pathway: Decision tree analysis of dna quality
    • Naegeli, H. & Sugasawa, K. The xeroderma pigmentosum pathway: decision tree analysis of DNA quality. DNA Repair 10, 673-683 (2011
    • (2011) DNA Repair , vol.10 , pp. 673-683
    • Naegeli, H.1    Sugasawa, K.2
  • 44
    • 77956608305 scopus 로고    scopus 로고
    • Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ercc1 xpf expression
    • Usanova, S. et al. Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1 XPF expression. Mol. Cancer 9, 248 (2010
    • (2010) Mol. Cancer , vol.9 , pp. 248
    • Usanova, S.1
  • 46
    • 75149192733 scopus 로고    scopus 로고
    • 3 O methylfunicone, a selective inhibitor of mammalian y family dna polymerases from an australian sea salt fungal strain
    • Mizushina, Y. et al. 3 O methylfunicone, a selective inhibitor of mammalian Y family DNA polymerases from an Australian sea salt fungal strain. Mar. Drugs 7, 624-639 (2009
    • (2009) Mar. Drugs , vol.7 , pp. 624-639
    • Mizushina, Y.1
  • 47
    • 71049146040 scopus 로고    scopus 로고
    • A real-time fluorescence method for enzymatic characterization of specialized human dna polymerases
    • Dorjsuren, D. et al. A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases. Nucleic Acids Res. 37, e128 (2009
    • (2009) Nucleic Acids Res. , vol.37
    • Dorjsuren, D.1
  • 49
    • 81755181064 scopus 로고    scopus 로고
    • Causal link between microsatellite instability and hmre11 dysfunction in human cancers
    • Wu, X., Xu, Y., Chai, W. & Her, C. Causal link between microsatellite instability and hMRE11 dysfunction in human cancers. Mol. Cancer Res. 9, 1443-1448 (2011
    • (2011) Mol. Cancer Res. , vol.9 , pp. 1443-1448
    • Wu, X.1    Xu, Y.2    Chai, W.3    Her, C.4
  • 50
    • 33646009986 scopus 로고    scopus 로고
    • Impairment of double-strand breaks repair and aberrant splicing of atm and mre11 in leukemia-lymphoma cell lines with microsatellite instability
    • Demonstration of the impact of MMR defects on the function of HRR pathways.
    • Ham, M. F. et al. Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability. Cancer Sci. 97, 226-234 (2006). Demonstration of the impact of MMR defects on the function of HRR pathways.
    • (2006) Cancer Sci. , vol.97 , pp. 226-234
    • Ham, M.F.1
  • 51
    • 0028533694 scopus 로고
    • Dna damage tolerance, mismatch repair and genome instability
    • Karran, P. & Bignami, M. DNA damage tolerance, mismatch repair and genome instability. Bioessays 16, 833-839 (1994
    • (1994) Bioessays , vol.16 , pp. 833-839
    • Karran, P.1    Bignami, M.2
  • 52
    • 79958177781 scopus 로고    scopus 로고
    • Dna mismatch repair status affects cellular response to ara c and other anti-leukemic nucleoside analogs
    • Fordham, S. E., Matheson, E. C., Scott, K., Irving, J. A. & Allan, J. M. DNA mismatch repair status affects cellular response to Ara C and other anti-leukemic nucleoside analogs. Leukemia 25, 1046-1049 (2011
    • (2011) Leukemia , vol.25 , pp. 1046-1049
    • Fordham, S.E.1    Matheson, E.C.2    Scott, K.3    Irving, J.A.4    Allan, J.M.5
  • 53
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2? Deoxy 5 azacytidine-induced demethylation of the hmlh1 gene promoter
    • Plumb, J. A., Strathdee, G., Sludden, J., Kaye, S. B. & Brown, R. Reversal of drug resistance in human tumor xenografts by 2? deoxy 5 azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res. 60, 6039-6044 (2000
    • (2000) Cancer Res. , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5
  • 55
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of dna double-strand break repair pathway choice
    • Shrivastav, M., De Haro, L. P. & Nickoloff, J. A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 18, 134-147 (2008
    • (2008) Cell Res. , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 56
    • 59849089955 scopus 로고    scopus 로고
    • Repair of ionizing radiation-induced dna double-strand breaks by non-homologous end-joining
    • Mahaney, B. L., Meek, K. & Lees-Miller, S. P. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem. J. 417, 639-650 (2009
    • (2009) Biochem. J. , vol.417 , pp. 639-650
    • Mahaney, B.L.1    Meek, K.2    Lees-Miller, S.P.3
  • 57
    • 70350763838 scopus 로고    scopus 로고
    • Atm and artemis promote homologous recombination of radiation-induced dna double-strand breaks in g2
    • Beucher, A. et al. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J. 28, 3413-3427 (2009
    • (2009) EMBO J. , vol.28 , pp. 3413-3427
    • Beucher, A.1
  • 58
    • 34548391416 scopus 로고    scopus 로고
    • Dna topoisomerase ii, genotoxicity, cancer
    • McClendon, A. K.& Osheroff, N. DNA topoisomerase II, genotoxicity, cancer. Mutat. Res. 623, 83-97 (2007
    • (2007) Mutat. Res. , vol.623 , pp. 83-97
    • McClendon, A.K.1    Osheroff, N.2
  • 59
    • 0030814125 scopus 로고    scopus 로고
    • 2-M delay
    • Rosenzweig, K. E., Youmell, M. B., Palayoor, S. T. & Price, B. D. Radiosensitization of human tumor cells by the phosphatidylinositol3 kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2 M delay. Clin. Cancer Res. 3, 1149-1156 (1997). Early demonstration that PI3K inhibitors that also inhibit purified and cellular DNA-PKcs are radiosensitizers. (Pubitemid 27319761)
    • (1997) Clinical Cancer Research , vol.3 , Issue.7 , pp. 1149-1156
    • Rosenzweig, K.E.1    Youmell, M.B.2    Palayoor, S.T.3    Price, B.D.4
  • 60
    • 0034010521 scopus 로고    scopus 로고
    • Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin
    • DOI 10.1016/S0959-8049(99)00311-1, PII S0959804999003111
    • Boulton, S., Kyle, S. & Durkacz, B. W. Mechanisms of enhancement of cytotoxicity in etoposide and ionising radiation-treated cells by the protein kinase inhibitor wortmannin. Eur. J. Cancer 36, 535-541 (2000 (Pubitemid 30136235)
    • (2000) European Journal of Cancer , vol.36 , Issue.4 , pp. 535-541
    • Boulton, S.1    Kyle, S.2    Durkacz, B.W.3
  • 64
    • 84864875154 scopus 로고    scopus 로고
    • Chemosensitisation of cancer cells by ku 0060648; a dual inhibitor of dna pk and pi 3k
    • Munck, J. M. et al. Chemosensitisation of cancer cells by KU 0060648; a dual inhibitor of DNA PK and PI 3K. Mol. Can. Ther. 11, 1789-1798 (2012
    • (2012) Mol. Can. Ther. , vol.11 , pp. 1789-1798
    • Munck, J.M.1
  • 65
    • 2942591949 scopus 로고    scopus 로고
    • A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia
    • DOI 10.1182/blood-2003-07-2527
    • Willmore, E. et al. A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Blood 103, 4659-4665 (2004 (Pubitemid 38745999)
    • (2004) Blood , vol.103 , Issue.12 , pp. 4659-4665
    • Willmore, E.1    De Caux, S.2    Sunter, N.J.3    Tilby, M.J.4    Jackson, G.H.5    Austin, C.A.6    Durkacz, B.W.7
  • 66
    • 77952559374 scopus 로고    scopus 로고
    • Cohesin: A regulator of genome integrity and gene expression
    • Feeney, K. M., Wasson, C. W. & Parish, J. L. Cohesin: a regulator of genome integrity and gene expression. Biochem. J. 428, 147-161 (2010
    • (2010) Biochem. J. , vol.428 , pp. 147-161
    • Feeney, K.M.1    Wasson, C.W.2    Parish, J.L.3
  • 67
    • 23344444636 scopus 로고    scopus 로고
    • Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
    • DOI 10.1128/MCB.25.16.7158-7169.2005
    • Saleh-Gohari, N. et al. Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Mol.Cell Biol. 25, 7158-7169 (2005 (Pubitemid 41105912)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.16 , pp. 7158-7169
    • Saleh-Gohari, N.1    Bryant, H.E.2    Schultz, N.3    Parker, K.M.4    Cassel, T.N.5    Helleday, T.6
  • 68
    • 79959635260 scopus 로고    scopus 로고
    • Dna interstrand crosslink repair and cancer
    • Deans, A. J. & West, S. C. DNA interstrand crosslink repair and cancer. Nature Rev. Cancer 11, 467-480 (2011
    • (2011) Nature Rev. Cancer , vol.11 , pp. 467-480
    • Deans, A.J.1    West, S.C.2
  • 69
    • 77955278619 scopus 로고    scopus 로고
    • Targeting homologous recombination repair defects in cancer
    • Evers, B., Helleday, T. & Jonkers, J. Targeting homologous recombination repair defects in cancer. Trends Pharmacol.Sci. 31, 372-380 (2010
    • (2010) Trends Pharmacol.Sci. , vol.31 , pp. 372-380
    • Evers, B.1    Helleday, T.2    Jonkers, J.3
  • 70
    • 38349008365 scopus 로고    scopus 로고
    • A forward chemical genetic screen reveals an inhibitor of the mre11 rad50 nbs1 complex
    • Dupré, A. et al. A forward chemical genetic screen reveals an inhibitor of the Mre11 Rad50 Nbs1 complex. Nature Chem. Biol. 4, 119-125 (2008
    • (2008) Nature Chem. Biol. , vol.4 , pp. 119-125
    • Dupré, A.1
  • 71
    • 68249138694 scopus 로고    scopus 로고
    • Role of mre11 in chromosomal nonhomologous end joining in mammalian cells
    • Rass, E. et al. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nature Struct. Mol. Biol. 16, 819-824 (2009
    • (2009) Nature Struct. Mol. Biol. , vol.16 , pp. 819-824
    • Rass, E.1
  • 73
    • 58149490629 scopus 로고    scopus 로고
    • Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity
    • Choudhury, A. et al. Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity. Mol. Cancer Ther. 8, 203-213 (2009
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 203-213
    • Choudhury, A.1
  • 74
    • 77955847245 scopus 로고    scopus 로고
    • Multiple roles of atm in monitoring and maintaining dna integrity
    • Dernheimer, F.A. & Kastan, M,B. Multiple roles of ATM in monitoring and maintaining DNA integrity. Febs Letts. 584, 3675-3681 (2010
    • (2010) Febs Letts. , vol.584 , pp. 3675-3681
    • Dernheimer, F.A.1    Kastan, M.B.2
  • 75
    • 9244251125 scopus 로고    scopus 로고
    • Cell cycle checkpoints and cancer
    • Kastan, M. B. & Bartek, J. Cell cycle checkpoints and cancer. Nature 432, 316-323 (2004
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 76
    • 77953291328 scopus 로고    scopus 로고
    • 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
    • Novel observation that deletion of a component of NHEJ restores HRR function in BRCA1 mutant cells.
    • Bouwman, P. et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nature Struct. Mol. Biol. 17, 688-695 (2010). Novel observation that deletion of a component of NHEJ restores HRR function in BRCA1 mutant cells.
    • (2010) Nature Struct. Mol. Biol. , vol.17 , pp. 688-695
    • Bouwman, P.1
  • 77
    • 4944257913 scopus 로고    scopus 로고
    • ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining
    • DOI 10.1158/0008-5472.CAN-04-1289
    • Wang, H., Wang, H., Powel, S. N., Iliakis, G. & Wang, Y. ATR affecting cell radiosensitivity is dependent on homologous recombination but independent of non-homologous end joining. Cancer Res. 64, 7139-7143 (2004 (Pubitemid 39331028)
    • (2004) Cancer Research , vol.64 , Issue.19 , pp. 7139-7143
    • Wang, H.1    Wang, H.2    Powell, S.N.3    Iliakis, G.4    Wang, Y.5
  • 78
    • 79952454660 scopus 로고    scopus 로고
    • Atr: A master conductor of cellular responses to dna replication stress
    • Flynn, R. L. & Zou, L. ATR: a master conductor of cellular responses to DNA replication stress. Trends Biochem. Sci. 36, 133-140 (2011
    • (2011) Trends Biochem. Sci. , vol.36 , pp. 133-140
    • Flynn, R.L.1    Zou, L.2
  • 79
    • 23844442111 scopus 로고    scopus 로고
    • Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance
    • DOI 10.1158/0008-5472.CAN-05-1019
    • Lewis, K. A. et al. Heterozygous ATR mutations in mismatch repair-deficient cancer cells have functional significance. Cancer Res. 65, 7091-7095 (2005 (Pubitemid 41161237)
    • (2005) Cancer Research , vol.65 , Issue.16 , pp. 7091-7095
    • Lewis, K.A.1    Mullany, S.2    Thomas, B.3    Chien, J.4    Loewen, R.5    Shridhar, V.6    Cliby, W.A.7
  • 83
    • 9244239811 scopus 로고    scopus 로고
    • G1 cell cycle control and cancer
    • Massague, J. G1 cell cycle control and cancer. Nature 432, 298-306 (2004
    • (2004) Nature , vol.432 , pp. 298-306
    • Massague, J.1
  • 84
    • 0032472330 scopus 로고    scopus 로고
    • Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
    • DOI 10.1093/emboj/17.1.159
    • Cliby, W. A. et al. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA damaging agents and defects in cell cycle checkpoints. EMBO J. 17, 159-169 (1998). The first demonstration of the potential chemosensitization effect of ATR activation using an ATR kinase-dead dominant-negative approach. (Pubitemid 28041057)
    • (1998) EMBO Journal , vol.17 , Issue.1 , pp. 159-169
    • Cliby, W.A.1    Roberts, C.J.2    Cimprich, K.A.3    Stringer, C.M.4    Lamb, J.R.5    Schreiber, S.L.6    Friend, S.H.7
  • 85
    • 8444252707 scopus 로고    scopus 로고
    • Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: Differential activity in cells expressing or not p53
    • Carrassa, L. Broggini, M., Erba, E. & Damia, G. Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53. Cell Cycle 3, 1177-1181 (2004 (Pubitemid 40268636)
    • (2004) Cell Cycle , vol.3 , Issue.9 , pp. 1177-1181
    • Carrassa, L.1    Broggini, M.2    Erba, E.3    Damia, G.4
  • 87
    • 79955720082 scopus 로고    scopus 로고
    • Anticancer therapy with checkpoint inhibitors: What, where and when?
    • Garrett, M. D. & Collins, I. Anticancer therapy with checkpoint inhibitors: what, where and when? Trends Pharm. Sci. 32, 308-316 (2011
    • (2011) Trends Pharm. Sci. , vol.32 , pp. 308-316
    • Garrett, M.D.1    Collins, I.2
  • 88
    • 53349156857 scopus 로고    scopus 로고
    • Breaching the dna damage checkpoint via pf 00477736, a novel small-molecule inhibitor of checkpoint kinase 1
    • Blasina, A. et al. Breaching the DNA damage checkpoint via PF 00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Mol. Cancer Ther. 7, 2394-2404 (2008
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2394-2404
    • Blasina, A.1
  • 89
    • 52949139387 scopus 로고    scopus 로고
    • Azd7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates dna-targeted therapies
    • Zabludoff, S. D. et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 7, 2955-2966 (2008
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2955-2966
    • Zabludoff, S.D.1
  • 93
    • 79958865837 scopus 로고    scopus 로고
    • A cell-based screen identifies atr inhibitors with synthetic lethal properties for cancer-associated mutations
    • Toledo, L. I. et al. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nature Struct. Mol. Biol. 18, 721-727 (2011
    • (2011) Nature Struct. Mol. Biol. , vol.18 , pp. 721-727
    • Toledo, L.I.1
  • 94
    • 79959376888 scopus 로고    scopus 로고
    • Selective killing of atm- or p53 deficient cancer cells through inhibition of atr
    • The first report of a potent and specific small-molecule ATR inhibitor.
    • Reaper, P. M. et al. Selective killing of ATM- or p53 deficient cancer cells through inhibition of ATR. Nature Chem. Biol. 7, 428-430 (2011). The first report of a potent and specific small-molecule ATR inhibitor.
    • (2011) Nature Chem. Biol. , vol.7 , pp. 428-430
    • Reaper, P.M.1
  • 95
    • 79960834396 scopus 로고    scopus 로고
    • Identification and evaluation of a potent novel atr inhibitor, nu6027, in breast and ovarian cancer cell lines
    • Peasland, A., et al. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br. J. Cancer 105, 372-381 (2011
    • (2011) Br. J. Cancer , vol.105 , pp. 372-381
    • Peasland, A.1
  • 96
    • 0030667434 scopus 로고    scopus 로고
    • Integrating genetic approaches into the discovery of anticancer drugs
    • DOI 10.1126/science.278.5340.1064
    • Hartwell, L. H., Szankasi, P., Roberts, C. J., Murray, A. W. & Friend, S. H. Integrating Genetic approaches into the discovery of anticancer drugs. Science 278, 1064-1068 (1997). The first paper to identify the potential use of synthetic lethality in cancer. (Pubitemid 27517876)
    • (1997) Science , vol.278 , Issue.5340 , pp. 1064-1068
    • Hartwell, L.H.1    Szankasi, P.2    Roberts, C.J.3    Murray, A.W.4    Friend, S.H.5
  • 97
    • 0037932865 scopus 로고    scopus 로고
    • Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
    • Dolma, S., Lessnick, S. L., Hahn, W. C. & Stockwell, B. R. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3, 285-289(2003
    • (2003) Cancer Cell , vol.3 , pp. 285-289
    • Dolma, S.1    Lessnick, S.L.2    Hahn, W.C.3    Stockwell, B.R.4
  • 100
    • 80052168685 scopus 로고    scopus 로고
    • The underlying mechanism for the parp & brca synthetic lethality: Clearing up the misunderstandings
    • Helleday, T. The underlying mechanism for the PARP & BRCA synthetic lethality: clearing up the misunderstandings. Mol. Oncol. 5, 387-393 (2011
    • (2011) Mol. Oncol. , vol.5 , pp. 387-393
    • Helleday, T.1
  • 101
    • 78049252736 scopus 로고    scopus 로고
    • Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment
    • Chan, N. et al. Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Res. 70, 8045-8054 (2010
    • (2010) Cancer Res. , vol.70 , pp. 8045-8054
    • Chan, N.1
  • 102
    • 79960003299 scopus 로고    scopus 로고
    • Mild hyperthermia inhibits homologous recombination, induces brca2 degradation, and sensitizes cancer cells to poly (adp-ribose) polymerase 1 inhibition
    • Krawczyk, P. M. et al. Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase 1 inhibition. Proc. Natl Acad. Sci. USA 108, 9851-9856 (2011
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 9851-9856
    • Krawczyk, P.M.1
  • 103
    • 77954032829 scopus 로고    scopus 로고
    • Poly(adp)-ribose polymerase inhibition: Frequent durable responses in brca carrier ovarian cancer correlating with platinum-free interval
    • Report of the first clinical trial of a PARPi in patients with BRCA-associated tumours, demonstrating a good response rate with minimal toxicity.
    • Fong, P. C. et al. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J. Clin. Oncol. 28, 2512-2519 (2010). Report of the first clinical trial of a PARPi in patients with BRCA-associated tumours, demonstrating a good response rate with minimal toxicity.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2512-2519
    • Fong, P.C.1
  • 104
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, non-randomised study
    • Gelmon, K. A. et al. Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol. 12, 852-861 (2011
    • (2011) Lancet Oncol. , vol.12 , pp. 852-861
    • Gelmon, K.A.1
  • 105
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of dna damage by homologous recombination and sensitivity to poly(adp-ribose) polymerase inhibition
    • Mccabe, N. et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res. 66, 8109-8115 (2006
    • (2006) Cancer Res. , vol.66 , pp. 8109-8115
    • Mccabe, N.1
  • 106
    • 84867082212 scopus 로고    scopus 로고
    • Synthetic lethal targeting of dna double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors
    • Sultana, R. et al. Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors. Int. J. Cancer 131, 2433-2444 (2012
    • (2012) Int. J. Cancer , vol.131 , pp. 2433-2444
    • Sultana, R.1
  • 108
    • 79952747328 scopus 로고    scopus 로고
    • Nonhomologous end joining drives poly(adp-ribose) polymerase (parp) inhibitor lethality in homologous recombination-deficient cells
    • Patel, A. G., Sarkaria, J. N. & Kaufmann, S. H. Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells. Proc. Natl Acad.Sci. USA 108, 3406-3411 (2011
    • (2011) Proc. Natl Acad.Sci. USA , vol.108 , pp. 3406-3411
    • Patel, A.G.1    Sarkaria, J.N.2    Kaufmann, S.H.3
  • 109
    • 77954310242 scopus 로고    scopus 로고
    • Preventing nonhomologous end joining suppresses dna repair defects of fanconi anemia
    • Adamo, A. et al. Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Mol. Cell. 39, 25-35 (2010
    • (2010) Mol. Cell. , vol.39 , pp. 25-35
    • Adamo, A.1
  • 111
    • 78649321855 scopus 로고    scopus 로고
    • The parp inhibitor olaparib induces significant killing of atm-deficient lymphoid tumor cells in vitro and in vivo
    • Weston, V. J. et al. The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Blood 116, 4578-4587 (2010
    • (2010) Blood , vol.116 , pp. 4578-4587
    • Weston, V.J.1
  • 112
    • 76649091939 scopus 로고    scopus 로고
    • Atm deficiency sensitizes mantle cell lymphoma cells to poly(adp-ribose) polymerase 1 inhibitors
    • Williamson, C. T. et al. ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase 1 inhibitors. Mol. Cancer Ther. 9, 347-357 (2010
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 347-357
    • Williamson, C.T.1
  • 113
    • 79953313615 scopus 로고    scopus 로고
    • Mre11 deficiency increases sensitivity to poly(adp-ribose) polymerase inhibition in microsatellite unstable colorectal cancers
    • Vilar, E. et al. MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite unstable colorectal cancers. Cancer Res. 71, 2632-2642 (2011
    • (2011) Cancer Res. , vol.71 , pp. 2632-2642
    • Vilar, E.1
  • 114
    • 77649311945 scopus 로고    scopus 로고
    • Dna polymerases as potential therapeutic targets for cancers deficient in the dna mismatch repair proteins msh2 or mlh1
    • Martin, S. A. et al. DNA polymerases as potential therapeutic targets for cancers deficient in the DNA mismatch repair proteins MSH2 or MLH1. Cancer Cell 17, 235-248 (2010
    • (2010) Cancer Cell , vol.17 , pp. 235-248
    • Martin, S.A.1
  • 115
    • 79960150694 scopus 로고    scopus 로고
    • Compromised cdk1 activity sensitizes brca-proficient cancers to parp inhibition
    • Demonstration of the synthetic lethality of CDK1 inhibition and PARP inhibition in tumours, whilst sparing normal tissues, in an animal model.
    • Johnson, N. et al. Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nature Med. 17, 875-883 (2011). Demonstration of the synthetic lethality of CDK1 inhibition and PARP inhibition in tumours, whilst sparing normal tissues, in an animal model.
    • (2011) Nature Med. , vol.17 , pp. 875-883
    • Johnson, N.1
  • 116
    • 77958149646 scopus 로고    scopus 로고
    • Poly(adp-ribose) polymerase 1 modulates the lethality of chk1 inhibitors in carcinoma cells
    • Mitchell, C. et al. Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells. Mol. Pharmacol. 78, 909-917 (2010
    • (2010) Mol. Pharmacol. , vol.78 , pp. 909-917
    • Mitchell, C.1
  • 117
    • 80055108191 scopus 로고    scopus 로고
    • Chk2 deficiency in myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with parp inhibition
    • Höglund, A., Strömvall, K., Li, Y., Forshell, L. P. & Nilsson, J. A. Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. Cell Cycle. 10, 3598-3607 (2011
    • (2011) Cell Cycle. , vol.10 , pp. 3598-3607
    • Höglund, A.1    Strömvall, K.2    Li, Y.3    Forshell, L.P.4    Nilsson, J.A.5
  • 119
    • 65449142073 scopus 로고    scopus 로고
    • Chk1 inhibition as a strategy for targeting fanconi anemia (fa) dna repair pathway deficient tumors
    • Chen, C. C., Kennedy, R. D., Sidi, S., Look, A. T. & D'Andrea, A. CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol. Cancer 8, 24 (2009
    • (2009) Mol. Cancer , vol.8 , pp. 24
    • Chen, C.C.1    Kennedy, R.D.2    Sidi, S.3    Look, A.T.4    D'Andrea, A.5
  • 120
    • 78649929369 scopus 로고    scopus 로고
    • Combining atr suppression with oncogenic ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner
    • Gilad, O. et al. Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner. Cancer Res. 70, 9693-9702 (2010
    • (2010) Cancer Res. , vol.70 , pp. 9693-9702
    • Gilad, O.1
  • 121
    • 84859428543 scopus 로고    scopus 로고
    • Efficacy of chk inhibitors as single agents in myc-driven lymphoma cells
    • Ferrao, P. T. Bukczynska, E. P., Johnstone, R. W. & McArthur, G. A. Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells. Oncogene 31, 1661-1672 (2011
    • (2011) Oncogene , vol.31 , pp. 1661-1672
    • Ferrao, P.T.1    Bukczynska, E.P.2    Johnstone, R.W.3    McArthur, G.A.4
  • 122
    • 79955968629 scopus 로고    scopus 로고
    • Mechanistic rationale for inhibition of poly(adp-ribose) polymerase in ets gene fusion-positive prostate cancer
    • Demonstration that ETS fusion genes, which are transforming events in prostate cancer, AML and Ewing's sarcoma, associate with PARP1 and DNA PK and are synthetically lethal with PARP inhibition.
    • Brenner, J. C. et al. Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell 19, 664-678 (2011). Demonstration that ETS fusion genes, which are transforming events in prostate cancer, AML and Ewing's sarcoma, associate with PARP1 and DNA PK and are synthetically lethal with PARP inhibition.
    • (2011) Cancer Cell , vol.19 , pp. 664-678
    • Brenner, J.C.1
  • 123
    • 84859391984 scopus 로고    scopus 로고
    • Parp 1 inhibition as a targeted strategy to treat ewing's sarcoma
    • Brenner, J. C. et al. PARP 1 inhibition as a targeted strategy to treat Ewing's sarcoma. Cancer Res. 72, 1608-1613 (2012
    • (2012) Cancer Res. , vol.72 , pp. 1608-1613
    • Brenner, J.C.1
  • 124
    • 84859187259 scopus 로고    scopus 로고
    • Systematic identification of genomic markers of drug sensitivity in cancer cells
    • Garnett, M. J. et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 483, 570-575 (2012
    • (2012) Nature , vol.483 , pp. 570-575
    • Garnett, M.J.1
  • 126
    • 79953306841 scopus 로고    scopus 로고
    • Dna repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy
    • Moeller, B. J. et al. DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy. Clin. Can. Res. 17, 2035-2043 (2011
    • (2011) Clin. Can. Res. , vol.17 , pp. 2035-2043
    • Moeller, B.J.1
  • 127
    • 67349284098 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy with cisplatin in brca1 positive breast cancer patients
    • Byrski, T. et al. Response to neoadjuvant therapy with cisplatin in BRCA1 positive breast cancer patients. Breast Cancer Res. Treat. 115, 359-363 (2009
    • (2009) Breast Cancer Res. Treat. , vol.115 , pp. 359-363
    • Byrski, T.1
  • 130
    • 77955894453 scopus 로고    scopus 로고
    • Gene expression profile of brcaness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer
    • Konstantinopoulos, P. A. et al. Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. J. Clin. Oncol. 28, 3555-3561 (2010
    • (2010) J. Clin. Oncol. , vol.28 , pp. 3555-3561
    • Konstantinopoulos, P.A.1
  • 131
    • 0034898120 scopus 로고    scopus 로고
    • DNA methylation in ovarian cancer: II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells
    • DOI 10.1006/gyno.2001.6284
    • Ahluwalia, A., Hurteau, J. A., Bigsby, R. M. & Nephew, K. P. DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells. Gynecol. Oncol. 82, 299-304 (2001 (Pubitemid 32730607)
    • (2001) Gynecologic Oncology , vol.82 , Issue.2 , pp. 299-304
    • Ahluwalia, A.1    Hurteau, J.A.2    Bigsby, R.M.3    Nephew, K.P.4
  • 132
    • 84856230867 scopus 로고    scopus 로고
    • Genomic instability in breast and ovarian cancers: Translation into clinical predictive biomarkers
    • Vollebergh, M. A. Jonkers, J. & Linn, S. C. Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers. Cell. Mol. Life Sci. 69, 223-245 (2012
    • (2012) Cell. Mol. Life Sci. , vol.69 , pp. 223-245
    • Vollebergh, M.A.1    Jonkers, J.2    Linn, S.C.3
  • 133
    • 69449090092 scopus 로고    scopus 로고
    • Utility of dna repair protein foci for the detection of putative brca1 pathway defects in breast cancer biopsies
    • Willers, H. et al. Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies. Mol. Cancer Res. 7, 1304-1309 (2009
    • (2009) Mol. Cancer Res. , vol.7 , pp. 1304-1309
    • Willers, H.1
  • 134
    • 66049084743 scopus 로고    scopus 로고
    • Inhibitors of poly adp-ribose polymerase (parp) induce apoptosis of myeloid leukemic cells: Potential for therapy of myeloid leukemia and myelodysplastic syndromes
    • Gaymes, T. J. et al. Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 94, 638-646 (2009
    • (2009) Haematologica , vol.94 , pp. 638-646
    • Gaymes, T.J.1
  • 135
    • 77950974130 scopus 로고    scopus 로고
    • Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(adp-ribose) polymerase inhibitors
    • Mukhopadhyay, A. et al. Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors. Clin. Cancer Res. 16, 2344-2351 (2010
    • (2010) Clin. Cancer Res. , vol.16 , pp. 2344-2351
    • Mukhopadhyay, A.1
  • 136
    • 77958045536 scopus 로고    scopus 로고
    • A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer
    • Graeser, M. et al. A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer. Clin. Cancer Res. 16, 6159-6168 (2010
    • (2010) Clin. Cancer Res. , vol.16 , pp. 6159-6168
    • Graeser, M.1
  • 137
    • 77956268304 scopus 로고    scopus 로고
    • Circulating tumour cells in cancer patients: Challenges and perspectives
    • Pantel, K. & Alix-Panabières, C. Circulating tumour cells in cancer patients: challenges and perspectives. Trends Mol. Med. 16, 398-406 (2010
    • (2010) Trends Mol. Med. , vol.16 , pp. 398-406
    • Pantel, K.1    Alix-Panabières, C.2
  • 138
    • 57149136324 scopus 로고    scopus 로고
    • H2AX and cancer
    • Bonner, W. M. et al. H2AX and cancer. Nature Rev. Cancer 8, 957-967 (2008
    • (2008) Nature Rev. Cancer , vol.8 , pp. 957-967
    • Bonner, W.M.1
  • 139
    • 33847028014 scopus 로고    scopus 로고
    • Induction of atm activation, histone h2ax phosphorylation and apoptosis by etoposide: Relation to cell cycle phase
    • Tanaka, T., Halicka, H. D., Traganos, F., Seiter, K. & Darzynkiewicz, Z. Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase. Cell Cycle. 6, 371-376 (2007
    • (2007) Cell Cycle. , vol.6 , pp. 371-376
    • Tanaka, T.1    Halicka, H.D.2    Traganos, F.3    Seiter, K.4    Darzynkiewicz, Z.5
  • 140
    • 77956686608 scopus 로고    scopus 로고
    • Histone ?h2ax and poly(adp-ribose) as clinical pharmacodynamic biomarkers
    • Redon, C. E. et al. Histone ?H2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers. Clin. Cancer Res. 16, 4532-4542 (2010
    • (2010) Clin. Cancer Res. , vol.16 , pp. 4532-4542
    • Redon, C.E.1
  • 141
    • 67650471685 scopus 로고    scopus 로고
    • Inhibition of poly(adp-ribose) polymerase in tumors from brca mutation carriers
    • Fong, P. C. et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 361, 123-134 (2009
    • (2009) N. Engl. J. Med. , vol.361 , pp. 123-134
    • Fong, P.C.1
  • 142
    • 80052238687 scopus 로고    scopus 로고
    • Phase i study of parp inhibitor abt 888 in combination with topotecan in adults with refractory solid tumors and lymphomas
    • Kummar, S. et al. Phase I study of PARP inhibitor ABT 888 in combination with topotecan in adults with refractory solid tumors and lymphomas. Cancer Res. 71, 5626-5634 (2011
    • (2011) Cancer Res. , vol.71 , pp. 5626-5634
    • Kummar, S.1
  • 143
    • 84863236347 scopus 로고    scopus 로고
    • A phase i study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas
    • Kummar, S. et al. A phase I study of veliparib in combination with metronomic cyclophosphamide in adults with refractory solid tumors and lymphomas. Clin. Cancer Res. 18, 1726-1734 (2012
    • (2012) Clin. Cancer Res. , vol.18 , pp. 1726-1734
    • Kummar, S.1
  • 144
    • 34247599335 scopus 로고    scopus 로고
    • A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification
    • DOI 10.1016/j.dnarep.2007.01.009, PII S1568786407000274
    • Almeida, K. H. & Sobol, R. W. A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair 6, 695-711 (2007 (Pubitemid 46670095)
    • (2007) DNA Repair , vol.6 , Issue.6 , pp. 695-711
    • Almeida, K.H.1    Sobol, R.W.2
  • 146
    • 0033618621 scopus 로고    scopus 로고
    • Association of brca1 with the hrad50 hmre11 p95 complex and the dna damage response
    • Zhong, Q. et al. Association of BRCA1 with the hRad50 hMre11 p95 complex and the DNA damage response. Science 285, 747-770 (1999
    • (1999) Science , vol.285 , pp. 747-770
    • Zhong, Q.1
  • 147
    • 38149057387 scopus 로고    scopus 로고
    • Parp1 dependent kinetics of recruitment of mre11 and nbs1 proteins to multiple dna damage sites
    • Haince, J. F. et al. PARP1 dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites. J. Biol. Chem. 283, 1197-1208 (2008
    • (2008) J. Biol. Chem. , vol.283 , pp. 1197-1208
    • Haince, J.F.1
  • 148
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
    • DOI 10.1158/0008-5472.CAN-03-3207
    • Stiff, T. et al. ATM and DNA PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64, 2390-2396 (2004 (Pubitemid 38523891)
    • (2004) Cancer Research , vol.64 , Issue.7 , pp. 2390-2396
    • Stiff, T.1    O'Driscoll, M.2    Rief, N.3    Iwabuchi, K.4    Lobrich, M.5    Jeggo, P.A.6
  • 149
    • 77957975815 scopus 로고    scopus 로고
    • Purified human brca2 stimulates rad51 mediated recombination
    • The first successful purification of full-length BRCA2, demonstrating that it binds RAD51 and promotes the displacement of replication protein A (RPA) on the single-stranded DNA filament that invades the complementary sequence in the sister chromatid.
    • Jensen, R. B., Carreira, A. & Kowalczykowski, S. C. Purified human BRCA2 stimulates RAD51 mediated recombination. Nature 467, 678-683 (2010). The first successful purification of full-length BRCA2, demonstrating that it binds RAD51 and promotes the displacement of replication protein A (RPA) on the single-stranded DNA filament that invades the complementary sequence in the sister chromatid.
    • (2010) Nature , vol.467 , pp. 678-683
    • Jensen, R.B.1    Carreira, A.2    Kowalczykowski, S.C.3
  • 150
    • 31544464704 scopus 로고    scopus 로고
    • Targeted modulation of MGMT: Clinical implications
    • DOI 10.1158/1078-0432.CCR-05-2543
    • Liu, L. & Gerson, S. L. Targeted modulation of MGMT: clinical implications. Clin. Cancer Res. 12, 328-331 (2006 (Pubitemid 43166117)
    • (2006) Clinical Cancer Research , vol.12 , Issue.2 , pp. 328-331
    • Liu, L.1    Gerson, S.L.2
  • 153
    • 79957726564 scopus 로고    scopus 로고
    • Poly(adp-ribose) polymerase 1 (parp 1) parmacogenetics, activity and expression analysis in cancer patients and healthy volunteers
    • Zaremba, T. et al. Poly(ADP-ribose) polymerase 1 (PARP 1) parmacogenetics, activity and expression analysis in cancer patients and healthy volunteers. Biochem. J. 436, 671-679 (2011
    • (2011) Biochem. J. , vol.436 , pp. 671-679
    • Zaremba, T.1
  • 154
    • 81255138410 scopus 로고    scopus 로고
    • Dna repair: From genome maintenance to biomarker and therapeutic target
    • Jalal, S., Earley, J. N. & Turchi, J. J. DNA repair: from genome maintenance to biomarker and therapeutic target. Clin. Cancer Res. 17, 6973-6984 (2011
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6973-6984
    • Jalal, S.1    Earley, J.N.2    Turchi, J.J.3
  • 155
    • 45749123993 scopus 로고    scopus 로고
    • NBS1 heterozygosity and cancer risk
    • DOI 10.2174/138920208784533610
    • di Masi, A. & Antoccia, A. NBS1 Heterozygosity and cancer risk. Curr. Genom. 9, 275-281 (2008 (Pubitemid 351864253)
    • (2008) Current Genomics , vol.9 , Issue.4 , pp. 275-281
    • Di Masi, A.1    Antoccia, A.2
  • 156
    • 3242892589 scopus 로고    scopus 로고
    • Nijmegen breakage syndrome: Clinical manifestation of defective response to DNA double-strand breaks
    • DOI 10.1016/j.dnarep.2004.03.004, PII S1568786404000631
    • Digweed, M. & Sperling, K. Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair 3, 1207-1217 (2004 (Pubitemid 38997964)
    • (2004) DNA Repair , vol.3 , Issue.8-9 , pp. 1207-1217
    • Digweed, M.1    Sperling, K.2
  • 157
    • 1542542679 scopus 로고    scopus 로고
    • Mutation screening of mre11 complex genes: Indication of rad50 involvement in breast and ovarian cancer susceptibility
    • Heikkinen, K., Karppinen, S. M., Soini, Y., Makinen, M. & Winqvist, R. Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility. J. Med.Genet. 40, e131 (2003
    • (2003) J. Med.Genet. , vol.40
    • Heikkinen, K.1    Karppinen, S.M.2    Soini, Y.3    Makinen, M.4    Winqvist, R.5
  • 159
    • 33749028012 scopus 로고    scopus 로고
    • Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks
    • DOI 10.1074/jbc.M603747200
    • Takemura, H. et al. Defective Mre11 dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J. Biol. Chem. 281, 30814-30823 (2006 (Pubitemid 44582136)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.41 , pp. 30814-30823
    • Takemura, H.1    Rao, V.A.2    Sordet, O.3    Furuta, T.4    Miao, Z.-H.5    Meng, L.6    Zhang, H.7    Pommier, Y.8
  • 160
    • 38049046205 scopus 로고    scopus 로고
    • Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity
    • Willems, P. et al. Polymorphisms in nonhomologous end-joining genes associated with breast cancer risk and chromosomal radiosensitivity. Genes Chromosomes Cancer 47, 137-148 (2008
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 137-148
    • Willems, P.1
  • 161
    • 33847355994 scopus 로고    scopus 로고
    • Epigenetic inactivation of the chromosomal stability control genes brca1, brca2, and xrcc5 in non-small cell lung cancer
    • Lee, M. N. et al. Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer. Clin. Cancer Res. 13, 832-838 (2007
    • (2007) Clin. Cancer Res. , vol.13 , pp. 832-838
    • Lee, M.N.1
  • 163
    • 77958133262 scopus 로고    scopus 로고
    • Targeting dna-pkcs and atm with mir 101 sensitizes tumors to radiation
    • Yan, D. et al. Targeting DNA-PKcs and ATM with miR 101 sensitizes tumors to radiation. PLoS ONE 5, e11397 (2010
    • (2010) PLoS ONE , vol.5
    • Yan, D.1
  • 164
    • 0029680501 scopus 로고    scopus 로고
    • A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals
    • Berman, D. B. et al. A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals. Cancer Res. 56, 3409-3414 (1996 (Pubitemid 26251628)
    • (1996) Cancer Research , vol.56 , Issue.15 , pp. 3409-3414
    • Berman, D.B.1    Costalas, J.2    Schultz, D.C.3    Grana, G.4    Daly, M.5    Godwin, A.K.6
  • 167
    • 0035135548 scopus 로고    scopus 로고
    • Frameshift mutations at coding mononucleotide repeats of the hrad50 gene in gastrointestinal carcinomas with microsatellite instability
    • Kim, N. G. et al. Frameshift mutations at coding mononucleotide repeats of the hRAD50 gene in gastrointestinal carcinomas with microsatellite instability. Cancer Res. 61, 36-38 (2001
    • (2001) Cancer Res. , vol.61 , pp. 36-38
    • Kim, N.G.1
  • 168
    • 0037306904 scopus 로고    scopus 로고
    • Cancer incidence in persons with Fanconi anemia
    • DOI 10.1182/blood-2002-05-1498
    • Rosenberg, P. S., Greene, M. H. & Alter, B. P. Cancer incidence in persons with Fanconi anemia. Blood 101, 822-826 (2003 (Pubitemid 36139345)
    • (2003) Blood , vol.101 , Issue.3 , pp. 822-826
    • Rosenberg, P.S.1    Greene, M.H.2    Alter, B.P.3
  • 169
    • 1342301467 scopus 로고    scopus 로고
    • Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: Implications for treatment and survival
    • DOI 10.1038/sj.onc.1207256
    • Marsit, C. J. et al. Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene 23, 1000-1004 (2004 (Pubitemid 38250946)
    • (2004) Oncogene , vol.23 , Issue.4 , pp. 1000-1004
    • Marsit, C.J.1    Liu, M.2    Nelson, H.H.3    Posner, M.4    Suzuki, M.5    Kelsey, K.T.6
  • 171
  • 172
    • 36448973875 scopus 로고    scopus 로고
    • CHK2 kinase: Cancer susceptibility and cancer therapy - Two sides of the same coin?
    • DOI 10.1038/nrc2251, PII NRC2251
    • Antoni, L., Sodha, N., Collins, I. & Garrett, M. D. CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin? Nature Rev. Cancer 7, 925-936 (2007 (Pubitemid 350165855)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.12 , pp. 925-936
    • Antoni, L.1    Sodha, N.2    Collins, I.3    Garrett, M.D.4
  • 173
    • 70350236645 scopus 로고    scopus 로고
    • Amino acid asp181 of 5' flap endonuclease 1 is a useful target for chemotherapeutic development
    • Panda, H. et al. Amino acid Asp181 of 5' flap endonuclease 1 is a useful target for chemotherapeutic development. Biochemistry 48, 9952-9958 (2009
    • (2009) Biochemistry , vol.48 , pp. 9952-9958
    • Panda, H.1
  • 174
    • 42149157403 scopus 로고    scopus 로고
    • Inhibitors of DNA polymerase β: Activity and mechanism
    • DOI 10.1016/j.bmc.2008.02.071, PII S0968089608001922
    • Gao, Z., Maloney, D. J., Dedkova, L. M. & Hecht, S. M. Inhibitors of DNA polymerase ß: activity and mechanism. Bioorg. Med. Chem. 16, 4331-4340 (2008 (Pubitemid 351539042)
    • (2008) Bioorganic and Medicinal Chemistry , vol.16 , Issue.8 , pp. 4331-4340
    • Gao, Z.1    Maloney, D.J.2    Dedkova, L.M.3    Hecht, S.M.4
  • 175
    • 77149155961 scopus 로고    scopus 로고
    • Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - A mammalian dna polymerase inhibitor
    • Kumamoto-Yonezawa, Y. et al. Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - a mammalian DNA polymerase inhibitor. Int. J. Oncol. 36, 577-584 (2010
    • (2010) Int. J. Oncol. , vol.36 , pp. 577-584
    • Kumamoto-Yonezawa, Y.1
  • 176
    • 44849117230 scopus 로고    scopus 로고
    • Rational design of human dna ligase inhibitors that target cellular dna replication and repair
    • Chen, X. et al. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 68, 3169-3177 (2008
    • (2008) Cancer Res. , vol.68 , pp. 3169-3177
    • Chen, X.1
  • 177
    • 84881361881 scopus 로고    scopus 로고
    • Final results from a phase 1 study of oral trc102 (methoxyamine hcl), an inhibitor of base-excision repair, to potentiate the activity of pemetrexedin patients with refractory cancer
    • Weiss, G. J. et al. Final results from a phase 1 study of oral TRC102 (methoxyamine HCl), an inhibitor of base-excision repair, to potentiate the activity of pemetrexedin patients with refractory cancer. J. Clin. Oncol. Abstr. 2576 (2010
    • (2010) J. Clin. Oncol. Abstr. , vol.2576
    • Weiss, G.J.1
  • 179
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(adp-ribose) polymerase inhibitor olaparib in patients with brca1 or brca2 mutations and advanced breast cancer: A proof of concept trial
    • Tutt, A. et al. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof of concept trial. Lancet 376, 235-244 (2010
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1
  • 180
    • 84866564290 scopus 로고    scopus 로고
    • Safety and tolerability of the poly(adp-ribose) polymerase (parp) inhibitor, olaparib (azd2281) in combination with topotecan for the treatment of patients with advanced solid tumors: A phase i study
    • Samol, J. et al. Safety and tolerability of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib (AZD2281) in combination with topotecan for the treatment of patients with advanced solid tumors: a phase I study. Invest. New Drugs 30, 1493-1500 (2012
    • (2012) Invest. New Drugs , vol.30 , pp. 1493-1500
    • Samol, J.1
  • 181
    • 79952281417 scopus 로고    scopus 로고
    • A phase i study of the safety and tolerability of olaparib (azd2281, ku0059436) and dacarbazine in patients with advanced solid tumours
    • Khan, O. A. et al. A phase I study of the safety and tolerability of olaparib (AZD2281, KU0059436) and dacarbazine in patients with advanced solid tumours. Br. J. Cancer 104, 750-755 (2011
    • (2011) Br. J. Cancer , vol.104 , pp. 750-755
    • Khan, O.A.1
  • 183
    • 80052965032 scopus 로고    scopus 로고
    • Cyclosporin a inhibits nucleotide excision repair via downregulation of the xeroderma pigmentosum group a and g proteins, which is mediated by calcineurin inhibition
    • Kuschal, C. et al. Cyclosporin A inhibits nucleotide excision repair via downregulation of the xeroderma pigmentosum group A and G proteins, which is mediated by calcineurin inhibition. Exp. Dermatol. 20, 795-799 (2011
    • (2011) Exp. Dermatol. , vol.20 , pp. 795-799
    • Kuschal, C.1
  • 184
    • 37549007196 scopus 로고    scopus 로고
    • Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab
    • Prewett, M. et al. Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab. Clin. Cancer Res. 13, 7432-7440 (2007
    • (2007) Clin. Cancer Res. , vol.13 , pp. 7432-7440
    • Prewett, M.1
  • 185
    • 0345404241 scopus 로고    scopus 로고
    • Differential inhibitory effect of OK-1035 on DNA repair in L5178Y murine lymphoma sublines with functional or defective repair of double strand breaks
    • DOI 10.1016/S0921-8777(98)00040-8, PII S0921877798000408
    • Kruszewski, M., Wojewodzka, M., Iwanenko, T., Szumiel, I. & Okuyama, A. Differential inhibitory effect of OK 1035 on DNA repair in L5178Y murine lymphoma sublines with functional or defective repair of double strand breaks. Mutat. Res. 409, 31-36 (1998 (Pubitemid 28464459)
    • (1998) Mutation Research - DNA Repair , vol.409 , Issue.1 , pp. 31-36
    • Kruszewski, M.1    Wojewodzka, M.2    Iwanenko, T.3    Szumiel, I.4    Okuyama, A.5
  • 186
    • 1342343930 scopus 로고    scopus 로고
    • SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization
    • DOI 10.1038/sj.onc.1207303
    • Ismail, I. H. et al. SU11752 inhibits the DNA-dependent protein kinase and DNA double-strand break repair resulting in ionizing radiation sensitization. Oncogene 23, 873-882 (2004 (Pubitemid 38250932)
    • (2004) Oncogene , vol.23 , Issue.4 , pp. 873-882
    • Ismail, I.H.1    Martensson, S.2    Moshinsky, D.3    Rice, A.4    Tang, C.5    Howlett, A.6    McMahon, G.7    Hammarsten, O.8
  • 187
    • 79961077772 scopus 로고    scopus 로고
    • Identification of specific inhibitors of human rad51 recombinase using high-throughput screening
    • Huang, F. et al. Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. ACS Chem. Biol. 6, 628-635 (2011
    • (2011) ACS Chem. Biol. , vol.6 , pp. 628-635
    • Huang, F.1
  • 188
    • 54749148734 scopus 로고    scopus 로고
    • Transient inhibition of atm kinase is sufficient to enhance cellular sensitivity to ionizing radiation
    • Rainey, M. D., Charlton, M. E., Stanton, R. V. & Kastan, M. B. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 68, 7466-7467 (2008
    • (2008) Cancer Res. , vol.68 , pp. 7466-7467
    • Rainey, M.D.1    Charlton, M.E.2    Stanton, R.V.3    Kastan, M.B.4
  • 189
    • 70350238489 scopus 로고    scopus 로고
    • Improved atm kinase inhibitor ku 60019 radiosensitizes glioma cells, compromises insulin, akt and erk prosurvival signaling, and inhibits migration and invasion
    • Golding, S. E. et al. Improved ATM kinase inhibitor KU 60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol. Cancer Ther. 8, 2894-2902 (2009
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2894-2902
    • Golding, S.E.1
  • 190
    • 70949083026 scopus 로고    scopus 로고
    • Small-molecule inhibition of wee1 kinase by mk 1775 selectively sensitizes p53 deficient tumor cells to dna-damaging agents
    • Hirai, H. et al. Small-molecule inhibition of Wee1 kinase by MK 1775 selectively sensitizes p53 deficient tumor cells to DNA-damaging agents. Mol. Cancer Ther. 8, 2992-3000 (2009
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 2992-3000
    • Hirai, H.1
  • 191
    • 79955492036 scopus 로고    scopus 로고
    • Mk 1775, a potent wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53 deficient pancreatic cancer xenografts clin
    • Rajeshkumar, N. V. et al. MK 1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53 deficient pancreatic cancer xenografts Clin. Cancer Res. 17, 2799-2806 (2011
    • (2011) Cancer Res. , vol.17 , pp. 2799-2806
    • Rajeshkumar, N.V.1
  • 192
    • 84855645086 scopus 로고    scopus 로고
    • Mk1775, a selective wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells
    • Kreahling, J. M. et al. MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells. Mol. Cancer Ther. 11, 174-182 (2012
    • (2012) Mol. Cancer Ther. , vol.11 , pp. 174-182
    • Kreahling, J.M.1
  • 193
    • 84858833041 scopus 로고    scopus 로고
    • Update on a phase i pharmacologic and pharmacodynamic study of mk 1775, a wee1 tyrosine kinase inhibitor, in monotherapy and combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors
    • Schellens, J. H. M. et al. Update on a phase I pharmacologic and pharmacodynamic study of MK 1775, a Wee1 tyrosine kinase inhibitor, in monotherapy and combination with gemcitabine, cisplatin, or carboplatin in patients with advanced solid tumors. J. Clin. Oncol. Abstr. 29, 3068 (2011
    • (2011) J. Clin. Oncol. Abstr. , vol.29 , pp. 3068
    • Schellens, J.H.M.1
  • 194
    • 60549098655 scopus 로고    scopus 로고
    • Irc 083864, a novel bisquinone inhibitor of cdc25 phosphatases active against human cancer cells
    • Brezak, M. C. et al. IRC 083864, a novel bisquinone inhibitor of CDC25 phosphatases active against human cancer cells. Int. J. Cancer 124, 1449-1456 (2009
    • (2009) Int. J. Cancer , vol.124 , pp. 1449-1456
    • Brezak, M.C.1
  • 195
    • 77649085550 scopus 로고    scopus 로고
    • Inhibitors of cdc25 phosphatases as anticancer agents: A patent review
    • Lavecchia, A., Di Giovanni, C. & Novellino, E. Inhibitors of Cdc25 phosphatases as anticancer agents: a patent review. Expert Opin. Ther. Patents 20, 405-425 (2010
    • (2010) Expert Opin. Ther. Patents , vol.20 , pp. 405-425
    • Lavecchia, A.1    Di Giovanni, C.2    Novellino, E.3
  • 196
    • 73349093106 scopus 로고    scopus 로고
    • Cellular inhibition of checkpoint kinase 2 (chk2) and potentiation of camptothecins and radiation by the novel chk2 inhibitor pv1019 [7 nitro 1h indole-2 carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]
    • Jobson, A. G. et al. Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7 nitro 1H indole-2 carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]- phenyl}-amide]. J. Pharmacol. Exp. Ther. 331, 816-826 (2009
    • (2009) J. Pharmacol. Exp. Ther. , vol.331 , pp. 816-826
    • Jobson, A.G.1
  • 197
    • 42349096328 scopus 로고    scopus 로고
    • Secondary BRCA1 mutations in BRCA1-mutated ovarian carcinomas with platinum resistance
    • DOI 10.1158/0008-5472.CAN-08-0088
    • Swisher, E. M. et al. Secondary Brca1 mutations in Brca1-mutated ovarian carcinomas with platinum resistance. Cancer Res. 68, 2581-2586 (2008). (Pubitemid 351556255)
    • (2008) Cancer Research , vol.68 , Issue.8 , pp. 2581-2586
    • Swisher, E.M.1    Sakai, W.2    Karlan, B.Y.3    Wurz, K.4    Urban, N.5    Taniguchi, T.6


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