-
1
-
-
0034652297
-
The subcellular localization of acetyl-CoA carboxylase 2
-
Abu-Elheiga L, Brinkley WR, Zhong L, Chirala SS, Woldegiorgis G, Wakil SJ. The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci U S A 97: 1444-1449, 2000.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 1444-1449
-
-
Abu-Elheiga, L.1
Brinkley, W.R.2
Zhong, L.3
Chirala, S.S.4
Woldegiorgis, G.5
Wakil, S.J.6
-
2
-
-
0035970805
-
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
-
Abu-Elheiga L, Matzuk MM, Abo-Hashema KA,Wakil SJ. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 291: 2613-2616, 2001.
-
(2001)
Science
, vol.291
, pp. 2613-2616
-
-
Abu-Elheiga, L.1
Matzuk, M.M.2
Abo-Hashema, K.A.3
Wakil, S.J.4
-
3
-
-
24744448667
-
Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal
-
Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z, Wakil SJ. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc Natl Acad Sci U S A 102: 12011-12016, 2005.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 12011-12016
-
-
Abu-Elheiga, L.1
Matzuk, M.M.2
Kordari, P.3
Oh, W.4
Shaikenov, T.5
Gu, Z.6
Wakil, S.J.7
-
4
-
-
49649099805
-
Glucokinase and molecular aspects of liver glycogen metabolism
-
Agius L. Glucokinase and molecular aspects of liver glycogen metabolism. Biochem J 414: 1-18, 2008.
-
(2008)
Biochem J
, vol.414
, pp. 1-18
-
-
Agius, L.1
-
5
-
-
33645884425
-
Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
-
Andreelli F, Foretz M, Knauf C, Cani PD, Perrin C, Iglesias MA, Pillot B, Bado A, Tronche F, Mithieux G, Vaulont S, Burcelin R, Viollet B. Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. Endocrinology 147: 2432-2441, 2006.
-
(2006)
Endocrinology
, vol.147
, pp. 2432-2441
-
-
Andreelli, F.1
Foretz, M.2
Knauf, C.3
Cani, P.D.4
Perrin, C.5
Iglesias, M.A.6
Pillot, B.7
Bado, A.8
Tronche, F.9
Mithieux, G.10
Vaulont, S.11
Burcelin, R.12
Viollet, B.13
-
6
-
-
84876558435
-
Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?
-
Arafat AM, Kaczmarek P, Skrzypski M, Pruszynska-Oszmalek E, Kolodziejski P, Szczepankiewicz D, Sassek M, Wojciechowicz T, Wiedenmann B, Pfeiffer AF, Nowak KW, Strowski MZ. Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis? Diabetologia 56: 588-597, 2013.
-
(2013)
Diabetologia
, vol.56
, pp. 588-597
-
-
Arafat, A.M.1
Kaczmarek, P.2
Skrzypski, M.3
Pruszynska-Oszmalek, E.4
Kolodziejski, P.5
Szczepankiewicz, D.6
Sassek, M.7
Wojciechowicz, T.8
Wiedenmann, B.9
Pfeiffer, A.F.10
Nowak, K.W.11
Strowski, M.Z.12
-
7
-
-
84858327557
-
Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes
-
Arden C, Tudhope SJ, Petrie JL, Al-Oanzi ZH, Cullen KS, Lange AJ, Towle HC, Agius L. Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes. Biochem J 443: 111-123, 2012.
-
(2012)
Biochem J
, vol.443
, pp. 111-123
-
-
Arden, C.1
Tudhope, S.J.2
Petrie, J.L.3
Al-Oanzi, Z.H.4
Cullen, K.S.5
Lange, A.J.6
Towle, H.C.7
Agius, L.8
-
8
-
-
20044387026
-
IKK-beta links inflammation to obesity-induced insulin resistance
-
Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11: 191-198, 2005.
-
(2005)
Nat Med
, vol.11
, pp. 191-198
-
-
Arkan, M.C.1
Hevener, A.L.2
Greten, F.R.3
Maeda, S.4
Li, Z.W.5
Long, J.M.6
Wynshaw-Boris, A.7
Poli, G.8
Olefsky, J.9
Karin, M.10
-
9
-
-
34249711964
-
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
-
Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 5: 426-437, 2007.
-
(2007)
Cell Metab
, vol.5
, pp. 426-437
-
-
Badman, M.K.1
Pissios, P.2
Kennedy, A.R.3
Koukos, G.4
Flier, J.S.5
Maratos-Flier, E.6
-
10
-
-
67349205002
-
Kupffer cells in non-alcoholic fatty liver disease: The emerging view
-
Baffy G. Kupffer cells in non-alcoholic fatty liver disease: The emerging view. J Hepatol 51: 212-223, 2009.
-
(2009)
J Hepatol
, vol.51
, pp. 212-223
-
-
Baffy, G.1
-
11
-
-
79960938560
-
Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control
-
Bedford DC, Kasper LH, Wang R, Chang Y, Green DR, Brindle PK. Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metab 14: 219-230, 2011.
-
(2011)
Cell Metab
, vol.14
, pp. 219-230
-
-
Bedford, D.C.1
Kasper, L.H.2
Wang, R.3
Chang, Y.4
Green, D.R.5
Brindle, P.K.6
-
12
-
-
84876155050
-
Hepatic-specific activation of peroxisome proliferator-activated receptor gamma coactivator-1beta protects against steatohepatitis
-
Bellafante E, Murzilli S, Salvatore L, Latorre D,Villani G, Moschetta A. Hepatic-specific activation of peroxisome proliferator-activated receptor gamma coactivator-1beta protects against steatohepatitis. Hepatology 57: 1343-1356, 2013.
-
(2013)
Hepatology
, vol.57
, pp. 1343-1356
-
-
Bellafante, E.1
Murzilli, S.2
Salvatore, L.3
Latorre, D.4
Villani, G.5
Moschetta, A.6
-
13
-
-
84861809881
-
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
-
Benhamed F, Denechaud PD, Lemoine M, Robichon C, Moldes M, Bertrand-Michel J, Ratziu V, Serfaty L, Housset C, Capeau J, Girard J, Guillou H, Postic C. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J Clin Invest 122: 2176-2194, 2012.
-
(2012)
J Clin Invest
, vol.122
, pp. 2176-2194
-
-
Benhamed, F.1
Denechaud, P.D.2
Lemoine, M.3
Robichon, C.4
Moldes, M.5
Bertrand-Michel, J.6
Ratziu, V.7
Serfaty, L.8
Housset, C.9
Capeau, J.10
Girard, J.11
Guillou, H.12
Postic, C.13
-
14
-
-
80755148711
-
Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver
-
Berglund ED, Lustig DG, Baheza RA, Hasenour CM, Lee-Young RS, Donahue EP,Lynes SE, Swift LL, Charron MJ, Damon BM, Wasserman DH. Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver. Diabetes 60: 2720-2729, 2011.
-
(2011)
Diabetes
, vol.60
, pp. 2720-2729
-
-
Berglund, E.D.1
Lustig, D.G.2
Baheza, R.A.3
Hasenour, C.M.4
Lee-Young, R.S.5
Donahue, E.P.6
Lynes, S.E.7
Swift, L.L.8
Charron, M.J.9
Damon, B.M.10
Wasserman, D.H.11
-
15
-
-
84863267488
-
Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice
-
Berglund ED, Vianna CR, Donato J, Jr., Kim MH, Chuang JC, Lee CE, Lauzon DA, Lin P, Brule LJ, Scott MM, Coppari R, Elmquist JK. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. J Clin Invest 122: 1000-1009, 2012.
-
(2012)
J Clin Invest
, vol.122
, pp. 1000-1009
-
-
Berglund, E.D.1
Vianna, C.R.2
Donato Jr, J.3
Kim, M.H.4
Chuang, J.C.5
Lee, C.E.6
Lauzon, D.A.7
Lin, P.8
Brule, L.J.9
Scott, M.M.10
Coppari, R.11
Elmquist, J.K.12
-
16
-
-
65649152582
-
Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis
-
Bhatnagar S, Damron HA, Hillgartner FB. Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. J Biol Chem 284: 10023-10033, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 10023-10033
-
-
Bhatnagar, S.1
Damron, H.A.2
Hillgartner, F.B.3
-
17
-
-
78649855297
-
Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice
-
Bricambert J, Miranda J, Benhamed F, Girard J, Postic C, Dentin R. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest 120: 4316-4331, 2010.
-
(2010)
J Clin Invest
, vol.120
, pp. 4316-4331
-
-
Bricambert, J.1
Miranda, J.2
Benhamed, F.3
Girard, J.4
Postic, C.5
Dentin, R.6
-
18
-
-
78149314978
-
Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways
-
Bu SY, Mashek DG. Hepatic long-chain acyl-CoA synthetase 5 mediates fatty acid channeling between anabolic and catabolic pathways. J Lipid Res 51: 3270-3280, 2010.
-
(2010)
J Lipid Res
, vol.51
, pp. 3270-3280
-
-
Bu, S.Y.1
Mashek, D.G.2
-
19
-
-
33745362866
-
Critical role of STAT3 in leptin's metabolic actions
-
Buettner C, Pocai A, Muse ED, Etgen AM, Myers MG, Jr., Rossetti L. Critical role of STAT3 in leptin's metabolic actions. Cell Metab 4: 49-60, 2006.
-
(2006)
Cell Metab
, vol.4
, pp. 49-60
-
-
Buettner, C.1
Pocai, A.2
Muse, E.D.3
Etgen, A.M.4
Myers Jr, M.G.5
Rossetti, L.6
-
20
-
-
84859329911
-
Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function
-
Bugge A, Feng D, Everett LJ, Briggs ER, Mullican SE, Wang F, Jager J, Lazar MA. Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function. Genes Dev 26: 657-667, 2012.
-
(2012)
Genes Dev
, vol.26
, pp. 657-667
-
-
Bugge, A.1
Feng, D.2
Everett, L.J.3
Briggs, E.R.4
Mullican, S.E.5
Wang, F.6
Jager, J.7
Lazar, M.A.8
-
21
-
-
10344219509
-
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase
-
Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD. Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase. J Biol Chem279: 48941-48949, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 48941-48949
-
-
Burgess, S.C.1
Hausler, N.2
Merritt, M.3
Jeffrey, F.M.4
Storey, C.5
Milde, A.6
Koshy, S.7
Lindner, J.8
Magnuson, M.A.9
Malloy, C.R.10
Sherry, A.D.11
-
22
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
-
Cai D,Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 11: 183-190, 2005.
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
Lee, J.6
Shoelson, S.E.7
-
23
-
-
84858796689
-
Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
-
Calkin AC, Tontonoz P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR. Nat Rev Mol Cell Biol 13: 213-224, 2012.
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, pp. 213-224
-
-
Calkin, A.C.1
Tontonoz, P.2
-
24
-
-
51549107903
-
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism
-
Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 134: 933-944, 2008.
-
(2008)
Cell
, vol.134
, pp. 933-944
-
-
Cao, H.1
Gerhold, K.2
Mayers, J.R.3
Wiest, M.M.4
Watkins, S.M.5
Hotamisligil, G.S.6
-
25
-
-
84877292005
-
Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production
-
Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab 17: 768-778, 2013.
-
(2013)
Cell Metab
, vol.17
, pp. 768778
-
-
Cao, H.1
Sekiya, M.2
Ertunc, M.E.3
Burak, M.F.4
Mayers, J.R.5
White, A.6
Inouye, K.7
Rickey, L.M.8
Ercal, B.C.9
Furuhashi, M.10
Tuncman, G.11
Hotamisligil, G.S.12
-
26
-
-
30044436829
-
p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis
-
Cao W, Collins QF, Becker TC, Robidoux J, Lupo EG, Jr., Xiong Y, Daniel KW, Floering L, Collins S. p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis. J Biol Chem 280: 42731-42737, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 42731-42737
-
-
Cao, W.1
Collins, Q.F.2
Becker, T.C.3
Robidoux, J.4
Lupo Jr, E.G.5
Xiong, Y.6
Daniel, K.W.7
Floering, L.8
Collins, S.9
-
27
-
-
84878972563
-
The farnesoid X receptor inhibits the transcriptional activity of the carbohydrate response element binding protein in human hepatocytes - R2
-
Caron S, Samanez CH, Dehondt H, Ploton M, Briand O, Lien F, Dorchies E, Dumont J, Postic C, Cariou B, Lefebvre P, Staels B. The farnesoid X receptor inhibits the transcriptional activity of the carbohydrate response element binding protein in human hepatocytes - R2. Mol Cell Biol 33: 2202-2211, 2013.
-
(2013)
Mol Cell Biol
, vol.33
, pp. 2202-2211
-
-
Caron, S.1
Samanez, C.H.2
Dehondt, H.3
Ploton, M.4
Briand, O.5
Lien, F.6
Dorchies, E.7
Dumont, J.8
Postic, C.9
Cariou, B.10
Lefebvre, P.11
Staels, B.12
-
28
-
-
0033593229
-
Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver
-
Casado M, Vallet VS, Kahn A, Vaulont S. Essential role in vivo of upstream stimulatory factors for a normal dietary response of the fatty acid synthase gene in the liver. J Biol Chem 274: 2009-2013, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 2009-2013
-
-
Casado, M.1
Vallet, V.S.2
Kahn, A.3
Vaulont, S.4
-
29
-
-
33847006599
-
The liver X receptor (LXR) and hepatic lipogenesis The carbohydrate-response element-binding protein is a target gene of LXR
-
Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 282: 743-751, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 743-751
-
-
Cha, J.Y.1
Repa, J.J.2
-
30
-
-
68149098866
-
Identification of a physiologically relevant endogenous ligand for PPARalpha in liver
-
Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF. Identification of a physiologically relevant endogenous ligand for PPARalpha in liver. Cell 138: 476-488, 2009.
-
(2009)
Cell
, vol.138
, pp. 476-488
-
-
Chakravarthy, M.V.1
Lodhi, I.J.2
Yin, L.3
Malapaka, R.R.4
Xu, H.E.5
Turk, J.6
Semenkovich, C.F.7
-
31
-
-
22544480378
-
"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis
-
Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF. "New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab 1: 309-322, 2005.
-
(2005)
Cell Metab
, vol.1
, pp. 309-322
-
-
Chakravarthy, M.V.1
Pan, Z.2
Zhu, Y.3
Tordjman, K.4
Schneider, J.G.5
Coleman, T.6
Turk, J.7
Semenkovich, C.F.8
-
32
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev 22: 1753-1757, 2008.
-
(2008)
Genes Dev
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
Bruno, J.2
Easlon, E.3
Lin, S.J.4
Cheng, H.L.5
Alt, F.W.6
Guarente, L.7
-
33
-
-
3843061127
-
Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
-
Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc Natl Acad Sci U S A 101: 11245-11250, 2004.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 11245-11250
-
-
Chen, G.1
Liang, G.2
Ou, J.3
Goldstein, J.L.4
Brown, M.S.5
-
34
-
-
27644581888
-
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency
-
Chen M, Gavrilova O, Zhao WQ, Nguyen A, Lorenzo J, Shen L, Nackers L, Pack S, Jou W, Weinstein LS. Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. J Clin Invest 115: 3217-3227, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 3217-3227
-
-
Chen, M.1
Gavrilova, O.2
Zhao, W.Q.3
Nguyen, A.4
Lorenzo, J.5
Shen, L.6
Nackers, L.7
Pack, S.8
Jou, W.9
Weinstein, L.S.10
-
35
-
-
33845587711
-
Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice
-
Chen W, Chen G, Head DL, Mangelsdorf DJ, Russell DW. Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice. Cell Metab 5: 73-79, 2007.
-
(2007)
Cell Metab
, vol.5
, pp. 73-79
-
-
Chen, W.1
Chen, G.2
Head, D.L.3
Mangelsdorf, D.J.4
Russell, D.W.5
-
36
-
-
84863161186
-
Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses
-
Chen Z, Sheng L, Shen H, Zhao Y, Wang S, Brink R, Rui L. Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses. Diabetes 61: 566-573, 2012.
-
(2012)
Diabetes
, vol.61
, pp. 566-573
-
-
Chen, Z.1
Sheng, L.2
Shen, H.3
Zhao, Y.4
Wang, S.5
Brink, R.6
Rui, L.7
-
37
-
-
67849124833
-
Intestinal cholecystokinin controls glucose production through a neuronal network
-
Cheung GW, Kokorovic A, Lam CK, Chari M, Lam TK. Intestinal cholecystokinin controls glucose production through a neuronal network. Cell Metab 10: 99-109, 2009.
-
(2009)
Cell Metab
, vol.10
, pp. 99-109
-
-
Cheung, G.W.1
Kokorovic, A.2
Lam, C.K.3
Chari, M.4
Lam, T.K.5
-
38
-
-
57149089662
-
Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease
-
Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science 322: 1395-1399, 2008.
-
(2008)
Science
, vol.322
, pp. 1395-1399
-
-
Chopra, A.R.1
Louet, J.F.2
Saha, P.3
An, J.4
Demayo, F.5
Xu, J.6
York, B.7
Karpen, S.8
Finegold, M.9
Moore, D.10
Chan, L.11
Newgard, C.B.12
O'Malley, B.W.13
-
39
-
-
0037067570
-
Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss
-
Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297: 240-243, 2002.
-
(2002)
Science
, vol.297
, pp. 240-243
-
-
Cohen, P.1
Miyazaki, M.2
Socci, N.D.3
Hagge-Greenberg, A.4
Liedtke, W.5
Soukas, A.A.6
Sharma, R.7
Hudgins, L.C.8
Ntambi, J.M.9
Friedman, J.M.10
-
40
-
-
33845919110
-
Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia
-
Conarello SL, Jiang G, Mu J, Li Z,Woods J, Zycband E, Ronan J, Liu F, Roy RS, Zhu L, Charron MJ, Zhang BB. Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia. Diabetologia 50: 142-150, 2007.
-
(2007)
Diabetologia
, vol.50
, pp. 142-150
-
-
Conarello, S.L.1
Jiang, G.2
Mu, J.3
Li, Z.4
Woods, J.5
Zycband, E.6
Ronan, J.7
Liu, F.8
Roy, R.S.9
Zhu, L.10
Charron, M.J.11
Zhang, B.B.12
-
41
-
-
0024511329
-
Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
-
Consoli A, Nurjhan N, Capani F, Gerich J. Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38: 550-557, 1989.
-
(1989)
Diabetes
, vol.38
, pp. 550-557
-
-
Consoli, A.1
Nurjhan, N.2
Capani, F.3
Gerich, J.4
-
42
-
-
34548321210
-
Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration
-
Cui Y, Hosui A, Sun R, Shen K, Gavrilova O, Chen W, Cam MC, Gao B, Robinson GW, Hennighausen L. Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology 46: 504-513, 2007.
-
(2007)
Hepatology
, vol.46
, pp. 504-513
-
-
Cui, Y.1
Hosui, A.2
Sun, R.3
Shen, K.4
Gavrilova, O.5
Chen, W.6
Cam, M.C.7
Gao, B.8
Robinson, G.W.9
Hennighausen, L.10
-
43
-
-
52749093917
-
Carcinoembryonic antigen-related cell adhesion molecule 1 A link between insulin and lipid metabolism
-
DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN, Kim JK, Najjar SM. Carcinoembryonic antigen-related cell adhesion molecule 1: A link between insulin and lipid metabolism. Diabetes 57: 2296-2303, 2008.
-
(2008)
Diabetes
, vol.57
, pp. 2296-2303
-
-
DeAngelis, A.M.1
Heinrich, G.2
Dai, T.3
Bowman, T.A.4
Patel, P.R.5
Lee, S.J.6
Hong, E.G.7
Jung, D.Y.8
Assmann, A.9
Kulkarni, R.N.10
Kim, J.K.11
Najjar, S.M.12
-
44
-
-
62749115187
-
Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress
-
Delibegovic M, Zimmer D, Kauffman C, Rak K, Hong EG, Cho YR, Kim JK, Kahn BB, Neel BG, Bence KK. Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress. Diabetes 58: 590-599, 2009.
-
(2009)
Diabetes
, vol.58
, pp. 590-599
-
-
Delibegovic, M.1
Zimmer, D.2
Kauffman, C.3
Rak, K.4
Hong, E.G.5
Cho, Y.R.6
Kim, J.K.7
Kahn, B.B.8
Neel, B.G.9
Bence, K.K.10
-
45
-
-
40549125618
-
ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver
-
Denechaud PD, Bossard P, Lobaccaro JM, Millatt L, Staels B, Girard J, Postic C. ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest 118: 956-964, 2008.
-
(2008)
J Clin Invest
, vol.118
, pp. 956-964
-
-
Denechaud, P.D.1
Bossard, P.2
Lobaccaro, J.M.3
Millatt, L.4
Staels, B.5
Girard, J.6
Postic, C.7
-
46
-
-
33749370739
-
Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
-
Dentin R, Benhamed F, Hainault I, Fauveau V, Foufelle F, Dyck JR, Girard J, Postic C. Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes 55: 2159-2170, 2006.
-
(2006)
Diabetes
, vol.55
, pp. 2159-2170
-
-
Dentin, R.1
Benhamed, F.2
Hainault, I.3
Fauveau, V.4
Foufelle, F.5
Dyck, J.R.6
Girard, J.7
Postic, C.8
-
47
-
-
34548831102
-
Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
-
Dentin R, Liu Y, Koo SH, Hedrick S, Vargas T, Heredia J, Yates J, 3rd, Montminy M. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449: 366-369, 2007.
-
(2007)
Nature
, vol.449
, pp. 366-369
-
-
Dentin, R.1
Liu, Y.2
Koo, S.H.3
Hedrick, S.4
Vargas, T.5
Heredia, J.6
Yates III, J.7
Montminy, M.8
-
48
-
-
83555160898
-
Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver
-
Dentin R, Tomas-Cobos L, Foufelle F, Leopold J, Girard J, Postic C, Ferre P. Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver. J Hepatol 56: 199-209, 2012.
-
(2012)
J Hepatol
, vol.56
, pp. 199-209
-
-
Dentin, R.1
Tomas-Cobos, L.2
Foufelle, F.3
Leopold, J.4
Girard, J.5
Postic, C.6
Ferre, P.7
-
49
-
-
33645994508
-
Targeted deletion of FATP5 reveals multiple functions in liver metabolism: Alterations in hepatic lipid homeostasis
-
Doege H, Baillie RA, Ortegon AM, Tsang B, Wu Q, Punreddy S, Hirsch D,Watson N, Gimeno RE, Stahl A. Targeted deletion of FATP5 reveals multiple functions in liver metabolism: Alterations in hepatic lipid homeostasis. Gastroenterology 130: 1245-1258, 2006.
-
(2006)
Gastroenterology
, vol.130
, pp. 1245-1258
-
-
Doege, H.1
Baillie, R.A.2
Ortegon, A.M.3
Tsang, B.4
Wu, Q.5
Punreddy, S.6
Hirsch, D.7
Watson, N.8
Gimeno, R.E.9
Stahl, A.10
-
50
-
-
31044446941
-
Irs1 andx Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth
-
Dong X, Park S, Lin X, Copps K, Yi X, White MF. Irs1 andx Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 116: 101-114, 2006.
-
(2006)
J Clin Invest
, vol.116
, pp. 101-114
-
-
Dong, X.1
Park, S.2
Lin, X.3
Copps, K.4
Yi, X.5
White, M.F.6
-
51
-
-
45549090182
-
Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
-
Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab 8: 65-76, 2008.
-
(2008)
Cell Metab
, vol.8
, pp. 65-76
-
-
Dong, X.C.1
Copps, K.D.2
Guo, S.3
Li, Y.4
Kollipara, R.5
DePinho, R.A.6
White, M.F.7
-
52
-
-
18244382304
-
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
-
Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115: 1343-1351, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 1343-1351
-
-
Donnelly, K.L.1
Smith, C.I.2
Schwarzenberg, S.J.3
Jessurun, J.4
Boldt, M.D.5
Parks, E.J.6
-
53
-
-
6344243617
-
SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin
-
Duan C, Li M, Rui L. SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin. J Biol Chem 279: 43684-43691, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 43684-43691
-
-
Duan, C.1
Li, M.2
Rui, L.3
-
54
-
-
4344581405
-
Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance
-
Duan C, Yang H, White MF, Rui L. Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol 24: 7435-7443, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7435-7443
-
-
Duan, C.1
Yang, H.2
White, M.F.3
Rui, L.4
-
56
-
-
70449927254
-
Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein
-
Erion DM, Ignatova ID, Yonemitsu S, Nagai Y, Chatterjee P, Weismann D, Hsiao JJ, Zhang D, Iwasaki T, Stark R, Flannery C, Kahn M, Carmean CM, Yu XX, Murray SF, Bhanot S, Monia BP, Cline GW, Samuel VT, Shulman GI. Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein. Cell Metab 10: 499-506, 2009.
-
(2009)
Cell Metab
, vol.10
, pp. 499-506
-
-
Erion, D.M.1
Ignatova, I.D.2
Yonemitsu, S.3
Nagai, Y.4
Chatterjee, P.5
Weismann, D.6
Hsiao, J.J.7
Zhang, D.8
Iwasaki, T.9
Stark, R.10
Flannery, C.11
Kahn, M.12
Carmean, C.M.13
Yu, X.X.14
Murray, S.F.15
Bhanot, S.16
Monia, B.P.17
Cline, G.W.18
Samuel, V.T.19
Shulman, G.I.20
more..
-
57
-
-
67650488877
-
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
-
Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, Samuel VT, Shulman GI. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc Natl Acad Sci U S A 106: 11288-11293, 2009.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 11288-11293
-
-
Erion, D.M.1
Yonemitsu, S.2
Nie, Y.3
Nagai, Y.4
Gillum, M.P.5
Hsiao, J.J.6
Iwasaki, T.7
Stark, R.8
Weismann, D.9
Yu, X.X.10
Murray, S.F.11
Bhanot, S.12
Monia, B.P.13
Horvath, T.L.14
Gao, Q.15
Samuel, V.T.16
Shulman, G.I.17
-
58
-
-
76649085804
-
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice
-
Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest 120: 545-558, 2010.
-
(2010)
J Clin Invest
, vol.120
, pp. 545-558
-
-
Escande, C.1
Chini, C.C.2
Nin, V.3
Dykhouse, K.M.4
Novak, C.M.5
Levine, J.6
van Deursen, J.7
Gores, G.J.8
Chen, J.9
Lou, Z.10
Chini, E.N.11
-
59
-
-
84856113332
-
A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism
-
Fafalios A, Ma J, Tan X, Stoops J, Luo J, Defrances MC, Zarnegar R. A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism. Nat Med 17: 1577-1584, 2011.
-
(2011)
Nat Med
, vol.17
, pp. 1577-1584
-
-
Fafalios, A.1
Ma, J.2
Tan, X.3
Stoops, J.4
Luo, J.5
Defrances, M.C.6
Zarnegar, R.7
-
60
-
-
77956803815
-
FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase
-
Falcon A, Doege H, Fluitt A, Tsang B, Watson N, Kay MA, Stahl A. FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase. Am J Physiol Endocrinol Metab 299: E384-393, 2010.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
-
-
Falcon, A.1
Doege, H.2
Fluitt, A.3
Tsang, B.4
Watson, N.5
Kay, M.A.6
Stahl, A.7
-
61
-
-
10144234128
-
Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acylcoenzyme A oxidase gene
-
Fan CY, Pan J, Chu R, Lee D, Kluckman KD, Usuda N, Singh I, Yeldandi AV, Rao MS, Maeda N, Reddy JK. Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acylcoenzyme A oxidase gene. J Biol Chem 271: 24698-24710, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 24698-24710
-
-
Fan, C.Y.1
Pan, J.2
Chu, R.3
Lee, D.4
Kluckman, K.D.5
Usuda, N.6
Singh, I.7
Yeldandi, A.V.8
Rao, M.S.9
Maeda, N.10
Reddy, J.K.11
-
62
-
-
67749111843
-
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism
-
Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, DiGirolamo DJ, Kopchick JJ, Le Roith D, Trucco M, Sperling MA. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem 284: 19937-19944, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 19937-19944
-
-
Fan, Y.1
Menon, R.K.2
Cohen, P.3
Hwang, D.4
Clemens, T.5
DiGirolamo, D.J.6
Kopchick, J.J.7
Le Roith, D.8
Trucco, M.9
Sperling, M.A.10
-
63
-
-
79952529158
-
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
-
Feng D, Liu T, Sun Z, Bugge A, Mullican SE, Alenghat T, Liu XS, Lazar MA. A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 331: 1315-1319, 2011.
-
(2011)
Science
, vol.331
, pp. 1315-1319
-
-
Feng, D.1
Liu, T.2
Sun, Z.3
Bugge, A.4
Mullican, S.E.5
Alenghat, T.6
Liu, X.S.7
Lazar, M.A.8
-
64
-
-
33747853190
-
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway
-
Finck BN, Gropler MC, Chen Z, Leone TC, Croce MA, Harris TE, Lawrence JC, Jr., Kelly DP. Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab 4: 199-210, 2006.
-
(2006)
Cell Metab
, vol.4
, pp. 199-210
-
-
Finck, B.N.1
Gropler, M.C.2
Chen, Z.3
Leone, T.C.4
Croce, M.A.5
Harris, T.E.6
Lawrence Jr, J.C.7
Kelly, D.P.8
-
65
-
-
0141446024
-
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
-
Gavrilova O, Haluzik M, Matsusue K, Cutson JJ, Johnson L, Dietz KR, Nicol CJ, Vinson C, Gonzalez FJ, Reitman ML. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J Biol Chem 278: 34268-34276, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 34268-34276
-
-
Gavrilova, O.1
Haluzik, M.2
Matsusue, K.3
Cutson, J.J.4
Johnson, L.5
Dietz, K.R.6
Nicol, C.J.7
Vinson, C.8
Gonzalez, F.J.9
Reitman, M.L.10
-
66
-
-
0037417984
-
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice
-
Gelling RW, Du XQ, Dichmann DS, Romer J, Huang H, Cui L, Obici S, Tang B, Holst JJ, Fledelius C, Johansen PB, Rossetti L, Jelicks LA, Serup P, Nishimura E, Charron MJ. Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci U S A 100: 1438-1443, 2003.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 1438-1443
-
-
Gelling, R.W.1
Du, X.Q.2
Dichmann, D.S.3
Romer, J.4
Huang, H.5
Cui, L.6
Obici, S.7
Tang, B.8
Holst, J.J.9
Fledelius, C.10
Johansen, P.B.11
Rossetti, L.12
Jelicks, L.A.13
Serup, P.14
Nishimura, E.15
Charron, M.J.16
-
67
-
-
71749098785
-
Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl)
-
Granneman JG, Moore HP, Krishnamoorthy R, Rathod M. Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl). J Biol Chem 284: 34538-34544, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 34538-34544
-
-
Granneman, J.G.1
Moore, H.P.2
Krishnamoorthy, R.3
Rathod, M.4
-
68
-
-
79957889560
-
The role of lipid droplets in metabolic disease in rodents and humans
-
Greenberg AS, Coleman RA, Kraemer FB, McManaman JL, Obin MS, Puri V, Yan QW, Miyoshi H, Mashek DG. The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest 121: 2102-2110, 2011.
-
(2011)
J Clin Invest
, vol.121
, pp. 2102-2110
-
-
Greenberg, A.S.1
Coleman, R.A.2
Kraemer, F.B.3
McManaman, J.L.4
Obin, M.S.5
Puri, V.6
Yan, Q.W.7
Miyoshi, H.8
Mashek, D.G.9
-
69
-
-
79959473762
-
O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver
-
Guinez C, Filhoulaud G, Rayah-Benhamed F, Marmier S, Dubuquoy C, Dentin R, Moldes M, Burnol AF, Yang X, Lefebvre T, Girard J, Postic C. O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver. Diabetes 60: 1399-1413, 2011.
-
(2011)
Diabetes
, vol.60
, pp. 1399-1413
-
-
Guinez, C.1
Filhoulaud, G.2
Rayah-Benhamed, F.3
Marmier, S.4
Dubuquoy, C.5
Dentin, R.6
Moldes, M.7
Burnol, A.F.8
Yang, X.9
Lefebvre, T.10
Girard, J.11
Postic, C.12
-
70
-
-
70249108137
-
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis
-
Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol 29: 5070-5083, 2009.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5070-5083
-
-
Guo, S.1
Copps, K.D.2
Dong, X.3
Park, S.4
Cheng, Z.5
Pocai, A.6
Rossetti, L.7
Sajan, M.8
Farese, R.V.9
White, M.F.10
-
71
-
-
0033546192
-
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence
-
Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem 274: 17184-17192, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 17184-17192
-
-
Guo, S.1
Rena, G.2
Cichy, S.3
He, X.4
Cohen, P.5
Unterman, T.6
-
72
-
-
84876542381
-
Fibroblast growth factor 21 mediates specific glucagon actions
-
Habegger KM, Stemmer K, Cheng C, Muller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, Dimarchi RD, Tschop MH. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes 62: 1453-1463, 2013.
-
(2013)
Diabetes
, vol.62
, pp. 1453-1463
-
-
Habegger, K.M.1
Stemmer, K.2
Cheng, C.3
Muller, T.D.4
Heppner, K.M.5
Ottaway, N.6
Holland, J.7
Hembree, J.L.8
Smiley, D.9
Gelfanov, V.10
Krishna, R.11
Arafat, A.M.12
Konkar, A.13
Belli, S.14
Kapps, M.15
Woods, S.C.16
Hofmann, S.M.17
D'Alessio, D.18
Pfluger, P.T.19
Perez-Tilve, D.20
Seeley, R.J.21
Konishi, M.22
Itoh, N.23
Kharitonenkov, A.24
Spranger, J.25
Dimarchi, R.D.26
Tschop, M.H.27
more..
-
73
-
-
78149272381
-
FoxOs function synergistically to promote glucose production
-
Haeusler RA, Kaestner KH, Accili D. FoxOs function synergistically to promote glucose production. J Biol Chem 285: 35245-35248, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 35245-35248
-
-
Haeusler, R.A.1
Kaestner, K.H.2
Accili, D.3
-
74
-
-
84860454425
-
Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c
-
Hagiwara A, Cornu M, Cybulski N, Polak P, Betz C, Trapani F, Terracciano L, Heim MH, Ruegg MA, Hall MN. Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metab 15: 725-738, 2012.
-
(2012)
Cell Metab
, vol.15
, pp. 725-738
-
-
Hagiwara, A.1
Cornu, M.2
Cybulski, N.3
Polak, P.4
Betz, C.5
Trapani, F.6
Terracciano, L.7
Heim, M.H.8
Ruegg, M.A.9
Hall, M.N.10
-
75
-
-
78651468707
-
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
-
Hallows WC, Yu W, Smith BC, Devries MK, Ellinger JJ, Someya S, Shortreed MR, Prolla T, Markley JL, Smith LM, Zhao S, Guan KL, Denu JM. Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction. Molecular cell 41: 139-149, 2011.
-
(2011)
Molecular cell
, vol.41
, pp. 139-149
-
-
Hallows, W.C.1
Yu, W.2
Smith, B.C.3
Devries, M.K.4
Ellinger, J.J.5
Someya, S.6
Shortreed, M.R.7
Prolla, T.8
Markley, J.L.9
Smith, L.M.10
Zhao, S.11
Guan, K.L.12
Denu, J.M.13
-
76
-
-
77954980506
-
Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice
-
Hancock AS, Du A, Liu J, Miller M, May CL. Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice. Mol Endocrinol 24: 1605-1614, 2010.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1605-1614
-
-
Hancock, A.S.1
Du, A.2
Liu, J.3
Miller, M.4
May, C.L.5
-
77
-
-
33847232207
-
Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice
-
Harada N, Oda Z, Hara Y, Fujinami K, Okawa M, Ohbuchi K, Yonemoto M, Ikeda Y, Ohwaki K, Aragane K, Tamai Y, Kusunoki J. Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice. Mol Cell Biol 27: 1881-1888, 2007.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 1881-1888
-
-
Harada, N.1
Oda, Z.2
Hara, Y.3
Fujinami, K.4
Okawa, M.5
Ohbuchi, K.6
Yonemoto, M.7
Ikeda, Y.8
Ohwaki, K.9
Aragane, K.10
Tamai, Y.11
Kusunoki, J.12
-
78
-
-
65549136655
-
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
-
He L, Sabet A, Djedjos S, Miller R, Sun XJ, Hussain MA, Radovick S, Wondisford FE. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell 137: 635-646, 2009.
-
(2009)
Cell
, vol.137
, pp. 635-646
-
-
He, L.1
Sabet, A.2
Djedjos, S.3
Miller, R.4
Sun, X.J.5
Hussain, M.A.6
Radovick, S.7
Wondisford, F.E.8
-
79
-
-
84856957894
-
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
-
Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482: 179-185, 2012.
-
(2012)
Nature
, vol.482
, pp. 179-185
-
-
Henao-Mejia, J.1
Elinav, E.2
Jin, C.3
Hao, L.4
Mehal, W.Z.5
Strowig, T.6
Thaiss, C.A.7
Kau, A.L.8
Eisenbarth, S.C.9
Jurczak, M.J.10
Camporez, J.P.11
Shulman, G.I.12
Gordon, J.I.13
Hoffman, H.M.14
Flavell, R.A.15
-
80
-
-
0344010662
-
CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma
-
Herzig S, Hedrick S, Morantte I, Koo SH, Galimi F, Montminy M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-gamma. Nature 426: 190-193, 2003.
-
(2003)
Nature
, vol.426
, pp. 190-193
-
-
Herzig, S.1
Hedrick, S.2
Morantte, I.3
Koo, S.H.4
Galimi, F.5
Montminy, M.6
-
81
-
-
0035855905
-
-
Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC- Nature 413: 179-183, 2001.
-
(2001)
CREB regulates hepatic gluconeogenesis through the coactivator PGC- Nature
, vol.413
, pp. 179-183
-
-
Herzig, S.1
Long, F.2
Jhala, U.S.3
Hedrick, S.4
Quinn, R.5
Bauer, A.6
Rudolph, D.7
Schutz, G.8
Yoon, C.9
Puigserver, P.10
Spiegelman, B.11
Montminy, M.12
-
82
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
-
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Jr., Alt FW, Kahn CR, Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464: 121-125, 2010.
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
Shimazu, T.2
Goetzman, E.3
Jing, E.4
Schwer, B.5
Lombard, D.B.6
Grueter, C.A.7
Harris, C.8
Biddinger, S.9
Ilkayeva, O.R.10
Stevens, R.D.11
Li, Y.12
Saha, A.K.13
Ruderman, N.B.14
Bain, J.R.15
Newgard, C.B.16
Farese Jr, R.V.17
Alt, F.W.18
Kahn, C.R.19
Verdin, E.20
more..
-
83
-
-
84877272187
-
An FGF21-adiponectinceramide axis controls energy expenditure and insulin action in mice
-
Holland WL, Adams AC, Brozinick JT, Bui HH, Miyauchi Y, Kusminski CM, Bauer SM, Wade M, Singhal E, Cheng CC, Volk K, Kuo MS, Gordillo R, Kharitonenkov A, Scherer PE. An FGF21-adiponectinceramide axis controls energy expenditure and insulin action in mice. Cell Metab 17: 790-797, 2013.
-
(2013)
Cell Metab
, vol.17
, pp. 790-797
-
-
Holland, W.L.1
Adams, A.C.2
Brozinick, J.T.3
Bui, H.H.4
Miyauchi, Y.5
Kusminski, C.M.6
Bauer, S.M.7
Wade, M.8
Singhal, E.9
Cheng, C.C.10
Volk, K.11
Kuo, M.S.12
Gordillo, R.13
Kharitonenkov, A.14
Scherer, P.E.15
-
84
-
-
0036251153
-
SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
Horton JD, Goldstein JL, Brown MS. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109: 1125-1131, 2002.
-
(2002)
J Clin Invest
, vol.109
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
85
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS. Inflammation and metabolic disorders. Nature 444: 860-867, 2006.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
86
-
-
84863012730
-
Sustained activation of PPARalpha by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice
-
Huang J, Jia Y, Fu T, Viswakarma N, Bai L, Rao MS, Zhu Y, Borensztajn J, Reddy JK. Sustained activation of PPARalpha by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice. FASEB J 26: 628-638, 2012.
-
(2012)
FASEB J
, vol.26
, pp. 628-638
-
-
Huang, J.1
Jia, Y.2
Fu, T.3
Viswakarma, N.4
Bai, L.5
Rao, M.S.6
Zhu, Y.7
Borensztajn, J.8
Reddy, J.K.9
-
87
-
-
77449117735
-
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
-
Huang W, Metlakunta A, Dedousis N, Zhang P, Sipula I, Dube JJ, Scott DK, O'Doherty RM. Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance. Diabetes 59: 347-357, 2010.
-
(2010)
Diabetes
, vol.59
, pp. 347-357
-
-
Huang, W.1
Metlakunta, A.2
Dedousis, N.3
Zhang, P.4
Sipula, I.5
Dube, J.J.6
Scott, D.K.7
O'Doherty, R.M.8
-
88
-
-
2442435802
-
Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
-
Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A 101: 7281-7286, 2004.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 7281-7286
-
-
Iizuka, K.1
Bruick, R.K.2
Liang, G.3
Horton, J.D.4
Uyeda, K.5
-
89
-
-
33745896223
-
Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice
-
Iizuka K, Miller B, Uyeda K. Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.AmJ Physiol Endocrinol Metab 291: E358-364, 2006.
-
(2006)
AmJ Physiol Endocrinol Metab
, vol.291
-
-
Iizuka, K.1
Miller, B.2
Uyeda, K.3
-
90
-
-
27844546989
-
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
-
Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, Kliewer SA. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2: 217-225, 2005.
-
(2005)
Cell Metab
, vol.2
, pp. 217-225
-
-
Inagaki, T.1
Choi, M.2
Moschetta, A.3
Peng, L.4
Cummins, C.L.5
McDonald, J.G.6
Luo, G.7
Jones, S.A.8
Goodwin, B.9
Richardson, J.A.10
Gerard, R.D.11
Repa, J.J.12
Mangelsdorf, D.J.13
Kliewer, S.A.14
-
91
-
-
34249686631
-
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
-
Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 5: 415-425, 2007.
-
(2007)
Cell Metab
, vol.5
, pp. 415-425
-
-
Inagaki, T.1
Dutchak, P.2
Zhao, G.3
Ding, X.4
Gautron, L.5
Parameswara, V.6
Li, Y.7
Goetz, R.8
Mohammadi, M.9
Esser, V.10
Elmquist, J.K.11
Gerard, R.D.12
Burgess, S.C.13
Hammer, R.E.14
Mangelsdorf, D.J.15
Kliewer, S.A.16
-
92
-
-
45649085226
-
Inhibition of growth hormone signaling by the fasting-induced hormone FGF21
-
Inagaki T, Lin VY, Goetz R, Mohammadi M, Mangelsdorf DJ, Kliewer SA. Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab 8: 77-83, 2008.
-
(2008)
Cell Metab
, vol.8
, pp. 77-83
-
-
Inagaki, T.1
Lin, V.Y.2
Goetz, R.3
Mohammadi, M.4
Mangelsdorf, D.J.5
Kliewer, S.A.6
-
93
-
-
33645579324
-
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
-
Inoue H, Ogawa W, Asakawa A, Okamoto Y, Nishizawa A, Matsumoto M, Teshigawara K, Matsuki Y, Watanabe E, Hiramatsu R. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metabolism 3: 267-275, 2006.
-
(2006)
Cell Metabolism
, vol.3
, pp. 267-275
-
-
Inoue, H.1
Ogawa, W.2
Asakawa, A.3
Okamoto, Y.4
Nishizawa, A.5
Matsumoto, M.6
Teshigawara, K.7
Matsuki, Y.8
Watanabe, E.9
Hiramatsu, R.10
-
94
-
-
11144357516
-
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
-
Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat Med 10: 168-174, 2004.
-
(2004)
Nat Med
, vol.10
, pp. 168-174
-
-
Inoue, H.1
Ogawa, W.2
Ozaki, M.3
Haga, S.4
Matsumoto, M.5
Furukawa, K.6
Hashimoto, N.7
Kido, Y.8
Mori, T.9
Sakaue, H.10
Teshigawara, K.11
Jin, S.12
Iguchi, H.13
Hiramatsu, R.14
LeRoith, D.15
Takeda, K.16
Akira, S.17
Kasuga, M.18
-
95
-
-
7244221588
-
Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and agedependent hepatosteatosis
-
Inoue Y, Inoue J, Lambert G, Yim SH, Gonzalez FJ. Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and agedependent hepatosteatosis. J Biol Chem 279: 44740-44748, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 44740-44748
-
-
Inoue, Y.1
Inoue, J.2
Lambert, G.3
Yim, S.H.4
Gonzalez, F.J.5
-
96
-
-
33749076673
-
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127: 125-137, 2006.
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
Huang, Q.7
Qin, J.8
Su, B.9
-
97
-
-
0029805887
-
An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
-
Janowski BA,Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383: 728-731, 1996.
-
(1996)
Nature
, vol.383
, pp. 728-731
-
-
Janowski, B.A.1
Willy, P.J.2
Devi, T.R.3
Falck, J.R.4
Mangelsdorf, D.J.5
-
98
-
-
84870554857
-
Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes
-
Jelen S, Gena P, Lebeck J, Rojek A, Praetorius J, Frokiaer J, Fenton RA, Nielsen S, Calamita G, Rutzler M. Aquaporin-9 and urea transporter-A gene deletions affect urea transmembrane passage in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol 303: G1279-G1287, 2012.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.303
-
-
Jelen, S.1
Gena, P.2
Lebeck, J.3
Rojek, A.4
Praetorius, J.5
Frokiaer, J.6
Fenton, R.A.7
Nielsen, S.8
Calamita, G.9
Rutzler, M.10
-
99
-
-
84870281398
-
Transcriptional regulation of pyruvate dehydrogenase kinase
-
Jeong JY, Jeoung NH, Park KG, Lee IK. Transcriptional regulation of pyruvate dehydrogenase kinase. Diabetes Metab J 36: 328-335, 2012.
-
(2012)
Diabetes Metab J
, vol.36
, pp. 328-335
-
-
Jeong, J.Y.1
Jeoung, N.H.2
Park, K.G.3
Lee, I.K.4
-
100
-
-
50349094001
-
Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice
-
Jeoung NH, Harris RA. Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice. Am J Physiol Endocrinol Metab 295: E46-54, 2008.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
-
-
Jeoung, N.H.1
Harris, R.A.2
-
101
-
-
33746863679
-
Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation
-
Jeoung NH, Wu P, Joshi MA, Jaskiewicz J, Bock CB, Depaoli-Roach AA, Harris RA. Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation. Biochem J 397: 417-425, 2006.
-
(2006)
Biochem J
, vol.397
, pp. 417-425
-
-
Jeoung, N.H.1
Wu, P.2
Joshi, M.A.3
Jaskiewicz, J.4
Bock, C.B.5
Depaoli-Roach, A.A.6
Harris, R.A.7
-
103
-
-
79959906869
-
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase
-
Jiang W, Wang S, Xiao M, Lin Y, Zhou L, Lei Q, Xiong Y, Guan KL, Zhao S. Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Molecular cell 43: 33-44, 2011.
-
(2011)
Molecular cell
, vol.43
, pp. 33-44
-
-
Jiang, W.1
Wang, S.2
Xiao, M.3
Lin, Y.4
Zhou, L.5
Lei, Q.6
Xiong, Y.7
Guan, K.L.8
Zhao, S.9
-
104
-
-
84860497397
-
Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance
-
Jornayvaz FR, Shulman GI. Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance. Cell Metab 15: 574-584, 2012.
-
(2012)
Cell Metab
, vol.15
, pp. 574-584
-
-
Jornayvaz, F.R.1
Shulman, G.I.2
-
105
-
-
0038561165
-
Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
-
Kabashima T, Kawaguchi T, Wadzinski BE, Uyeda K. Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver. Proc Natl Acad Sci U S A 100: 5107-5112, 2003.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 5107-5112
-
-
Kabashima, T.1
Kawaguchi, T.2
Wadzinski, B.E.3
Uyeda, K.4
-
106
-
-
66449137379
-
GRP78 expression inhibits insulin and ER stressinduced SREBP-1c activation and reduces hepatic steatosis in mice
-
Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, Koike T, Ferre P, Foufelle F. GRP78 expression inhibits insulin and ER stressinduced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 119: 1201-1215, 2009.
-
(2009)
J Clin Invest
, vol.119
, pp. 1201-1215
-
-
Kammoun, H.L.1
Chabanon, H.2
Hainault, I.3
Luquet, S.4
Magnan, C.5
Koike, T.6
Ferre, P.7
Foufelle, F.8
-
107
-
-
77957311822
-
The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in beta-cells
-
Kaufman RJ, Back SH, Song B, Han J, Hassler J. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in beta-cells. Diabetes Obes Metab 12(Suppl 2): 99-107, 2010.
-
(2010)
Diabetes Obes Metab
, vol.12
, Issue.Suppl 2
, pp. 99-107
-
-
Kaufman, R.J.1
Back, S.H.2
Song, B.3
Han, J.4
Hassler, J.5
-
108
-
-
0035923516
-
Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/ dephosphorylation of the carbohydrate response element binding protein
-
Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K. Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/ dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci U S A 98: 13710-13715, 2001.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 13710-13715
-
-
Kawaguchi, T.1
Takenoshita, M.2
Kabashima, T.3
Uyeda, K.4
-
109
-
-
70350606061
-
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
-
Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, Tsang S, Wu SY, Chiang CM, Veenstra TD. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab 10: 392-404, 2009.
-
(2009)
Cell Metab
, vol.10
, pp. 392-404
-
-
Kemper, J.K.1
Xiao, Z.2
Ponugoti, B.3
Miao, J.4
Fang, S.5
Kanamaluru, D.6
Tsang, S.7
Wu, S.Y.8
Chiang, C.M.9
Veenstra, T.D.10
-
110
-
-
0032699670
-
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
-
Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W. Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 103: 1489-1498, 1999.
-
(1999)
J Clin Invest
, vol.103
, pp. 1489-1498
-
-
Kersten, S.1
Seydoux, J.2
Peters, J.M.3
Gonzalez, F.J.4
Desvergne, B.5
Wahli, W.6
-
111
-
-
80755148700
-
FoxO6 integrates insulin signaling with gluconeogenesis in the liver
-
Kim DH, Perdomo G, Zhang T, Slusher S, Lee S, Phillips BE, Fan Y, Giannoukakis N, Gramignoli R, Strom S, Ringquist S, Dong HH. FoxO6 integrates insulin signaling with gluconeogenesis in the liver. Diabetes 60: 2763-2774, 2011.
-
(2011)
Diabetes
, vol.60
, pp. 2763-2774
-
-
Kim, D.H.1
Perdomo, G.2
Zhang, T.3
Slusher, S.4
Lee, S.5
Phillips, B.E.6
Fan, Y.7
Giannoukakis, N.8
Gramignoli, R.9
Strom, S.10
Ringquist, S.11
Dong, H.H.12
-
112
-
-
77956315551
-
Hepaticspecific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
-
Kim HS, Xiao C, Wang RH, Lahusen T, Xu X, Vassilopoulos A, Vazquez-Ortiz G, Jeong WI, Park O, Ki SH, Gao B, Deng CX. Hepaticspecific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab 12: 224-236, 2010.
-
(2010)
Cell Metab
, vol.12
, pp. 224-236
-
-
Kim, H.S.1
Xiao, C.2
Wang, R.H.3
Lahusen, T.4
Xu, X.5
Vassilopoulos, A.6
Vazquez-Ortiz, G.7
Jeong, W.I.8
Park, O.9
Ki, S.H.10
Gao, B.11
Deng, C.X.12
-
113
-
-
38749088678
-
DBC1 is a negative regulator of SIRT1
-
Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature 451: 583-586, 2008.
-
(2008)
Nature
, vol.451
, pp. 583-586
-
-
Kim, J.E.1
Chen, J.2
Lou, Z.3
-
114
-
-
0035912744
-
Tissue-specific overexpression of lipoprotein lipase causes tissuespecific insulin resistance
-
Kim JK, Fillmore JJ, Chen Y, Yu C, Moore IK, Pypaert M, Lutz EP, Kako Y, Velez-Carrasco W, Goldberg IJ, Breslow JL, Shulman GI. Tissue-specific overexpression of lipoprotein lipase causes tissuespecific insulin resistance. Proc Natl Acad Sci U S A 98: 7522-7527, 2001.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 7522-7527
-
-
Kim, J.K.1
Fillmore, J.J.2
Chen, Y.3
Yu, C.4
Moore, I.K.5
Pypaert, M.6
Lutz, E.P.7
Kako, Y.8
Velez-Carrasco, W.9
Goldberg, I.J.10
Breslow, J.L.11
Shulman, G.I.12
-
115
-
-
84866601834
-
Metformin inhibits growth hormone-mediated hepatic PDK4 gene expression through induction of orphan nuclear receptor small heterodimer partner
-
Kim YD, Kim YH, Tadi S, Yu JH, Yim YH, Jeoung NH, Shong M, Hennighausen L, Harris RA, Lee IK, Lee CH, Choi HS. Metformin inhibits growth hormone-mediated hepatic PDK4 gene expression through induction of orphan nuclear receptor small heterodimer partner. Diabetes 61: 2484-2494, 2012.
-
(2012)
Diabetes
, vol.61
, pp. 2484-2494
-
-
Kim, Y.D.1
Kim, Y.H.2
Tadi, S.3
Yu, J.H.4
Yim, Y.H.5
Jeoung, N.H.6
Shong, M.7
Hennighausen, L.8
Harris, R.A.9
Lee, I.K.10
Lee, C.H.11
Choi, H.S.12
-
116
-
-
84868249301
-
Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation
-
Kim YD, Li T, Ahn SW, Kim DK, Lee JM, Hwang SL, Kim YH, Lee CH, Lee IK, Chiang JY, Choi HS. Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation. J Biol Chem 287: 37098-37108, 2012.
-
(2012)
J Biol Chem
, vol.287
, pp. 37098-37108
-
-
Kim, Y.D.1
Li, T.2
Ahn, S.W.3
Kim, D.K.4
Lee, J.M.5
Hwang, S.L.6
Kim, Y.H.7
Lee, C.H.8
Lee, I.K.9
Chiang, J.Y.10
Choi, H.S.11
-
117
-
-
0032538639
-
Hypoglycemiaassociated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice
-
Kimura T, Christoffels VM, Chowdhury S, Iwase K, Matsuzaki H, Mori M, Lamers WH, Darlington GJ, Takiguchi M. Hypoglycemiaassociated hyperammonemia caused by impaired expression of ornithine cycle enzyme genes in C/EBPalpha knockout mice. J Biol Chem 273: 27505-27510, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 27505-27510
-
-
Kimura, T.1
Christoffels, V.M.2
Chowdhury, S.3
Iwase, K.4
Matsuzaki, H.5
Mori, M.6
Lamers, W.H.7
Darlington, G.J.8
Takiguchi, M.9
-
118
-
-
79953129095
-
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis
-
Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 331: 1621-1624, 2011.
-
(2011)
Science
, vol.331
, pp. 1621-1624
-
-
Kir, S.1
Beddow, S.A.2
Samuel, V.T.3
Miller, P.4
Previs, S.F.5
Suino-Powell, K.6
Xu, H.E.7
Shulman, G.I.8
Kliewer, S.A.9
Mangelsdorf, D.J.10
-
119
-
-
41949120723
-
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
-
Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J 27: 1017-1028, 2008.
-
(2008)
EMBO J
, vol.27
, pp. 1017-1028
-
-
Knutson, S.K.1
Chyla, B.J.2
Amann, J.M.3
Bhaskara, S.4
Huppert, S.S.5
Hiebert, S.W.6
-
120
-
-
34249651956
-
Insulin Action in AgRP-expressing neurons is required for suppression of hepatic glucose production
-
Konner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Bruning JC. Insulin Action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab 5: 438-449, 2007.
-
(2007)
Cell Metab
, vol.5
, pp. 438-449
-
-
Konner, A.C.1
Janoschek, R.2
Plum, L.3
Jordan, S.D.4
Rother, E.5
Ma, X.6
Xu, C.7
Enriori, P.8
Hampel, B.9
Barsh, G.S.10
Kahn, C.R.11
Cowley, M.A.12
Ashcroft, F.M.13
Bruning, J.C.14
-
121
-
-
27144506185
-
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
-
Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437: 1109-1111, 2005.
-
(2005)
Nature
, vol.437
, pp. 1109-1111
-
-
Koo, S.H.1
Flechner, L.2
Qi, L.3
Zhang, X.4
Screaton, R.A.5
Jeffries, S.6
Hedrick, S.7
Xu, W.8
Boussouar, F.9
Brindle, P.10
Takemori, H.11
Montminy, M.12
-
123
-
-
21144444486
-
HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
-
Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP. HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Molecular cell 18: 601-607, 2005.
-
(2005)
Molecular cell
, vol.18
, pp. 601-607
-
-
Kovacs, J.J.1
Murphy, P.J.2
Gaillard, S.3
Zhao, X.4
Wu, J.T.5
Nicchitta, C.V.6
Yoshida, M.7
Toft, D.O.8
Pratt, W.B.9
Yao, T.P.10
-
124
-
-
79953765467
-
Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia
-
Kulozik P, Jones A, Mattijssen F, Rose AJ, Reimann A, Strzoda D, Kleinsorg S, Raupp C, Kleinschmidt J, Muller-Decker K, Wahli W, Sticht C, Gretz N, von Loeffelholz C, Stockmann M, Pfeiffer A, Stohr S, Dallinga-Thie GM, Nawroth PP, Berriel Diaz M, Herzig S. Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab 13: 389-400, 2011.
-
(2011)
Cell Metab
, vol.13
, pp. 389-400
-
-
Kulozik, P.1
Jones, A.2
Mattijssen, F.3
Rose, A.J.4
Reimann, A.5
Strzoda, D.6
Kleinsorg, S.7
Raupp, C.8
Kleinschmidt, J.9
Muller-Decker, K.10
Wahli, W.11
Sticht, C.12
Gretz, N.13
von Loeffelholz, C.14
Stockmann, M.15
Pfeiffer, A.16
Stohr, S.17
Dallinga-Thie, G.M.18
Nawroth, P.P.19
Berriel Diaz, M.20
Herzig, S.21
more..
-
125
-
-
33846988243
-
Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins
-
Lam TK, Gutierrez-Juarez R, Pocai A, Bhanot S, Tso P, Schwartz GJ, Rossetti L. Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins. Nat Med 13: 171-180, 2007.
-
(2007)
Nat Med
, vol.13
, pp. 171-180
-
-
Lam, T.K.1
Gutierrez-Juarez, R.2
Pocai, A.3
Bhanot, S.4
Tso, P.5
Schwartz, G.J.6
Rossetti, L.7
-
126
-
-
23244458439
-
Regulation of blood glucose by hypothalamic pyruvate metabolism
-
Lam TK, Gutierrez-Juarez R, Pocai A, Rossetti L. Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309: 943-947, 2005.
-
(2005)
Science
, vol.309
, pp. 943-947
-
-
Lam, T.K.1
Gutierrez-Juarez, R.2
Pocai, A.3
Rossetti, L.4
-
127
-
-
16244388931
-
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
-
Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, Schwartz GJ, Rossetti L. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 11: 320-327, 2005.
-
(2005)
Nat Med
, vol.11
, pp. 320-327
-
-
Lam, T.K.1
Pocai, A.2
Gutierrez-Juarez, R.3
Obici, S.4
Bryan, J.5
Aguilar-Bryan, L.6
Schwartz, G.J.7
Rossetti, L.8
-
128
-
-
84255206549
-
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
-
Lamia KA, Papp SJ, Yu RT, Barish GD, Uhlenhaut NH, Jonker JW, Downes M, Evans RM. Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature 480: 552-556, 2011.
-
(2011)
Nature
, vol.480
, pp. 552-556
-
-
Lamia, K.A.1
Papp, S.J.2
Yu, R.T.3
Barish, G.D.4
Uhlenhaut, N.H.5
Jonker, J.W.6
Downes, M.7
Evans, R.M.8
-
129
-
-
33646128723
-
Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome
-
Lass A, Zimmermann R, Haemmerle G, Riederer M, Schoiswohl G, Schweiger M, Kienesberger P, Strauss JG, Gorkiewicz G, Zechner R. Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab 3: 309-319, 2006.
-
(2006)
Cell Metab
, vol.3
, pp. 309-319
-
-
Lass, A.1
Zimmermann, R.2
Haemmerle, G.3
Riederer, M.4
Schoiswohl, G.5
Schweiger, M.6
Kienesberger, P.7
Strauss, J.G.8
Gorkiewicz, G.9
Zechner, R.10
-
130
-
-
67649657842
-
CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis
-
Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metab 10: 55-62, 2009.
-
(2009)
Cell Metab
, vol.10
, pp. 55-62
-
-
Le Lay, J.1
Tuteja, G.2
White, P.3
Dhir, R.4
Ahima, R.5
Kaestner, K.H.6
-
131
-
-
45849137877
-
Regulation of hepatic lipogenesis by the transcription factor XBP1
-
Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492-1496, 2008.
-
(2008)
Science
, vol.320
, pp. 1492-1496
-
-
Lee, A.H.1
Scapa, E.F.2
Cohen, D.E.3
Glimcher, L.H.4
-
132
-
-
79960110157
-
The transcription factor cyclic AMP-responsive element-binding proteinHregulates triglyceride metabolism
-
Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH. The transcription factor cyclic AMP-responsive element-binding proteinHregulates triglyceride metabolism. Nat Med 17: 812-815, 2011.
-
(2011)
Nat Med
, vol.17
, pp. 812-815
-
-
Lee, J.H.1
Giannikopoulos, P.2
Duncan, S.A.3
Wang, J.4
Johansen, C.T.5
Brown, J.D.6
Plutzky, J.7
Hegele, R.A.8
Glimcher, L.H.9
Lee, A.H.10
-
133
-
-
77955488532
-
A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis
-
Lee JH, Wada T, Febbraio M, He J, Matsubara T, Lee MJ, Gonzalez FJ, Xie W. A novel role for the dioxin receptor in fatty acid metabolism and hepatic steatosis. Gastroenterology 139: 653-663, 2010.
-
(2010)
Gastroenterology
, vol.139
, pp. 653-663
-
-
Lee, J.H.1
Wada, T.2
Febbraio, M.3
He, J.4
Matsubara, T.5
Lee, M.J.6
Gonzalez, F.J.7
Xie, W.8
-
134
-
-
79959560633
-
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects
-
Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474: 506-510, 2011.
-
(2011)
Nature
, vol.474
, pp. 506-510
-
-
Lee, J.M.1
Lee, Y.K.2
Mamrosh, J.L.3
Busby, S.A.4
Griffin, P.R.5
Pathak, M.C.6
Ortlund, E.A.7
Moore, D.D.8
-
135
-
-
77950285163
-
Regulation of hepatic gluconeogenesis by an ER-bound transcription factor CREBH
-
Lee MW, Chanda D, Yang J, Oh H, Kim SS, Yoon YS, Hong S, Park KG, Lee IK, Choi CS, Hanson RW, Choi HS, Koo SH. Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell Metab 11: 331-339, 2010.
-
(2010)
Cell Metab
, vol.11
, pp. 331-339
-
-
Lee, M.W.1
Chanda, D.2
Yang, J.3
Oh, H.4
Kim, S.S.5
Yoon, Y.S.6
Hong, S.7
Park, K.G.8
Lee, I.K.9
Choi, C.S.10
Hanson, R.W.11
Choi, H.S.12
Koo, S.H.13
-
136
-
-
57249094022
-
Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice
-
Lee SJ, Heinrich G, Fedorova L, Al-Share QY, Ledford KJ, Fernstrom MA, McInerney MF, Erickson SK, Gatto-Weis C, Najjar SM. Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. Gastroenterology 135: 2084-2095, 2008.
-
(2008)
Gastroenterology
, vol.135
, pp. 2084-2095
-
-
Lee, S.J.1
Heinrich, G.2
Fedorova, L.3
Al-Share, Q.Y.4
Ledford, K.J.5
Fernstrom, M.A.6
McInerney, M.F.7
Erickson, S.K.8
Gatto-Weis, C.9
Najjar, S.M.10
-
137
-
-
79551600048
-
Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice
-
Lee Y,Wang MY, Du XQ, Charron MJ, Unger RH. Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice. Diabetes 60: 391-397, 2011.
-
(2011)
Diabetes
, vol.60
, pp. 391-397
-
-
Lee, Y.1
Wang, M.Y.2
Du, X.Q.3
Charron, M.J.4
Unger, R.H.5
-
138
-
-
84865304883
-
Nuclear receptor PPARgamma-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis
-
Lee YJ, Ko EH, Kim JE, Kim E, Lee H, Choi H, Yu JH, Kim HJ, Seong JK, Kim KS, Kim JW. Nuclear receptor PPARgamma-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis. Proc Natl Acad Sci U S A 109: 13656-13661, 2012.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 13656-13661
-
-
Lee, Y.J.1
Ko, E.H.2
Kim, J.E.3
Kim, E.4
Lee, H.5
Choi, H.6
Yu, J.H.7
Kim, H.J.8
Seong, J.K.9
Kim, K.S.10
Kim, J.W.11
-
139
-
-
50049104872
-
The glucocorticoid receptor controls hepatic dyslipidemia through Hes1
-
Lemke U, Krones-Herzig A, Berriel Diaz M, Narvekar P, Ziegler A, Vegiopoulos A, Cato AC, Bohl S, Klingmuller U, Screaton RA, Muller-Decker K, Kersten S, Herzig S. The glucocorticoid receptor controls hepatic dyslipidemia through Hes1. Cell Metab 8: 212-223, 2008.
-
(2008)
Cell Metab
, vol.8
, pp. 212-223
-
-
Lemke, U.1
Krones-Herzig, A.2
Berriel Diaz, M.3
Narvekar, P.4
Ziegler, A.5
Vegiopoulos, A.6
Cato, A.C.7
Bohl, S.8
Klingmuller, U.9
Screaton, R.A.10
Muller-Decker, K.11
Kersten, S.12
Herzig, S.13
-
140
-
-
0033594980
-
A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
-
Leone TC,Weinheimer CJ, Kelly DP. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A 96: 7473-7478, 1999.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 7473-7478
-
-
Leone, T.C.1
Weinheimer, C.J.2
Kelly, D.P.3
-
141
-
-
33744534726
-
GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha
-
Lerin C, Rodgers JT, Kalume DE, Kim SH, Pandey A, Puigserver P. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab 3: 429-438, 2006.
-
(2006)
Cell Metab
, vol.3
, pp. 429-438
-
-
Lerin, C.1
Rodgers, J.T.2
Kalume, D.E.3
Kim, S.H.4
Pandey, A.5
Puigserver, P.6
-
142
-
-
77949311823
-
Nonalcoholic fatty liver disease: A review and update
-
Lewis JR, Mohanty SR. Nonalcoholic fatty liver disease: A review and update. Dig Dis Sci 55: 560-578, 2010.
-
(2010)
Dig Dis Sci
, vol.55
, pp. 560-578
-
-
Lewis, J.R.1
Mohanty, S.R.2
-
143
-
-
70350450243
-
Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition
-
Li LO, Ellis JM, Paich HA,Wang S, Gong N, Altshuller G, Thresher RJ, Koves TR,Watkins SM, Muoio DM, Cline GW, Shulman GI, Coleman RA. Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. J Biol Chem 284: 27816-27826, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 27816-27826
-
-
Li, L.O.1
Ellis, J.M.2
Paich, H.A.3
Wang, S.4
Gong, N.5
Altshuller, G.6
Thresher, R.J.7
Koves, T.R.8
Watkins, S.M.9
Muoio, D.M.10
Cline, G.W.11
Shulman, G.I.12
Coleman, R.A.13
-
144
-
-
77649264504
-
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
-
Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A 107: 3441-3446, 2010.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 3441-3446
-
-
Li, S.1
Brown, M.S.2
Goldstein, J.L.3
-
145
-
-
48349108293
-
Genomewide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism
-
Li S, Liu C, Li N, Hao T, Han T, Hill DE, Vidal M, Lin JD. Genomewide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. Cell Metab 8: 105-117, 2008.
-
(2008)
Cell Metab
, vol.8
, pp. 105-117
-
-
Li, S.1
Liu, C.2
Li, N.3
Hao, T.4
Han, T.5
Hill, D.E.6
Vidal, M.7
Lin, J.D.8
-
146
-
-
34250740323
-
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator
-
Li X, Monks B, Ge Q, Birnbaum MJ. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 447: 1012-1016, 2007.
-
(2007)
Nature
, vol.447
, pp. 1012-1016
-
-
Li, X.1
Monks, B.2
Ge, Q.3
Birnbaum, M.J.4
-
147
-
-
79953755370
-
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulinresistant mice
-
Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY, Gao B,Wierzbicki M,Verbeuren TJ, ShawRJ, Cohen RA, Zang M. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulinresistant mice. Cell Metab 13: 376-388, 2011.
-
(2011)
Cell Metab
, vol.13
, pp. 376-388
-
-
Li, Y.1
Xu, S.2
Mihaylova, M.M.3
Zheng, B.4
Hou, X.5
Jiang, B.6
Park, O.7
Luo, Z.8
Lefai, E.9
Shyy, J.Y.10
Gao, B.11
Wierzbicki, M.12
Verbeuren, T.J.13
Shaw, R.J.14
Cohen, R.A.15
Zang, M.16
-
148
-
-
0842288445
-
Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice
-
Liang Y, Osborne MC, Monia BP, Bhanot S, GaardeWA, Reed C, She P, Jetton TL, Demarest KT. Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Diabetes 53: 410-417, 2004.
-
(2004)
Diabetes
, vol.53
, pp. 410-417
-
-
Liang, Y.1
Osborne, M.C.2
Monia, B.P.3
Bhanot, S.4
Gaarde, W.A.5
Reed, C.6
She, P.7
Jetton, T.L.8
Demarest, K.T.9
-
149
-
-
19944430411
-
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP
-
Lin J,Yang R, Tarr PT, Wu PH, Handschin C, Li S,Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell 120: 261-273, 2005.
-
(2005)
Cell
, vol.120
, pp. 261-273
-
-
Lin, J.1
Yang, R.2
Tarr, P.T.3
Wu, P.H.4
Handschin, C.5
Li, S.6
Yang, W.7
Pei, L.8
Uldry, M.9
Tontonoz, P.10
Newgard, C.B.11
Spiegelman, B.M.12
-
150
-
-
84877260638
-
Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice
-
Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, Itoh N, Wang Y, Bornstein SR, Xu A, Li X. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab 17: 779-789, 2013.
-
(2013)
Cell Metab
, vol.17
, pp. 779-789
-
-
Lin, Z.1
Tian, H.2
Lam, K.S.3
Lin, S.4
Hoo, R.C.5
Konishi, M.6
Itoh, N.7
Wang, Y.8
Bornstein, S.R.9
Xu, A.10
Li, X.11
-
151
-
-
79551707018
-
Wnt signaling regulates hepatic metabolism
-
Liu H, Fergusson MM, Wu JJ, Rovira, II, Liu J, Gavrilova O, Lu T, Bao J, Han D, Sack MN, Finkel T. Wnt signaling regulates hepatic metabolism. Sci Signal 4: ra6, 2011.
-
(2011)
Sci Signal
, vol.4
-
-
Liu, H.1
Fergusson, M.M.2
Wu, J.J.3
Rovira, I.I.4
Liu, J.5
Gavrilova, O.6
Lu, T.7
Bao, J.8
Han, D.9
Sack, M.N.10
Finkel, T.11
-
152
-
-
0032947501
-
Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPbeta gene
-
Liu S, Croniger C, Arizmendi C, Harada-Shiba M, Ren J, Poli V, Hanson RW, Friedman JE. Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPbeta gene. J Clin Invest 103: 207-213, 1999.
-
(1999)
J Clin Invest
, vol.103
, pp. 207-213
-
-
Liu, S.1
Croniger, C.2
Arizmendi, C.3
Harada-Shiba, M.4
Ren, J.5
Poli, V.6
Hanson, R.W.7
Friedman, J.E.8
-
153
-
-
78651384181
-
Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation
-
Liu S, Hatano B, Zhao M, Yen CC, Kang K, Reilly SM, Gangl MR, Gorgun C, Balschi JA, Ntambi JM, Lee CH. Role of peroxisome proliferator-activated receptor {delta}/{beta} in hepatic metabolic regulation. J Biol Chem 286: 1237-1247, 2011.
-
(2011)
J Biol Chem
, vol.286
, pp. 1237-1247
-
-
Liu, S.1
Hatano, B.2
Zhao, M.3
Yen, C.C.4
Kang, K.5
Reilly, S.M.6
Gangl, M.R.7
Gorgun, C.8
Balschi, J.A.9
Ntambi, J.M.10
Lee, C.H.11
-
154
-
-
56249100986
-
A fasting inducible switch modulates gluconeogenesis via activator/ coactivator exchange
-
Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, III, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/ coactivator exchange. Nature 456: 269-273, 2008.
-
(2008)
Nature
, vol.456
, pp. 269-273
-
-
Liu, Y.1
Dentin, R.2
Chen, D.3
Hedrick, S.4
Ravnskjaer, K.5
Schenk, S.6
Milne, J.7
Meyers, D.J.8
Cole, P.9
Yates III, J.10
Olefsky, J.11
Guarente, L.12
Montminy, M.13
-
155
-
-
33751210100
-
Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice
-
Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, Lutfy K, Friedman TC. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology 147: 5061-5068, 2006.
-
(2006)
Endocrinology
, vol.147
, pp. 5061-5068
-
-
Liu, Y.1
Yan, C.2
Wang, Y.3
Nakagawa, Y.4
Nerio, N.5
Anghel, A.6
Lutfy, K.7
Friedman, T.C.8
-
156
-
-
54849431792
-
The glucagon receptor is required for the adaptive metabolic response to fasting
-
Longuet C, Sinclair EM, Maida A, Baggio LL, Maziarz M, Charron MJ, Drucker DJ. The glucagon receptor is required for the adaptive metabolic response to fasting. Cell Metabolism 8: 359-371, 2008.
-
(2008)
Cell Metabolism
, vol.8
, pp. 359-371
-
-
Longuet, C.1
Sinclair, E.M.2
Maida, A.3
Baggio, L.L.4
Maziarz, M.5
Charron, M.J.6
Drucker, D.J.7
-
157
-
-
78649516570
-
The coactivator SRC-1 is an essential coordinator of hepatic glucose production
-
Louet JF, Chopra AR, Sagen JV, An J, York B, Tannour-Louet M, Saha PK, Stevens RD, Wenner BR, Ilkayeva OR, Bain JR, Zhou S, DeMayo F, Xu J, Newgard CB, O'Malley BW. The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metab 12: 606-618, 2010.
-
(2010)
Cell Metab
, vol.12
, pp. 606-618
-
-
Louet, J.F.1
Chopra, A.R.2
Sagen, J.V.3
An, J.4
York, B.5
Tannour-Louet, M.6
Saha, P.K.7
Stevens, R.D.8
Wenner, B.R.9
Ilkayeva, O.R.10
Bain, J.R.11
Zhou, S.12
DeMayo, F.13
Xu, J.14
Newgard, C.B.15
O'Malley, B.W.16
-
158
-
-
84857934301
-
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
-
Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR, Birnbaum MJ. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nat Med 18: 388-395, 2012.
-
(2012)
Nat Med
, vol.18
, pp. 388-395
-
-
Lu, M.1
Wan, M.2
Leavens, K.F.3
Chu, Q.4
Monks, B.R.5
Fernandez, S.6
Ahima, R.S.7
Ueki, K.8
Kahn, C.R.9
Birnbaum, M.J.10
-
159
-
-
84875472538
-
Yin Yang 1 promotes hepatic gluconeogenesis through upregulation of glucocorticoid receptor
-
Lu Y, Xiong X, Wang X, Zhang Z, Li J, Shi G, Yang J, Zhang H, Ning G, Li X. Yin Yang 1 promotes hepatic gluconeogenesis through upregulation of glucocorticoid receptor. Diabetes 62: 1064-1073, 2013.
-
(2013)
Diabetes
, vol.62
, pp. 1064-1073
-
-
Lu, Y.1
Xiong, X.2
Wang, X.3
Zhang, Z.4
Li, J.5
Shi, G.6
Yang, J.7
Zhang, H.8
Ning, G.9
Li, X.10
-
160
-
-
79959635928
-
Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase
-
Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes Dev 25: 1232-1244, 2011.
-
(2011)
Genes Dev
, vol.25
, pp. 1232-1244
-
-
Lustig, Y.1
Ruas, J.L.2
Estall, J.L.3
Lo, J.C.4
Devarakonda, S.5
Laznik, D.6
Choi, J.H.7
Ono, H.8
Olsen, J.V.9
Spiegelman, B.M.10
-
161
-
-
0026488079
-
Increased rate of gluconeogenesis in type II diabetes mellitus A 13C nuclear magnetic resonance study
-
Magnusson I, Rothman DL, Katz LD, Shulman RG, Shulman GI. Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J Clin Invest 90: 1323-1327, 1992.
-
(1992)
J Clin Invest
, vol.90
, pp. 1323-1327
-
-
Magnusson, I.1
Rothman, D.L.2
Katz, L.D.3
Shulman, R.G.4
Shulman, G.I.5
-
162
-
-
33744781581
-
Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis
-
Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC, Wakil SJ. Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis. Proc Natl Acad Sci U S A 103: 8552-8557, 2006.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8552-8557
-
-
Mao, J.1
DeMayo, F.J.2
Li, H.3
Abu-Elheiga, L.4
Gu, Z.5
Shaikenov, T.E.6
Kordari, P.7
Chirala, S.S.8
Heird, W.C.9
Wakil, S.J.10
-
163
-
-
80053153521
-
PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism
-
Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Y, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W. PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism. Proc Natl Acad Sci U S A 108: 15852-15857, 2011.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 15852-15857
-
-
Mao, T.1
Shao, M.2
Qiu, Y.3
Huang, J.4
Zhang, Y.5
Song, B.6
Wang, Q.7
Jiang, L.8
Liu, Y.9
Han, J.D.10
Cao, P.11
Li, J.12
Gao, X.13
Rui, L.14
Qi, L.15
Li, W.16
-
164
-
-
0038498152
-
Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene
-
Martin GG, Danneberg H, Kumar LS, Atshaves BP, Erol E, Bader M, Schroeder F, Binas B. Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene. J Biol Chem 278: 21429-21438, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 21429-21438
-
-
Martin, G.G.1
Danneberg, H.2
Kumar, L.S.3
Atshaves, B.P.4
Erol, E.5
Bader, M.6
Schroeder, F.7
Binas, B.8
-
165
-
-
33845573067
-
Coordinated control of bile acids and lipogenesis through FXRdependent regulation of fatty acid synthase
-
Matsukuma KE, Bennett MK, Huang J, Wang L, Gil G, Osborne TF. Coordinated control of bile acids and lipogenesis through FXRdependent regulation of fatty acid synthase. J Lipid Res 47: 2754-2761, 2006.
-
(2006)
J Lipid Res
, vol.47
, pp. 2754-2761
-
-
Matsukuma, K.E.1
Bennett, M.K.2
Huang, J.3
Wang, L.4
Gil, G.5
Osborne, T.F.6
-
166
-
-
34548349302
-
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
-
Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab 6: 208-216, 2007.
-
(2007)
Cell Metab
, vol.6
, pp. 208-216
-
-
Matsumoto, M.1
Pocai, A.2
Rossetti, L.3
Depinho, R.A.4
Accili, D.5
-
167
-
-
0037373008
-
Liver-specific disruption of PPARgammain leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
-
Matsusue K, Haluzik M, Lambert G, Yim SH, Gavrilova O, Ward JM, Brewer B, Jr., Reitman ML, Gonzalez FJ. Liver-specific disruption of PPARgammain leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 111: 737-747, 2003.
-
(2003)
J Clin Invest
, vol.111
, pp. 737-747
-
-
Matsusue, K.1
Haluzik, M.2
Lambert, G.3
Yim, S.H.4
Gavrilova, O.5
Ward, J.M.6
Brewer Jr, B.7
Reitman, M.L.8
Gonzalez, F.J.9
-
168
-
-
41449098953
-
Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27
-
Matsusue K, Kusakabe T, Noguchi T, Takiguchi S, Suzuki T, Yamano S, Gonzalez FJ. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp27. Cell Metab 7: 302-311, 2008.
-
(2008)
Cell Metab
, vol.7
, pp. 302-311
-
-
Matsusue, K.1
Kusakabe, T.2
Noguchi, T.3
Takiguchi, S.4
Suzuki, T.5
Yamano, S.6
Gonzalez, F.J.7
-
169
-
-
84870541988
-
Elovl6 promotes nonalcoholic steatohepatitis
-
Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A, Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H. Elovl6 promotes nonalcoholic steatohepatitis. Hepatology 56: 2199-2208, 2012.
-
(2012)
Hepatology
, vol.56
, pp. 2199-2208
-
-
Matsuzaka, T.1
Atsumi, A.2
Matsumori, R.3
Nie, T.4
Shinozaki, H.5
Suzuki-Kemuriyama, N.6
Kuba, M.7
Nakagawa, Y.8
Ishii, K.9
Shimada, M.10
Kobayashi, K.11
Yatoh, S.12
Takahashi, A.13
Takekoshi, K.14
Sone, H.15
Yahagi, N.16
Suzuki, H.17
Murata, S.18
Nakamuta, M.19
Yamada, N.20
Shimano, H.21
more..
-
170
-
-
23844485211
-
Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation
-
Matsuzaki H, Daitoku H, Hatta M, Aoyama H, Yoshimochi K, Fukamizu A. Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A 102: 11278-11283, 2005.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 11278-11283
-
-
Matsuzaki, H.1
Daitoku, H.2
Hatta, M.3
Aoyama, H.4
Yoshimochi, K.5
Fukamizu, A.6
-
171
-
-
3543150636
-
The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3
-
Merla G, Howald C, Antonarakis SE, Reymond A. The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. Human molecular genetics 13: 1505-1514, 2004.
-
(2004)
Human molecular genetics
, vol.13
, pp. 1505-1514
-
-
Merla, G.1
Howald, C.2
Antonarakis, S.E.3
Reymond, A.4
-
172
-
-
0032146567
-
Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus
-
Meyer C, Stumvoll M, Nadkarni V, Dostou J, Mitrakou A, Gerich J. Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus. J Clin Invest 102: 619-624, 1998.
-
(1998)
J Clin Invest
, vol.102
, pp. 619-624
-
-
Meyer, C.1
Stumvoll, M.2
Nadkarni, V.3
Dostou, J.4
Mitrakou, A.5
Gerich, J.6
-
173
-
-
0033636523
-
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
-
MichaelMD,Kulkarni RN, Postic C, Previs SF, Shulman GI, Magnuson MA, Kahn CR. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Molecular cell 6: 87-97, 2000.
-
(2000)
Molecular cell
, vol.6
, pp. 87-97
-
-
Michael, M.D.1
Kulkarni, R.N.2
Postic, C.3
Previs, S.F.4
Shulman, G.I.5
Magnuson, M.A.6
Kahn, C.R.7
-
174
-
-
79955815135
-
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
-
Mihaylova MM, Vasquez DS, Ravnskjaer K, Denechaud PD, Yu RT, Alvarez JG, Downes M, Evans RM, Montminy M, Shaw RJ. Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145: 607-621, 2011.
-
(2011)
Cell
, vol.145
, pp. 607-621
-
-
Mihaylova, M.M.1
Vasquez, D.S.2
Ravnskjaer, K.3
Denechaud, P.D.4
Yu, R.T.5
Alvarez, J.G.6
Downes, M.7
Evans, R.M.8
Montminy, M.9
Shaw, R.J.10
-
175
-
-
36448991861
-
Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
-
Miyazaki M, Flowers MT, Sampath H, Chu K, Otzelberger C, Liu X, Ntambi JM. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab 6: 484-496, 2007.
-
(2007)
Cell Metab
, vol.6
, pp. 484-496
-
-
Miyazaki, M.1
Flowers, M.T.2
Sampath, H.3
Chu, K.4
Otzelberger, C.5
Liu, X.6
Ntambi, J.M.7
-
176
-
-
84860568860
-
Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnal glucose metabolism through 11beta-hydroxysteroid dehydrogenase 1
-
Molusky MM, Li S, Ma D, Yu L, Lin JD. Ubiquitin-specific protease 2 regulates hepatic gluconeogenesis and diurnal glucose metabolism through 11beta-hydroxysteroid dehydrogenase 1. Diabetes 61: 1025-1035, 2012.
-
(2012)
Diabetes
, vol.61
, pp. 1025-1035
-
-
Molusky, M.M.1
Li, S.2
Ma, D.3
Yu, L.4
Lin, J.D.5
-
177
-
-
84863393589
-
The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals
-
Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Brown MS, Goldstein JL, Horton JD. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. Cell Metab 15: 240-246, 2012.
-
(2012)
Cell Metab
, vol.15
, pp. 240-246
-
-
Moon, Y.A.1
Liang, G.2
Xie, X.3
Frank-Kamenetsky, M.4
Fitzgerald, K.5
Koteliansky, V.6
Brown, M.S.7
Goldstein, J.L.8
Horton, J.D.9
-
178
-
-
80051706346
-
Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts
-
Moran-Salvador E, Lopez-Parra M, Garcia-Alonso V, Titos E, Martinez-Clemente M, Gonzalez-Periz A, Lopez-Vicario C, Barak Y, Arroyo V, Claria J. Role for PPARgamma in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J 25: 2538-2550, 2011.
-
(2011)
FASEB J
, vol.25
, pp. 2538-2550
-
-
Moran-Salvador, E.1
Lopez-Parra, M.2
Garcia-Alonso, V.3
Titos, E.4
Martinez-Clemente, M.5
Gonzalez-Periz, A.6
Lopez-Vicario, C.7
Barak, Y.8
Arroyo, V.9
Claria, J.10
-
179
-
-
70349086181
-
SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins
-
Morris DL, Cho KW, Zhou Y, Rui L. SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins. Diabetes 58: 2039-2047, 2009.
-
(2009)
Diabetes
, vol.58
, pp. 2039-2047
-
-
Morris, D.L.1
Cho, K.W.2
Zhou, Y.3
Rui, L.4
-
180
-
-
72249092928
-
Recent advances in understanding leptin signaling and leptin resistance
-
Morris DLRui L. Recent advances in understanding leptin signaling and leptin resistance. Am J Physiol Endocrinol Metab 297: E1247-E1259, 2009.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
-
-
Morris, D.L.1
Rui, L.2
-
181
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124: 315-329, 2006.
-
(2006)
Cell
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
Gellon, L.6
Liu, P.7
Mostoslavsky, G.8
Franco, S.9
Murphy, M.M.10
Mills, K.D.11
Patel, P.12
Hsu, J.T.13
Hong, A.L.14
Ford, E.15
Cheng, H.L.16
Kennedy, C.17
Nunez, N.18
Bronson, R.19
Frendewey, D.20
Auerbach, W.21
Valenzuela, D.22
Karow, M.23
Hottiger, M.O.24
Hursting, S.25
Barrett, J.C.26
Guarente, L.27
Mulligan, R.28
Demple, B.29
Yancopoulos, G.D.30
Alt, F.W.31
more..
-
182
-
-
84864353016
-
Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development
-
Mueller KM, Themanns M, Friedbichler K, Kornfeld JW, Esterbauer H, Tuckermann JP, Moriggl R. Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development. Mol Cell Endocrinol 361: 1-11, 2012.
-
(2012)
Mol Cell Endocrinol
, vol.361
, pp. 1-11
-
-
Mueller, K.M.1
Themanns, M.2
Friedbichler, K.3
Kornfeld, J.W.4
Esterbauer, H.5
Tuckermann, J.P.6
Moriggl, R.7
-
183
-
-
79951672283
-
Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas
-
Mutel E, Abdul-Wahed A, Ramamonjisoa N, Stefanutti A, Houberdon I, Cavassila S, Pilleul F, Beuf O, Gautier-Stein A, Penhoat A, Mithieux G, Rajas F. Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas. Journal of hepatology 54: 529-537, 2011.
-
(2011)
Journal of hepatology
, vol.54
, pp. 529-537
-
-
Mutel, E.1
Abdul-Wahed, A.2
Ramamonjisoa, N.3
Stefanutti, A.4
Houberdon, I.5
Cavassila, S.6
Pilleul, F.7
Beuf, O.8
Gautier-Stein, A.9
Penhoat, A.10
Mithieux, G.11
Rajas, F.12
-
184
-
-
84863373226
-
Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: Implications for the carbohydrate metabolism
-
Nader N, Ng SS, Wang Y, Abel BS, Chrousos GP, Kino T. Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: Implications for the carbohydrate metabolism. PLoS One 7: e26751, 2012.
-
(2012)
PLoS One
, vol.7
-
-
Nader, N.1
Ng, S.S.2
Wang, Y.3
Abel, B.S.4
Chrousos, G.P.5
Kino, T.6
-
185
-
-
60649109153
-
The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance
-
Nagai Y, Yonemitsu S, Erion DM, Iwasaki T, Stark R, Weismann D, Dong J, Zhang D, Jurczak MJ, Loffler MG, Cresswell J, Yu XX, Murray SF, Bhanot S, Monia BP, Bogan JS, Samuel V, Shulman GI. The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance. Cell Metab 9: 252-264, 2009.
-
(2009)
Cell Metab
, vol.9
, pp. 252-264
-
-
Nagai, Y.1
Yonemitsu, S.2
Erion, D.M.3
Iwasaki, T.4
Stark, R.5
Weismann, D.6
Dong, J.7
Zhang, D.8
Jurczak, M.J.9
Loffler, M.G.10
Cresswell, J.11
Yu, X.X.12
Murray, S.F.13
Bhanot, S.14
Monia, B.P.15
Bogan, J.S.16
Samuel, V.17
Shulman, G.I.18
-
186
-
-
27244458206
-
Insulin acutely decreases hepatic fatty acid synthase activity
-
Najjar SM, Yang Y, Fernstrom MA, Lee SJ, Deangelis AM, Rjaily GA, Al-Share QY, Dai T, Miller TA, Ratnam S, Ruch RJ, Smith S, Lin SH, Beauchemin N, Oyarce AM. Insulin acutely decreases hepatic fatty acid synthase activity. Cell Metab 2: 43-53, 2005.
-
(2005)
Cell Metab
, vol.2
, pp. 43-53
-
-
Najjar, S.M.1
Yang, Y.2
Fernstrom, M.A.3
Lee, S.J.4
Deangelis, A.M.5
Rjaily, G.A.6
Al-Share, Q.Y.7
Dai, T.8
Miller, T.A.9
Ratnam, S.10
Ruch, R.J.11
Smith, S.12
Lin, S.H.13
Beauchemin, N.14
Oyarce, A.M.15
-
187
-
-
0035185021
-
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
-
Nakae J, Kitamura T, Silver DL, Accili D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 108: 1359-1367, 2001.
-
(2001)
J Clin Invest
, vol.108
, pp. 1359-1367
-
-
Nakae, J.1
Kitamura, T.2
Silver, D.L.3
Accili, D.4
-
188
-
-
65249087389
-
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
-
Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137: 560-570, 2009.
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
189
-
-
0347065337
-
Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acidbinding protein gene
-
Newberry EP, Xie Y, Kennedy S, Han X, Buhman KK, Luo J, Gross RW, Davidson NO. Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acidbinding protein gene. J Biol Chem 278: 51664-51672, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 51664-51672
-
-
Newberry, E.P.1
Xie, Y.2
Kennedy, S.3
Han, X.4
Buhman, K.K.5
Luo, J.6
Gross, R.W.7
Davidson, N.O.8
-
190
-
-
33750998524
-
Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice
-
Newberry EP, Xie Y, Kennedy SM, Luo J, Davidson NO. Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Hepatology 44: 1191-1205, 2006.
-
(2006)
Hepatology
, vol.44
, pp. 1191-1205
-
-
Newberry, E.P.1
Xie, Y.2
Kennedy, S.M.3
Luo, J.4
Davidson, N.O.5
-
191
-
-
64049109876
-
STAT3 inhibition of gluconeogenesis is downregulated by SirT1
-
Nie Y, Erion DM, Yuan Z, Dietrich M, Shulman GI, Horvath TL, Gao Q. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol 11: 492-500, 2009.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 492-500
-
-
Nie, Y.1
Erion, D.M.2
Yuan, Z.3
Dietrich, M.4
Shulman, G.I.5
Horvath, T.L.6
Gao, Q.7
-
192
-
-
79956292356
-
Constitutive role for IRE1alpha-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program
-
Ning J, Hong T, Ward A, Pi J, Liu Z, Liu HY, Cao W. Constitutive role for IRE1alpha-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program. Endocrinology 152: 2247-2255, 2011.
-
(2011)
Endocrinology
, vol.152
, pp. 2247-2255
-
-
Ning, J.1
Hong, T.2
Ward, A.3
Pi, J.4
Liu, Z.5
Liu, H.Y.6
Cao, W.7
-
193
-
-
0037143752
-
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
-
Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A 99: 11482-11486, 2002.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 11482-11486
-
-
Ntambi, J.M.1
Miyazaki, M.2
Stoehr, J.P.3
Lan, H.4
Kendziorski, C.M.5
Yandell, B.S.6
Song, Y.7
Cohen, P.8
Friedman, J.M.9
Attie, A.D.10
-
194
-
-
0036267472
-
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
-
Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. 5: 566-572, 2002.
-
(2002)
, vol.5
, pp. 566-572
-
-
Obici, S.1
Feng, Z.2
Karkanias, G.3
Baskin, D.G.4
Rossetti, L.5
-
195
-
-
0036065628
-
Central administration of oleic acid inhibits glucose production and food intake
-
Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51: 271-275, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 271-275
-
-
Obici, S.1
Feng, Z.2
Morgan, K.3
Stein, D.4
Karkanias, G.5
Rossetti, L.6
-
196
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
Obici S, Zhang BB, Karkanias G, Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8: 1376-1382, 2002.
-
(2002)
Nat Med
, vol.8
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
197
-
-
0035146957
-
PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate
-
Okar DA, Manzano A, Navarro-Sabate A, Riera L, Bartrons R, Lange AJ. PFK-2/FBPase-2: maker and breaker of the essential biofactor fructose-2,6-bisphosphate. Trends Biochem Sci 26: 30-35, 2001.
-
(2001)
Trends Biochem Sci
, vol.26
, pp. 30-35
-
-
Okar, D.A.1
Manzano, A.2
Navarro-Sabate, A.3
Riera, L.4
Bartrons, R.5
Lange, A.J.6
-
198
-
-
84864752368
-
LRH-1-dependent glucose sensing determines intermediary metabolism in liver
-
Oosterveer MH, Mataki C, Yamamoto H, Harach T, Moullan N, van Dijk TH, Ayuso E, Bosch F, Postic C, Groen AK, Auwerx J, Schoonjans K. LRH-1-dependent glucose sensing determines intermediary metabolism in liver. J Clin Invest 122: 2817-2826, 2012.
-
(2012)
J Clin Invest
, vol.122
, pp. 2817-2826
-
-
Oosterveer, M.H.1
Mataki, C.2
Yamamoto, H.3
Harach, T.4
Moullan, N.5
van Dijk, T.H.6
Ayuso, E.7
Bosch, F.8
Postic, C.9
Groen, A.K.10
Auwerx, J.11
Schoonjans, K.12
-
199
-
-
2542495763
-
Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus
-
Opherk C, Tronche F, Kellendonk C, Kohlmuller D, Schulze A, Schmid W, Schutz G. Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol Endocrinol 18: 1346-1353, 2004.
-
(2004)
Mol Endocrinol
, vol.18
, pp. 1346-1353
-
-
Opherk, C.1
Tronche, F.2
Kellendonk, C.3
Kohlmuller, D.4
Schulze, A.5
Schmid, W.6
Schutz, G.7
-
200
-
-
44349163999
-
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice
-
Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab 7: 520-532, 2008.
-
(2008)
Cell Metab
, vol.7
, pp. 520-532
-
-
Oyadomari, S.1
Harding, H.P.2
Zhang, Y.3
Oyadomari, M.4
Ron, D.5
-
201
-
-
84860427618
-
Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity
-
Ozcan L, Wong CC, Li G, Xu T, Pajvani U, Park SK, Wronska A, Chen BX, Marks AR, Fukamizu A, Backs J, Singer HA, Yates JR, III, Accili D, Tabas I. Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Cell Metab 15: 739-751, 2012.
-
(2012)
Cell Metab
, vol.15
, pp. 739-751
-
-
Ozcan, L.1
Wong, C.C.2
Li, G.3
Xu, T.4
Pajvani, U.5
Park, S.K.6
Wronska, A.7
Chen, B.X.8
Marks, A.R.9
Fukamizu, A.10
Backs, J.11
Singer, H.A.12
Yates III, J.R.13
Accili, D.14
Tabas, I.15
-
202
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U, Cao Q,Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E,Tuncman G, Gorgun C, Glimcher LH, Hotamisligil GS. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306: 457-461, 2004.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
203
-
-
84864292975
-
Role of ceramides in nonalcoholic fatty liver disease
-
Pagadala M, Kasumov T, McCullough AJ, Zein NN, Kirwan JP. Role of ceramides in nonalcoholic fatty liver disease. Trends Endocrinol Metabol 23: 365-371, 2012.
-
(2012)
Trends Endocrinol Metabol
, vol.23
, pp. 365-371
-
-
Pagadala, M.1
Kasumov, T.2
McCullough, A.J.3
Zein, N.N.4
Kirwan, J.P.5
-
204
-
-
84864657351
-
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
-
Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, Ray S, Majumdar SS, Bhattacharya S. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 18: 1279-1285, 2012.
-
(2012)
Nat Med
, vol.18
, pp. 1279-1285
-
-
Pal, D.1
Dasgupta, S.2
Kundu, R.3
Maitra, S.4
Das, G.5
Mukhopadhyay, S.6
Ray, S.7
Majumdar, S.S.8
Bhattacharya, S.9
-
205
-
-
0036296165
-
Glycemic control in mice with targeted disruption of the glucagon receptor gene
-
Parker JC, Andrews KM, Allen MR, Stock JL, McNeish JD. Glycemic control in mice with targeted disruption of the glucagon receptor gene. Biochem Biophys Res Commun 290: 839-843, 2002.
-
(2002)
Biochem Biophys Res Commun
, vol.290
, pp. 839-843
-
-
Parker, J.C.1
Andrews, K.M.2
Allen, M.R.3
Stock, J.L.4
McNeish, J.D.5
-
206
-
-
78650933929
-
LXRbeta is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice
-
Patel R, Patel M, Tsai R, Lin V, Bookout AL, Zhang Y, Magomedova L, Li T, Chan JF, Budd C, Mangelsdorf DJ, Cummins CL. LXRbeta is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. J Clin Invest 121: 431-441, 2011.
-
(2011)
J Clin Invest
, vol.121
, pp. 431-441
-
-
Patel, R.1
Patel, M.2
Tsai, R.3
Lin, V.4
Bookout, A.L.5
Zhang, Y.6
Magomedova, L.7
Li, T.8
Chan, J.F.9
Budd, C.10
Mangelsdorf, D.J.11
Cummins, C.L.12
-
207
-
-
79961165137
-
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146: 408-420, 2011.
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
Guertin, D.A.7
Madden, K.L.8
Carpenter, A.E.9
Finck, B.N.10
Sabatini, D.M.11
-
208
-
-
0037315190
-
Bile acids induce the expression of the human peroxisome proliferatoractivated receptor alpha gene via activation of the farnesoid X receptor
-
Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. Bile acids induce the expression of the human peroxisome proliferatoractivated receptor alpha gene via activation of the farnesoid X receptor. Mol Endocrinol 17: 259-272, 2003.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 259-272
-
-
Pineda Torra, I.1
Claudel, T.2
Duval, C.3
Kosykh, V.4
Fruchart, J.C.5
Staels, B.6
-
209
-
-
77958595135
-
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism
-
Ponugoti B, Kim DH, Xiao Z, Smith Z, Miao J, Zang M, Wu SY, Chiang CM, Veenstra TD, Kemper JK. SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism. J Biol Chem 285: 33959-33970, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 33959-33970
-
-
Ponugoti, B.1
Kim, D.H.2
Xiao, Z.3
Smith, Z.4
Miao, J.5
Zang, M.6
Wu, S.Y.7
Chiang, C.M.8
Veenstra, T.D.9
Kemper, J.K.10
-
210
-
-
0032898369
-
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
-
Postic C, Shiota M, Niswender KD, Jetton TL, Chen Y, Moates JM, Shelton KD, Lindner J, Cherrington AD, Magnuson MA. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 274: 305-315, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 305-315
-
-
Postic, C.1
Shiota, M.2
Niswender, K.D.3
Jetton, T.L.4
Chen, Y.5
Moates, J.M.6
Shelton, K.D.7
Lindner, J.8
Cherrington, A.D.9
Magnuson, M.A.10
-
211
-
-
79958066536
-
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1alpha pathway
-
Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA. FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1alpha pathway. Cell Metab 13: 729-738, 2011.
-
(2011)
Cell Metab
, vol.13
, pp. 729-738
-
-
Potthoff, M.J.1
Boney-Montoya, J.2
Choi, M.3
He, T.4
Sunny, N.E.5
Satapati, S.6
Suino-Powell, K.7
Xu, H.E.8
Gerard, R.D.9
Finck, B.N.10
Burgess, S.C.11
Mangelsdorf, D.J.12
Kliewer, S.A.13
-
212
-
-
67649823642
-
FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
-
Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, Burgess SC. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A 106: 10853-10858, 2009.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 10853-10858
-
-
Potthoff, M.J.1
Inagaki, T.2
Satapati, S.3
Ding, X.4
He, T.5
Goetz, R.6
Mohammadi, M.7
Finck, B.N.8
Mangelsdorf, D.J.9
Kliewer, S.A.10
Burgess, S.C.11
-
213
-
-
0036510160
-
CEACAM1 regulates insulin clearance in liver
-
Poy MN, Yang Y, Rezaei K, Fernstrom MA, Lee AD, Kido Y, Erickson SK, Najjar SM. CEACAM1 regulates insulin clearance in liver. Nat Genet 30: 270-276, 2002.
-
(2002)
Nat Genet
, vol.30
, pp. 270-276
-
-
Poy, M.N.1
Yang, Y.2
Rezaei, K.3
Fernstrom, M.A.4
Lee, A.D.5
Kido, Y.6
Erickson, S.K.7
Najjar, S.M.8
-
214
-
-
0038187621
-
Insulinregulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
-
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM. Insulinregulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423: 550-555, 2003.
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
Rhee, J.2
Donovan, J.3
Walkey, C.J.4
Yoon, J.C.5
Oriente, F.6
Kitamura, Y.7
Altomonte, J.8
Dong, H.9
Accili, D.10
Spiegelman, B.M.11
-
215
-
-
45549093204
-
Cidea is associated with lipid droplets and insulin sensitivity in humans
-
Puri V, Ranjit S, Konda S, Nicoloro SM, Straubhaar J, Chawla A, Chouinard M, Lin C, Burkart A, Corvera S, Perugini RA, Czech MP. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci U S A 105: 7833-7838, 2008.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 7833-7838
-
-
Puri, V.1
Ranjit, S.2
Konda, S.3
Nicoloro, S.M.4
Straubhaar, J.5
Chawla, A.6
Chouinard, M.7
Lin, C.8
Burkart, A.9
Corvera, S.10
Perugini, R.A.11
Czech, M.P.12
-
216
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
-
Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 9: 327-338, 2009.
-
(2009)
Cell Metab
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
Schug, T.T.2
Xu, Q.3
Surapureddi, S.4
Guo, X.5
Li, X.6
-
217
-
-
34248681601
-
CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
-
Rahman SM, Schroeder-Gloeckler JM, Janssen RC, Jiang H, Qadri I, Maclean KN, Friedman JE. CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. Hepatology 45: 1108-1117, 2007.
-
(2007)
Hepatology
, vol.45
, pp. 1108-1117
-
-
Rahman, S.M.1
Schroeder-Gloeckler, J.M.2
Janssen, R.C.3
Jiang, H.4
Qadri, I.5
Maclean, K.N.6
Friedman, J.E.7
-
218
-
-
0042330251
-
Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis
-
Rajala MW, Scherer PE. Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144: 3765-3773, 2003.
-
(2003)
Endocrinology
, vol.144
, pp. 3765-3773
-
-
Rajala, M.W.1
Scherer, P.E.2
-
219
-
-
66449091275
-
STAT3 targets the regulatory regions of gluconeogenic genes in vivo
-
Ramadoss P, Unger-Smith NE, Lam FS, Hollenberg AN. STAT3 targets the regulatory regions of gluconeogenic genes in vivo. Mol Endocrinol 23: 827-837, 2009.
-
(2009)
Mol Endocrinol
, vol.23
, pp. 827-837
-
-
Ramadoss, P.1
Unger-Smith, N.E.2
Lam, F.S.3
Hollenberg, A.N.4
-
220
-
-
80052345224
-
Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
-
Ramnanan CJ, Saraswathi V, Smith MS, Donahue EP, Farmer B, Farmer TD, Neal D, Williams PE, Lautz M, Mari A, Cherrington AD, Edgerton DS. Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs. J Clin Invest 121: 3713-3723, 2011.
-
(2011)
J Clin Invest
, vol.121
, pp. 3713-3723
-
-
Ramnanan, C.J.1
Saraswathi, V.2
Smith, M.S.3
Donahue, E.P.4
Farmer, B.5
Farmer, T.D.6
Neal, D.7
Williams, P.E.8
Lautz, M.9
Mari, A.10
Cherrington, A.D.11
Edgerton, D.S.12
-
221
-
-
33645828659
-
Lipid metabolism and liver inflammation II. Fatty liver disease and fatty acid oxidation
-
Reddy JK, Rao MS. Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol 290: G852-G858, 2006.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Reddy, J.K.1
Rao, M.S.2
-
222
-
-
25144523930
-
Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice
-
Ren D, Li M, Duan C, Rui L. Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice. Cell Metabolism 2: 95-104, 2005.
-
(2005)
Cell Metabolism
, vol.2
, pp. 95-104
-
-
Ren, D.1
Li, M.2
Duan, C.3
Rui, L.4
-
223
-
-
33846822094
-
Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
-
Ren D, Zhou Y, Morris D, Li M, Li Z, Rui L. Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest 117: 397-406, 2007.
-
(2007)
J Clin Invest
, vol.117
, pp. 397-406
-
-
Ren, D.1
Zhou, Y.2
Morris, D.3
Li, M.4
Li, Z.5
Rui, L.6
-
224
-
-
0034669025
-
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors LXRalpha and LXRbeta
-
Repa JJ, Liang G, Ou J, Bashmakov Y, Lobaccaro JM, Shimomura I, Shan B, Brown MS, Goldstein JL, Mangelsdorf DJ. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev 14: 2819-2830, 2000.
-
(2000)
Genes Dev
, vol.14
, pp. 2819-2830
-
-
Repa, J.J.1
Liang, G.2
Ou, J.3
Bashmakov, Y.4
Lobaccaro, J.M.5
Shimomura, I.6
Shan, B.7
Brown, M.S.8
Goldstein, J.L.9
Mangelsdorf, D.J.10
-
225
-
-
4344618856
-
6-phosphofructo-2-kinase/fructose-2 6-bisphosphatase: Headto-head with a bifunctional enzyme that controls glycolysis
-
Rider MH, Bertrand L, Vertommen D, Michels PA, Rousseau GG, Hue L. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: Headto-head with a bifunctional enzyme that controls glycolysis. Biochem J 381: 561-579, 2004.
-
(2004)
Biochem J
, vol.381
, pp. 561-579
-
-
Rider, M.H.1
Bertrand, L.2
Vertommen, D.3
Michels, P.A.4
Rousseau, G.G.5
Hue, L.6
-
226
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-118, 2005.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
227
-
-
34547906123
-
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
-
Rodgers JT, Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A 104: 12861-12866, 2007.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 12861-12866
-
-
Rodgers, J.T.1
Puigserver, P.2
-
228
-
-
0036830636
-
SOCS-1 and SOCS-3 Block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
-
Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 Block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem 277: 42394-42398, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 42394-42398
-
-
Rui, L.1
Yuan, M.2
Frantz, D.3
Shoelson, S.4
White, M.F.5
-
229
-
-
57049111040
-
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
-
Rutkowski DT,Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J,Wang J, Yau GD, Kaufman RJ. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Developmental cell 15: 829-840, 2008.
-
(2008)
Developmental cell
, vol.15
, pp. 829-840
-
-
Rutkowski, D.T.1
Wu, J.2
Back, S.H.3
Callaghan, M.U.4
Ferris, S.P.5
Iqbal, J.6
Clark, R.7
Miao, H.8
Hassler, J.R.9
Fornek, J.10
Katze, M.G.11
Hussain, M.M.12
Song, B.13
Swathirajan, J.14
Wang, J.15
Yau, G.D.16
Kaufman, R.J.17
-
230
-
-
70449927269
-
Prevention of steatosis by hepatic JNK1
-
Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab 10: 491-498, 2009.
-
(2009)
Cell Metab
, vol.10
, pp. 491-498
-
-
Sabio, G.1
Cavanagh-Kyros, J.2
Ko, H.J.3
Jung, D.Y.4
Gray, S.5
Jun, J.Y.6
Barrett, T.7
Mora, A.8
Kim, J.K.9
Davis, R.J.10
-
231
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322: 1539-1543, 2008.
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
232
-
-
54049105746
-
Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): Interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation
-
Sakiyama H, Wynn RM, Lee WR, Fukasawa M, Mizuguchi H, Gardner KH, Repa JJ, Uyeda K. Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): Interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation. J Biol Chem 283: 24899-24908, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 24899-24908
-
-
Sakiyama, H.1
Wynn, R.M.2
Lee, W.R.3
Fukasawa, M.4
Mizuguchi, H.5
Gardner, K.H.6
Repa, J.J.7
Uyeda, K.8
-
233
-
-
0035856949
-
Insulin signalling and the regulation of glucose and lipid metabolism
-
Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806, 2001.
-
(2001)
Nature
, vol.414
, pp. 799-806
-
-
Saltiel, A.R.1
Kahn, C.R.2
-
234
-
-
71949101616
-
Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver
-
Sanderson LM, Degenhardt T, Koppen A, Kalkhoven E, Desvergne B, Muller M, Kersten S. Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver. Mol Cell Biol 29: 6257-6267, 2009.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 6257-6267
-
-
Sanderson, L.M.1
Degenhardt, T.2
Koppen, A.3
Kalkhoven, E.4
Desvergne, B.5
Muller, M.6
Kersten, S.7
-
235
-
-
84857398069
-
Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
-
Santoro N, Zhang CK, Zhao H, Pakstis AJ, Kim G, Kursawe R, Dykas DJ, Bale AE, Giannini C, Pierpont B, Shaw MM, Groop L, Caprio S. Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents. Hepatology 55: 781-789, 2012.
-
(2012)
Hepatology
, vol.55
, pp. 781-789
-
-
Santoro, N.1
Zhang, C.K.2
Zhao, H.3
Pakstis, A.J.4
Kim, G.5
Kursawe, R.6
Dykas, D.J.7
Bale, A.E.8
Giannini, C.9
Pierpont, B.10
Shaw, M.M.11
Groop, L.12
Caprio, S.13
-
236
-
-
33644654777
-
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
-
Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A, Zhang XM, Cline GW, Yu XX, Geisler JG, Bhanot S, Monia BP, Shulman GI. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J Clin Invest 116: 817-824, 2006.
-
(2006)
J Clin Invest
, vol.116
, pp. 817-824
-
-
Savage, D.B.1
Choi, C.S.2
Samuel, V.T.3
Liu, Z.X.4
Zhang, D.5
Wang, A.6
Zhang, X.M.7
Cline, G.W.8
Yu, X.X.9
Geisler, J.G.10
Bhanot, S.11
Monia, B.P.12
Shulman, G.I.13
-
237
-
-
34447529373
-
CCAAT/enhancerbinding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice
-
Schroeder-Gloeckler JM, Rahman SM, Janssen RC, Qiao L, Shao J, Roper M, Fischer SJ, Lowe E, Orlicky DJ, McManaman JL, Palmer C, Gitomer WL, Huang W, O'Doherty RM, Becker TC, Klemm DJ, Jensen DR, Pulawa LK, Eckel RH, Friedman JE. CCAAT/enhancerbinding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. J Biol Chem 282: 15717-15729, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 15717-15729
-
-
Schroeder-Gloeckler, J.M.1
Rahman, S.M.2
Janssen, R.C.3
Qiao, L.4
Shao, J.5
Roper, M.6
Fischer, S.J.7
Lowe, E.8
Orlicky, D.J.9
McManaman, J.L.10
Palmer, C.11
Gitomer, W.L.12
Huang, W.13
O'Doherty, R.M.14
Becker, T.C.15
Klemm, D.J.16
Jensen, D.R.17
Pulawa, L.K.18
Eckel, R.H.19
Friedman, J.E.20
more..
-
238
-
-
0034669171
-
Role of LXRs in control of lipogenesis
-
Schultz JR, Tu H, Luk A, Repa JJ, Medina JC, Li L, Schwendner S, Wang S, Thoolen M, Mangelsdorf DJ, Lustig KD, Shan B. Role of LXRs in control of lipogenesis. Genes Dev 14: 2831-2838, 2000.
-
(2000)
Genes Dev
, vol.14
, pp. 2831-2838
-
-
Schultz, J.R.1
Tu, H.2
Luk, A.3
Repa, J.J.4
Medina, J.C.5
Li, L.6
Schwendner, S.7
Wang, S.8
Thoolen, M.9
Mangelsdorf, D.J.10
Lustig, K.D.11
Shan, B.12
-
239
-
-
34547824172
-
Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development
-
Sekine K, Chen YR, Kojima N, Ogata K, Fukamizu A, Miyajima A. Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. EMBO J 26: 3607-3615, 2007.
-
(2007)
EMBO J
, vol.26
, pp. 3607-3615
-
-
Sekine, K.1
Chen, Y.R.2
Kojima, N.3
Ogata, K.4
Fukamizu, A.5
Miyajima, A.6
-
240
-
-
78650848337
-
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
-
Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468: 1100-1104, 2010.
-
(2010)
Nature
, vol.468
, pp. 1100-1104
-
-
Sengupta, S.1
Peterson, T.R.2
Laplante, M.3
Oh, S.4
Sabatini, D.M.5
-
241
-
-
84875851816
-
Hepatic glucose sensing is required to preserve beta cell glucose competence
-
Seyer P, Vallois D, Poitry-Yamate C, Schutz F, Metref S, Tarussio D, Maechler P, Staels B, Lanz B, Grueter R, Decaris J, Turner S, da Costa A, Preitner F, Minehira K, Foretz M, Thorens B. Hepatic glucose sensing is required to preserve beta cell glucose competence. J Clin Invest 123: 1662-1676, 2013.
-
(2013)
J Clin Invest
, vol.123
, pp. 1662-1676
-
-
Seyer, P.1
Vallois, D.2
Poitry-Yamate, C.3
Schutz, F.4
Metref, S.5
Tarussio, D.6
Maechler, P.7
Staels, B.8
Lanz, B.9
Grueter, R.10
Decaris, J.11
Turner, S.12
da Costa, A.13
Preitner, F.14
Minehira, K.15
Foretz, M.16
Thorens, B.17
-
242
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646, 2005.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
Montminy, M.7
Cantley, L.C.8
-
243
-
-
0033847132
-
Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism
-
She P, Shiota M, Shelton KD, Chalkley R, Postic C, Magnuson MA. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol 20: 6508-6517, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 6508-6517
-
-
She, P.1
Shiota, M.2
Shelton, K.D.3
Chalkley, R.4
Postic, C.5
Magnuson, M.A.6
-
244
-
-
84862000588
-
NF-kappaB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action
-
Sheng L, Zhou Y, Chen Z, Ren D, Cho KW, Jiang L, Shen H, Sasaki Y, Rui L. NF-kappaB-inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat Med 18: 943-949, 2012.
-
(2012)
Nat Med
, vol.18
, pp. 943-949
-
-
Sheng, L.1
Zhou, Y.2
Chen, Z.3
Ren, D.4
Cho, K.W.5
Jiang, L.6
Shen, H.7
Sasaki, Y.8
Rui, L.9
-
245
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116: 3015-3025, 2006.
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
246
-
-
78649509214
-
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
-
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab 12: 654-661, 2010.
-
(2010)
Cell Metab
, vol.12
, pp. 654-661
-
-
Shimazu, T.1
Hirschey, M.D.2
Hua, L.3
Dittenhafer-Reed, K.E.4
Schwer, B.5
Lombard, D.B.6
Li, Y.7
Bunkenborg, J.8
Alt, F.W.9
Denu, J.M.10
Jacobson, M.P.11
Verdin, E.12
-
247
-
-
0034664729
-
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
-
Sinal CJ, Tohkin M, Miyata M, Ward JM, Lambert G, Gonzalez FJ. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102: 731-744, 2000.
-
(2000)
Cell
, vol.102
, pp. 731-744
-
-
Sinal, C.J.1
Tohkin, M.2
Miyata, M.3
Ward, J.M.4
Lambert, G.5
Gonzalez, F.J.6
-
248
-
-
85047693695
-
Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors
-
Sloop KW, Cao JX, Siesky AM, Zhang HY, Bodenmiller DM, Cox AL, Jacobs SJ,Moyers JS, Owens RA, Showalter AD, Brenner MB, Raap A, Gromada J, Berridge BR, Monteith DK, Porksen N, McKay RA, Monia BP, Bhanot S, Watts LM, Michael MD. Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors. J Clin Invest 113: 1571-1581, 2004.
-
(2004)
J Clin Invest
, vol.113
, pp. 1571-1581
-
-
Sloop, K.W.1
Cao, J.X.2
Siesky, A.M.3
Zhang, H.Y.4
Bodenmiller, D.M.5
Cox, A.L.6
Jacobs, S.J.7
Moyers, J.S.8
Owens, R.A.9
Showalter, A.D.10
Brenner, M.B.11
Raap, A.12
Gromada, J.13
Berridge, B.R.14
Monteith, D.K.15
Porksen, N.16
McKay, R.A.17
Monia, B.P.18
Bhanot, S.19
Watts, L.M.20
Michael, M.D.21
more..
-
249
-
-
84867038186
-
Silencing of lipid metabolism genes through IRE1alpha-mediated mRNA decay lowers plasma lipids in mice
-
So JS, Hur KY, Tarrio M, Ruda V, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V, Lichtman AH, Iwawaki T, Glimcher LH, Lee AH. Silencing of lipid metabolism genes through IRE1alpha-mediated mRNA decay lowers plasma lipids in mice. Cell Metab 16: 487-499, 2012.
-
(2012)
Cell Metab
, vol.16
, pp. 487-499
-
-
So, J.S.1
Hur, K.Y.2
Tarrio, M.3
Ruda, V.4
Frank-Kamenetsky, M.5
Fitzgerald, K.6
Koteliansky, V.7
Lichtman, A.H.8
Iwawaki, T.9
Glimcher, L.H.10
Lee, A.H.11
-
250
-
-
79953301147
-
Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocytespecific deletion of JAK2
-
Sos BC, Harris C, Nordstrom SM, Tran JL, Balazs M, Caplazi P, Febbraio M, Applegate MA, Wagner KU, Weiss EJ. Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocytespecific deletion of JAK2. J Clin Invest 121: 1412-1423, 2011.
-
(2011)
J Clin Invest
, vol.121
, pp. 1412-1423
-
-
Sos, B.C.1
Harris, C.2
Nordstrom, S.M.3
Tran, J.L.4
Balazs, M.5
Caplazi, P.6
Febbraio, M.7
Applegate, M.A.8
Wagner, K.U.9
Weiss, E.J.10
-
251
-
-
70350075402
-
Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice
-
Spruss A, Kanuri G,Wagnerberger S, Haub S, Bischoff SC, Bergheim I. Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. Hepatology 50: 1094-1104, 2009.
-
(2009)
Hepatology
, vol.50
, pp. 1094-1104
-
-
Spruss, A.1
Kanuri, G.2
Wagnerberger, S.3
Haub, S.4
Bischoff, S.C.5
Bergheim, I.6
-
252
-
-
77951029840
-
Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically
-
Stanley S, Pinto S, Segal J, Perez CA, Viale A, DeFalco J, Cai X, Heisler LK, Friedman JM. Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proc Natl Acad Sci U S A 107: 7024-7029, 2010.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 7024-7029
-
-
Stanley, S.1
Pinto, S.2
Segal, J.3
Perez, C.A.4
Viale, A.5
DeFalco, J.6
Cai, X.7
Heisler, L.K.8
Friedman, J.M.9
-
253
-
-
84873804024
-
Direct control of hepatic glucose production by interleukin-13 in mice
-
Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie AN, Lee CH. Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest 123: 261-271, 2013.
-
(2013)
J Clin Invest
, vol.123
, pp. 261-271
-
-
Stanya, K.J.1
Jacobi, D.2
Liu, S.3
Bhargava, P.4
Dai, L.5
Gangl, M.R.6
Inouye, K.7
Barlow, J.L.8
Ji, Y.9
Mizgerd, J.P.10
Qi, L.11
Shi, H.12
McKenzie, A.N.13
Lee, C.H.14
-
254
-
-
2442614148
-
Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes
-
Stoeckman AK, Ma L, Towle HC. Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. J Biol Chem279: 15662-15669, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 15662-15669
-
-
Stoeckman, A.K.1
Ma, L.2
Towle, H.C.3
-
255
-
-
84867171595
-
Loss of intracellular lipid binding proteins differentially impacts saturated fatty acid uptake and nuclear targeting in mouse hepatocytes
-
Storey SM, McIntosh AL, Huang H, Martin GG, Landrock KK, Landrock D, Payne HR, Kier AB, Schroeder F. Loss of intracellular lipid binding proteins differentially impacts saturated fatty acid uptake and nuclear targeting in mouse hepatocytes. Am J Physiol Gastrointest Liver Physiol 303: G837-G850, 2012.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.303
-
-
Storey, S.M.1
McIntosh, A.L.2
Huang, H.3
Martin, G.G.4
Landrock, K.K.5
Landrock, D.6
Payne, H.R.7
Kier, A.B.8
Schroeder, F.9
-
256
-
-
84555195141
-
Hypothalamic leucine metabolism regulates liver glucose production
-
Su Y, Lam TK, He W, Pocai A, Bryan J, Aguilar-Bryan L, and Gutierrez-Juarez R. Hypothalamic leucine metabolism regulates liver glucose production. Diabetes 61: 85-93, 2012.
-
(2012)
Diabetes
, vol.61
, pp. 85-93
-
-
Su, Y.1
Lam, T.K.2
He, W.3
Pocai, A.4
Bryan, J.5
Aguilar-Bryan, L.6
Gutierrez-Juarez, R.7
-
257
-
-
84871451681
-
Gut-derived serotonin is a multifunctional determinant to fasting adaptation
-
Sumara G, Sumara O, Kim JK, Karsenty G. Gut-derived serotonin is a multifunctional determinant to fasting adaptation. Cell Metab 16: 588-600, 2012.
-
(2012)
Cell Metab
, vol.16
, pp. 588-600
-
-
Sumara, G.1
Sumara, O.2
Kim, J.K.3
Karsenty, G.4
-
258
-
-
82955239838
-
Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
-
Sunny NE, Parks EJ, Browning JD, Burgess SC. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab 14: 804-810, 2011.
-
(2011)
Cell Metab
, vol.14
, pp. 804-810
-
-
Sunny, N.E.1
Parks, E.J.2
Browning, J.D.3
Burgess, S.C.4
-
260
-
-
0037155935
-
Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis
-
Tobin KA, Ulven SM, Schuster GU, Steineger HH, Andresen SM, Gustafsson JA, Nebb HI. Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis. J Biol Chem 277: 10691-10697, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 10691-10697
-
-
Tobin, K.A.1
Ulven, S.M.2
Schuster, G.U.3
Steineger, H.H.4
Andresen, S.M.5
Gustafsson, J.A.6
Nebb, H.I.7
-
261
-
-
34247616021
-
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
-
Tong Q, Ye C, McCrimmon RJ, Dhillon H, Choi B, Kramer MD, Yu J, Yang Z, Christiansen LM, Lee CE, Choi CS, Zigman JM, Shulman GI, Sherwin RS, Elmquist JK, Lowell BB. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5: 383-393, 2007.
-
(2007)
Cell Metab
, vol.5
, pp. 383-393
-
-
Tong, Q.1
Ye, C.2
McCrimmon, R.J.3
Dhillon, H.4
Choi, B.5
Kramer, M.D.6
Yu, J.7
Yang, Z.8
Christiansen, L.M.9
Lee, C.E.10
Choi, C.S.11
Zigman, J.M.12
Shulman, G.I.13
Sherwin, R.S.14
Elmquist, J.K.15
Lowell, B.B.16
-
262
-
-
63249123500
-
Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats
-
Torres TP, Catlin RL, Chan R, Fujimoto Y, Sasaki N, Printz RL, Newgard CB, Shiota M. Restoration of hepatic glucokinase expression corrects hepatic glucose flux and normalizes plasma glucose in zucker diabetic fatty rats. Diabetes 58: 78-86, 2009.
-
(2009)
Diabetes
, vol.58
, pp. 78-86
-
-
Torres, T.P.1
Catlin, R.L.2
Chan, R.3
Fujimoto, Y.4
Sasaki, N.5
Printz, R.L.6
Newgard, C.B.7
Shiota, M.8
-
263
-
-
2942628012
-
Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
-
Ueki K,Kondo T, Kahn CR. Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol Cell Biol 24: 5434-5446, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 5434-5446
-
-
Ueki, K.1
Kondo, T.2
Kahn, C.R.3
-
264
-
-
84855459920
-
Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover
-
Unger RH, Cherrington AD. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J Clin Invest 122: 4-12, 2012.
-
(2012)
J Clin Invest
, vol.122
, pp. 4-12
-
-
Unger, R.H.1
Cherrington, A.D.2
-
265
-
-
33746536677
-
Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis
-
Uyeda K, Repa JJ. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 4: 107-110, 2006.
-
(2006)
Cell Metab
, vol.4
, pp. 107-110
-
-
Uyeda, K.1
Repa, J.J.2
-
266
-
-
0033977890
-
The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
-
Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 20: 1868-1876, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1868-1876
-
-
Vega, R.B.1
Huss, J.M.2
Kelly, D.P.3
-
267
-
-
34547885436
-
Glucocorticoids, metabolism and metabolic diseases
-
Vegiopoulos A, Herzig S. Glucocorticoids, metabolism and metabolic diseases. Mol Cell Endocrinol 275: 43-61, 2007.
-
(2007)
Mol Cell Endocrinol
, vol.275
, pp. 43-61
-
-
Vegiopoulos, A.1
Herzig, S.2
-
268
-
-
81055140116
-
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans
-
Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ, Vance DE, Tzoneva M, Hart AC, Naar AM. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 147: 840-852, 2011.
-
(2011)
Cell
, vol.147
, pp. 840-852
-
-
Walker, A.K.1
Jacobs, R.L.2
Watts, J.L.3
Rottiers, V.4
Jiang, K.5
Finnegan, D.M.6
Shioda, T.7
Hansen, M.8
Yang, F.9
Niebergall, L.J.10
Vance, D.E.11
Tzoneva, M.12
Hart, A.C.13
Naar, A.M.14
-
269
-
-
77954488637
-
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP
-
Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Naar AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev 24: 1403-1417, 2010.
-
(2010)
Genes Dev
, vol.24
, pp. 1403-1417
-
-
Walker, A.K.1
Yang, F.2
Jiang, K.3
Ji, J.Y.4
Watts, J.L.5
Purushotham, A.6
Boss, O.7
Hirsch, M.L.8
Ribich, S.9
Smith, J.J.10
Israelian, K.11
Westphal, C.H.12
Rodgers, J.T.13
Shioda, T.14
Elson, S.L.15
Mulligan, P.16
Najafi-Shoushtari, H.17
Black, J.C.18
Thakur, J.K.19
Kadyk, L.C.20
Whetstine, J.R.21
Mostoslavsky, R.22
Puigserver, P.23
Li, X.24
Dyson, N.J.25
Hart, A.C.26
Naar, A.M.27
more..
-
270
-
-
80053927531
-
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c
-
Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab 14: 516-527, 2011.
-
(2011)
Cell Metab
, vol.14
, pp. 516-527
-
-
Wan, M.1
Leavens, K.F.2
Saleh, D.3
Easton, R.M.4
Guertin, D.A.5
Peterson, T.R.6
Kaestner, K.H.7
Sabatini, D.M.8
Birnbaum, M.J.9
-
271
-
-
0029160028
-
Impaired energy homeostasis in C/EBP alpha knockout mice
-
Wang ND, Finegold MJ, Bradley A, Ou CN, Abdelsayed SV, Wilde MD, Taylor LR, Wilson DR, Darlington GJ. Impaired energy homeostasis in C/EBP alpha knockout mice. Science 269: 1108-1112, 1995.
-
(1995)
Science
, vol.269
, pp. 1108-1112
-
-
Wang, N.D.1
Finegold, M.J.2
Bradley, A.3
Ou, C.N.4
Abdelsayed, S.V.5
Wilde, M.D.6
Taylor, L.R.7
Wilson, D.R.8
Darlington, G.J.9
-
272
-
-
42549118500
-
Upper intestinal lipids trigger a gutbrain-liver axis to regulate glucose production
-
Wang PY, Caspi L, Lam CK, Chari M, Li X, Light PE, Gutierrez-Juarez R, Ang M, Schwartz GJ, Lam TK. Upper intestinal lipids trigger a gutbrain-liver axis to regulate glucose production. Nature 452: 1012-1016, 2008.
-
(2008)
Nature
, vol.452
, pp. 1012-1016
-
-
Wang, P.Y.1
Caspi, L.2
Lam, C.K.3
Chari, M.4
Li, X.5
Light, P.E.6
Gutierrez-Juarez, R.7
Ang, M.8
Schwartz, G.J.9
Lam, T.K.10
-
273
-
-
80555146753
-
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
-
Wang RH, Kim HS, Xiao C, Xu X, Gavrilova O, Deng CX. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest 121: 4477-4490, 2011.
-
(2011)
J Clin Invest
, vol.121
, pp. 4477-4490
-
-
Wang, R.H.1
Kim, H.S.2
Xiao, C.3
Xu, X.4
Gavrilova, O.5
Deng, C.X.6
-
274
-
-
77649253906
-
Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity
-
Wang Y, Inoue H, Ravnskjaer K, Viste K, Miller N, Liu Y, Hedrick S, Vera L, Montminy M. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc Natl Acad Sci U S A 107: 3087-3092, 2010.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 3087-3092
-
-
Wang, Y.1
Inoue, H.2
Ravnskjaer, K.3
Viste, K.4
Miller, N.5
Liu, Y.6
Hedrick, S.7
Vera, L.8
Montminy, M.9
-
275
-
-
84860510820
-
Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes
-
Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, Montminy M. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature, 2012.
-
(2012)
Nature
-
-
Wang, Y.1
Li, G.2
Goode, J.3
Paz, J.C.4
Ouyang, K.5
Screaton, R.6
Fischer, W.H.7
Chen, J.8
Tabas, I.9
Montminy, M.10
-
276
-
-
67749135249
-
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
-
Wang Y, Vera L, Fischer WH, Montminy M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460: 534-537, 2009.
-
(2009)
Nature
, vol.460
, pp. 534-537
-
-
Wang, Y.1
Vera, L.2
Fischer, W.H.3
Montminy, M.4
-
277
-
-
82955239851
-
Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity
-
Warne JP, Alemi F, Reed AS, Varonin JM, Chan H, Piper ML, Mullin ME, Myers MG, Jr., Corvera CU, and Xu AW. Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity. Cell Metab 14: 791-803, 2011.
-
(2011)
Cell Metab
, vol.14
, pp. 791-803
-
-
Warne, J.P.1
Alemi, F.2
Reed, A.S.3
Varonin, J.M.4
Chan, H.5
Piper, M.L.6
Mullin, M.E.7
Myers Jr, M.G.8
Corvera, C.U.9
Xu, A.W.10
-
278
-
-
0024321062
-
Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work
-
Wasserman DH, Spalding JA, Lacy DB, Colburn CA, Goldstein RE, Cherrington AD. Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Am J Physiol 257: E108-117, 1989.
-
(1989)
Am J Physiol
, vol.257
-
-
Wasserman, D.H.1
Spalding, J.A.2
Lacy, D.B.3
Colburn, C.A.4
Goldstein, R.E.5
Cherrington, A.D.6
-
279
-
-
85047694456
-
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
-
Watanabe M, Houten SM, Wang L, Moschetta A, Mangelsdorf DJ, Heyman RA, Moore DD, Auwerx J. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 113: 1408-1418, 2004.
-
(2004)
J Clin Invest
, vol.113
, pp. 1408-1418
-
-
Watanabe, M.1
Houten, S.M.2
Wang, L.3
Moschetta, A.4
Mangelsdorf, D.J.5
Heyman, R.A.6
Moore, D.D.7
Auwerx, J.8
-
280
-
-
79251544870
-
Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1
-
Wei D, Tao R, Zhang Y, White MF, Dong XC. Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. Am J Physiol Endocrinol Metab 300: E312-320, 2011.
-
(2011)
Am J Physiol Endocrinol Metab
, vol.300
-
-
Wei, D.1
Tao, R.2
Zhang, Y.3
White, M.F.4
Dong, X.C.5
-
281
-
-
84858953557
-
C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes
-
Wei Z, Peterson JM, Lei X, Cebotaru L,Wolfgang MJ, Baldeviano GC, Wong GW. C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. J Biol Chem 287: 10301-10315, 2012.
-
(2012)
J Biol Chem
, vol.287
, pp. 10301-10315
-
-
Wei, Z.1
Peterson, J.M.2
Lei, X.3
Cebotaru, L.4
Wolfgang, M.J.5
Baldeviano, G.C.6
Wong, G.W.7
-
282
-
-
0036710280
-
IRS proteins and the common path to diabetes
-
White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 283: E413-422, 2002.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
White, M.F.1
-
283
-
-
84856541549
-
Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoidinduced hepatic gluconeogenesis
-
Winkler R, Benz V, Clemenz M, Bloch M, Foryst-Ludwig A, Wardat S,Witte N, Trappiel M, Namsolleck P, Mai K, Spranger J, Matthias G, Roloff T, Truee O, Kappert K, Schupp M, Matthias P, Kintscher U. Histone deacetylase 6 (HDAC6) is an essential modifier of glucocorticoidinduced hepatic gluconeogenesis. Diabetes 61: 513-523, 2012.
-
(2012)
Diabetes
, vol.61
, pp. 513-523
-
-
Winkler, R.1
Benz, V.2
Clemenz, M.3
Bloch, M.4
Foryst-Ludwig, A.5
Wardat, S.6
Witte, N.7
Trappiel, M.8
Namsolleck, P.9
Mai, K.10
Spranger, J.11
Matthias, G.12
Roloff, T.13
Truee, O.14
Kappert, K.15
Schupp, M.16
Matthias, P.17
Kintscher, U.18
-
284
-
-
62149105212
-
A role of DNA-PK for the metabolic gene regulation in response to insulin
-
Wong RH, Chang I, Hudak CS, Hyun S, Kwan HY, Sul HS. A role of DNA-PK for the metabolic gene regulation in response to insulin. Cell 136: 1056-1072, 2009.
-
(2009)
Cell
, vol.136
, pp. 1056-1072
-
-
Wong, R.H.1
Chang, I.2
Hudak, C.S.3
Hyun, S.4
Kwan, H.Y.5
Sul, H.S.6
-
285
-
-
84860326574
-
Fasting Energy Homeostasis in Mice with Adipose Deficiency of Desnutrin/Adipose Triglyceride Lipase
-
Wu JW, Wang SP, Casavant S, Moreau A, Yang GS, Mitchell GA. Fasting Energy Homeostasis in Mice with Adipose Deficiency of Desnutrin/Adipose Triglyceride Lipase. Endocrinology 153: 2198-2207, 2012.
-
(2012)
Endocrinology
, vol.153
, pp. 2198-2207
-
-
Wu, J.W.1
Wang, S.P.2
Casavant, S.3
Moreau, A.4
Yang, G.S.5
Mitchell, G.A.6
-
286
-
-
78049448761
-
MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice
-
Wu Z, Jiao P, Huang X, Feng B, Feng Y, Yang S, Hwang P, Du J, Nie Y, Xiao G, Xu H. MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice. J Clin Invest 120: 3901-3911, 2010.
-
(2010)
J Clin Invest
, vol.120
, pp. 3901-3911
-
-
Wu, Z.1
Jiao, P.2
Huang, X.3
Feng, B.4
Feng, Y.5
Yang, S.6
Hwang, P.7
Du, J.8
Nie, Y.9
Xiao, G.10
Xu, H.11
-
287
-
-
78751494753
-
C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: Role of mitogen-activated protein kinases
-
Xi L, Xiao C, Bandsma RH, Naples M, Adeli K, Lewis GF. C-reactive protein impairs hepatic insulin sensitivity and insulin signaling in rats: Role of mitogen-activated protein kinases. Hepatology 53: 127-135, 2011.
-
(2011)
Hepatology
, vol.53
, pp. 127-135
-
-
Xi, L.1
Xiao, C.2
Bandsma, R.H.3
Naples, M.4
Adeli, K.5
Lewis, G.F.6
-
288
-
-
0041302377
-
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
-
Xu A,Wang Y,KeshawH, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 112: 91-100, 2003.
-
(2003)
J Clin Invest
, vol.112
, pp. 91-100
-
-
Xu, A.1
Wang, Y.2
Keshaw, H.3
Xu, L.Y.4
Lam, K.S.5
Cooper, G.J.6
-
289
-
-
84864383688
-
Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance
-
Xu E, Charbonneau A, Rolland Y, Bellmann K, Pao L, Siminovitch KA, Neel BG, Beauchemin N, Marette A. Hepatocyte-specific Ptpn6 deletion protects from obesity-linked hepatic insulin resistance. Diabetes 61: 1949-1958, 2012.
-
(2012)
Diabetes
, vol.61
, pp. 1949-1958
-
-
Xu, E.1
Charbonneau, A.2
Rolland, Y.3
Bellmann, K.4
Pao, L.5
Siminovitch, K.A.6
Neel, B.G.7
Beauchemin, N.8
Marette, A.9
-
290
-
-
0035979214
-
A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver
-
Yamashita H, Takenoshita M, Sakurai M, Bruick RK, Henzel WJ, Shillinglaw W, Arnot D, Uyeda K. A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc Natl Acad Sci U S A 98: 9116-9121, 2001.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 9116-9121
-
-
Yamashita, H.1
Takenoshita, M.2
Sakurai, M.3
Bruick, R.K.4
Henzel, W.J.5
Shillinglaw, W.6
Arnot, D.7
Uyeda, K.8
-
291
-
-
0036851817
-
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
-
Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8: 1288-1295, 2002.
-
(2002)
Nat Med
, vol.8
, pp. 1288-1295
-
-
Yamauchi, T.1
Kamon, J.2
Minokoshi, Y.3
Ito, Y.4
Waki, H.5
Uchida, S.6
Yamashita, S.7
Noda, M.8
Kita, S.9
Ueki, K.10
Eto, K.11
Akanuma, Y.12
Froguel, P.13
Foufelle, F.14
Ferre, P.15
Carling, D.16
Kimura, S.17
Nagai, R.18
Kahn, B.B.19
Kadowaki, T.20
more..
-
292
-
-
77249118270
-
The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase
-
Yang X, Lu X, Lombes M, Rha GB, Chi YI, Guerin TM, Smart EJ, Liu J. The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab 11: 194-205, 2010.
-
(2010)
Cell Metab
, vol.11
, pp. 194-205
-
-
Yang, X.1
Lu, X.2
Lombes, M.3
Rha, G.B.4
Chi, Y.I.5
Guerin, T.M.6
Smart, E.J.7
Liu, J.8
-
293
-
-
79960960007
-
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways
-
Yecies JL, Zhang HH, Menon S, Liu S, Yecies D, Lipovsky AI, Gorgun C, Kwiatkowski DJ, Hotamisligil GS, Lee CH, Manning BD. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab 14: 21-32, 2011.
-
(2011)
Cell Metab
, vol.14
, pp. 21-32
-
-
Yecies, J.L.1
Zhang, H.H.2
Menon, S.3
Liu, S.4
Yecies, D.5
Lipovsky, A.I.6
Gorgun, C.7
Kwiatkowski, D.J.8
Hotamisligil, G.S.9
Lee, C.H.10
Manning, B.D.11
-
294
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
-
Yoon JC, Puigserver P, Chen G, Donovan J,Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413: 131-138, 2001.
-
(2001)
Nature
, vol.413
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
Donovan, J.4
Wu, Z.5
Rhee, J.6
Adelmant, G.7
Stafford, J.8
Kahn, C.R.9
Granner, D.K.10
Newgard, C.B.11
Spiegelman, B.M.12
-
295
-
-
84874900503
-
Biochemistry and pathophysiology of intravascular and intracellular lipolysis
-
Young SG, Zechner R. Biochemistry and pathophysiology of intravascular and intracellular lipolysis. Genes Dev 27: 459-484, 2013.
-
(2013)
Genes Dev
, vol.27
, pp. 459-484
-
-
Young, S.G.1
Zechner, R.2
-
296
-
-
36749082168
-
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance
-
Zhang D, Liu ZX, Choi CS, Tian L, Kibbey R, Dong J, Cline GW,Wood PA, Shulman GI. Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance. Proc Natl Acad Sci U S A 104: 17075-17080, 2007.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 17075-17080
-
-
Zhang, D.1
Liu, Z.X.2
Choi, C.S.3
Tian, L.4
Kibbey, R.5
Dong, J.6
Cline, G.W.7
Wood, P.A.8
Shulman, G.I.9
-
297
-
-
77957821693
-
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
-
Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med 16: 1152-1156, 2010.
-
(2010)
Nat Med
, vol.16
, pp. 1152-1156
-
-
Zhang, E.E.1
Liu, Y.2
Dentin, R.3
Pongsawakul, P.Y.4
Liu, A.C.5
Hirota, T.6
Nusinow, D.A.7
Sun, X.8
Landais, S.9
Kodama, Y.10
Brenner, D.A.11
Montminy, M.12
Kay, S.A.13
-
298
-
-
84862909028
-
Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice
-
Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T, Guo S. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology 153: 631-646, 2012.
-
(2012)
Endocrinology
, vol.153
, pp. 631-646
-
-
Zhang, K.1
Li, L.2
Qi, Y.3
Zhu, X.4
Gan, B.5
DePinho, R.A.6
Averitt, T.7
Guo, S.8
-
299
-
-
84855449701
-
Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1
-
Zhang T, Wang S, Lin Y, Xu W, Ye D, Xiong Y, Zhao S, Guan KL. Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab 15: 75-87, 2012.
-
(2012)
Cell Metab
, vol.15
, pp. 75-87
-
-
Zhang, T.1
Wang, S.2
Lin, Y.3
Xu, W.4
Ye, D.5
Xiong, Y.6
Zhao, S.7
Guan, K.L.8
-
300
-
-
0942279602
-
Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR
-
Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA. Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes Dev 18: 157-169, 2004.
-
(2004)
Genes Dev
, vol.18
, pp. 157-169
-
-
Zhang, Y.1
Castellani, L.W.2
Sinal, C.J.3
Gonzalez, F.J.4
Edwards, P.A.5
-
301
-
-
32244447570
-
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
-
Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, Willson TM, Edwards PA. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A 103: 1006-1011, 2006.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1006-1011
-
-
Zhang, Y.1
Lee, F.Y.2
Barrera, G.3
Lee, H.4
Vales, C.5
Gonzalez, F.J.6
Willson, T.M.7
Edwards, P.A.8
-
302
-
-
84860558086
-
Liver X receptor alpha is involved in the transcriptional regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene
-
Zhao LF, Iwasaki Y, Nishiyama M, Taguchi T, Tsugita M, Okazaki M, Nakayama S, Kambayashi M, Fujimoto S, Hashimoto K, Murao K, Terada Y. Liver X receptor alpha is involved in the transcriptional regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. Diabetes 61: 1062-1071, 2012.
-
(2012)
Diabetes
, vol.61
, pp. 1062-1071
-
-
Zhao, L.F.1
Iwasaki, Y.2
Nishiyama, M.3
Taguchi, T.4
Tsugita, M.5
Okazaki, M.6
Nakayama, S.7
Kambayashi, M.8
Fujimoto, S.9
Hashimoto, K.10
Murao, K.11
Terada, Y.12
-
303
-
-
77149148756
-
Regulation of cellular metabolism by protein lysine acetylation
-
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Regulation of cellular metabolism by protein lysine acetylation. Science 327: 1000-1004, 2010.
-
(2010)
Science
, vol.327
, pp. 1000-1004
-
-
Zhao, S.1
Xu, W.2
Jiang, W.3
Yu, W.4
Lin, Y.5
Zhang, T.6
Yao, J.7
Zhou, L.8
Zeng, Y.9
Li, H.10
Li, Y.11
Shi, J.12
An, W.13
Hancock, S.M.14
He, F.15
Qin, L.16
Chin, J.17
Yang, P.18
Chen, X.19
Lei, Q.20
Xiong, Y.21
Guan, K.L.22
more..
-
304
-
-
38749132992
-
Negative regulation of the deacetylase SIRT1 by DBC1
-
Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 451: 587-590, 2008.
-
(2008)
Nature
, vol.451
, pp. 587-590
-
-
Zhao, W.1
Kruse, J.P.2
Tang, Y.3
Jung, S.Y.4
Qin, J.5
Gu, W.6
-
305
-
-
33744948052
-
A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway
-
Zhou J, Zhai Y, Mu Y, Gong H, Uppal H, Toma D, Ren S, Evans RM, Xie W. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein-independent lipogenic pathway. J Biol Chem 281: 15013-15020, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 15013-15020
-
-
Zhou, J.1
Zhai, Y.2
Mu, Y.3
Gong, H.4
Uppal, H.5
Toma, D.6
Ren, S.7
Evans, R.M.8
Xie, W.9
-
306
-
-
2942729543
-
Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein
-
Zhou XY, Shibusawa N, Naik K, Porras D, Temple K, Ou H, Kaihara K, Roe MW, Brady MJ, Wondisford FE. Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein. Nat Med 10: 633-637, 2004.
-
(2004)
Nat Med
, vol.10
, pp. 633-637
-
-
Zhou, X.Y.1
Shibusawa, N.2
Naik, K.3
Porras, D.4
Temple, K.5
Ou, H.6
Kaihara, K.7
Roe, M.W.8
Brady, M.J.9
Wondisford, F.E.10
-
307
-
-
79952381078
-
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction
-
Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Fisher SJ, White MF, Biddinger SB, Ozcan U. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med 17: 356-365, 2011.
-
(2011)
Nat Med
, vol.17
, pp. 356-365
-
-
Zhou, Y.1
Lee, J.2
Reno, C.M.3
Sun, C.4
Park, S.W.5
Chung, J.6
Fisher, S.J.7
White, M.F.8
Biddinger, S.B.9
Ozcan, U.10
|