-
1
-
-
0034703217
-
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
-
Lin, S. J., Defossez, P. A. & Guarente, L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-2128 (2000).
-
(2000)
Science
, vol.289
, pp. 2126-2128
-
-
Lin, S.J.1
Defossez, P.A.2
Guarente, L.3
-
2
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum, H. A. & Guarente, L. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227-230 (2001).
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
3
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
Wood, J. G. et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-689 (2004).
-
(2004)
Nature
, vol.430
, pp. 686-689
-
-
Wood, J.G.1
-
4
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
-
Rodgers, J. T. et al. Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434, 113-118 (2005).
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
-
5
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri, H. et al. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159 (2001).
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
-
6
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo, J. et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107, 137-148 (2001).
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
-
7
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet, A. et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015 (2004).
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
-
8
-
-
33744774692
-
SIRT1: Tumor promoter or tumor suppressor?
-
Lim, C. S. SIRT1: tumor promoter or tumor suppressor? Med. Hypotheses 67, 341-344 (2006).
-
(2006)
Med. Hypotheses
, vol.67
, pp. 341-344
-
-
Lim, C.S.1
-
9
-
-
18644364411
-
DBC2, a candidate for a tumor suppressor gene involved in breast cancer
-
Hamaguchi, M. et al. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proc. Natl Acad. Sci. USA 99, 13647-13652 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 13647-13652
-
-
Hamaguchi, M.1
-
10
-
-
13944253348
-
Calorie restriction - the SIR2 connection
-
Guarente, L. & Picard, F. Calorie restriction - the SIR2 connection. Cell 120, 473-482 (2005).
-
(2005)
Cell
, vol.120
, pp. 473-482
-
-
Guarente, L.1
Picard, F.2
-
11
-
-
33746228121
-
Sirtuins in aging and age-related disease
-
Longo, V. D. & Kennedy, B. K. Sirtuins in aging and age-related disease. Cell 126, 257-268 (2006).
-
(2006)
Cell
, vol.126
, pp. 257-268
-
-
Longo, V.D.1
Kennedy, B.K.2
-
12
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta, M. C. et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 116, 551-563 (2004).
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
-
13
-
-
3042750643
-
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
-
Daitoku, H. et al. Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc. Natl Acad. Sci. USA 101, 10042-10047 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 10042-10047
-
-
Daitoku, H.1
-
14
-
-
3142742707
-
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)
-
van der Horst, A. et al. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J. Biol. Chem. 279, 28873-28879 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 28873-28879
-
-
van der Horst, A.1
-
15
-
-
3242719545
-
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung, F. et al. Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369-2380 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
-
16
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen, H. Y. et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305, 390-392 (2004).
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
-
17
-
-
0043244921
-
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
-
Fulco, M. et al. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol. Cell 12, 51-62 (2003).
-
(2003)
Mol. Cell
, vol.12
, pp. 51-62
-
-
Fulco, M.1
-
18
-
-
4944245398
-
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
-
Vaquero, A. et al. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell 16, 93-105 (2004).
-
(2004)
Mol. Cell
, vol.16
, pp. 93-105
-
-
Vaquero, A.1
-
19
-
-
27244435939
-
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
-
Chua, K. F. et al. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab. 2, 67-76 (2005).
-
(2005)
Cell Metab
, vol.2
, pp. 67-76
-
-
Chua, K.F.1
-
20
-
-
28544444366
-
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
-
Ford, J., Jiang, M. & Milner, J. Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res. 65, 10457-10463 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 10457-10463
-
-
Ford, J.1
Jiang, M.2
Milner, J.3
-
21
-
-
33646254136
-
Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes
-
Heltweg, B. et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 66, 4368-4377 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 4368-4377
-
-
Heltweg, B.1
-
22
-
-
30544445468
-
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells
-
Ota, H. et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene 25, 176-185 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 176-185
-
-
Ota, H.1
-
23
-
-
33645768490
-
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation
-
Pruitt, K. et al. Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet 2, e40 (2006).
-
(2006)
PLoS Genet
, vol.2
-
-
Pruitt, K.1
-
24
-
-
13844315463
-
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation
-
Kuzmichev, A. et al. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc. Natl Acad. Sci. USA 102, 1859-1864 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 1859-1864
-
-
Kuzmichev, A.1
-
25
-
-
27544434763
-
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
-
Chen, W. Y. et al. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell 123, 437-448 (2005).
-
(2005)
Cell
, vol.123
, pp. 437-448
-
-
Chen, W.Y.1
-
26
-
-
23744485726
-
Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling
-
Sundararajan, R., Chen, G., Mukherjee, C. & White, E. Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling. Oncogene 24, 4908-4920 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 4908-4920
-
-
Sundararajan, R.1
Chen, G.2
Mukherjee, C.3
White, E.4
-
27
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu, W. & Roeder, R. G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606 (1997).
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
28
-
-
33748200050
-
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
-
Wang, C. et al. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nature Cell Biol. 8, 1025-1031 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 1025-1031
-
-
Wang, C.1
-
29
-
-
10844236451
-
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
-
Nemoto, S., Fergusson, M. M. & Finkel, T. Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306, 2105-2108 (2004).
-
(2004)
Science
, vol.306
, pp. 2105-2108
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
30
-
-
4043165678
-
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
-
Araki, T., Sasaki, Y. & Milbrandt, J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305, 1010-1013 (2004).
-
(2004)
Science
, vol.305
, pp. 1010-1013
-
-
Araki, T.1
Sasaki, Y.2
Milbrandt, J.3
|