Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 43, 2007, Pages 17075-17080

  Zhang, Dongyan ^a   Liu, Zhen Xiang ^a   Cheol, Soo Choi ^a   Tian, Liqun ^b   Kibbey, Richard ^a   Dong, Jianying ^a   Cline, Gary W ^a   Wood, Philip A ^b   Shulman, Gerald I ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Diacylglycerol; Mitochondria; Nonalcoholic fatty liver disease; PKC

Indexed keywords

LONG CHAIN ACYL COENZYME A DEHYDROGENASE; PROTEIN KINASE B BETA; PROTEIN KINASE C EPSILON;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY BALANCE; ENZYME ACTIVATION; ENZYME DEFICIENCY; FATTY ACID ANALYSIS; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FATTY LIVER; GLUCONEOGENESIS; HORMONE ACTION; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL;

ACYL COENZYME A; ACYL-COA DEHYDROGENASE, LONG-CHAIN; ANIMALS; CALORIMETRY; CARBON ISOTOPES; DIGLYCERIDES; ENERGY METABOLISM; FATTY LIVER; GENE EXPRESSION REGULATION; GLUCOSE; HOMEOSTASIS; INSULIN; INSULIN RESISTANCE; LIVER; MICE; MITOCHONDRIA; MUSCLE, SKELETAL; OXIDATION-REDUCTION; PROTEIN KINASE C-EPSILON; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

MUS;

EID: 36749082168     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0707060104     Document Type: Article

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