Impairment of central leptin-mediated PI3K signaling manifested as hepatic steatosis independent of hyperphagia and obesity

Cell Metabolism

Volumn 14, Issue 6, 2011, Pages 791-803

  Warne, James P ^a   Alemi, Farzad ^b   Reed, Alison S ^a   Varonin, Jillian M ^a   Chan, Helen ^a   Piper, Merisa L ^a   Mullin, Mark E ^a   Myers Jr , Martin G ^c   Corvera, Carlos U ^b   Xu, Allison W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; MESSENGER RNA; NORADRENALIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; STAT3 PROTEIN; TRIACYLGLYCEROL;

ADRENERGIC SYSTEM; ARTICLE; BODY WEIGHT; DISEASE SEVERITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY LIVER; FEEDING; FOOD INTAKE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERPHAGIA; HYPOTHALAMUS; INSULIN BLOOD LEVEL; LIPID METABOLISM; LIPID STORAGE; LIPOGENESIS; NONHUMAN; NORADRENALIN BLOOD LEVEL; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SYMPATHETIC TONE; TRIACYLGLYCEROL BLOOD LEVEL;

ABSORPTIOMETRY, PHOTON; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BODY COMPOSITION; FATTY LIVER; GENE EXPRESSION REGULATION; INFUSIONS, INTRAVENTRICULAR; LEPTIN; MICE; MICE, TRANSGENIC; NOREPINEPHRINE; PHOSPHATIDYLINOSITOL 3-KINASES; PTEN PHOSPHOHYDROLASE; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRIGLYCERIDES;

EID: 82955239851     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2011.11.001     Document Type: Article

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