메뉴 건너뛰기




Volumn 15, Issue 5, 2012, Pages 574-584

Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; PROTEIN KINASE C EPSILON; ROSIGLITAZONE; THIAZOLIDINE DERIVATIVE;

EID: 84860497397     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2012.03.005     Document Type: Review
Times cited : (248)

References (83)
  • 2
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • P. Angulo Nonalcoholic fatty liver disease N. Engl. J. Med. 346 2002 1221 1231
    • (2002) N. Engl. J. Med. , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 3
    • 77956534963 scopus 로고    scopus 로고
    • Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
    • NIH Mouse Metabolic Phenotyping Center Consortium
    • J.E. Ayala, V.T. Samuel, G.J. Morton, S. Obici, C.M. Croniger, G.I. Shulman, D.H. Wasserman, O.P. McGuinness NIH Mouse Metabolic Phenotyping Center Consortium Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice Dis Model Mech 3 2010 525 534
    • (2010) Dis Model Mech , vol.3 , pp. 525-534
    • Ayala, J.E.1    Samuel, V.T.2    Morton, G.J.3    Obici, S.4    Croniger, C.M.5    Shulman, G.I.6    Wasserman, D.H.7    McGuinness, O.P.8
  • 4
    • 34248141686 scopus 로고    scopus 로고
    • Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients
    • DOI 10.2337/db06-0783
    • D.E. Befroy, K.F. Petersen, S. Dufour, G.F. Mason, R.A. de Graaf, D.L. Rothman, and G.I. Shulman Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients Diabetes 56 2007 1376 1381 (Pubitemid 46715630)
    • (2007) Diabetes , vol.56 , Issue.5 , pp. 1376-1381
    • Befroy, D.E.1    Petersen, K.F.2    Dufour, S.3    Mason, G.F.4    De Graaf, R.A.5    Rothman, D.L.6    Shulman, G.I.7
  • 6
    • 80054712654 scopus 로고    scopus 로고
    • Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism
    • A.L. Birkenfeld, H.Y. Lee, S. Majumdar, M.J. Jurczak, J.P. Camporez, F.R. Jornayvaz, D.W. Frederick, B. Guigni, M. Kahn, and D. Zhang Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism J. Biol. Chem. 286 2011 36163 36170
    • (2011) J. Biol. Chem. , vol.286 , pp. 36163-36170
    • Birkenfeld, A.L.1    Lee, H.Y.2    Majumdar, S.3    Jurczak, M.J.4    Camporez, J.P.5    Jornayvaz, F.R.6    Frederick, D.W.7    Guigni, B.8    Kahn, M.9    Zhang, D.10
  • 7
    • 29044447292 scopus 로고    scopus 로고
    • Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-κb pathway in rat liver
    • DOI 10.2337/diabetes.54.12.3458
    • G. Boden, P. She, M. Mozzoli, P. Cheung, K. Gumireddy, P. Reddy, X. Xiang, Z. Luo, and N. Ruderman Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver Diabetes 54 2005 3458 3465 (Pubitemid 43334336)
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3458-3465
    • Boden, G.1    She, P.2    Mozzoli, M.3    Cheung, P.4    Gumireddy, K.5    Reddy, P.6    Xiang, X.7    Luo, Z.8    Ruderman, N.9
  • 8
    • 52749091008 scopus 로고    scopus 로고
    • Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals
    • G. Boden, X. Duan, C. Homko, E.J. Molina, W. Song, O. Perez, P. Cheung, and S. Merali Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals Diabetes 57 2008 2438 2444
    • (2008) Diabetes , vol.57 , pp. 2438-2444
    • Boden, G.1    Duan, X.2    Homko, C.3    Molina, E.J.4    Song, W.5    Perez, O.6    Cheung, P.7    Merali, S.8
  • 14
    • 1542269161 scopus 로고    scopus 로고
    • Progress in antisense technology
    • DOI 10.1146/annurev.med.55.091902.104408
    • S.T. Crooke Progress in antisense technology Annu. Rev. Med. 55 2004 61 95 (Pubitemid 38316716)
    • (2004) Annual Review of Medicine , vol.55 , pp. 61-95
    • Crooke, S.T.1
  • 15
    • 33847746323 scopus 로고    scopus 로고
    • A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production
    • DOI 10.1074/jbc.C600268200
    • D.R. Dries, L.L. Gallegos, and A.C. Newton A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol production J. Biol. Chem. 282 2007 826 830 (Pubitemid 47076514)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.2 , pp. 826-830
    • Dries, D.R.1    Gallegos, L.L.2    Newton, A.C.3
  • 18
    • 75449094816 scopus 로고    scopus 로고
    • Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications
    • E. Fabbrini, S. Sullivan, and S. Klein Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications Hepatology 51 2010 679 689
    • (2010) Hepatology , vol.51 , pp. 679-689
    • Fabbrini, E.1    Sullivan, S.2    Klein, S.3
  • 19
    • 70949092540 scopus 로고    scopus 로고
    • Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: Regulation of lipogenesis by protein kinase C delta
    • G. Frangioudakis, J.G. Burchfield, S. Narasimhan, G.J. Cooney, M. Leitges, T.J. Biden, and C. Schmitz-Peiffer Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta Diabetologia 52 2009 2616 2620
    • (2009) Diabetologia , vol.52 , pp. 2616-2620
    • Frangioudakis, G.1    Burchfield, J.G.2    Narasimhan, S.3    Cooney, G.J.4    Leitges, M.5    Biden, T.J.6    Schmitz-Peiffer, C.7
  • 22
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade
    • DOI 10.2337/diabetes.48.6.1270
    • M.E. Griffin, M.J. Marcucci, G.W. Cline, K. Bell, N. Barucci, D. Lee, L.J. Goodyear, E.W. Kraegen, M.F. White, and G.I. Shulman Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade Diabetes 48 1999 1270 1274 (Pubitemid 29241025)
    • (1999) Diabetes , vol.48 , Issue.6 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3    Bell, K.4    Barucci, N.5    Lee, D.6    Goodyear, L.J.7    Kraegen, E.W.8    White, M.F.9    Shulman, G.I.10
  • 23
    • 33644750396 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes
    • G.S. Hotamisligil Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes Diabetes 54 Suppl 2 2005 S73 S78
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Hotamisligil, G.S.1
  • 24
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • DOI 10.1038/nature05485, PII NATURE05485
    • G.S. Hotamisligil Inflammation and metabolic disorders Nature 444 2006 860 867 (Pubitemid 46024993)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 25
    • 58149484392 scopus 로고    scopus 로고
    • Inflammation and endoplasmic reticulum stress in obesity and diabetes
    • G.S. Hotamisligil Inflammation and endoplasmic reticulum stress in obesity and diabetes Int. J. Obes. (Lond.) 32 Suppl. 7 2008 S52 S54
    • (2008) Int. J. Obes. (Lond.) , vol.32 , Issue.SUPPL. 7
    • Hotamisligil, G.S.1
  • 27
    • 77955642542 scopus 로고    scopus 로고
    • The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome
    • F.R. Jornayvaz, V.T. Samuel, and G.I. Shulman The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome Annu. Rev. Nutr. 30 2010 273 290
    • (2010) Annu. Rev. Nutr. , vol.30 , pp. 273-290
    • Jornayvaz, F.R.1    Samuel, V.T.2    Shulman, G.I.3
  • 30
    • 84862908245 scopus 로고    scopus 로고
    • Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice
    • M.J. Jurczak, A.H. Lee, F.R. Jornayvaz, H.Y. Lee, A.L. Birkenfeld, B.A. Guigni, M. Kahn, V.T. Samuel, L.H. Glimcher, and G.I. Shulman Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice J. Biol. Chem. 287 2012 2558 2567
    • (2012) J. Biol. Chem. , vol.287 , pp. 2558-2567
    • Jurczak, M.J.1    Lee, A.H.2    Jornayvaz, F.R.3    Lee, H.Y.4    Birkenfeld, A.L.5    Guigni, B.A.6    Kahn, M.7    Samuel, V.T.8    Glimcher, L.H.9    Shulman, G.I.10
  • 37
    • 15244358817 scopus 로고    scopus 로고
    • GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization
    • DOI 10.1172/JCI200421341
    • K. Kotani, O.D. Peroni, Y. Minokoshi, O. Boss, and B.B. Kahn GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization J. Clin. Invest. 114 2004 1666 1675 (Pubitemid 40385558)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.11 , pp. 1666-1675
    • Kotani, K.1    Peroni, O.D.2    Minokoshi, Y.3    Boss, O.4    Kahn, B.B.5
  • 39
    • 12344266697 scopus 로고    scopus 로고
    • How obesity causes diabetes: Not a tall tale
    • DOI 10.1126/science.1104342
    • M.A. Lazar How obesity causes diabetes: not a tall tale Science 307 2005 373 375 (Pubitemid 40139971)
    • (2005) Science , vol.307 , Issue.5708 , pp. 373-375
    • Lazar, M.A.1
  • 42
    • 80054091845 scopus 로고    scopus 로고
    • Reversal of type 2 diabetes: Normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    • E.L. Lim, K.G. Hollingsworth, B.S. Aribisala, M.J. Chen, J.C. Mathers, and R. Taylor Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol Diabetologia 54 2011 2506 2514
    • (2011) Diabetologia , vol.54 , pp. 2506-2514
    • Lim, E.L.1    Hollingsworth, K.G.2    Aribisala, B.S.3    Chen, M.J.4    Mathers, J.C.5    Taylor, R.6
  • 44
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • A.B. Mayerson, R.S. Hundal, S. Dufour, V. Lebon, D. Befroy, G.W. Cline, S. Enocksson, S.E. Inzucchi, G.I. Shulman, and K.F. Petersen The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes Diabetes 51 2002 797 802 (Pubitemid 34760191)
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 797-802
    • Mayerson, A.B.1    Hundal, R.S.2    Dufour, S.3    Lebon, V.4    Befroy, D.5    Cline, G.W.6    Enocksson, S.7    Inzucchi, S.E.8    Shulman, G.I.9    Petersen, K.F.10
  • 50
    • 84859544293 scopus 로고    scopus 로고
    • Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin resistant offspring of parents with type 2 diabetes
    • K. Morino, K.F. Petersen, S. Sono, C.S. Choi, V.T. Samuel, A. Lin, A. Gallo, H. Zhao, A. Kashiwagi, and I.J. Goldberg Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin resistant offspring of parents with type 2 diabetes Diabetes 61 2012 877 887
    • (2012) Diabetes , vol.61 , pp. 877-887
    • Morino, K.1    Petersen, K.F.2    Sono, S.3    Choi, C.S.4    Samuel, V.T.5    Lin, A.6    Gallo, A.7    Zhao, H.8    Kashiwagi, A.9    Goldberg, I.J.10
  • 51
  • 53
    • 0037337159 scopus 로고    scopus 로고
    • Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
    • DOI 10.1042/BJ20021626
    • A.C. Newton Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm Biochem. J. 370 2003 361 371 (Pubitemid 36315124)
    • (2003) Biochemical Journal , vol.370 , Issue.2 , pp. 361-371
    • Newton, A.C.1
  • 56
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • DOI 10.1126/science.1128294
    • U. Ozcan, E. Yilmaz, L. Ozcan, M. Furuhashi, E. Vaillancourt, R.O. Smith, C.Z. Görgün, and G.S. Hotamisligil Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 313 2006 1137 1140 (Pubitemid 44300242)
    • (2006) Science , vol.313 , Issue.5790 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5    Smith, R.O.6    Gorgun, C.Z.7    Hotamisligil, G.S.8
  • 57
    • 0029849462 scopus 로고    scopus 로고
    • Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects
    • DOI 10.1056/NEJM199610313351804
    • G. Perseghin, T.B. Price, K.F. Petersen, M. Roden, G.W. Cline, K. Gerow, D.L. Rothman, and G.I. Shulman Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects N. Engl. J. Med. 335 1996 1357 1362 (Pubitemid 26360454)
    • (1996) New England Journal of Medicine , vol.335 , Issue.18 , pp. 1357-1362
    • Perseghin, G.1    Price, T.B.2    Petersen, K.F.3    Roden, M.4    Cline, G.W.5    Gerow, K.6    Rothman, D.L.7    Shulman, G.I.8
  • 60
    • 1642377274 scopus 로고    scopus 로고
    • Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes
    • DOI 10.1056/NEJMoa031314
    • K.F. Petersen, S. Dufour, D. Befroy, R. Garcia, and G.I. Shulman Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N. Engl. J. Med. 350 2004 664 671 (Pubitemid 38364625)
    • (2004) New England Journal of Medicine , vol.350 , Issue.7 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 61
    • 14644435731 scopus 로고    scopus 로고
    • Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    • DOI 10.2337/diabetes.54.3.603
    • K.F. Petersen, S. Dufour, D. Befroy, M. Lehrke, R.E. Hendler, and G.I. Shulman Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes Diabetes 54 2005 603 608 (Pubitemid 40322060)
    • (2005) Diabetes , vol.54 , Issue.3 , pp. 603-608
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Lehrke, M.4    Hendler, R.E.5    Shulman, G.I.6
  • 65
    • 0025329008 scopus 로고
    • Phorbol ester-induced downregulation of protein kinase C potentiates insulin receptor tyrosine autophosphorylation: Evidence for a major constitutive role in insulin receptor regulation
    • T.S. Pillay, J. Whittaker, and K. Siddle Phorbol ester-induced downregulation of protein kinase C potentiates insulin receptor tyrosine autophosphorylation: evidence for a major constitutive role in insulin receptor regulation Biochem. Soc. Trans. 18 1990 494 495 (Pubitemid 20181127)
    • (1990) Biochemical Society Transactions , vol.18 , Issue.3 , pp. 494-495
    • Pillay, T.S.1    Whittaker, J.2    Siddle, K.3
  • 66
    • 80051971972 scopus 로고    scopus 로고
    • Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals
    • R. Rabol, K.F. Petersen, S. Dufour, C. Flannery, and G.I. Shulman Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals Proc. Natl. Acad. Sci. USA 108 2011 13705 13709
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 13705-13709
    • Rabol, R.1    Petersen, K.F.2    Dufour, S.3    Flannery, C.4    Shulman, G.I.5
  • 67
    • 0021774491 scopus 로고
    • The stereospecific activation of protein kinase C
    • R.R. Rando, and N. Young The stereospecific activation of protein kinase C Biochem. Biophys. Res. Commun. 122 1984 818 823
    • (1984) Biochem. Biophys. Res. Commun. , vol.122 , pp. 818-823
    • Rando, R.R.1    Young, N.2
  • 72
    • 0028152492 scopus 로고
    • Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein
    • DOI 10.1016/0092-8674(94)90252-6
    • J.E. Schaffer, and H.F. Lodish Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein Cell 79 1994 427 436 (Pubitemid 24346058)
    • (1994) Cell , vol.79 , Issue.3 , pp. 427-436
    • Schaffer, J.E.1    Lodish, H.F.2
  • 73
    • 79951697487 scopus 로고    scopus 로고
    • Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes
    • A.I. Schmid, J. Szendroedi, M. Chmelik, M. Krssák, E. Moser, and M. Roden Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes Diabetes Care 34 2011 448 453
    • (2011) Diabetes Care , vol.34 , pp. 448-453
    • Schmid, A.I.1    Szendroedi, J.2    Chmelik, M.3    Krssák, M.4    Moser, E.5    Roden, M.6
  • 74
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • I. Shimomura, R.E. Hammer, S. Ikemoto, M.S. Brown, and J.L. Goldstein Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature 401 1999 73 76
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 76
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • G.I. Shulman Cellular mechanisms of insulin resistance J. Clin. Invest. 106 2000 171 176 (Pubitemid 30483118)
    • (2000) Journal of Clinical Investigation , vol.106 , Issue.2 , pp. 171-176
    • Shulman, G.I.1
  • 78
    • 82955239838 scopus 로고    scopus 로고
    • Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease
    • N.E. Sunny, E.J. Parks, J.D. Browning, and S.C. Burgess Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease Cell Metab. 14 2011 804 810
    • (2011) Cell Metab. , vol.14 , pp. 804-810
    • Sunny, N.E.1    Parks, E.J.2    Browning, J.D.3    Burgess, S.C.4
  • 79
    • 0023834876 scopus 로고
    • Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity
    • S. Takayama, M.F. White, and C.R. Kahn Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity J. Biol. Chem. 263 1988 3440 3447 (Pubitemid 18072805)
    • (1988) Journal of Biological Chemistry , vol.263 , Issue.7 , pp. 3440-3447
    • Takayama, S.1    White, M.F.2    Kahn, C.R.3
  • 80
    • 67650831488 scopus 로고    scopus 로고
    • Insulin resistance. Prosperity's plague
    • G. Taubes Insulin resistance. Prosperity's plague Science 325 2009 256 260
    • (2009) Science , vol.325 , pp. 256-260
    • Taubes, G.1
  • 81
    • 3242745192 scopus 로고    scopus 로고
    • Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes
    • DOI 10.2337/diabetes.53.8.2169
    • M. Tiikkainen, A.M. Häkkinen, E. Korsheninnikova, T. Nyman, S. Mäkimattila, and H. Yki-Järvinen Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes Diabetes 53 2004 2169 2176 (Pubitemid 38970772)
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 2169-2176
    • Tiikkainen, M.1    Hakkinen, A.-M.2    Korsheninnikova, E.3    Nyman, T.4    Makimattila, S.5    Yki-Jarvinen, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.