FGF21 induces PGC-1α and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 26, 2009, Pages 10853-10858

  Potthoff, Matthew J ^a,b   Inagaki, Takeshi ^b   Satapati, Santhosh ^b   Ding, Xunshan ^a,b   He, Tianteng ^b   Goetz, Regina ^c   Mohammadi, Moosa ^c   Finck, Brian N ^d   Mangelsdorf, David J ^a,b   Kliewer, Steven A ^a,b   Burgess, Shawn C ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gluconeogenesis; Glycogenolysis; Ketogenesis; Lipid metabolism; Liver

Indexed keywords

FIBROBLAST GROWTH FACTOR 21; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; DIET RESTRICTION; ENERGY RESOURCE; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GLUCONEOGENESIS; GLYCOGENOLYSIS; KETOGENESIS; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STARVATION; TRANSCRIPTION REGULATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BLOOD GLUCOSE; BLOTTING, WESTERN; BODY WEIGHT; CARBOHYDRATE METABOLISM; FASTING; FATTY ACIDS; FEMALE; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; INSULIN; LIPID METABOLISM; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OXIDATION-REDUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STARVATION; TRANS-ACTIVATORS; TRIGLYCERIDES;

MUS;

EID: 67649823642     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904187106     Document Type: Article

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