Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice

Diabetes

Volumn 55, Issue 8, 2006, Pages 2159-2170

  Dentin, Renaud ^a   Benhamed, Fadila ^a   Hainault, Isabelle ^b   Fauveau, Véronique ^a   Foufelle, Fabienne ^b   Dyck, Jason R B ^c   Girard, Jean ^a   Postic, Catherine ^a  

^a INSTITUT COCHIN   (France)

^b INSERM   (France)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

ACC, acetyl CoA carboxylase; Ad GFP, GFP adenovirus; Ad shChREBP, recombinant adenovirus expressing short hairpin RNA against ChREBP; ChREBP, carbohydrate responsive element binding protein; ERK, extracellular signal related kinase

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BINDING PROTEIN; CARBOHYDRATE RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOKINASE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN SYNTHASE KINASE; GREEN FLUORESCENT PROTEIN; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN, MOUSE; FATTY ACID; GLUCOSE; GLYCOGEN; INSULIN; LIPID; MESSENGER RNA; NUCLEAR PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL MODEL; FATTY ACID SYNTHESIS; FATTY LIVER; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; HYPERLIPIDEMIA; IMMUNOBLOTTING; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPOGENESIS; LIVER CIRRHOSIS; MALE; METABOLIC DISORDER; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PRIORITY JOURNAL; RNA ISOLATION; TRANSCRIPTION REGULATION; ADIPOSE TISSUE; ANIMAL; BIOSYNTHESIS; BLOOD; CARBOHYDRATE DIET; CHEMISTRY; DOWN REGULATION; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; LIVER; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; DIETARY CARBOHYDRATES; DOWN-REGULATION; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; GLUCOSE; GLUCOSE TOLERANCE TEST; GLYCOGEN; INSULIN; INSULIN RESISTANCE; LEPTIN; LIPIDS; LIVER; MALE; MICE; MICE, OBESE; MUSCLE, SKELETAL; NUCLEAR PROTEINS; OBESITY; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION; TRIGLYCERIDES;

EID: 33749370739     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-0200     Document Type: Article

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