Medicine: The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

Science

Volumn 310, Issue 5754, 2005, Pages 1642-1646

  Shaw, Reuben J ^a,b,c   Lamia, Katja A ^a,b   Vasquez, Debbie ^b   Koo, Seung Hoi ^c,d   Bardeesy, Nabeel ^e   DePinho, Ronald A ^a   Montminy, Marc ^c   Cantley, Lewis C ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d Sungkyunkwan University School of Medicine   (South Korea)

^e MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; MEDICINE;

ADENOSINE MONOPHOSPHATE (AMP); GENE EXPRESSION;

GLUCOSE;

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE LKB1; PROTEIN TORC2; RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; 5' AMP ACTIVATED PROTEIN KINASE; 5'-AMP-ACTIVATED PROTEIN KINASE; ANTIDIABETIC AGENT; MULTIENZYME COMPLEX; PPARGC1A PROTEIN, MOUSE; PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, MOUSE; TORC2 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE EXPRESSION; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; LIPOGENESIS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PEUTZ JEGHERS SYNDROME; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE; ANIMAL; ENZYME ACTIVATION; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE BLOOD LEVEL; HELA CELL; HOMEOSTASIS; HUMAN; LIVER; MALE; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALIA;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; GLUCONEOGENESIS; GLUCOSE; HELA CELLS; HOMEOSTASIS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; LIPOGENESIS; LIVER; MALE; METFORMIN; MICE; MICE, OBESE; MULTIENZYME COMPLEXES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

EID: 28844433635     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1120781     Document Type: Article

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