메뉴 건너뛰기




Volumn 146, Issue 3, 2011, Pages 408-420

MTOR complex 1 regulates lipin 1 localization to control the srebp pathway

Author keywords

[No Author keywords available]

Indexed keywords

LIPIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDATE PHOSPHATASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 79961165137     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2011.06.034     Document Type: Article
Times cited : (953)

References (85)
  • 1
    • 39649101082 scopus 로고    scopus 로고
    • Mammalian target of rapamycin as a therapeutic target in oncology
    • DOI 10.1517/14728222.12.2.209
    • R.T. Abraham, and C.H. Eng Mammalian target of rapamycin as a therapeutic target in oncology Expert Opin. Ther. Targets 12 2008 209 222 (Pubitemid 351284963)
    • (2008) Expert Opinion on Therapeutic Targets , vol.12 , Issue.2 , pp. 209-222
    • Abraham, R.T.1    Eng, C.H.2
  • 2
    • 0036664390 scopus 로고    scopus 로고
    • Effects of sirolimus on lipids in renal allograft recipients: An analysis using the Framingham risk model
    • DOI 10.1034/j.1600-6143.2002.20610.x
    • C.B. Blum Effects of sirolimus on lipids in renal allograft recipients: an analysis using the Framingham risk model Am. J. Transplant. 2 2002 551 559 (Pubitemid 36306875)
    • (2002) American Journal of Transplantation , vol.2 , Issue.6 , pp. 551-559
    • Blum, C.B.1
  • 3
    • 32144442169 scopus 로고    scopus 로고
    • Nuclear lamin A inhibits adipocyte differentiation: Implications for Dunnigan-type familial partial lipodystrophy
    • DOI 10.1093/hmg/ddi480
    • R.L. Boguslavsky, C.L. Stewart, and H.J. Worman Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy Hum. Mol. Genet. 15 2006 653 663 (Pubitemid 43205428)
    • (2006) Human Molecular Genetics , vol.15 , Issue.4 , pp. 653-663
    • Boguslavsky, R.L.1    Stewart, C.L.2    Worman, H.J.3
  • 6
    • 66349134748 scopus 로고    scopus 로고
    • Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL
    • M.S. Brown, and J.L. Goldstein Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL J. Lipid Res. 50 Suppl 2009 S15 S27
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Brown, M.S.1    Goldstein, J.L.2
  • 7
    • 0030881836 scopus 로고    scopus 로고
    • Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
    • DOI 10.1126/science.277.5322.99
    • G.J. Brunn, C.C. Hudson, A. Sekulić, J.M. Williams, H. Hosoi, P.J. Houghton, J.C. Lawrence Jr.; and R.T. Abraham Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin Science 277 1997 99 101 (Pubitemid 27450655)
    • (1997) Science , vol.277 , Issue.5322 , pp. 99-101
    • Brunn, G.J.1    Hudson, C.C.2    Sekulic, A.3    Williams, J.M.4    Hosoi, H.5    Houghton, P.J.6    Lawrence Jr., J.C.7    Abraham, R.T.8
  • 10
    • 33845286555 scopus 로고    scopus 로고
    • Human laminopathies: Nuclei gone genetically awry
    • DOI 10.1038/nrg1906, PII NRG1906
    • B.C. Capell, and F.S. Collins Human laminopathies: nuclei gone genetically awry Nat. Rev. Genet. 7 2006 940 952 (Pubitemid 44871397)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.12 , pp. 940-952
    • Capell, B.C.1    Collins, F.S.2
  • 11
    • 1042263432 scopus 로고    scopus 로고
    • Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation
    • DOI 10.1097/00002030-200311210-00005
    • M. Caron, M. Auclair, H. Sterlingot, M. Kornprobst, and J. Capeau Some HIV protease inhibitors alter lamin A/C maturation and stability, SREBP-1 nuclear localization and adipocyte differentiation AIDS 17 2003 2437 2444 (Pubitemid 38393315)
    • (2003) AIDS , vol.17 , Issue.17 , pp. 2437-2444
    • Caron, M.1    Auclair, M.2    Sterlingot, H.3    Kornprobst, M.4    Capeau, J.5
  • 13
    • 0028598672 scopus 로고
    • RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
    • M.I. Chiu, H. Katz, and V. Berlin RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex Proc. Natl. Acad. Sci. USA 91 1994 12574 12578
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12574-12578
    • Chiu, M.I.1    Katz, H.2    Berlin, V.3
  • 14
    • 56249147509 scopus 로고    scopus 로고
    • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    • A.Y. Choo, S.O. Yoon, S.G. Kim, P.P. Roux, and J. Blenis Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation Proc. Natl. Acad. Sci. USA 105 2008 17414 17419
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 17414-17419
    • Choo, A.Y.1    Yoon, S.O.2    Kim, S.G.3    Roux, P.P.4    Blenis, J.5
  • 15
    • 36749081539 scopus 로고    scopus 로고
    • mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
    • DOI 10.1038/nature06322, PII NATURE06322
    • J.T. Cunningham, J.T. Rodgers, D.H. Arlow, F. Vazquez, V.K. Mootha, and P. Puigserver mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex Nature 450 2007 736 740 (Pubitemid 350207689)
    • (2007) Nature , vol.450 , Issue.7170 , pp. 736-740
    • Cunningham, J.T.1    Rodgers, J.T.2    Arlow, D.H.3    Vazquez, F.4    Mootha, V.K.5    Puigserver, P.6
  • 19
    • 33747853190 scopus 로고    scopus 로고
    • Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway
    • DOI 10.1016/j.cmet.2006.08.005, PII S1550413106002750
    • B.N. Finck, M.C. Gropler, Z. Chen, T.C. Leone, M.A. Croce, T.E. Harris, J.C. Lawrence Jr.; and D.P. Kelly Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway Cell Metab. 4 2006 199 210 (Pubitemid 44283957)
    • (2006) Cell Metabolism , vol.4 , Issue.3 , pp. 199-210
    • Finck, B.N.1    Gropler, M.C.2    Chen, Z.3    Leone, T.C.4    Croce, M.A.5    Harris, T.E.6    Lawrence Jr., J.C.7    Kelly, D.P.8
  • 23
    • 33646920976 scopus 로고    scopus 로고
    • 2+-dependent phosphatidate phosphatase enzyme
    • DOI 10.1074/jbc.M600425200
    • G.S. Han, W.I. Wu, and G.M. Carman The Saccharomyces cerevisiae Lipin homolog is a Mg2+-dependent phosphatidate phosphatase enzyme J. Biol. Chem. 281 2006 9210 9218 (Pubitemid 43864636)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.14 , pp. 9210-9218
    • Han, G.-S.1    Wu, W.-I.2    Carman, G.M.3
  • 24
    • 0037178781 scopus 로고    scopus 로고
    • Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    • DOI 10.1016/S0092-8674(02)00833-4
    • K. Hara, Y. Maruki, X. Long, K. Yoshino, N. Oshiro, S. Hidayat, C. Tokunaga, J. Avruch, and K. Yonezawa Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action Cell 110 2002 177 189 (Pubitemid 34876546)
    • (2002) Cell , vol.110 , Issue.2 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3    Yoshino, K.-I.4    Oshiro, N.5    Hidayat, S.6    Tokunaga, C.7    Avruch, J.8    Yonezawa, K.9
  • 25
    • 33846975789 scopus 로고    scopus 로고
    • Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1
    • DOI 10.1074/jbc.M609537200
    • T.E. Harris, T.A. Huffman, A. Chi, J. Shabanowitz, D.F. Hunt, A. Kumar, and J.C. Lawrence Jr. Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1 J. Biol. Chem. 282 2007 277 286 (Pubitemid 47076630)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.1 , pp. 277-286
    • Harris, T.E.1    Huffman, T.A.2    Chi, A.3    Shabanowitz, J.4    Hunt, D.F.5    Kumar, A.6    Lawrence Jr., J.C.7
  • 26
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • J. Heitman, N.R. Movva, and M.N. Hall Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast Science 253 1991 905 909 (Pubitemid 21917235)
    • (1991) Science , vol.253 , Issue.5022 , pp. 905-909
    • Hietman, J.1    Movva, N.R.2    Hall, M.N.3
  • 27
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • DOI 10.1172/JCI200215593
    • J.D. Horton, J.L. Goldstein, and M.S. Brown SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J. Clin. Invest. 109 2002 1125 1131 (Pubitemid 34496588)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.9 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 30
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • DOI 10.1038/ncb1183
    • E. Jacinto, R. Loewith, A. Schmidt, S. Lin, M.A. Rüegg, A. Hall, and M.N. Hall Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive Nat. Cell Biol. 6 2004 1122 1128 (Pubitemid 39468014)
    • (2004) Nature Cell Biology , vol.6 , Issue.11 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3    Lin, S.4    Ruegg, M.A.5    Hall, A.6    Hall, M.N.7
  • 31
    • 44849114657 scopus 로고    scopus 로고
    • The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake
    • DOI 10.2353/ajpath.2008.070958
    • X. Jiang, H. Kenerson, L. Aicher, R. Miyaoka, J. Eary, J. Bissler, and R.S. Yeung The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake Am. J. Pathol. 172 2008 1748 1756 (Pubitemid 351793365)
    • (2008) American Journal of Pathology , vol.172 , Issue.6 , pp. 1748-1756
    • Jiang, X.1    Kenerson, H.2    Aicher, L.3    Miyaoka, R.4    Eary, J.5    Bissler, J.6    Yeung, R.S.7
  • 34
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • DOI 10.1016/S0092-8674(02)00808-5
    • D.H. Kim, D.D. Sarbassov, S.M. Ali, J.E. King, R.R. Latek, H. Erdjument-Bromage, P. Tempst, and D.M. Sabatini mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery Cell 110 2002 163 175 (Pubitemid 34876545)
    • (2002) Cell , vol.110 , Issue.2 , pp. 163-175
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 35
    • 0037623417 scopus 로고    scopus 로고
    • GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
    • DOI 10.1016/S1097-2765(03)00114-X
    • D.H. Kim, D.D. Sarbassov, S.M. Ali, R.R. Latek, K.V. Guntur, H. Erdjument-Bromage, P. Tempst, and D.M. Sabatini GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR Mol. Cell 11 2003 895 904 (Pubitemid 36566312)
    • (2003) Molecular Cell , vol.11 , Issue.4 , pp. 895-904
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    Latek, R.R.4    Guntur, K.V.P.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 37
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • S. Li, M.S. Brown, and J.L. Goldstein Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis Proc. Natl. Acad. Sci. USA 107 2010 3441 3446
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 3441-3446
    • Li, S.1    Brown, M.S.2    Goldstein, J.L.3
  • 38
    • 77957903550 scopus 로고    scopus 로고
    • Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)- 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer
    • Q. Liu, J.W. Chang, J. Wang, S.A. Kang, C.C. Thoreen, A. Markhard, W. Hur, J. Zhang, T. Sim, D.M. Sabatini, and N.S. Gray Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl) benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer J. Med. Chem. 53 2010 7146 7155
    • (2010) J. Med. Chem. , vol.53 , pp. 7146-7155
    • Liu, Q.1    Chang, J.W.2    Wang, J.3    Kang, S.A.4    Thoreen, C.C.5    Markhard, A.6    Hur, W.7    Zhang, J.8    Sim, T.9    Sabatini, D.M.10    Gray, N.S.11
  • 39
    • 0036537888 scopus 로고    scopus 로고
    • A novel interaction between lamin A and SREBP1: Implications for partial lipodystrophy and other laminopathies
    • D.J. Lloyd, R.C. Trembath, and S. Shackleton A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies Hum. Mol. Genet. 11 2002 769 777 (Pubitemid 34428644)
    • (2002) Human Molecular Genetics , vol.11 , Issue.7 , pp. 769-777
    • Lloyd, D.J.1    Trembath, R.C.2    Shackleton, S.3
  • 40
    • 0028829053 scopus 로고
    • Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells
    • S.K. Moule, N.J. Edgell, G.I. Welsh, T.A. Diggle, E.J. Foulstone, K.J. Heesom, C.G. Proud, and R.M. Denton Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat cells Biochem. J. 311 1995 595 601
    • (1995) Biochem. J. , vol.311 , pp. 595-601
    • Moule, S.K.1    Edgell, N.J.2    Welsh, G.I.3    Diggle, T.A.4    Foulstone, E.J.5    Heesom, K.J.6    Proud, C.G.7    Denton, R.M.8
  • 42
    • 0035163850 scopus 로고    scopus 로고
    • Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
    • DOI 10.1038/83685
    • M. Péterfy, J. Phan, P. Xu, and K. Reue Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin Nat. Genet. 27 2001 121 124 (Pubitemid 32044532)
    • (2001) Nature Genetics , vol.27 , Issue.1 , pp. 121-124
    • Peterfy, M.1    Phan, J.2    Xu, P.3    Reue, K.4
  • 43
    • 77950467109 scopus 로고    scopus 로고
    • Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes
    • M. Péterfy, T.E. Harris, N. Fujita, and K. Reue Insulin-stimulated interaction with 14-3-3 promotes cytoplasmic localization of lipin-1 in adipocytes J. Biol. Chem. 285 2010 3857 3864
    • (2010) J. Biol. Chem. , vol.285 , pp. 3857-3864
    • Péterfy, M.1    Harris, T.E.2    Fujita, N.3    Reue, K.4
  • 44
    • 67349241955 scopus 로고    scopus 로고
    • DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    • T.R. Peterson, M. Laplante, C.C. Thoreen, Y. Sancak, S.A. Kang, W.M. Kuehl, N.S. Gray, and D.M. Sabatini DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival Cell 137 2009 873 886
    • (2009) Cell , vol.137 , pp. 873-886
    • Peterson, T.R.1    Laplante, M.2    Thoreen, C.C.3    Sancak, Y.4    Kang, S.A.5    Kuehl, W.M.6    Gray, N.S.7    Sabatini, D.M.8
  • 46
    • 0031753503 scopus 로고    scopus 로고
    • The fatty liver dystrophy mutant mouse: Microvesicular steatosis associated with altered expression levels of peroxisome proliferator- regulated proteins
    • S. Rehnmark, C.S. Giometti, B.G. Slavin, M.H. Doolittle, and K. Reue The fatty liver dystrophy mutant mouse: microvesicular steatosis associated with altered expression levels of peroxisome proliferator-regulated proteins J. Lipid Res. 39 1998 2209 2217 (Pubitemid 28523127)
    • (1998) Journal of Lipid Research , vol.39 , Issue.11 , pp. 2209-2217
    • Rehnmark, S.1    Giometti, C.S.2    Slavin, B.G.3    Doolittle, M.H.4    Reue, K.5
  • 47
    • 0028239893 scopus 로고
    • RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • DOI 10.1016/0092-8674(94)90570-3
    • D.M. Sabatini, H. Erdjument-Bromage, M. Lui, P. Tempst, and S.H. Snyder RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs Cell 78 1994 35 43 (Pubitemid 24228298)
    • (1994) Cell , vol.78 , Issue.1 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 48
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • DOI 10.1016/j.cub.2004.06.054, PII S0960982204004713
    • D.D. Sarbassov, S.M. Ali, D.H. Kim, D.A. Guertin, R.R. Latek, H. Erdjument-Bromage, P. Tempst, and D.M. Sabatini Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton Curr. Biol. 14 2004 1296 1302 (Pubitemid 38991819)
    • (2004) Current Biology , vol.14 , Issue.14 , pp. 1296-1302
    • Dos D. Sarbassov1    Ali, S.M.2    Kim, D.-H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 49
    • 0037718389 scopus 로고    scopus 로고
    • TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
    • DOI 10.1016/S0960-9822(03)00329-4
    • S.S. Schalm, D.C. Fingar, D.M. Sabatini, and J. Blenis TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function Curr. Biol. 13 2003 797 806 (Pubitemid 36573247)
    • (2003) Current Biology , vol.13 , Issue.10 , pp. 797-806
    • Schalm, S.S.1    Fingar, D.C.2    Sabatini, D.M.3    Blenis, J.4
  • 50
    • 78650848337 scopus 로고    scopus 로고
    • MTORC1 controls fasting-induced ketogenesis and its modulation by ageing
    • S. Sengupta, T.R. Peterson, M. Laplante, S. Oh, and D.M. Sabatini mTORC1 controls fasting-induced ketogenesis and its modulation by ageing Nature 468 2010 1100 1104
    • (2010) Nature , vol.468 , pp. 1100-1104
    • Sengupta, S.1    Peterson, T.R.2    Laplante, M.3    Oh, S.4    Sabatini, D.M.5
  • 51
    • 48949115069 scopus 로고    scopus 로고
    • Rapamycin down-regulates LDL-receptor expression independently of SREBP-2
    • L.J. Sharpe, and A.J. Brown Rapamycin down-regulates LDL-receptor expression independently of SREBP-2 Biochem. Biophys. Res. Commun. 373 2008 670 674
    • (2008) Biochem. Biophys. Res. Commun. , vol.373 , pp. 670-674
    • Sharpe, L.J.1    Brown, A.J.2
  • 52
    • 0029797604 scopus 로고    scopus 로고
    • Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    • H. Shimano, J.D. Horton, R.E. Hammer, I. Shimomura, M.S. Brown, and J.L. Goldstein Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a J. Clin. Invest. 98 1996 1575 1584 (Pubitemid 26327867)
    • (1996) Journal of Clinical Investigation , vol.98 , Issue.7 , pp. 1575-1584
    • Shimano, H.1    Horton, J.D.2    Hammer, R.E.3    Shimomura, I.4    Brown, M.S.5    Goldstein, J.L.6
  • 53
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • I. Shimomura, R.E. Hammer, S. Ikemoto, M.S. Brown, and J.L. Goldstein Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature 401 1999 73 76
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 54
    • 0018606537 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action
    • K. Singh, S. Sun, and C. Vézina Rapamycin (AY-22,989), a new antifungal antibiotic. IV. Mechanism of action J. Antibiot. 32 1979 630 645 (Pubitemid 10067618)
    • (1979) Journal of Antibiotics , vol.32 , Issue.6 , pp. 630-645
    • Singh, K.1    Sun, S.2    Vezina, C.3
  • 55
    • 1842856797 scopus 로고    scopus 로고
    • An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin
    • DOI 10.1242/jcs.00135
    • Y. Tange, A. Hirata, and O. Niwa An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin J. Cell Sci. 115 2002 4375 4385 (Pubitemid 35460707)
    • (2002) Journal of Cell Science , vol.115 , Issue.22 , pp. 4375-4385
    • Tange, Y.1    Hirata, A.2    Niwa, O.3
  • 57
    • 0028225462 scopus 로고
    • SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
    • X. Wang, R. Sato, M.S. Brown, X. Hua, and J.L. Goldstein SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Cell 77 1994 53 62
    • (1994) Cell , vol.77 , pp. 53-62
    • Wang, X.1    Sato, R.2    Brown, M.S.3    Hua, X.4    Goldstein, J.L.5
  • 59
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 2006 471 484 (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 60
    • 77953091045 scopus 로고    scopus 로고
    • Structure of the human mTOR complex i and its implications for rapamycin inhibition
    • C.K. Yip, K. Murata, T. Walz, D.M. Sabatini, and S.A. Kang Structure of the human mTOR complex I and its implications for rapamycin inhibition Mol. Cell 38 2010 768 774
    • (2010) Mol. Cell , vol.38 , pp. 768-774
    • Yip, C.K.1    Murata, K.2    Walz, T.3    Sabatini, D.M.4    Kang, S.A.5
  • 62
    • 0034815771 scopus 로고    scopus 로고
    • Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: Transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol
    • DOI 10.1006/bbrc.2001.5102
    • Bené, H.; Lasky, D.; and Ntambi, J.M. (2001). Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol. Biochem. Biophys. Res. Commun. 284, 1194-1198. (Pubitemid 32917965)
    • (2001) Biochemical and Biophysical Research Communications , vol.284 , Issue.5 , pp. 1194-1198
    • Bene, H.1    Lasky, D.2    Ntambi, J.M.3
  • 64
    • 0032539664 scopus 로고    scopus 로고
    • RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
    • Burnett, P.E.; Barrow, R.K.; Cohen, N.A.; Snyder, S.H.; Sabatini, D.M.
    • Burnett, P.E.; Barrow, R.K.; Cohen, N.A.; Snyder, S.H.; and Sabatini, D.M. (1998). RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA 95, 1432-1437.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 1432-1437
  • 65
    • 0025813301 scopus 로고
    • Phosphatidate phosphatase from yeast
    • Carman, G.M.; and Lin, Y.P. (1991). Phosphatidate phosphatase from yeast. Methods Enzymol. 197, 548-553.
    • (1991) Methods Enzymol. , vol.197 , pp. 548-553
    • Carman, G.M.1    Lin, Y.P.2
  • 66
    • 53449092350 scopus 로고    scopus 로고
    • Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion
    • Chen, Z.; Gropler, M.C.; Norris, J.; Lawrence, J.C.; Jr.; Harris, T.E.; and Finck, B.N. (2008). Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion. Arterioscler. Thromb. Vasc. Biol. 28, 1738-1744.
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 1738-1744
    • Chen, Z.1    Gropler, M.C.2    Norris, J.3    Lawrence Jr., J.C.4    Harris, T.E.5    Finck, B.N.6
  • 67
    • 33747853190 scopus 로고    scopus 로고
    • Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway
    • DOI 10.1016/j.cmet.2006.08.005, PII S1550413106002750
    • Finck, B.N.; Gropler, M.C.; Chen, Z.; Leone, T.C.; Croce, M.A.; Harris, T.E.; Lawrence, J.C.; Jr.; and Kelly, D.P. (2006). Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. Cell Metab. 4, 199-210. (Pubitemid 44283957)
    • (2006) Cell Metabolism , vol.4 , Issue.3 , pp. 199-210
    • Finck, B.N.1    Gropler, M.C.2    Chen, Z.3    Leone, T.C.4    Croce, M.A.5    Harris, T.E.6    Lawrence Jr., J.C.7    Kelly, D.P.8
  • 68
    • 33846975789 scopus 로고    scopus 로고
    • Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1
    • DOI 10.1074/jbc.M609537200
    • Harris, T.E.; Huffman, T.A.; Chi, A.; Shabanowitz, J.; Hunt, D.F.; Kumar, A.; and Lawrence, J.C.; Jr. (2007). Insulin controls subcellular localization and multisite phosphorylation of the phosphatidic acid phosphatase, lipin 1. J. Biol. Chem. 282, 277-286. (Pubitemid 47076630)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.1 , pp. 277-286
    • Harris, T.E.1    Huffman, T.A.2    Chi, A.3    Shabanowitz, J.4    Hunt, D.F.5    Kumar, A.6    Lawrence Jr., J.C.7
  • 70
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • DOI 10.1016/S0092-8674(02)00808-5
    • Kim, D.-H.; Sarbassov, D.D.; Ali, S.M.; King, J.E.; Latek, R.R.; Erdjument-Bromage, H.; Tempst, P.; and Sabatini, D.M. (2002). mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163-175. (Pubitemid 34876545)
    • (2002) Cell , vol.110 , Issue.2 , pp. 163-175
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    King, J.E.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 71
    • 0037623417 scopus 로고    scopus 로고
    • GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
    • DOI 10.1016/S1097-2765(03)00114-X
    • Kim, D.H.; Sarbassov, D.D.; Ali, S.M.; Latek, R.R.; Guntur, K.V.; Erdjument-Bromage, H.; Tempst, P.; and Sabatini, D.M. (2003). GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 11, 895-904. (Pubitemid 36566312)
    • (2003) Molecular Cell , vol.11 , Issue.4 , pp. 895-904
    • Kim, D.-H.1    Sarbassov, D.D.2    Ali, S.M.3    Latek, R.R.4    Guntur, K.V.P.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 72
    • 77953400436 scopus 로고    scopus 로고
    • Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors
    • Kim, H.B.; Kumar, A.; Wang, L.; Liu, G.H.; Keller, S.R.; Lawrence, J.C.; Jr.; Finck, B.N.; and Harris, T.E. (2010). Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors. Mol. Cell. Biol. 30, 3126-3139.
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 3126-3139
    • Kim, H.B.1    Kumar, A.2    Wang, L.3    Liu, G.H.4    Keller, S.R.5    Lawrence Jr., J.C.6    Finck, B.N.7    Harris, T.E.8
  • 74
    • 77957903550 scopus 로고    scopus 로고
    • Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)- 9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer
    • Liu, Q.; Chang, J.W.; Wang, J.; Kang, S.A.; Thoreen, C.C.; Markhard, A.; Hur, W.; Zhang, J.; Sim, T.; Sabatini, D.M.; and Gray, N.S. (2010). Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl) benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J. Med. Chem. 53, 7146-7155.
    • (2010) J. Med. Chem. , vol.53 , pp. 7146-7155
    • Liu, Q.1    Chang, J.W.2    Wang, J.3    Kang, S.A.4    Thoreen, C.C.5    Markhard, A.6    Hur, W.7    Zhang, J.8    Sim, T.9    Sabatini, D.M.10    Gray, N.S.11
  • 76
    • 0034721874 scopus 로고    scopus 로고
    • Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies
    • Mothe-Satney, I.; Brunn, G.J.; McMahon, L.P.; Capaldo, C.T.; Abraham, R.T.; and Lawrence, J.C.; Jr. (2000). Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies. J. Biol. Chem. 275, 33836-33843.
    • (2000) J. Biol. Chem. , vol.275 , pp. 33836-33843
    • Mothe-Satney, I.1    Brunn, G.J.2    McMahon, L.P.3    Capaldo, C.T.4    Abraham, R.T.5    Lawrence Jr., J.C.6
  • 77
    • 67349241955 scopus 로고    scopus 로고
    • DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    • Peterson, T.R.; Laplante, M.; Thoreen, C.C.; Sancak, Y.; Kang, S.A.; Kuehl, W.M.; Gray, N.S.; and Sabatini, D.M. (2009). DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137, 873-886.
    • (2009) Cell , vol.137 , pp. 873-886
    • Peterson, T.R.1    Laplante, M.2    Thoreen, C.C.3    Sancak, Y.4    Kang, S.A.5    Kuehl, W.M.6    Gray, N.S.7    Sabatini, D.M.8
  • 79
    • 45849105156 scopus 로고    scopus 로고
    • The rag GTPases bind raptor and mediate amino acid signaling to mTORC1
    • DOI 10.1126/science.1157535
    • Sancak, Y.; Peterson, T.R.; Shaul, Y.D.; Lindquist, R.A.; Thoreen, C.C.; Bar-Peled, L.; and Sabatini, D.M. (2008). The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 320, 1496-1501. (Pubitemid 351929429)
    • (2008) Science , vol.320 , Issue.5882 , pp. 1496-1501
    • Sancak, Y.1    Peterson, T.R.2    Shaul, Y.D.3    Lindquist, R.A.4    Thoreen, C.C.5    Bar-Peled, L.6    Sabatini, D.M.7
  • 80
    • 78650848337 scopus 로고    scopus 로고
    • MTORC1 controls fasting-induced ketogenesis and its modulation by ageing
    • Sengupta, S.; Peterson, T.R.; Laplante, M.; Oh, S.; and Sabatini, D.M. (2010). mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468, 1100-1104.
    • (2010) Nature , vol.468 , pp. 1100-1104
    • Sengupta, S.1    Peterson, T.R.2    Laplante, M.3    Oh, S.4    Sabatini, D.M.5
  • 81
    • 0029797604 scopus 로고    scopus 로고
    • Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    • Shimano, H.; Horton, J.D.; Hammer, R.E.; Shimomura, I.; Brown, M.S.; and Goldstein, J.L. (1996). Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J. Clin. Invest. 98, 1575-1584. (Pubitemid 26327867)
    • (1996) Journal of Clinical Investigation , vol.98 , Issue.7 , pp. 1575-1584
    • Shimano, H.1    Horton, J.D.2    Hammer, R.E.3    Shimomura, I.4    Brown, M.S.5    Goldstein, J.L.6
  • 84
    • 67649344456 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR
    • Wang, L.; Lawrence, J.C.; Jr.; Sturgill, T.W.; and Harris, T.E. (2009). Mammalian target of rapamycin complex 1 (mTORC1) activity is associated with phosphorylation of raptor by mTOR. J. Biol. Chem. 284, 14693-14697.
    • (2009) J. Biol. Chem. , vol.284 , pp. 14693-14697
    • Wang, L.1    Lawrence Jr., J.C.2    Sturgill, T.W.3    Harris, T.E.4
  • 85
    • 77953091045 scopus 로고    scopus 로고
    • Structure of the human mTOR complex i and its implications for rapamycin inhibition
    • Yip, C.K.; Murata, K.; Walz, T.; Sabatini, D.M.; and Kang, S.A. (2010). Structure of the human mTOR complex I and its implications for rapamycin inhibition. Mol. Cell 38, 768-774.
    • (2010) Mol. Cell , vol.38 , pp. 768-774
    • Yip, C.K.1    Murata, K.2    Walz, T.3    Sabatini, D.M.4    Kang, S.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.