Liver-specific loss of long chain Acyl-CoA synthetase-1 decreases triacylglycerol synthesis and β-oxidation and alters phospholipid fatty acid composition

Journal of Biological Chemistry

Volumn 284, Issue 41, 2009, Pages 27816-27826

  Li, Lei O ^a   Ellis, Jessica M ^a   Paich, Heather A ^a   Wang, Shuli ^a   Gong, Nan ^a   Altshuller, George ^b   Thresher, Randy J ^b   Koves, Timothy R ^c   Watkins, Steven M ^d   Muoio, Deborah M ^c   Cline, Gary W ^e   Shulman, Gerald I ^e   Coleman, Rosalind A ^a  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Lipomics Technologies Inc   (United States)

^e YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL-COA; ACYL-COA SYNTHETASE; CONCOMITANT DECREASE; FATTY ACID CHAINS; HEPATIC INSULIN RESISTANCE; HEPATIC STEATOSIS; HIGH-FAT DIET; INSULIN RESISTANCE; ISOFORMS; KNOCK OUTS; LONG CHAIN FATTY ACID; LONG CHAINS; LYSOPHOSPHATIDYL-CHOLINE; MOUSE MODELS; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID FATTY ACIDS; PRIMARY HEPATOCYTES; SYNTHETASES; TRIACYLGLYCEROLS;

FATTY ACIDS; GLYCEROL; INSULIN; LIVER; MAMMALS; NUTRITION; OXIDATION; PHOSPHOLIPIDS;

ACIDS;

CARNITINE PALMITOYLTRANSFERASE; FATTY ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; LYSOPHOSPHATIDYLCHOLINE; LYSOPHOSPHATIDYLSERINE; OLEIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; FATTY ACID OXIDATION; INSULIN RESISTANCE; LIPID COMPOSITION; LIPID DIET; LIPOGENESIS; LIVER CELL; LIVER PROTECTION; LOW FAT DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELLS, CULTURED; COENZYME A LIGASES; DIET; FASTING; FATTY ACIDS; GENE TARGETING; GLUCOSE TOLERANCE TEST; HEPATOCYTES; ISOENZYMES; LIVER; MALE; MICE; MICE, KNOCKOUT; OXIDATION-REDUCTION; PHOSPHOLIPIDS; TRIGLYCERIDES;

MAMMALIA; MUS;

EID: 70350450243     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.022467     Document Type: Article

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