메뉴 건너뛰기




Volumn 18, Issue 2, 2004, Pages 157-169

Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR

Author keywords

FXR; HNF4 ; PGC 1 ; PPAR ; Triglyceride

Indexed keywords

2 [1 CARBOXY 2 [4 [2 (5 METHYL 2 PHENYL 4 OXAZOLYL)ETHOXY]PHENYL]ETHYLAMINO]BENZOIC ACID METHYL ESTER; 3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; DIMETHYL SULFOXIDE; FARNESOID X RECEPTOR; GLUCOSE; GW 2433; GW 7447; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; LIGAND; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 0942279602     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1138104     Document Type: Article
Times cited : (318)

References (49)
  • 1
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Ananthanarayanan, M., Balasubramanian, N., Makishima, M., Mangelsdorf, D.J., and Suchy, F.J. 2001. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J. Biol. Chem. 276: 28857-28865.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 3
    • 0014645531 scopus 로고
    • High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study
    • Berry, M.N. and Friend, D.S. 1969. High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study. J. Cell Biol. 43: 506-520.
    • (1969) J. Cell Biol. , vol.43 , pp. 506-520
    • Berry, M.N.1    Friend, D.S.2
  • 4
    • 0025943204 scopus 로고
    • Relationships between fatty acid synthesis and lipid secretion in the isolated perfused rat liver: Effects of hyperthyroidism, glucose and oleate
    • Castellani, L.W., Wilcox, H.C., and Heimberg, M. 1991. Relationships between fatty acid synthesis and lipid secretion in the isolated perfused rat liver: Effects of hyperthyroidism, glucose and oleate. Biochim. Biophys. Acta 1086: 197-208.
    • (1991) Biochim. Biophys. Acta , vol.1086 , pp. 197-208
    • Castellani, L.W.1    Wilcox, H.C.2    Heimberg, M.3
  • 5
    • 0034332715 scopus 로고    scopus 로고
    • Evidence that triglycerides are an independent coronary heart disease risk factor
    • Cullen, P. 2000. Evidence that triglycerides are an independent coronary heart disease risk factor. Am. J. Cardiol. 86: 943-949.
    • (2000) Am. J. Cardiol. , vol.86 , pp. 943-949
    • Cullen, P.1
  • 7
    • 0036164154 scopus 로고    scopus 로고
    • BAREing it all: The adoption of LXR and FXR and their roles in lipid homeostasis
    • Edwards, P.A., Kast, H.R., and Anisfeld, A.M. 2002. BAREing it all: The adoption of LXR and FXR and their roles in lipid homeostasis. J. Lipid Res. 43: 2-12.
    • (2002) J. Lipid Res. , vol.43 , pp. 2-12
    • Edwards, P.A.1    Kast, H.R.2    Anisfeld, A.M.3
  • 8
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch, J., Lees, M., and Sloane-Stanley, G.H. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-509.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane-Stanley, G.H.3
  • 10
    • 0034864668 scopus 로고    scopus 로고
    • Triglycerides: Risk factor or fellow traveler?
    • Forrester, J.S. 2001. Triglycerides: Risk factor or fellow traveler? Curr. Opin. Cardiol. 16: 261-264.
    • (2001) Curr. Opin. Cardiol. , vol.16 , pp. 261-264
    • Forrester, J.S.1
  • 11
    • 0028332036 scopus 로고
    • Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers
    • Glass, C.K. 1994. Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocr. Rev. 15: 391-407.
    • (1994) Endocr. Rev. , vol.15 , pp. 391-407
    • Glass, C.K.1
  • 14
    • 0033570028 scopus 로고    scopus 로고
    • Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer
    • Grober, J., Zaghini, I., Fujii, H., Jones, S.A., Kliewer, S.A., Willson, T.M., Ono, T., and Besnard, P. 1999. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. J. Biol. Chem. 274: 29749-29754.
    • (1999) J. Biol. Chem. , vol.274 , pp. 29749-29754
    • Grober, J.1    Zaghini, I.2    Fujii, H.3    Jones, S.A.4    Kliewer, S.A.5    Willson, T.M.6    Ono, T.7    Besnard, P.8
  • 15
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton, J.D., Goldstein, J.L., and Brown, M.S. 2002. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 9: 1125-1131.
    • (2002) J. Clin. Invest. , vol.9 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 17
    • 0034791544 scopus 로고    scopus 로고
    • Farnesoid X-activated receptor induces apolipoprotein C-II transcription: A molecular mechanism linking plasma triglyceride levels to bile acids
    • Kast, H.R., Nguyen, C.M., Sinal, C.J., Jones, S.A., Laffitte, B.A., Reue, K., Gonzalez, F.J., Willson, T.M., and Edwards, P.A. 2001. Farnesoid X-activated receptor induces apolipoprotein C-II transcription: A molecular mechanism linking plasma triglyceride levels to bile acids. Mol. Endocrinol. 15: 1720-1728.
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1720-1728
    • Kast, H.R.1    Nguyen, C.M.2    Sinal, C.J.3    Jones, S.A.4    Laffitte, B.A.5    Reue, K.6    Gonzalez, F.J.7    Willson, T.M.8    Edwards, P.A.9
  • 18
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
    • Kast, H.R., Goodwin, B., Tarr, P.T., Jones, S.A., Anisfeld, A.M., Stoltz, C.M., Tontonoz, P., Kliewer, S., Willson, T.M., and Edwards, P.A. 2002. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J. Biol. Chem. 277: 2908-2915.
    • (2002) J. Biol. Chem. , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6    Tontonoz, P.7    Kliewer, S.8    Willson, T.M.9    Edwards, P.A.10
  • 19
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting
    • Kersten, S., Seydoux, J., Peters, J.M., Gonzalez, F.J., Desvergne, B., and Wahli, W. 1999. Peroxisome proliferator-activated receptor α mediates the adaptive response to fasting. J. Clin. Invest. 103: 1489-1498.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 20
    • 0034116143 scopus 로고    scopus 로고
    • A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen
    • Knutti, D., Kaul, A., and Kralli, A. 2000. A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol. Cell. Biol. 20: 2411-2422.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2411-2422
    • Knutti, D.1    Kaul, A.2    Kralli, A.3
  • 21
    • 0034616147 scopus 로고    scopus 로고
    • Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
    • Laffitte, B.A., Kast, H.R., Nguyen, C.M., Zavacki, A.M., Moore, D.D., and Edwards, P.A. 2000. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. J. Biol. Chem. 275: 10638-10647.
    • (2000) J. Biol. Chem. , vol.275 , pp. 10638-10647
    • Laffitte, B.A.1    Kast, H.R.2    Nguyen, C.M.3    Zavacki, A.M.4    Moore, D.D.5    Edwards, P.A.6
  • 24
    • 0037127204 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ co-activator 1β (PGC-1β), a novel PGC-1 related transcription coactivator associated with host cell factor
    • Lin, J., Puigserver, P., Donovan, J., Tarr, P., and Spiegelman, B.M. 2002a. Peroxisome proliferator-activated receptor γ co-activator 1β (PGC-1β), a novel PGC-1 related transcription coactivator associated with host cell factor. J. Biol. Chem. 277: 1645-1648.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1645-1648
    • Lin, J.1    Puigserver, P.2    Donovan, J.3    Tarr, P.4    Spiegelman, B.M.5
  • 27
    • 0035851188 scopus 로고    scopus 로고
    • Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism
    • Lu, T.T., Repa, J.J., and Mangelsdorf, D.J. 2001. Orphan nuclear receptors as eLiXiRs and FiXeRs of sterol metabolism. J. Biol. Chem. 276: 37735-37738.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37735-37738
    • Lu, T.T.1    Repa, J.J.2    Mangelsdorf, D.J.3
  • 30
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf, D.J. and Evans, R.M. 1995. The RXR heterodimers and orphan receptors. Cell 83: 841-850.
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 34
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): Transcriptional coactivator and metabolic regulator
    • Puigserver, P. and Spiegelman, P.M. 2003. Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): Transcriptional coactivator and metabolic regulator. Endocr. Rev. 24: 78-90.
    • (2003) Endocr. Rev. , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, P.M.2
  • 35
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P., Wu, Z., Park, C.W., Graves, R., Wright, M., and Spiegelman, B.M. 1998. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92: 829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 37
    • 0028111690 scopus 로고
    • A microprecipitation technique suitable for measuring α-lipoprotein cholesterol
    • Puppione, D.L. and Charugundla, S. 1994. A microprecipitation technique suitable for measuring α-lipoprotein cholesterol. Lipids 29: 595-597.
    • (1994) Lipids , vol.29 , pp. 595-597
    • Puppione, D.L.1    Charugundla, S.2
  • 38
    • 0242349197 scopus 로고    scopus 로고
    • Regulation of hepatic fasting response by PPARγ coactivator-α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis
    • Rhee, J., Inoue, Y., Yoon, J.C., Puigserver, P., Fan, M., Gonzalez, F.J., and Spiegelman, B.M. 2003. Regulation of hepatic fasting response by PPARγ coactivator-α (PGC-1): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis. Proc. Natl. Acad. Sci. 100: 4012-4017.
    • (2003) Proc. Natl. Acad. Sci. , vol.100 , pp. 4012-4017
    • Rhee, J.1    Inoue, Y.2    Yoon, J.C.3    Puigserver, P.4    Fan, M.5    Gonzalez, F.J.6    Spiegelman, B.M.7
  • 39
    • 0028836714 scopus 로고
    • Isolation of proteins that interact specifically with the retinoid X receptor: Two novel orphan receptors
    • Seol, W., Choi, H.S., and Moore, D.D. 1995. Isolation of proteins that interact specifically with the retinoid X receptor: Two novel orphan receptors. Mol. Endocrinol. 9: 72-85.
    • (1995) Mol. Endocrinol. , vol.9 , pp. 72-85
    • Seol, W.1    Choi, H.S.2    Moore, D.D.3
  • 41
    • 0034664729 scopus 로고    scopus 로고
    • Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
    • Sinal, C.J., Tohkin, M., Miyata, M., Ward, J.M., Lambert, G., and Gonzalez, F.J. 2000. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell 102: 731-744.
    • (2000) Cell , vol.102 , pp. 731-744
    • Sinal, C.J.1    Tohkin, M.2    Miyata, M.3    Ward, J.M.4    Lambert, G.5    Gonzalez, F.J.6
  • 42
  • 43
    • 0034671526 scopus 로고    scopus 로고
    • The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression
    • Urizar, N.L., Dowhan, D.H., and Moore, D.D. 2000. The farnesoid X-activated receptor mediates bile acid activation of phospholipid transfer protein gene expression. J. Biol. Chem. 275: 39313-39317.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39313-39317
    • Urizar, N.L.1    Dowhan, D.H.2    Moore, D.D.3
  • 44
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega, R.B., Huss, J.M., and Kelly, D.P. 2000. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20: 1868-1876.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 45
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang, H., Chen, J., Hollister, K., Sowers, L.C., and Forman, B.M. 1999. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell 3: 543-553.
    • (1999) Mol. Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 46
    • 0022556123 scopus 로고
    • Enzymatic methods for quantification of lipoprotein lipids
    • Warnick, G.R. 1986. Enzymatic methods for quantification of lipoprotein lipids. Methods Enzymol. 129: 101-123.
    • (1986) Methods Enzymol. , vol.129 , pp. 101-123
    • Warnick, G.R.1
  • 49
    • 0037414757 scopus 로고    scopus 로고
    • Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
    • Zhang, Y., Kast-Woelbern, H.R., and Edwards, P.A. 2003. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J. Biol. Chem. 278: 104-110.
    • (2003) J. Biol. Chem. , vol.278 , pp. 104-110
    • Zhang, Y.1    Kast-Woelbern, H.R.2    Edwards, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.