-
1
-
-
0033515429
-
Deconstructing type 2 diabetes
-
Taylor, S.I. Deconstructing type 2 diabetes. Cell 97, 9-12 (1999).
-
(1999)
Cell
, vol.97
, pp. 9-12
-
-
Taylor, S.I.1
-
2
-
-
0026468362
-
What if Minkowski had been ageusic? An alternative angle on diabetes
-
McGarry, J.D. What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258, 766-770 (1992).
-
(1992)
Science
, vol.258
, pp. 766-770
-
-
McGarry, J.D.1
-
3
-
-
0036092239
-
Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
-
McGarry, J.D. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51, 7-18 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 7-18
-
-
McGarry, J.D.1
-
4
-
-
0031014830
-
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
-
Boden, G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46, 3-10 (1997).
-
(1997)
Diabetes
, vol.46
, pp. 3-10
-
-
Boden, G.1
-
5
-
-
0033927667
-
Cellular mechanisms of insulin resistance
-
Shulman, G.I. Cellular mechanisms of insulin resistance. J. Clin. Invest 106, 171-176 (2000).
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 171-176
-
-
Shulman, G.I.1
-
6
-
-
0344406146
-
Mechanisms of the free fatty acid-induced increase in hepatic glucose production
-
Lam, T.K. et al. Mechanisms of the free fatty acid-induced increase in hepatic glucose production. Am. J. Physiol. Endocrinol. Metab. 284, E863-E873 (2003).
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.284
-
-
Lam, T.K.1
-
7
-
-
0028342686
-
Mechanisms of fatty acid-induced inhibition of glucose uptake
-
Boden, G., Chen, X., Ruiz, J., White, J.V. & Rossetti, L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J. Clin. Invest. 93, 2438-2446 (1994).
-
(1994)
J. Clin. Invest.
, vol.93
, pp. 2438-2446
-
-
Boden, G.1
Chen, X.2
Ruiz, J.3
White, J.V.4
Rossetti, L.5
-
8
-
-
0037303077
-
Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites
-
Lam, T.K., van de Werve, G. & Giacca, A. Free fatty acids increase basal hepatic glucose production and induce hepatic insulin resistance at different sites. Am. J. Physiol. Endocrinol. Metab. 284, E281-E290 (2003).
-
(2003)
Am. J. Physiol. Endocrinol. Metab.
, vol.284
-
-
Lam, T.K.1
Van De Werve, G.2
Giacca, A.3
-
9
-
-
0029861999
-
Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs
-
Rebrin, K., Steil, G.M., Mittelman, S.D. & Bergman, R.N. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J. Clin. Invest. 98, 741-749 (1996).
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 741-749
-
-
Rebrin, K.1
Steil, G.M.2
Mittelman, S.D.3
Bergman, R.N.4
-
10
-
-
0030969441
-
The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog
-
Sindelar, D.K. et al. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabeteses, 187-196 (1997).
-
(1997)
Diabeteses
, pp. 187-196
-
-
Sindelar, D.K.1
-
11
-
-
0036084279
-
Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs
-
Chu, C.A. et al. Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs. Am. J. Physiol. Endocrinol. Metab. 282, E402-E411 (2002).
-
(2002)
Am. J. Physiol. Endocrinol. Metab.
, vol.282
-
-
Chu, C.A.1
-
12
-
-
0032905885
-
The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects
-
Chen, X., Iqbal, N. & Boden, G. The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. J. Clin. Invest. 103, 365-372 (1999).
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 365-372
-
-
Chen, X.1
Iqbal, N.2
Boden, G.3
-
13
-
-
0035082482
-
Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes
-
Boden, G., Chen, X., Capulong, E. & Mozzoli, M. Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes. Diabetes 50, 810-816 (2001).
-
(2001)
Diabetes
, vol.50
, pp. 810-816
-
-
Boden, G.1
Chen, X.2
Capulong, E.3
Mozzoli, M.4
-
14
-
-
0023636723
-
Utilization of plasma fatty acid in rat brain: Distribution of [14C]palmitate between oxidative and synthetic pathways
-
Miller, J.C., Gnaedinger, J.M. & Rapoport, S.I. Utilization of plasma fatty acid in rat brain: distribution of [14C]palmitate between oxidative and synthetic pathways. J. Neurochem. 49, 1507-1514 (1987).
-
(1987)
J. Neurochem.
, vol.49
, pp. 1507-1514
-
-
Miller, J.C.1
Gnaedinger, J.M.2
Rapoport, S.I.3
-
15
-
-
0034733730
-
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
-
Loftus, T.M. et al. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379-2381 (2000).
-
(2000)
Science
, vol.288
, pp. 2379-2381
-
-
Loftus, T.M.1
-
16
-
-
0036065628
-
Central administration of oleic acid inhibits glucose production and food intake
-
Obici, S. et al. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51, 271-275 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 271-275
-
-
Obici, S.1
-
17
-
-
0038037734
-
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
-
Obici, S., Feng, Z., Arduini, A., Conti, R. & Rossetti, L. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat. Med. 9, 756-761 (2003).
-
(2003)
Nat. Med.
, vol.9
, pp. 756-761
-
-
Obici, S.1
Feng, Z.2
Arduini, A.3
Conti, R.4
Rossetti, L.5
-
18
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
Obici, S., Zhang, B.B., Karkanias, G. & Rossetti, L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat. Med. 8, 1376-1382 (2002).
-
(2002)
Nat. Med.
, vol.8
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
19
-
-
12944333126
-
Important role of the hepatic vagus nerve in glucose uptake and production by the liver
-
Matsuhisa, M. et al. Important role of the hepatic vagus nerve in glucose uptake and production by the liver. Metabolism 49, 11-16 (2000).
-
(2000)
Metabolism
, vol.49
, pp. 11-16
-
-
Matsuhisa, M.1
-
20
-
-
0027449311
-
Effect of hepatic nerves on disposition of an intraduodenal glucose load
-
Moore, M.C. et al. Effect of hepatic nerves on disposition of an intraduodenal glucose load. Am. J. Physiol 265, E487-E496 (1993).
-
(1993)
Am. J. Physiol.
, vol.265
-
-
Moore, M.C.1
-
21
-
-
0034193742
-
Isolated hepatic cholinergic denervation impairs glucose and glycogen metabolism
-
Xue, C. et al. Isolated hepatic cholinergic denervation impairs glucose and glycogen metabolism. J. Surg. Res. 90, 19-25 (2000).
-
(2000)
J. Surg. Res.
, vol.90
, pp. 19-25
-
-
Xue, C.1
-
22
-
-
0029024314
-
Cloning of the beta cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
-
Aguilar-Bryan, L. et al. Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science 268, 423-426 (1995).
-
(1995)
Science
, vol.268
, pp. 423-426
-
-
Aguilar-Bryan, L.1
-
23
-
-
0032788372
-
Molecular biology of adenosine triphosphate-sensitive potassium channels
-
Aguilar-Bryan, L. & Bryan, J. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr. Rev. 20, 101-135 (1999).
-
(1999)
Endocr. Rev.
, vol.20
, pp. 101-135
-
-
Aguilar-Bryan, L.1
Bryan, J.2
-
24
-
-
0037306308
-
Physiological and pathophysiological roles of ATP-sensitive K+ channels
-
Seino, S. & Miki, T. Physiological and pathophysiological roles of ATP-sensitive K+ channels. Prog. Biophys. Mol. Biol. 81, 133-176 (2003).
-
(2003)
Prog. Biophys. Mol. Biol.
, vol.81
, pp. 133-176
-
-
Seino, S.1
Miki, T.2
-
25
-
-
0029898253
-
A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels
-
Inagaki, N. et al. A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Neuron 16, 1011-1017 (1996).
-
(1996)
Neuron
, vol.16
, pp. 1011-1017
-
-
Inagaki, N.1
-
26
-
-
0030845066
-
Evidence for a unique long chain acyl-CoA ester binding site on the ATP-regulated potassium channel in mouse pancreatic beta cells
-
Branstrom, R., Corkey, B.E., Berggren, P.O. & Larsson, O. Evidence for a unique long chain acyl-CoA ester binding site on the ATP-regulated potassium channel in mouse pancreatic beta cells. J. Biol. Chem. 272, 17390-17394 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 17390-17394
-
-
Branstrom, R.1
Corkey, B.E.2
Berggren, P.O.3
Larsson, O.4
-
27
-
-
0032500529
-
Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA
-
Gribble, F.M., Proks, P., Corkey, B.E. & Ashcroft, F.M. Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. J. Biol. Chem. 273, 26383-26387 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26383-26387
-
-
Gribble, F.M.1
Proks, P.2
Corkey, B.E.3
Ashcroft, F.M.4
-
28
-
-
3843114555
-
Hypothalamic responses to long-chain fatty acids are nutritionally regulated
-
Morgan, K., Obici, S. & Rossetti, L. Hypothalamic responses to long-chain fatty acids are nutritionally regulated. J. Biol. Chem. 279, 31139-31148 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 31139-31148
-
-
Morgan, K.1
Obici, S.2
Rossetti, L.3
-
29
-
-
0035654626
-
Overfeeding rapidly induces leptin and insulin resistance
-
Wang, J. et al. Overfeeding rapidly induces leptin and insulin resistance. Diabetes 50, 2786-2791 (2001).
-
(2001)
Diabetes
, vol.50
, pp. 2786-2791
-
-
Wang, J.1
-
30
-
-
0842324779
-
Obesity wars: Molecular progress confronts an expanding epidemic
-
Flier, J.S. Obesity wars: molecular progress confronts an expanding epidemic. Cell 116, 337-350 (2004).
-
(2004)
Cell
, vol.116
, pp. 337-350
-
-
Flier, J.S.1
-
31
-
-
0017863307
-
Interrelations between ureogenesis and gluconeogenesis in isolated hepatocytes. The role of antion transport and the competition for energy
-
Wojtczak, A.B., Walajtys-Rode, E.I. & Geelen, M.J. Interrelations between ureogenesis and gluconeogenesis in isolated hepatocytes. The role of antion transport and the competition for energy. Biochem. J. 170, 379-385 (1978).
-
(1978)
Biochem. J.
, vol.170
, pp. 379-385
-
-
Wojtczak, A.B.1
Walajtys-Rode, E.I.2
Geelen, M.J.3
-
32
-
-
0013923479
-
Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver
-
Williamson, J.R., Kreisberg, R.A. & Felts, P.W. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc. Natl. Acad. Sci. USA 56, 247-254 (1966).
-
(1966)
Proc. Natl. Acad. Sci. USA
, vol.56
, pp. 247-254
-
-
Williamson, J.R.1
Kreisberg, R.A.2
Felts, P.W.3
-
33
-
-
0026005773
-
In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans
-
Clore, J.N., Glickman, P.S., Nestler, J.E. & Blackard, W.G. In vivo evidence for hepatic autoregulation during FFA-stimulated gluconeogenesis in normal humans, Am. J. Physiol. 261, E425-E429 (1991).
-
(1991)
Am. J. Physiol.
, vol.261
-
-
Clore, J.N.1
Glickman, P.S.2
Nestler, J.E.3
Blackard, W.G.4
-
34
-
-
0034072554
-
Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans
-
Roden, M. et al. Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans. Diabetes 49, 701-707 (2000).
-
(2000)
Diabetes
, vol.49
, pp. 701-707
-
-
Roden, M.1
-
35
-
-
0014670584
-
Control mechanisms of gluconeogenesis and ketogenesis. I. Effects of oleate on gluconeogenesis in perfused rat liver
-
Williamson, J.R., Browning, E.T. & Scholz, R. Control mechanisms of gluconeogenesis and ketogenesis. I. Effects of oleate on gluconeogenesis in perfused rat liver. J. Biol. Chem. 244, 4607-4616 (1969).
-
(1969)
J. Biol. Chem.
, vol.244
, pp. 4607-4616
-
-
Williamson, J.R.1
Browning, E.T.2
Scholz, R.3
-
36
-
-
16244383657
-
A brain-liver circuit regulates glucose homeostasis
-
Pocai, A., Obici, S., Schwartz, G.J. & Rossetti, L. A brain-liver circuit regulates glucose homeostasis. Cell Metab. 1, 53-61 (2005).
-
(2005)
Cell Metab.
, vol.1
, pp. 53-61
-
-
Pocai, A.1
Obici, S.2
Schwartz, G.J.3
Rossetti, L.4
-
37
-
-
0030876205
-
Heterogeneity of astrocyte resting membrane potentials and intercellular coupling revealed by whole-cell and gramicidin-perforated patch recordings from cultured neocortical and hippocampal slice astrocytes
-
McKhann, G.M., D'Ambrosio, R. & Janigro, D. Heterogeneity of astrocyte resting membrane potentials and intercellular coupling revealed by whole-cell and gramicidin-perforated patch recordings from cultured neocortical and hippocampal slice astrocytes. J. Neurosci. 17, 6850-6863 (1997).
-
(1997)
J. Neurosci.
, vol.17
, pp. 6850-6863
-
-
McKhann, G.M.1
D'Ambrosio, R.2
Janigro, D.3
-
38
-
-
0032517821
-
Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain
-
Dunn-Meynell, A.A., Rawson, N.E. & Levin, B.E. Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain. Brain Res. 814, 41-54 (1998).
-
(1998)
Brain Res.
, vol.814
, pp. 41-54
-
-
Dunn-Meynell, A.A.1
Rawson, N.E.2
Levin, B.E.3
-
39
-
-
0035042796
-
ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis
-
Miki, T. et al. ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat. Neurosci. 4, 507-512 (2001)
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 507-512
-
-
Miki, T.1
-
40
-
-
0037424452
-
Acetylcholine affects rat liver metabolism via type 3 muscarinic receptors in hepatocytes
-
Vatamaniuk, M.Z., Horyn, O.V., Vatamaniuk, O.K. & Doliba, N.M. Acetylcholine affects rat liver metabolism via type 3 muscarinic receptors in hepatocytes. Life Sci. 72, 1871-1882 (2003).
-
(2003)
Life Sci.
, vol.72
, pp. 1871-1882
-
-
Vatamaniuk, M.Z.1
Horyn, O.V.2
Vatamaniuk, O.K.3
Doliba, N.M.4
-
41
-
-
0034789909
-
Central melanocortin receptors regulate insulin action
-
Obici, S. et al. Central melanocortin receptors regulate insulin action. J. Clin. Invest. 108, 1079-1085 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1079-1085
-
-
Obici, S.1
-
42
-
-
0037733115
-
Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats
-
Morton, G.J. et al. Arcuate nucleus-specific leptin receptor gene therapy attenuates the obesity phenotype of Koletsky (fa(k)/fa(k)) rats. Endocrinology 144, 2016-2024 (2003).
-
(2003)
Endocrinology
, vol.144
, pp. 2016-2024
-
-
Morton, G.J.1
-
43
-
-
0035663963
-
Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
-
Combs, T.P., Berg, A.H., Obici, S., Scherer, P.E. & Rossetti, L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J. Clin. Invest. 108, 1875-1881 (2001).
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1875-1881
-
-
Combs, T.P.1
Berg, A.H.2
Obici, S.3
Scherer, P.E.4
Rossetti, L.5
-
44
-
-
0036723838
-
Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1
-
Hansen, A.M. et al. Differential interactions of nateglinide and repaglinide on the human beta-cell sulphonylurea receptor 1. Diabetes 51, 2789-2795 (2002).
-
(2002)
Diabetes
, vol.51
, pp. 2789-2795
-
-
Hansen, A.M.1
-
45
-
-
0025911341
-
Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation
-
Tomoda, H., Igarashi, K., Cyong, J.C. & Omura, S. Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation. Inhibition of long chain acyl-CoA synthetase by triacsins caused inhibition of Raji cell proliferation. J. Biol. Chem. 266, 4214-4219 (1991).
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 4214-4219
-
-
Tomoda, H.1
Igarashi, K.2
Cyong, J.C.3
Omura, S.4
-
46
-
-
0031439778
-
Leptin selectively decreases visceral adiposity and enhances insulin action
-
Barzilai, N. et al. Leptin selectively decreases visceral adiposity and enhances insulin action. J. Clin. Invest. 100, 3105-3110 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 3105-3110
-
-
Barzilai, N.1
-
47
-
-
0041820107
-
The hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia
-
la Fleur, S.E., Ji, H., Manalo, S.L., Friedman, M.I. & Dallman, M.F. The hepatic vagus mediates fat-induced inhibition of diabetic hyperphagia. Diabetes 52, 2321-2330 (2003).
-
(2003)
Diabetes
, vol.52
, pp. 2321-2330
-
-
La Fleur, S.E.1
Ji, H.2
Manalo, S.L.3
Friedman, M.I.4
Dallman, M.F.5
-
48
-
-
0028019633
-
A method for selective section of vagal afferent or efferent axons in the rat
-
Norgren, R. & Smith, G.P. A method for selective section of vagal afferent or efferent axons in the rat. Am. J. Physiol. 267, R1136-R1141 (1994).
-
(1994)
Am. J. Physiol.
, vol.267
-
-
Norgren, R.1
Smith, G.P.2
-
49
-
-
0037308812
-
Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients
-
Sclafani, A., Ackroff, K. & Schwartz, G.J. Selective effects of vagal deafferentation and celiac-superior mesenteric ganglionectomy on the reinforcing and satiating action of intestinal nutrients. Physiol. Behav. 78, 285-294 (2003).
-
(2003)
Physiol. Behav.
, vol.78
, pp. 285-294
-
-
Sclafani, A.1
Ackroff, K.2
Schwartz, G.J.3
|