Critical role of STAT3 in leptin's metabolic actions

Cell Metabolism

Volumn 4, Issue 1, 2006, Pages 49-60

  Buettner, Christoph ^a   Pocai, Alessandro ^a   Muse, Evan D ^a   Etgen, Anne M ^a   Myers Jr , Martin G ^b   Rossetti, Luciano ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

HUMDISEASE; MOLNEURO; SIGNALING

Indexed keywords

GLUCOSE; LEPTIN; LEPTIN RECEPTOR; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HORMONE ACTION; HORMONE METABOLISM; HYPOTHALAMUS; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; APPETITE REGULATION; FEMALE; GLUCOSE; INSULIN RESISTANCE; LEPTIN; LIVER; LUTEINIZING HORMONE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 33745362866     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2006.04.014     Document Type: Article

References (59)

1. Ahima R.S., and Flier J.S. Leptin. Annu. Rev. Physiol. 62 (2000) 413-437
2. Barzilai N., Wang J., Massilon D., Vuguin P., Hawkins M., and Rossetti L. Leptin selectively decreases visceral adiposity and enhances insulin action. J. Clin. Invest. 100 (1997) 3105-3110
3. Barzilai N., She L., Liu L., Wang J., Hu M., Vuguin P., and Rossetti L. Decreased visceral adiposity accounts for leptin effect on hepatic but not peripheral insulin action. Am. J. Physiol. 277 (1999) E291-E298
4. Bates S.H., and Myers Jr. M.G. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol. Metab. 14 (2003) 447-452
5. Bates S.H., Stearns W.H., Dundon T.A., Schubert M., Tso A.W., Wang Y., Banks A.S., Lavery H.J., Haq A.K., Maratos-Flier E., et al. STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421 (2003) 856-859
6. Bates S.H., Kulkarni R.N., Seifert M., and Myers Jr. M.G. Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab. 1 (2005) 169-178
7. Baumann H., Morella K.K., White D.W., Dembski M., Bailon P.S., Kim H., Lai C.F., and Tartaglia L.A. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl. Acad. Sci. USA 93 (1996) 8374-8378
8. Bjorbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., and Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 1 (1998) 619-625
9. Bouret S.G., Draper S.J., and Simerly R.B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304 (2004) 108-110
10. Buettner C., Patel R., Muse E.D., Bhanot S., Monia B.P., McKay R., Obici S., and Rossetti L. Severe impairment in liver insulin signaling fails to alter hepatic insulin action in conscious mice. J. Clin. Invest. 115 (2005) 1306-1313
11. Cases J.A., Gabriely I., Ma X.H., Yang X.M., Michaeli T., Fleischer N., Rossetti L., and Barzilai N. Physiological increase in plasma leptin markedly inhibits insulin secretion in vivo. Diabetes 50 (2001) 348-352
12. Chehab F.F., Lim M.E., and Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat. Genet. 12 (1996) 318-320
13. Chinookoswong N., Wang J.L., and Shi Z.Q. Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes 48 (1999) 1487-1492
14. Cohen P., Zhao C., Cai X., Montez J.M., Rohani S.C., Feinstein P., Mombaerts P., and Friedman J.M. Selective deletion of leptin receptor in neurons leads to obesity. J. Clin. Invest. 108 (2001) 1113-1121
15. Coppari R., Ichinose M., Lee C.E., Pullen A.E., Kenny C.D., McGovern R.A., Tang V., Liu S.M., Ludwig T., Chua Jr. S.C., et al. The hypothalamic arcuate nucleus: A key site for mediating leptin's effects on glucose homeostasis and locomotor activity. Cell Metab. 1 (2005) 63-72
16. Cui Y., Huang L., Elefteriou F., Yang G., Shelton J.M., Giles J.E., Oz O.K., Pourbahrami T., Lu C.Y., Richardson J.A., et al. Essential role of STAT3 in body weight and glucose homeostasis. Mol. Cell. Biol. 24 (2004) 258-269
17. Dunican D.J., and Doherty P. Designing cell-permeant phosphopeptides to modulate intracellular signaling pathways. Biopolymers 60 (2001) 45-60
18. Flier J.S. Obesity wars: Molecular progress confronts an expanding epidemic. Cell 116 (2004) 337-350
19. Frederich R.C., Hamann A., Anderson S., Lollmann B., Lowell B.B., and Flier J.S. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat. Med. 1 (1995) 1311-1314
20. Gao Q., Wolfgang M.J., Neschen S., Morino K., Horvath T.L., Shulman G.I., and Fu X.Y. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proc. Natl. Acad. Sci. USA 101 (2004) 4661-4666
21. Ghilardi N., Ziegler S., Wiestner A., Stoffel R., Heim M.H., and Skoda R.C. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA 93 (1996) 6231-6235
22. Gibson M.J., Kokoris G.J., and Silverman A.J. Positive feedback in hypogonadal female mice with preoptic area brain transplants. Neuroendocrinology 48 (1988) 112-119
23. Gorogawa S., Fujitani Y., Kaneto H., Hazama Y., Watada H., Miyamoto Y., Takeda K., Akira S., Magnuson M.A., Yamasaki Y., et al. Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. Biochem. Biophys. Res. Commun. 319 (2004) 1159-1170
24. Gutierrez-Juarez R., Obici S., and Rossetti L. Melanocortin-independent effects of leptin on hepatic glucose fluxes. J. Biol. Chem. 279 (2004) 49704-49715
25. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., and Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 (1995) 543-546
26. Hirabayashi Y., and Gotoh Y. Stage-dependent fate determination of neural precursor cells in mouse forebrain. Neurosci. Res. 51 (2005) 331-336
27. Inoue H., Ogawa W., Ozaki M., Haga S., Matsumoto M., Furukawa K., Hashimoto N., Kido Y., Mori T., Sakaue H., et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat. Med. 10 (2004) 168-174
28. Kalra S.P., Xu B., Dube M.G., Moldawer L.L., Martin D., and Kalra P.S. Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y. Neurosci. Lett. 240 (1998) 45-49
29. Kitamura T., Feng Y., Kitamura Y.I., Chua S., Xu A.W., Barsh G., Rossetti L., and Accili D. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Nat. Med. 12 (2006) 534-540 10.1038/nm1392 Published online April 9, 2006
30. Kopelman P.G. Obesity as a medical problem. Nature 404 (2000) 635-643
31. Lam T.K., Pocai A., Gutierrez-Juarez R., Obici S., Bryan J., Aguilar-Bryan L., Schwartz G.J., and Rossetti L. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat. Med. 11 (2005) 320-327
32. Lee J.Y., and Hennighausen L. The transcription factor Stat3 is dispensable for pancreatic beta-cell development and function. Biochem. Biophys. Res. Commun. 334 (2005) 764-768
33. Liu L., Karkanias G.B., Morales J.C., Hawkins M., Barzilai N., Wang J., and Rossetti L. Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J. Biol. Chem. 273 (1998) 31160-31167
34. Mantzoros C.S., Frederich R.C., Qu D., Lowell B.B., Maratos-Flier E., and Flier J.S. Severe leptin resistance in brown fat-deficient uncoupling protein promoter-driven diphtheria toxin A mice despite suppression of hypothalamic neuropeptide Y and circulating corticosterone concentrations. Diabetes 47 (1998) 230-238
35. Minami M., Inoue M., Wei S., Takeda K., Matsumoto M., Kishimoto T., and Akira S. STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. Proc. Natl. Acad. Sci. USA 93 (1996) 3963-3966
36. Morton G.J., Gelling R.W., Niswender K.D., Morrison C.D., Rhodes C.J., and Schwartz M.W. Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons. Cell Metab. 2 (2005) 411-420
37. Munzberg H., Huo L., Nillni E.A., Hollenberg A.N., and Bjorbaek C. Role of signal transducer and activator of transcription 3 in regulation of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 144 (2003) 2121-2131
38. Nagatani S., Guthikonda P., Thompson R.C., Tsukamura H., Maeda K.I., and Foster D.L. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology 67 (1998) 370-376
39. Neal-Perry G.S., Zeevalk G.D., Santoro N.F., and Etgen A.M. Attenuation of preoptic area glutamate release correlates with reduced luteinizing hormone secretion in middle-aged female rats. Endocrinology 146 (2005) 4331-4339
40. Niswender K.D., Morton G.J., Stearns W.H., Rhodes C.J., Myers Jr. M.G., and Schwartz M.W. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 413 (2001) 794-795
41. Obici S., Feng Z., Karkanias G., Baskin D.G., and Rossetti L. Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat. Neurosci. 5 (2002) 566-572
42. Obici S., Feng Z., Morgan K., Stein D., Karkanias G., and Rossetti L. Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51 (2002) 271-275
43. Obici S., Feng Z., Arduini A., Conti R., and Rossetti L. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nat. Med. 9 (2003) 756-761
44. Pelleymounter M.A., Cullen M.J., Baker M.B., Hecht R., Winters D., Boone T., and Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269 (1995) 540-543
45. Pocai A., Lam T.K., Gutierrez-Juarez R., Obici S., Schwartz G.J., Bryan J., Aguilar-Bryan L., and Rossetti L. Hypothalamic K(ATP) channels control hepatic glucose production. Nature 434 (2005) 1026-1031
46. Pocai A., Morgan K., Buettner C., Gutierrez-Juarez R., Obici S., and Rossetti L. Central leptin acutely reverses diet-induced hepatic insulin resistance. Diabetes 54 (2005) 3182-3189
47. Pocai A., Obici S., Schwartz G.J., and Rossetti L. A brain-liver circuit regulates glucose homeostasis. Cell Metab. 1 (2005) 53-61
48. Rossetti L., Giaccari A., Barzilai N., Howard K., Sebel G., and Hu M. Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats. Implications for the pathophysiology of fasting hyperglycemia in diabetes. J. Clin. Invest. 92 (1993) 1126-1134
49. Rossetti L., Massillon D., Barzilai N., Vuguin P., Chen W., Hawkins M., Wu J., and Wang J. Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J. Biol. Chem. 272 (1997) 27758-27763
50. Schwartz M.W., Baskin D.G., Bukowski T.R., Kuijper J.L., Foster D., Lasser G., Prunkard D.E., Porte Jr. D., Woods S.C., Seeley R.J., and Weigle D.S. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45 (1996) 531-535
51. Seeley R.J., Yagaloff K.A., Fisher S.L., Burn P., Thiele T.E., van Dijk G., Baskin D.G., and Schwartz M.W. Melanocortin receptors in leptin effects. Nature 390 (1997) 349
52. Tartaglia L.A., Dembski M., Weng X., Deng N., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83 (1995) 1263-1271
53. Turkson J., Ryan D., Kim J.S., Zhang Y., Chen Z., Haura E., Laudano A., Sebti S., Hamilton A.D., and Jove R. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J. Biol. Chem. 276 (2001) 45443-45455
54. Unger R.H., Zhou Y.T., and Orci L. Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc. Natl. Acad. Sci. USA 96 (1999) 2327-2332
55. Vaisse C., Halaas J.L., Horvath C.M., Darnell Jr. J.E., Stoffel M., and Friedman J.M. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14 (1996) 95-97
56. Wang J., Obici S., Morgan K., Barzilai N., Feng Z., and Rossetti L. Overfeeding rapidly induces leptin and insulin resistance. Diabetes 50 (2001) 2786-2791
57. Watanobe H., and Schioth H.B. Nitric oxide mediates leptin-induced preovulatory luteinizing hormone and prolactin surges in rats. Brain Res. 923 (2001) 193-197
58. Watanobe H., Suda T., Wikberg J.E., and Schioth H.B. Evidence that physiological levels of circulating leptin exert a stimulatory effect on luteinizing hormone and prolactin surges in rats. Biochem. Biophys. Res. Commun. 263 (1999) 162-165
59. Welt C.K., Chan J.L., Bullen J., Murphy R., Smith P., DePaoli A.M., Karalis A., and Mantzoros C.S. Recombinant human leptin in women with hypothalamic amenorrhea. N. Engl. J. Med. 351 (2004) 987-997