Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus

Molecular Endocrinology

Volumn 18, Issue 6, 2004, Pages 1346-1353

  Opherk, Christian ^a   Tronche, François ^a,b   Kellendonk, Christoph ^a,c   Kohlmüller, Dirk ^a   Schulze, Andreas ^a   Schmid, Wolfgang ^a   Schütz, Günther ^a,d  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b l'alimentation et l'Environnement   (France)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; GLUCOCORTICOID RECEPTOR; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DEATH; DIABETES CONTROL; DIABETES MELLITUS; DIET RESTRICTION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HYPERGLYCEMIA; HYPOGLYCEMIA; LIVER; LIVER CELL; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; STARVATION; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; BLOTTING, NORTHERN; BODY WEIGHT; CARBOHYDRATE METABOLISM; CROSSES, GENETIC; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GENOTYPE; GLUCOSE; HEPATOCYTES; HYPOGLYCEMIA; LIGANDS; LIVER; MALE; MASS SPECTROMETRY; MICE; MICE, MUTANT STRAINS; ORGAN SIZE; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; STREPTOZOCIN; TIME FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 2542495763     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2003-0283     Document Type: Article

References (41)

1. Andrews RC, Walker BR 1999 Glucocorticoids and insulin resistance: old hormones, new targets. Clin Sci (Lond) 96:513-523
2. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, Flier JS 2001 A transgenic model of visceral obesity and the metabolic syndrome. Science 294:2166-2170
3. Delaunay F, Khan A, Cintra A, Davani B, Ling ZC, Andersson A, Ostenson CG, Gustafsson J, Efendic S, Okret S 1997 Pancreatic β cells are important targets for the diabetogenic effects of glucocorticoids. J Clin Invest 100:2094-2098
4. Rosmond R, Bjorntorp P 2000 The hypothalamic-pituitary-adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke. J Intern Med 247:188-197
5. Beato M, Herrlich P, Schutz G 1995 Steroid hormone receptors: many actors in search of a plot. Cell 83:851-857
6. Tronche F, Kellendonk C, Reichardt HM, Schütz G 1998 Genetic dissection of glucocorticoid receptor function in mice. Curr Opin Genet Dev 8:532-538
7. Hafezi-Moghadam A, Simoncini T, Yang E, Limbourg FP, Plumier JC, Rebsamen MC, Hsieh CM, Chui DS, Thomas KL, Prorock AJ, Laubach VE, Moskowitz MA, French BA, Ley K, Liao JK 2002 Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med 8:473-479
8. Herrlich P 2001 Cross-talk between glucocorticoid receptor and AP-1. Oncogene 20:2465-2475
9. Karin M, Chang L 2001 AP-1-glucocorticoid receptor crosstalk taken to a higher level. J Endocrinol 169:447-451
10. Yamamoto KR 1995-96 Multilayered control of intracellular receptor function. Harvey Lect 91:1-19
11. Pilkis SJ, Granner DK 1992 Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 54:885-909
12. Hanson RW, Reshef L 1997 Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem 66:581-611
13. Nitsch D, Stewart AF, Boshart M, Mestril R, Weih F, Schutz G 1990 Chromatin structures of the rat tyrosine amino transferase gene relate to the function of its cis-acting elements. Mol Cell Biol 10:3334-3342
14. Schmid E, Schmid W, Jantzen M, Mayer D, Jastorff B, Schutz G 1987 Transcription activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes. Eur J Biochem 165:499-506
15. Jantzen HM, Strahle U, Gloss B, Stewart F, Schmid W, Boshart M, Miksicek R, Schutz G 1987 Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell 49:29-38
16. van Schaftingen E, Gerin I 2002 The glucose-6-phosphatase system. Biochem J 362:513-532
17. Grange T, Cappabianca L, Flavin M, Sassi H, Thomassin H 2001 In vivo analysis of the model tyrosine aminotransferase gene reveals multiple sequential steps in glucocorticoid receptor action. Oncogene 20:3028-3038
18. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, Montminy M 2001 CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413:179-183
19. Kellendonk C, Opherk C, Anlag K, Schutz G, Tronche F 2000 Hepatocyte-specific expression of Cre recombinase. Genesis 26:151-153
20. Cole TJ, Blendy JA, Monaghan AP, Krieglstein K, Schmid W, Aguzzi A, Fantuzzi G, Hummler E, Unsicker K, Schutz G 1995 Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev 9:1608-1621
21. 20a. Tronche F, Opherk C, Moriggl R, Kellendonk C, Reimann A, Schwake L, Reichardt HM, Stangl K, Gau D, Hoeflich A, Beug H, Schmid W, Schutz G 2004 Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev 18:492-497
22. Lin B, Morris DW, Chou JY 1998 Hepatocyte nuclear factor 1α is an accessory factor required for activation of glucose-6-phosphatase gene transcription by glucocorticoids. DNA Cell Biol 17:967-974
23. Croniger C, Leahy P, Reshef L, Hanson RW 1998 C/EBP and the control of phosphoenolpyruvate carboxykinase gene transcription in the liver. J Biol Chem 273:31629-31632
24. Ruppert S, Boshart M, Bosch FX, Schmid W, Fournier RE, Schutz G 1990 Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes. Cell 61:895-904
25. Boshart M, Weih F, Schmidt A, Fournier RE, Schutz G 1990 A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Cell 61:905-916
26. Weih F, Nitsch D, Reik A, Schutz G, Becker PB 1991 Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo. EMBO J 10:2559-2567
27. Lee YH, Sauer B, Johnson PF, Gonzalez FJ 1997 Disruption of the c/ebp α gene in adult mouse liver. Mol Cell Biol 17:6014-6022
28. She P, Shiota M, Shelton KD, Chalkley R, Postic C, Magnuson MA 2000 Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol 20:6508-6517
29. Nordlie RC, Foster JD, Lange AJ 1999 Regulation of glucose production by the liver. Annu Rev Nutr 19: 379-406
30. Croniger C, Trus M, Lysek-Stupp K, Cohen H, Liu Y, Darlington GJ, Poli V, Hanson RW, Reshef L 1997 Role of the isoforms of CCAAT/enhancer-binding protein in the initiation of phosphoenolpyruvate carboxykinase (GTP) gene transcription at birth. J Biol Chem 272:26306-26312
31. Houssay BA 1942 Advancement of knowledge of role of hypophysis in carbohydrate metabolism during the last 25 years. Endocrinology 30:884-892
32. Friedman JE, Sun Y, Ishizuka T, Farrell CJ, McCormack SE, Herron LM, Hakimi P, Lechner P, Yun JS 1997 Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice. J Biol Chem 272:31475-31481
33. Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, Mullins JJ 1997 11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 94:14924-14929
34. Friedman JE, Yun JS, Patel YM, McGrane MM, Hanson RW 1993 Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes. J Biol Chem 268:12952-12957
35. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schutz G 1999 Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23:99-103
36. Sambrook J, Russell D 2001 Molecular cloning, a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
37. Vincent S, Marty L, Fort P 1993 S26 ribosomal protein RNA: an invariant control for gene regulation experiments in eucaryotic cells and tissues. Nucleic Acids Res 21:1498
38. Mulder C, Schouten JA, Popp-Snijders C 1983 Determination of free fatty acids: a comparative study of the enzymatic versus the gas chromatographic and the colorimetric method. J Clin Chem Clin Biochem 21:823-827
39. Rashed M, Ozand P, Bucknall M, Little D 1995 Diagnosis of inborn errors of metabolism from blood spots by acyl-carnitines and amino acids profiling using automated electrospray tandem mass spectrometry. Pediatr Res 38:324-331
40. Schulze A, Kohlmueller D, Mayatepek E 1999 Sensitivity of electrospray-tandem mass spectrometry using the phenylalanine/tyrosine-ratio for differential diagnosis of hyperphenylalaninemia in neonates. Clin Chim Acta 283:15-20
41. Roehrig KL, Allred JB 1974 Direct enzymatic procedure for the determination of liver glycogen. Anal Biochem 58:414-421