Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus

Journal of Clinical Investigation

Volumn 102, Issue 3, 1998, Pages 619-624

  Meyer, Christian ^a   Stumvoll, Michael ^a   Nadkarni, Veena ^a   Dostou, Jean ^a   Mitrakou, Asimina ^b   Gerich, John ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF ATHENS   (Greece)

Author keywords

Gluconeogenesis; Glucose production; Kidney; Liver

Indexed keywords

GLUCOSE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HUMAN; KIDNEY METABOLISM; LIVER METABOLISM; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

EID: 0032146567     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2415     Document Type: Article

References (50)

1. Dinneen, S., J. Gerich, and R. Rizza. 1992. Carbohydrate metabolism in noninsulin-dependent diabetes mellitus. N. Engl. J. Med. 327:707-713.
2. DeFronzo, R. 1988. The triumvirate: B-cell, muscle, and liver: a collusion responsible for NIDDM. Diabetes. 37:667-687.
3. Felig, P., and M. Bergman. 1995. The endocrine pancreas: Diabetes mellitus. In Endocrinology and Metabolism. P. Felig, J. Baxter, and L. Frohman, editors. McGraw-Hill, New York. 1107-1250.
4. Renold, A., C. Teng, F. Nesbett, and A. Hastings. 1953. Studies on carbohydrate metabolism in rat liver slices II: the effects of fasting and of hormonal deficiencies. J. Biol. Chem. 204:533-546.
5. Exton, J., S. Harper, A. Tucker, and R. Ho. 1973. Effects of insulin on gluconeogenesis and cyclic AMP levels in perfused livers from diabetic rats. Biochim. Biophys. Acta. 329:23-40.
6. Beam, A., B. Billing, and S. Sherlock. 1951. Hepatic glucose output and hepatic insulin sensitivity in diabetes mellitus. Lancet. 1:698-701.
7. Carlsten, B., B. Hallgren, R. Jagenburg, A. Svanborg, and L. Werko. 1967. Arterio-hepatic venous differences of free fatty acids and amino acids. Acta. Med. Scand. 181:199-207.
8. Felig, P., J. Wahren, and R. Hendler. 1978. Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion. Diabetes. 27:121-126.
9. Waldhausl, W., P. Brotusch-Marrain, S. Gasic, A. Korn, and P. Nowotny. 1982. Insulin production rate, hepatic insulin retention and splanchnic metabolism after oral glucose ingestion in hyperinsulinemic type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 23:6-15.
10. Stumvoll, M., U. Chintalapudi, G. Perriello, S. Welle, O. Gutierrez, and J. Gerich. 1995. Uptake and release of glucose by the human kidney: postabsorptive rates and responses to epinephrine. J. Clin. Invest. 96:2528-2533.
11. Meyer, C. V. Nadkarni, M. Stumvoll, and J. Gerich. 1997. Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. Am. J. Physiol. 273:E650-654.
12. Stumvoll, M., D. Overkamp, and J. Gerich. 1995. A primer on tracer methods for the study of glucose metabolism in man. Diab. Nutr. Metab. 8:298-314.
13. Weber, G., and A. Cantero. 1955. Glucose-6-phosphate activity in normal, precancerous, and neoplastic tissues. Cancer Res. 15:105-108.
14. DeFronzo, R., R. Gunnarsson, O. Bjorkman, M. Olsson, and J. Wahren. 1985. Effects of insulin on peripheral and splanchnic glucose metabolism in non-insulin-dependent (Type II) diabetes mellitus. J. Clin. Invest. 76:149-155.
15. Perriello, G., A. Mitrakou, B. Gumbiner, and J. Gerich. 1995. Non-esterified fatty acids in non-insulin-dependent diabetes: a critical update. Diabetes Annu. 7:91-106.
16. Taskinen, M., C. Bogardus, A. Kennedy, and B. Howard. 1985. Multiple disturbances of free fatty acid metabolism in non-insulin-dependent diabetes. J. Clin. Invest. 76:637-644.
17. Kelley, D., and J. Simoneau. 1994. Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J. Clin. Invest. 94: 2349-2356.
18. Lee, J., V. Vance, and G. Cahill. 1962. Metabolism of C14-labeled substrates by rabbit kidney cortex and medulla. Am. J. Physiol. 203:27-36.
19. Dzurik, R., and V. Chorvathova. 1972. Relation between the uptake of glucose and fatty acids by the rat kidney in vivo. Physiologia Bohemoslov. 21: 361-365.
20. Sochor, M., N. Baquer, and P. McLean. 1979. Glucose overutilization in diabetes: evidence from studies on the changes in hexokinase, the pentase phosphate pathway, and glucuronate-xylulose pathway in rat kidney cortex in diabetes. Biochem. Biophys. Res. Commun. 32-39.
21. World Health Organization Expert Committee. 1980. Diabetes mellitus: a second report. Geneva. Switzerland. Technical Report Series. 646:1-80.
22. Brun, C. 1951. A rapid method for the determination of para-aminohippuric acid in kidney function tests. J. Lab. Clin. Med. 37:955-458.
23. Nurjhan, N., F. Kennedy, A. Consoli, C. Martin, J. Miles, and J. Gerich. 1988. Quantification of the glycolytic origin of plasma glycerol as an index of lipolysis in vivo. Metabolism. 37:371-377.
24. Consoli, A., N. Nurjhan, J. Reilly, D. Bier, and J. Gerich. 1990. Mechanism of increased gluconeogenesis in non-insulin-dependent diabetes mellitus: role of alterations in systemic, hepatic and muscle lactate and alanine metabolism. J. Clin. Invest. 86:2038-2045.
25. Miles, J., R. Rizza, M. Haymond, and J. Gerich. 1980. Effect of acute insulin deficiency on glucose and ketone body turnover in man: evidence for the primacy of overproduction of glucose and ketone bodies in the genesis of diabetic ketoacidosis. Diabetes. 29:926-930.
26. Wolfe, R. 1992. Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. Wiley-Liss, New York.
27. 2 production from plasma free fatty acids by the intact functioning kidney of the dog. Am. J. Physiol. 227:1192-1198.
28. DeFronzo, R., E. Ferrannini, R. Hendler, R. Felig, and J. Wahren. 1983. Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes. 32:35-45.
29. Lemieux, G., M. Aranda, P. Fournel, and C. Lemieux. 1984. Renal enzymes during experimental diabetes mellitus in the rat. Role of insulin, carbohydrate metabolism, and ketoacidosis. Can. J. Physiol. Pharmacol. 62:70-75.
30. Weber, G., M. Lea, H. Convery, and N. Stamm. 1967. Regulation of gluconeogenesis and glycolysis: studies of mechanisms controlling enzyme activity. Adv. Enzyme Reg. 5:257-298.
31. Mithieux, G., H. Vidal, C. Zitoun, N. Bruni, N. Daniele, and C. Minasscan. 1996. Glucose-6-phosphatase mRNA and activity are increased to the same extent in kidney and liver of diabetic rats. Diabetes. 45:891-896.
32. Cersosimo, E., R. Judd, and J. Miles. 1994. Insulin regulation of renal glucose metabolism in conscious dogs. J. Clin. Invest. 93:2584-2589.
33. Bierman, E., V. Dole, and T. Roberts. 1957. An abnormality of nonesterified fatty acid metabolism in diabetes mellitus. Diabetes. 6:475-479.
34. Krebs, H., R. Speake, and R. Hems. 1965. Acceleration of renal gluconeogenesis by ketone bodies and fatty acids. Biochem. J. 94:712-720.
35. Williamson, J., R. Kreisberg, and P. Felts. 1966. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc. Natl. Acad. Sci. USA. 56:247-254.
36. Harmon, D., R. Britton, and R. Prior. 1984. In vitro rates of oxidation and gluconeogenesis from L(+)-and D(-)lactate in bovine tissues. Comp. Biochem. Physiol. 77B:365-368.
37. Wirthensohn, G., and W. Guder. 1986. Renal substrate metabolism. Physiol. Rev. 66:469-497.
38. Biava, C. A. Grossman, and M. West. 1966. Ultrastructural observations on renal glycogen in normal and pathologic human kidneys. Lab. Invest. 15:330-356.
39. Guder, W., and B. Ross. 1984. Enzyme distribution along the nephron. Kidney Int. 26:101-111.
40. Amico, J., and J. Klein. 1981. Diabetic management in patients with renal failure. Diabetes Care. 4:430-434.
41. Toth, E., and D. Lee. 1993. Spontaneous/uremic hypoglycemia is not a distinct entity: substantiation from a literature review. Nephron. 58:325-329.
42. Wahren, J., and P. Felig. 1975. Renal substrate exchange in human diabetes mellitus. Diabetes. 24:730-734.
43. Dominquez, J., K. Camp, L. Maianu, H. Feister, and T. Garvey. 1994. Molecular adaptations of glut 1 and glut 2 in renal proximal tubules of diabetic rats. Am. J. Physiol. F283-290.
44. Chin, E., A. Zamah, D. Landau, H. Gronbek, A. Flyvbjerg, D. LeRoith, and C. Bondy. 1997. Changes in facilitative glucose transporter messenger rebonucleic acid levels in the diabetic rat kidney. Endocrinology. 138:1267-1275.
45. Mauer, S., M. Stoffes, E. Ellis, D. Sutherland, D. Brown, and F. Goetz. 1984. Structural-functional relationships in diabetic nephropathy. J. Clin. Invest. 74:1143-1155.
46. Danne, T., M. Spiro, and R. Spiro. 1993. Effects of high glucose on type IV collagen production by cultured glomerular epithelial, endothelial and mesangial cells. Diabetes. 42:170-177.
47. Heilig, C., L. Concipcion, B. Riser, S. Freytog, M. Zhu, and P. Corts. 1995. Overexpression of glucose transporters in rate mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype. J. Clin. Invest. 96:1802-1814.
48. Craven, P., and F. DeRubertis. 1989. Protein kinase C is activated in glomeruli from streptozotocin diabetic rats: possible mediation by glucose. J. Clin. Invest. 83:1667-1675.
49. Brownlee, M. 1992. Glycation products and the pathogenesis of diabetic complications. Diabetes Care. 15:1835-1843.
50. Reaven, G. 1995. The fourth musketeer - from Alexandre Dumas to Claude Bernard. Diabetologia. 38:3-13.