Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease

Cell Metabolism

Volumn 14, Issue 6, 2011, Pages 804-810

  Sunny, Nishanth E ^a   Parks, Elizabeth J ^a,b   Browning, Jeffrey D ^a   Burgess, Shawn C ^a,c  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 13; DEUTERIUM; TRIACYLGLYCEROL;

ADULT; AEROBIC METABOLISM; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; GLUCONEOGENESIS; HUMAN; IN VIVO STUDY; KETOGENESIS; LIPOLYSIS; LIVER INJURY; LIVER METABOLISM; MALE; MITOCHONDRIAL RESPIRATION; NONALCOHOLIC FATTY LIVER; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADULT; AFRICAN AMERICANS; CARBON ISOTOPES; CITRIC ACID CYCLE; DEUTERIUM; FATTY LIVER; FEMALE; GLUCONEOGENESIS; GLUCOSE; HISPANIC AMERICANS; HUMANS; LIPOLYSIS; LIVER; MALE; MIDDLE AGED; MITOCHONDRIA;

EID: 82955239838     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2011.11.004     Document Type: Article

References (46)

1. B.R. Barrows, and E.J. Parks Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states J. Clin. Endocrinol. Metab. 91 2006 1446 1452
2. A. Bickerton, R. Roberts, B. Fielding, H. Tornqvist, E. Blaak, A. Wagenmakers, M. Gilbert, S. Humphreys, F. Karpe, and K. Frayn Adipose tissue fatty acid metabolism in insulin-resistant men Diabetologia 51 2008 1466 1474
3. R.C. Boston, D. Stefanovski, P.J. Moate, A.E. Sumner, R.M. Watanabe, and R.N. Bergman MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test Diabetes Technol. Ther. 5 2003 1003 1015 (Pubitemid 38009940)
4. J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J. Clin. Invest. 114 2004 147 152 (Pubitemid 39071617)
5. J.D. Browning, L.S. Szczepaniak, R. Dobbins, P. Nuremberg, J.D. Horton, J.C. Cohen, S.M. Grundy, and H.H. Hobbs Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity Hepatology 40 2004 1387 1395 (Pubitemid 39657013)
6. J.D. Browning, B. Weis, J. Davis, S. Satapati, M. Merritt, C.R. Malloy, and S.C. Burgess Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction Hepatology 48 2008 1487 1496
7. S.H. Caldwell, L.A.R. de Freitas, S.H. Park, M.L.V. Moreno, J.A. Redick, C.A. Davis, B.J. Sisson, J.T. Patrie, H. Cotrim, and C.K. Argo Intramitochondrial crystalline inclusions in nonalcoholic steatohepatitis Hepatology 49 2009 1888 1895
8. X. Chen, N. Iqbal, and G. Boden The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects J. Clin. Invest. 103 1999 365 372 (Pubitemid 29069986)
9. S.H. Choi, and H.N. Ginsberg Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance Trends Endocrinol. Metab. 22 2011 353 363
10. J.M. Clark, F.L. Brancati, and A.M. Diehl Nonalcoholic fatty liver disease Gastroenterology 122 2002 1649 1657 (Pubitemid 34533559)
11. H. Cortez-Pinto, J. Chatham, V.P. Chacko, C. Arnold, A. Rashid, and A.M. Diehl Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis JAMA 282 1999 1659 1664 (Pubitemid 29513973)
12. C.P. Day, and O.F. James Steatohepatitis: a tale of two "hits"? Gastroenterology 114 1998 842 845
13. R.A. DeFronzo Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM Diabetes 37 1988 667 687
14. A.M. Diehl, Z.P. Li, H.Z. Lin, and S.Q. Yang Cytokines and the pathogenesis of non-alcoholic steatohepatitis Gut 54 2005 303 306 (Pubitemid 40139250)
15. F. Diraison, P. Moulin, and M. Beylot Contribution of hepatic de novo lipogenesis and reesterification of plasma nonesterified fatty acids to plasma triglyceride synthesis during non-alcoholic fatty liver disease Diabetes Metab. 29 2003 478 485 (Pubitemid 37474259)
16. K.L. Donnelly, C.I. Smith, S.J. Schwarzenberg, J. Jessurun, M.D. Boldt, and E.J. Parks Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease J. Clin. Invest. 115 2005 1343 1351 (Pubitemid 40629054)
17. E. Fabbrini, B.S. Mohammed, F. Magkos, K.M. Korenblat, B.W. Patterson, and S. Klein Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease Gastroenterology 134 2008 424 431 (Pubitemid 351173050)
18. S.M. Grundy, H.B. Brewer, J.I. Cleeman, S.C. Smith, and C. Lenfant Definition of metabolic syndrome Circulation 109 2004 433 438
19. R. Guerrero, G.L. Vega, S.M. Grundy, and J.D. Browning Ethnic differences in hepatic steatosis: an insulin resistance paradox? Hepatology 49 2009 791 801
20. P. Iozzo, M. Bucci, A. Roivainen, K. Nagren, M.J. Jarvisalo, J. Kiss, L. Guiducci, B. Fielding, A.G. Naum, and R. Borra Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals Gastroenterology 139 2010 846 856
21. J.G. Jones, M.A. Solomon, S.M. Cole, A.D. Sherry, and C.R. Malloy An integrated (2)H and (13)C NMR study of gluconeogenesis and TCA cycle flux in humans Am. J. Physiol. Endocrinol. Metab. 281 2001 E848 E856
22. D.E. Kelley, J. He, E.V. Menshikova, and V.B. Ritov Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes Diabetes 51 2002 2944 2950
23. B. Kucejova, N.E. Sunny, A.D. Nguyen, R. Hallac, X. Fu, S. Pena-Llopis, R.P. Mason, R.J. Deberardinis, X.J. Xie, and R. Debose-Boyd Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death Oncogene 30 2011 2147 2160
24. T.K.T. Lam, H. Yoshii, C.A. Haber, E. Bogdanovic, L. Lam, I.G. Fantus, and A. Giacca Free fatty acid-induced hepatic insulin resistance: a potential role for protein kinase C-delta Am. J. Physiol. Endocrinol. Metab. 283 2002 E682 E691
25. B.R. Landau, W.C. Schumann, V. Chandramouli, I. Magnusson, K. Kumaran, and J. Wahren 14C-labeled propionate metabolism in vivo and estimates of hepatic gluconeogenesis relative to Krebs cycle flux Am. J. Physiol. Endocrinol. Metab. 265 1993 E636 E647
26. B.R. Landau, J. Wahren, V. Chandramouli, W.C. Schumann, K. Ekberg, and S.C. Kalhan Use of 2H2O for estimating rates of gluconeogenesis. Application to the fasted state J. Clin. Invest. 95 1995 172 178
27. I. Magnusson, W.C. Schumann, G.E. Bartsch, V. Chandramouli, K. Kumaran, J. Wahren, and B.R. Landau Noninvasive tracing of Krebs cycle metabolism in liver J. Biol. Chem. 266 1991 6975 6984 (Pubitemid 21906320)
28. J.D. McGarry, and D.W. Foster Regulation of hepatic fatty acid oxidation and ketone body production Annu. Rev. Biochem. 49 1980 395 420
29. D.M. Muoio, and C.B. Newgard Molecular and metabolic mechanisms of insulin resistance and [beta]-cell failure in type 2 diabetes Nat. Rev. Mol. Cell Biol. 9 2008 193 205 (Pubitemid 351301824)
30. B.A. Neuschwander-Tetri, and S.H. Caldwell Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference Hepatology 37 2003 1202 1219 (Pubitemid 36538699)
31. M. Pérez-Carreras, P.D. Hoyo, M.A. Martín, J.C. Rubio, A. Martín, G. Castellano, F. Colina, J. Arenas, and J.A. Solis-Herruzo Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis Hepatology 38 2003 999 1007 (Pubitemid 37221683)
32. D. Pessayre, and B. Fromenty NASH: a mitochondrial disease J. Hepatol. 42 2005 928 940 (Pubitemid 40693212)
33. K.F. Petersen, S. Dufour, D. Befroy, R. Garcia, and G.I. Shulman Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N. Engl. J. Med. 350 2004 664 671 (Pubitemid 38364625)
34. M. Roden, H. Stingl, V. Chandramouli, W. Schumann, A. Hofer, B. Landau, P. Nowotny, W. Waldhausl, and G. Shulman Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans Diabetes 49 2000 701 707 (Pubitemid 30339983)
35. V.T. Samuel, Z.-X. Liu, X. Qu, B.D. Elder, S. Bilz, D. Befroy, A.J. Romanelli, and G.I. Shulman Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease J. Biol. Chem. 279 2004 32345 32353 (Pubitemid 39014687)
36. A.J. Sanyal, C. Campbell-Sargent, F. Mirshahi, W.B. Rizzo, M.J. Contos, R.K. Sterling, V.A. Luketic, M.L. Shiffman, and J.N. Clore Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183 1192 (Pubitemid 32246672)
37. S. Satapati, T. He, T. Inagaki, M. Potthoff, M.E. Merritt, V. Esser, D.J. Mangelsdorf, S.A. Kliewer, J.D. Browning, and S.C. Burgess Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism Diabetes 57 2008 2012 2021
38. D.B. Savage, K.F. Petersen, and G.I. Shulman Disordered lipid metabolism and the pathogenesis of insulin resistance Physiol. Rev. 87 2007 507 520 (Pubitemid 47084679)
39. P.S. Schofield, M.C. Sugden, C.G. Corstorphine, and V.A. Zammit Altered interactions between lipogenesis and fatty acid oxidation in regenerating rat liver Biochem. J. 241 1987 469 474 (Pubitemid 17234184)
40. G. Serviddio, F. Bellanti, R. Tamborra, T. Rollo, N. Capitanio, A.D. Romano, J. Sastre, G. Vendemiale, and E. Altomare Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury Gut 57 2008 957 965 (Pubitemid 351919530)
41. L.M. Sparks, H. Xie, R.A. Koza, R. Mynatt, M.W. Hulver, G.A. Bray, and S.R. Smith A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle Diabetes 54 2005 1926 1933 (Pubitemid 40911253)
42. P. Staehr, O. Hother-Nielsen, B.R. Landau, V. Chandramouli, J.J. Holst, and H. Beck-Nielsen Effects of free fatty acids per se on glucose production, gluconeogenesis, and glycogenolysis Diabetes 52 2003 260 267 (Pubitemid 36173177)
43. J. Szendroedi, M. Chmelik, A.I. Schmid, P. Nowotny, A. Brehm, M. Krssak, E. Moser, and M. Roden Abnormal hepatic energy homeostasis in type 2 diabetes Hepatology 50 2009 1079 1086
44. P. Walter, V. Paetkau, and H.A. Lardy Paths of carbon in gluconeogenesis and lipogenesis J. Biol. Chem. 241 1966 2523 2532
45. Y. Wei, R.S. Rector, J.P. Thyfault, and J.A. Ibdah Nonalcoholic fatty liver disease and mitochondrial dysfunction World J. Gastroenterol. 14 2008 193 199 (Pubitemid 351314298)
46. D. Zhang, Z.X. Liu, C.S. Choi, L. Tian, R. Kibbey, J. Dong, G.W. Cline, P.A. Wood, and G.I. Shulman Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance Proc. Natl. Acad. Sci. USA 104 2007 17075 17080 (Pubitemid 350210994)