-
1
-
-
0141727772
-
Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice
-
Altomonte J, Richter A, Harbaran S, Suriawinata J, Nakae J, Thung SN, Meseck M, Accili D, Dong H. Inhibition of Foxo1 function is associated with improved fasting glycemia in diabetic mice. Am J Physiol Endocrinol Metab 285: E718-E728, 2003.
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
-
-
Altomonte, J.1
Richter, A.2
Harbaran, S.3
Suriawinata, J.4
Nakae, J.5
Thung, S.N.6
Meseck, M.7
Accili, D.8
Dong, H.9
-
2
-
-
52749091816
-
SirT1 gain of function increases energy efficiency and prevents diabetes in mice
-
Banks AS, Kon N, Knight C, Matsumoto M, Gutierrez-Juarez R, Rossetti L, Gu W, Accili D. SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab 8: 333-341, 2008.
-
(2008)
Cell Metab
, vol.8
, pp. 333-341
-
-
Banks, A.S.1
Kon, N.2
Knight, C.3
Matsumoto, M.4
Gutierrez-Juarez, R.5
Rossetti, L.6
Gu, W.7
Accili, D.8
-
3
-
-
77949493599
-
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5
-
Caton PW, Nayuni N, Kieswich J, Khan N, Yaqoob M, Corder R. Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5. J Endocrinol 205: 97-106, 2010.
-
(2010)
J Endocrinol
, vol.205
, pp. 97-106
-
-
Caton, P.W.1
Nayuni, N.2
Kieswich, J.3
Khan, N.4
Yaqoob, M.5
Corder, R.6
-
4
-
-
43449097571
-
Molecular basis of endocrine regulation by orphan nuclear receptor small heterodimer partner
-
DOI 10.1507/endocrj.K07E-103
-
Chanda D, Park JH, Choi HS. Molecular basis of endocrine regulation by orphan nuclear receptor small heterodimer partner. Endocr J 55: 253-268, 2008. (Pubitemid 351670949)
-
(2008)
Endocrine Journal
, vol.55
, Issue.2
, pp. 253-268
-
-
Chanda, D.1
Park, J.-H.2
Choi, H.-S.3
-
5
-
-
77955573162
-
Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
-
Chanda D, Xie YB, Choi HS. Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation. Nucleic Acids Res 38: 4607-4619 2010.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 4607-4619
-
-
Chanda, D.1
Xie, Y.B.2
Choi, H.S.3
-
6
-
-
46249100836
-
Tissue-specific regulation of SIRT1 by calorie restriction
-
DOI 10.1101/gad.1650608
-
Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L. Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev 22: 1753-1757, 2008. (Pubitemid 351915500)
-
(2008)
Genes and Development
, vol.22
, Issue.13
, pp. 1753-1757
-
-
Chen, D.1
Bruno, J.2
Easlon, E.3
Lin, S.-J.4
Cheng, H.-L.5
Alt, F.W.6
Guarente, L.7
-
7
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA 100: 10794-10799, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
Manis, J.P.4
Gu, Y.5
Patel, P.6
Bronson, R.7
Appella, E.8
Alt, F.W.9
Chua, K.F.10
-
8
-
-
77958488312
-
SIRT1 activation by small molecules: Kinetic and biophysical evidence for direct interaction of enzyme and activator
-
Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL. SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. J Biol Chem 285: 32695-32703, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 32695-32703
-
-
Dai, H.1
Kustigian, L.2
Carney, D.3
Case, A.4
Considine, T.5
Hubbard, B.P.6
Perni, R.B.7
Riera, T.V.8
Szczepankiewicz, B.9
Vlasuk, G.P.10
Stein, R.L.11
-
9
-
-
0037342151
-
Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR
-
Daitoku H, Yamagata K, Matsuzaki H, Hatta M, Fukamizu A. Regulation of PGC-1 promoter activity by protein kinase B and the forkhead transcription factor FKHR. Diabetes 52: 642-649, 2003.
-
(2003)
Diabetes
, vol.52
, pp. 642-649
-
-
Daitoku, H.1
Yamagata, K.2
Matsuzaki, H.3
Hatta, M.4
Fukamizu, A.5
-
10
-
-
77449140027
-
Current issues in the treatment of type 2 diabetes. Overview of newer agents: Where treatment is going
-
DeFronzo RA. Current issues in the treatment of type 2 diabetes. Overview of newer agents: where treatment is going. Am J Med 123: S38-S48, 2010.
-
(2010)
Am J Med
, vol.123
-
-
DeFronzo, R.A.1
-
11
-
-
34548831102
-
Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
-
Dentin R, Liu Y, Koo SH, Hedrick S, Vargas T, Heredia J, Yates J 3rd, Montminy M. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449: 366-369, 2007.
-
(2007)
Nature
, vol.449
, pp. 366-369
-
-
Dentin, R.1
Liu, Y.2
Koo, S.H.3
Hedrick, S.4
Vargas, T.5
Heredia, J.6
Yates III, J.7
Montminy, M.8
-
12
-
-
45549090182
-
Inactivation of Hepatic Foxo1 by Insulin Signaling Is Required for Adaptive Nutrient Homeostasis and Endocrine Growth Regulation
-
DOI 10.1016/j.cmet.2008.06.006, PII S1550413108001770
-
Dong XC, Copps KD, Guo S, Li Y, Kollipara R, Depinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab 8: 65-76, 2008. (Pubitemid 351863393)
-
(2008)
Cell Metabolism
, vol.8
, Issue.1
, pp. 65-76
-
-
Dong, X.C.1
Copps, K.D.2
Guo, S.3
Li, Y.4
Kollipara, R.5
DePinho, R.A.6
White, M.F.7
-
13
-
-
67650488877
-
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
-
Erion DM, Yonemitsu S, Nie Y, Nagai Y, Gillum MP, Hsiao JJ, Iwasaki T, Stark R, Weismann D, Yu XX, Murray SF, Bhanot S, Monia BP, Horvath TL, Gao Q, Samuel VT, Shulman GI. SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats. Proc Natl Acad Sci USA 106: 11288-11293, 2009.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 11288-11293
-
-
Erion, D.M.1
Yonemitsu, S.2
Nie, Y.3
Nagai, Y.4
Gillum, M.P.5
Hsiao, J.J.6
Iwasaki, T.7
Stark, R.8
Weismann, D.9
Yu, X.X.10
Murray, S.F.11
Bhanot, S.12
Monia, B.P.13
Horvath, T.L.14
Gao, Q.15
Samuel, V.T.16
Shulman, G.I.17
-
14
-
-
54849425547
-
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation
-
Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 8: 347-358, 2008.
-
(2008)
Cell Metab
, vol.8
, pp. 347-358
-
-
Feige, J.N.1
Lagouge, M.2
Canto, C.3
Strehle, A.4
Houten, S.M.5
Milne, J.C.6
Lambert, P.D.7
Mataki, C.8
Elliott, P.J.9
Auwerx, J.10
-
15
-
-
20144365700
-
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
-
Frescas D, Valenti L, Accili D. Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem 280: 20589-20595, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 20589-20595
-
-
Frescas, D.1
Valenti, L.2
Accili, D.3
-
16
-
-
0036889153
-
Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure
-
DOI 10.1128/MCB.22.23.8302-8319.2002
-
Ghoshal K, Datta J, Majumder S, Bai S, Dong X, Parthun M, Jacob ST. Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Mol Cell Biol 22: 8302-8319, 2002. (Pubitemid 35304062)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.23
, pp. 8302-8319
-
-
Ghoshal, K.1
Datta, J.2
Majumder, S.3
Bai, S.4
Dong, X.5
Parthun, M.6
Jacob, S.T.7
-
17
-
-
77949887506
-
Mammalian sirtuins: Biological insights and disease relevance
-
Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5: 253-295, 2010.
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
18
-
-
0036377351
-
Regulation of the activity of the pyruvate dehydrogenase complex
-
DOI 10.1016/S0065-2571(01)00061-9, PII S0065257101000619
-
Harris RA, Bowker-Kinley MM, Huang B, Wu P. Regulation of the activity of the pyruvate dehydrogenase complex. Adv Enzyme Regul 42: 249-259, 2002. (Pubitemid 35033542)
-
(2002)
Advances in Enzyme Regulation
, vol.42
, pp. 249-259
-
-
Harris, R.A.1
Bowker-Kinley, M.M.2
Huang, B.3
Wu, P.4
-
19
-
-
11144357516
-
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
-
Inoue H, Ogawa W, Ozaki M, Haga S, Matsumoto M, Furukawa K, Hashimoto N, Kido Y, Mori T, Sakaue H, Teshigawara K, Jin S, Iguchi H, Hiramatsu R, LeRoith D, Takeda K, Akira S, Kasuga M. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat Med 10: 168-174, 2004.
-
(2004)
Nat Med
, vol.10
, pp. 168-174
-
-
Inoue, H.1
Ogawa, W.2
Ozaki, M.3
Haga, S.4
Matsumoto, M.5
Furukawa, K.6
Hashimoto, N.7
Kido, Y.8
Mori, T.9
Sakaue, H.10
Teshigawara, K.11
Jin, S.12
Iguchi, H.13
Hiramatsu, R.14
LeRoith, D.15
Takeda, K.16
Akira, S.17
Kasuga, M.18
-
20
-
-
70350606061
-
FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states
-
Kemper JK, Xiao Z, Ponugoti B, Miao J, Fang S, Kanamaluru D, Tsang S, Wu SY, Chiang CM, Veenstra TD. FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states. Cell Metab 10: 392-404, 2009.
-
(2009)
Cell Metab
, vol.10
, pp. 392-404
-
-
Kemper, J.K.1
Xiao, Z.2
Ponugoti, B.3
Miao, J.4
Fang, S.5
Kanamaluru, D.6
Tsang, S.7
Wu, S.Y.8
Chiang, C.M.9
Veenstra, T.D.10
-
21
-
-
27744518040
-
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction
-
Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W, Accili D. FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction. Cell Metab 2: 153-163, 2005.
-
(2005)
Cell Metab
, vol.2
, pp. 153-163
-
-
Kitamura, Y.I.1
Kitamura, T.2
Kruse, J.P.3
Raum, J.C.4
Stein, R.5
Gu, W.6
Accili, D.7
-
22
-
-
1842475551
-
Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors
-
Kwon HS, Huang B, Unterman TG, Harris RA. Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors. Diabetes 53: 899-910, 2004.
-
(2004)
Diabetes
, vol.53
, pp. 899-910
-
-
Kwon, H.S.1
Huang, B.2
Unterman, T.G.3
Harris, R.A.4
-
23
-
-
77957768686
-
AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB/CRTC2 complex by orphan nuclear receptor SHP
-
Lee JM, Seo WY, Song KH, Chanda D, Kim YD, Kim DK, Lee MW, Ryu D, Kim YH, Noh JR, Lee CH, Chiang JY, Koo SH, Choi HS. AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB/CRTC2 complex by orphan nuclear receptor SHP. J Biol Chem 285: 32182-32191, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 32182-32191
-
-
Lee, J.M.1
Seo, W.Y.2
Song, K.H.3
Chanda, D.4
Kim, Y.D.5
Kim, D.K.6
Lee, M.W.7
Ryu, D.8
Kim, Y.H.9
Noh, J.R.10
Lee, C.H.11
Chiang, J.Y.12
Koo, S.H.13
Choi, H.S.14
-
24
-
-
9644260563
-
Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes
-
Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest 114: 908-916, 2004.
-
(2004)
J Clin Invest
, vol.114
, pp. 908-916
-
-
Lin, X.1
Taguchi, A.2
Park, S.3
Kushner, J.A.4
Li, F.5
Li, Y.6
White, M.F.7
-
25
-
-
56249100986
-
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
-
Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J III, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 456: 269-273, 2008.
-
(2008)
Nature
, vol.456
, pp. 269-273
-
-
Liu, Y.1
Dentin, R.2
Chen, D.3
Hedrick, S.4
Ravnskjaer, K.5
Schenk, S.6
Milne, J.7
Meyers, D.J.8
Cole, P.9
Yates III, J.10
Olefsky, J.11
Guarente, L.12
Montminy, M.13
-
26
-
-
34548349302
-
Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
-
Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab 6: 208-216, 2007.
-
(2007)
Cell Metab
, vol.6
, pp. 208-216
-
-
Matsumoto, M.1
Pocai, A.2
Rossetti, L.3
Depinho, R.A.4
Accili, D.5
-
27
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450: 712-716, 2007.
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
Gagne, D.J.6
Jin, L.7
Boss, O.8
Perni, R.B.9
Vu, C.B.10
Bemis, J.E.11
Xie, R.12
Disch, J.S.13
Ng, P.Y.14
Nunes, J.J.15
Lynch, A.V.16
Yang, H.17
Galonek, H.18
Israelian, K.19
Choy, W.20
Iffland, A.21
Lavu, S.22
Medvedik, O.23
Sinclair, D.A.24
Olefsky, J.M.25
Jirousek, M.R.26
Elliott, P.J.27
Westphal, C.H.28
more..
-
28
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L. Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563, 2004.
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
Kamel, C.4
Chen, D.5
Gu, W.6
Bultsma, Y.7
McBurney, M.8
Guarente, L.9
-
29
-
-
0035185021
-
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
-
Nakae J, Kitamura T, Silver DL, Accili D. The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 108: 1359-1367, 2001.
-
(2001)
J Clin Invest
, vol.108
, pp. 1359-1367
-
-
Nakae, J.1
Kitamura, T.2
Silver, D.L.3
Accili, D.4
-
30
-
-
64049109876
-
STAT3 inhibition of gluconeogenesis is downregulated by SirT1
-
Nie Y, Erion DM, Yuan Z, Dietrich M, Shulman GI, Horvath TL, Gao Q. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol 11: 492-500, 2009.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 492-500
-
-
Nie, Y.1
Erion, D.M.2
Yuan, Z.3
Dietrich, M.4
Shulman, G.I.5
Horvath, T.L.6
Gao, Q.7
-
31
-
-
33751547223
-
Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin
-
Onuma H, Vander Kooi BT, Boustead JN, Oeser JK, O'Brien RM. Correlation between FOXO1a (FKHR) and FOXO3a (FKHRL1) binding and the inhibition of basal glucose-6-phosphatase catalytic subunit gene transcription by insulin. Mol Endocrinol 20: 2831-2847, 2006.
-
(2006)
Mol Endocrinol
, vol.20
, pp. 2831-2847
-
-
Onuma, H.1
Vander Kooi, B.T.2
Boustead, J.N.3
Oeser, J.K.4
O'Brien, R.M.5
-
32
-
-
77950246109
-
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
-
Pacholec M, Chrunyk BA, Cunningham D, Flynn D, Griffith DA, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285: 8340-8351, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 8340-8351
-
-
Pacholec, M.1
Chrunyk, B.A.2
Cunningham, D.3
Flynn, D.4
Griffith, D.A.5
Griffor, M.6
Loulakis, P.7
Pabst, B.8
Qiu, X.9
Stockman, B.10
Thanabal, V.11
Varghese, A.12
Ward, J.13
Withka, J.14
Ahn, K.15
-
33
-
-
33947194446
-
Transcriptional repression of the gluconeogenic gene PEPCK by the orphan nuclear receptor SHP through inhibitory interaction with C/EB-Palpha
-
Park MJ, Kong HJ, Kim HY, Kim HH, Kim JH, Cheong JH. Transcriptional repression of the gluconeogenic gene PEPCK by the orphan nuclear receptor SHP through inhibitory interaction with C/EB-Palpha. Biochem J 402: 567-574, 2007.
-
(2007)
Biochem J
, vol.402
, pp. 567-574
-
-
Park, M.J.1
Kong, H.J.2
Kim, H.Y.3
Kim, H.H.4
Kim, J.H.5
Cheong, J.H.6
-
34
-
-
47749128879
-
Sirt1 protects against high-fat diet-induced metabolic damage
-
Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschop MH. Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci USA 105: 9793-9798, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 9793-9798
-
-
Pfluger, P.T.1
Herranz, D.2
Velasco-Miguel, S.3
Serrano, M.4
Tschop, M.H.5
-
35
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
-
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423: 550-555, 2003.
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
Rhee, J.2
Donovan, J.3
Walkey, C.J.4
Yoon, J.C.5
Oriente, F.6
Kitamura, Y.7
Altomonte, J.8
Dong, H.9
Accili, D.10
Spiegelman, B.M.11
-
36
-
-
77955948260
-
SIRT1 performs a balancing act on the tight-rope toward longevity
-
Purushotham A, Schug TT, Li X. SIRT1 performs a balancing act on the tight-rope toward longevity. Aging (Albany NY) 1: 669-673, 2009.
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 669-673
-
-
Purushotham, A.1
Schug, T.T.2
Li, X.3
-
37
-
-
63449112017
-
Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
-
Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 9: 327-338, 2009.
-
(2009)
Cell Metab
, vol.9
, pp. 327-338
-
-
Purushotham, A.1
Schug, T.T.2
Xu, Q.3
Surapureddi, S.4
Guo, X.5
Li, X.6
-
38
-
-
33747725908
-
CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase
-
DOI 10.1074/jbc.M603038200
-
Qiao L, Macdougald OA, Shao J. CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase. J Biol Chem 281: 24390-24397, 2006. (Pubitemid 44274211)
-
(2006)
Journal of Biological Chemistry
, vol.281
, Issue.34
, pp. 24390-24397
-
-
Qiao, L.1
MacDougald, O.A.2
Shao, J.3
-
39
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434: 113-118, 2005.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
Gygi, S.P.4
Spiegelman, B.M.5
Puigserver, P.6
-
40
-
-
34547906123
-
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
-
Rodgers JT, Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci USA 104: 12861-12866, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12861-12866
-
-
Rodgers, J.T.1
Puigserver, P.2
-
41
-
-
34248581989
-
Disordered lipid metabolism and the pathogenesis of insulin resistance
-
Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev 87: 507-520, 2007.
-
(2007)
Physiol Rev
, vol.87
, pp. 507-520
-
-
Savage, D.B.1
Petersen, K.F.2
Shulman, G.I.3
-
42
-
-
33749545356
-
Gluconeogenesis: Re-evaluating the FOXO1-PGC-1alpha connection
-
Schilling MM, Oeser JK, Boustead JN, Flemming BP, O'Brien RM. Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection. Nature 443: E10-E11, 2006.
-
(2006)
Nature
, vol.443
-
-
Schilling, M.M.1
Oeser, J.K.2
Boustead, J.N.3
Flemming, B.P.4
O'Brien, R.M.5
-
43
-
-
0036634105
-
Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia
-
Sugden MC, Holness MJ. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Curr Drug Targets Immune Endocr Metabol Disord 2: 151-165, 2002.
-
(2002)
Curr Drug Targets Immune Endocr Metabol Disord
, vol.2
, pp. 151-165
-
-
Sugden, M.C.1
Holness, M.J.2
-
44
-
-
0033324782
-
The phosphoenolpyruvate carboxykinase gene glucocorticoid response unit: Identification of the functional domains of accessory factors HNF3 beta (hepatic nuclear factor-3 beta) and HNF4 and the necessity of proper alignment of their cognate binding sites
-
Wang JC, Stromstedt PE, Sugiyama T, Granner DK. The phosphoenolpyruvate carboxykinase gene glucocorticoid response unit: identification of the functional domains of accessory factors HNF3 beta (hepatic nuclear factor-3 beta) and HNF4 and the necessity of proper alignment of their cognate binding sites. Mol Endocrinol 13: 604-618, 1999.
-
(1999)
Mol Endocrinol
, vol.13
, pp. 604-618
-
-
Wang, J.C.1
Stromstedt, P.E.2
Sugiyama, T.3
Granner, D.K.4
-
46
-
-
33947530431
-
p38 Mitogen-activated protein kinase plays an inhibitory role in hepatic lipogenesis
-
Xiong Y, Collins QF, An J, Lupo E Jr, Liu HY, Liu D, Robidoux J, Liu Z, Cao W. p38 Mitogen-activated protein kinase plays an inhibitory role in hepatic lipogenesis. J Biol Chem 282: 4975-4982, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 4975-4982
-
-
Xiong, Y.1
Collins, Q.F.2
An, J.3
Lupo Jr., E.4
Liu, H.Y.5
Liu, D.6
Robidoux, J.7
Liu, Z.8
Cao, W.9
-
47
-
-
2542435874
-
Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
-
Yamagata K, Daitoku H, Shimamoto Y, Matsuzaki H, Hirota K, Ishida J, Fukamizu A. Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1. J Biol Chem 279: 23158-23165, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 23158-23165
-
-
Yamagata, K.1
Daitoku, H.2
Shimamoto, Y.3
Matsuzaki, H.4
Hirota, K.5
Ishida, J.6
Fukamizu, A.7
-
48
-
-
34248592080
-
Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner
-
Yamagata K, Yoshimochi K, Daitoku H, Hirota K, Fukamizu A. Bile acid represses the peroxisome proliferator-activated receptor-gamma coactivator-1 promoter activity in a small heterodimer partner-dependent manner. Int J Mol Med 19: 751-756, 2007.
-
(2007)
Int J Mol Med
, vol.19
, pp. 751-756
-
-
Yamagata, K.1
Yoshimochi, K.2
Daitoku, H.3
Hirota, K.4
Fukamizu, A.5
-
49
-
-
11144354399
-
SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes
-
Yamamoto T, Shimano H, Nakagawa Y, Ide T, Yahagi N, Matsuzaka T, Nakakuki M, Takahashi A, Suzuki H, Sone H, Toyoshima H, Sato R, Yamada N. SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes. J Biol Chem 279: 12027-12035, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 12027-12035
-
-
Yamamoto, T.1
Shimano, H.2
Nakagawa, Y.3
Ide, T.4
Yahagi, N.5
Matsuzaka, T.6
Nakakuki, M.7
Takahashi, A.8
Suzuki, H.9
Sone, H.10
Toyoshima, H.11
Sato, R.12
Yamada, N.13
-
50
-
-
70350462145
-
What is the metabolic role of phosphoenolpyruvate carboxykinase?
-
Yang J, Kalhan SC, Hanson RW. What is the metabolic role of phosphoenolpyruvate carboxykinase? J Biol Chem 284: 27025-27029, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 27025-27029
-
-
Yang, J.1
Kalhan, S.C.2
Hanson, R.W.3
-
51
-
-
70350464163
-
Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha
-
Yang J, Kong X, Martins-Santos ME, Aleman G, Chaco E, Liu GE, Wu SY, Samols D, Hakimi P, Chiang CM, Hanson RW. Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alpha. J Biol Chem 284: 27042-27053, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 27042-27053
-
-
Yang, J.1
Kong, X.2
Martins-Santos, M.E.3
Aleman, G.4
Chaco, E.5
Liu, G.E.6
Wu, S.Y.7
Samols, D.8
Hakimi, P.9
Chiang, C.M.10
Hanson, R.W.11
-
52
-
-
0035855858
-
Control of hepatic gluconeogenesis through the transcriptional coaotivator PGC-1
-
DOI 10.1038/35093050
-
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413: 131-138, 2001. (Pubitemid 32867868)
-
(2001)
Nature
, vol.413
, Issue.6852
, pp. 131-138
-
-
Yoon, J.C.1
Puigserver, P.2
Chen, G.3
Donovan, J.4
Wu, Z.5
Rhee, J.6
Adelmant, G.7
Stafford, J.8
Kahn, C.R.9
Granner, D.K.10
Newgard, C.B.11
Spiegelman, B.M.12
-
53
-
-
70350441907
-
The role of sirtuins in the control of metabolic homeostasis
-
Yu J, Auwerx J. The role of sirtuins in the control of metabolic homeostasis. Ann NY Acad Sci 1173, Suppl 1: E10-E19, 2009.
-
(2009)
Ann NY Acad Sci
, vol.1173
, Issue.SUPPL. 1
-
-
Yu, J.1
Auwerx, J.2
-
54
-
-
33744515637
-
FoxO1 regulates multiple metabolic pathways in the liver: Effects on gluconeogenic, glycolytic, and lipogenic gene expression
-
Zhang W, Patil S, Chauhan B, Guo S, Powell DR, Le J, Klotsas A, Matika R, Xiao X, Franks R, Heidenreich KA, Sajan MP, Farese RV, Stolz DB, Tso P, Koo SH, Montminy M, Unterman TG. FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression. J Biol Chem 281: 10105-10117, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 10105-10117
-
-
Zhang, W.1
Patil, S.2
Chauhan, B.3
Guo, S.4
Powell, D.R.5
Le, J.6
Klotsas, A.7
Matika, R.8
Xiao, X.9
Franks, R.10
Heidenreich, K.A.11
Sajan, M.P.12
Farese, R.V.13
Stolz, D.B.14
Tso, P.15
Koo, S.H.16
Montminy, M.17
Unterman, T.G.18
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