SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

Journal of Biological Chemistry

Volumn 277, Issue 44, 2002, Pages 42394-42398

  Rui, Liangyou ^a,b   Yuan, Minsheng ^b   Frantz, Daniel ^b,c   Shoelson, Steven ^b   White, Morris F ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; GLUCOSE; INSULIN; PROTEINS; SIGNALING;

MUTATIONS;

BIOCHEMISTRY;

ADENOVIRUS VECTOR; CYTOKINE; ELONGATION FACTOR; ELONGIN BC; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LIGASE; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENE MUTATION; HORMONE ACTION; HUMAN; HUMAN CELL; INFLAMMATION; INSULIN RESISTANCE; LIVER LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; CARRIER PROTEINS; GLUCOSE; HOMEOSTASIS; HUMANS; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; PHOSPHOPROTEINS; PROTEINS; REPRESSOR PROTEINS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION FACTORS; UBIQUITIN;

ADENOVIRIDAE; ANIMALIA;

EID: 0036830636     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C200444200     Document Type: Article

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