Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

Nature Medicine

Volumn 16, Issue 10, 2010, Pages 1152-1156

  Zhang, Eric E ^a,b   Liu, Yi ^c,d   Dentin, Renaud ^c   Pongsawakul, Pagkapol Y ^a   Liu, Andrew C ^a,b,e   Hirota, Tsuyoshi ^a,b   Nusinow, Dmitri A ^a   Sun, Xiujie ^d   Landais, Severine ^c   Kodama, Yuzo ^f   Brenner, David A ^f   Montminy, Marc ^c   Kay, Steve A ^a  

^a SECTION OF CELL AND DEVELOPMENTAL BIOLOGY   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^e University of Memphis   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ADRENALIN; BETA GALACTOSIDASE; CREB REGULATED TRANSCRIPTION COACTIVATOR 2; CRYPTOCHROME 1; CRYPTOCHROME 2; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GLUCAGON; GLUCOSE; INSULIN; LUCIFERASE; LUCIFERIN; MELANOPSIN; MESSENGER RNA; PER 3 PROTEIN; PER1 PROTEIN; PER2 PROTEIN; PLASMID DNA; PROTEIN BMAL1; PYRUVATE SODIUM; REGULATOR PROTEIN; REPRESSOR PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR CLOCK; UNCLASSIFIED DRUG; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 2; CREB1 PROTEIN, MOUSE; CRY1 PROTEIN, MOUSE; CRY2 PROTEIN, MOUSE; CRYPTOCHROME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FRACTIONATION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DIET RESTRICTION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HORMONE ACTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIVER CELL CULTURE; LIVER METABOLISM; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; LIVER; METABOLISM; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; CIRCADIAN RHYTHM; CRYPTOCHROMES; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GLUCONEOGENESIS; LIVER; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

MAMMALIA; MUS;

EID: 77957821693     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2214     Document Type: Article

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