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Volumn 17, Issue 5, 2013, Pages 779-789

Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; FIBROBLAST GROWTH FACTOR 21; GLUCOSE;

EID: 84877260638     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.04.005     Document Type: Article
Times cited : (560)

References (50)
  • 2
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
    • M.K. Badman, P. Pissios, A.R. Kennedy, G. Koukos, J.S. Flier, and E. Maratos-Flier Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states Cell Metab. 5 2007 426 437
    • (2007) Cell Metab. , vol.5 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 3
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • A.H. Berg, T.P. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat. Med. 7 2001 947 953
    • (2001) Nat. Med. , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 5
    • 78049279362 scopus 로고    scopus 로고
    • Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway
    • J. Chang, Y. Li, Y. Huang, K.S. Lam, R.L. Hoo, W.T. Wong, K.K. Cheng, Y. Wang, P.M. Vanhoutte, and A. Xu Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway Diabetes 59 2010 2949 2959
    • (2010) Diabetes , vol.59 , pp. 2949-2959
    • Chang, J.1    Li, Y.2    Huang, Y.3    Lam, K.S.4    Hoo, R.L.5    Wong, W.T.6    Cheng, K.K.7    Wang, Y.8    Vanhoutte, P.M.9    Xu, A.10
  • 6
    • 77955434383 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway
    • M.D. Chau, J. Gao, Q. Yang, Z. Wu, and J. Gromada Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway Proc. Natl. Acad. Sci. USA 107 2010 12553 12558
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 12553-12558
    • Chau, M.D.1    Gao, J.2    Yang, Q.3    Wu, Z.4    Gromada, J.5
  • 7
    • 84855473367 scopus 로고    scopus 로고
    • High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: A 5.4-year population-based prospective study in Chinese subjects
    • C. Chen, B.M. Cheung, A.W. Tso, Y. Wang, L.S. Law, K.L. Ong, N.M. Wat, A. Xu, and K.S. Lam High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects Diabetes Care 34 2011 2113 2115
    • (2011) Diabetes Care , vol.34 , pp. 2113-2115
    • Chen, C.1    Cheung, B.M.2    Tso, A.W.3    Wang, Y.4    Law, L.S.5    Ong, K.L.6    Wat, N.M.7    Xu, A.8    Lam, K.S.9
  • 8
    • 80053409251 scopus 로고    scopus 로고
    • Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes
    • W. Chen, R.L. Hoo, M. Konishi, N. Itoh, P.C. Lee, H.Y. Ye, K.S. Lam, and A. Xu Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes J. Biol. Chem. 286 2011 34559 34566
    • (2011) J. Biol. Chem. , vol.286 , pp. 34559-34566
    • Chen, W.1    Hoo, R.L.2    Konishi, M.3    Itoh, N.4    Lee, P.C.5    Ye, H.Y.6    Lam, K.S.7    Xu, A.8
  • 10
    • 84865422329 scopus 로고    scopus 로고
    • TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: Involvement of JNK1 in the FGF21 pathway
    • J. Díaz-Delfín, E. Hondares, R. Iglesias, M. Giralt, C. Caelles, and F. Villarroya TNF-α represses β-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway Endocrinology 153 2012 4238 4245
    • (2012) Endocrinology , vol.153 , pp. 4238-4245
    • Díaz-Delfín, J.1    Hondares, E.2    Iglesias, R.3    Giralt, M.4    Caelles, C.5    Villarroya, F.6
  • 12
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones
    • P.A. Dutchak, T. Katafuchi, A.L. Bookout, J.H. Choi, R.T. Yu, D.J. Mangelsdorf, and S.A. Kliewer Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones Cell 148 2012 556 567
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3    Choi, J.H.4    Yu, R.T.5    Mangelsdorf, D.J.6    Kliewer, S.A.7
  • 16
    • 80053428117 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes
    • X. Ge, C. Chen, X. Hui, Y. Wang, K.S. Lam, and A. Xu Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes J. Biol. Chem. 286 2011 34533 34541
    • (2011) J. Biol. Chem. , vol.286 , pp. 34533-34541
    • Ge, X.1    Chen, C.2    Hui, X.3    Wang, Y.4    Lam, K.S.5    Xu, A.6
  • 18
    • 70349324370 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver
    • Y. Hotta, H. Nakamura, M. Konishi, Y. Murata, H. Takagi, S. Matsumura, K. Inoue, T. Fushiki, and N. Itoh Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver Endocrinology 150 2009 4625 4633
    • (2009) Endocrinology , vol.150 , pp. 4625-4633
    • Hotta, Y.1    Nakamura, H.2    Konishi, M.3    Murata, Y.4    Takagi, H.5    Matsumura, S.6    Inoue, K.7    Fushiki, T.8    Itoh, N.9
  • 20
    • 0037677767 scopus 로고    scopus 로고
    • Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors
    • M. Iwaki, M. Matsuda, N. Maeda, T. Funahashi, Y. Matsuzawa, M. Makishima, and I. Shimomura Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors Diabetes 52 2003 1655 1663
    • (2003) Diabetes , vol.52 , pp. 1655-1663
    • Iwaki, M.1    Matsuda, M.2    Maeda, N.3    Funahashi, T.4    Matsuzawa, Y.5    Makishima, M.6    Shimomura, I.7
  • 21
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, and K. Tobe Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome J. Clin. Invest. 116 2006 1784 1792
    • (2006) J. Clin. Invest. , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 27
    • 82255173963 scopus 로고    scopus 로고
    • Hypoadiponectinemia predicts impaired endothelium-independent vasodilation in newly diagnosed type 2 diabetic patients: An 8-year prospective study
    • H. Li, Y. Xiao, H. Liu, X.Y. Chen, X.Y. Li, W.L. Tang, S.P. Liu, A.M. Xu, and Z.G. Zhou Hypoadiponectinemia predicts impaired endothelium-independent vasodilation in newly diagnosed type 2 diabetic patients: an 8-year prospective study Chin. Med. J. (Engl.) 124 2011 3607 3612
    • (2011) Chin. Med. J. (Engl.) , vol.124 , pp. 3607-3612
    • Li, H.1    Xiao, Y.2    Liu, H.3    Chen, X.Y.4    Li, X.Y.5    Tang, W.L.6    Liu, S.P.7    Xu, A.M.8    Zhou, Z.G.9
  • 28
    • 84859529243 scopus 로고    scopus 로고
    • Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3
    • H. Li, Z. Gao, J. Zhang, X. Ye, A. Xu, J. Ye, and W. Jia Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3 Diabetes 61 2012 797 806
    • (2012) Diabetes , vol.61 , pp. 797-806
    • Li, H.1    Gao, Z.2    Zhang, J.3    Ye, X.4    Xu, A.5    Ye, J.6    Jia, W.7
  • 30
    • 72449141637 scopus 로고    scopus 로고
    • Transcriptional and post-translational regulation of adiponectin
    • M. Liu, and F. Liu Transcriptional and post-translational regulation of adiponectin Biochem. J. 425 2010 41 52
    • (2010) Biochem. J. , vol.425 , pp. 41-52
    • Liu, M.1    Liu, F.2
  • 32
    • 0037144394 scopus 로고    scopus 로고
    • Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin
    • K. Ma, A. Cabrero, P.K. Saha, H. Kojima, L. Li, B.H. Chang, A. Paul, and L. Chan Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin J. Biol. Chem. 277 2002 34658 34661
    • (2002) J. Biol. Chem. , vol.277 , pp. 34658-34661
    • Ma, K.1    Cabrero, A.2    Saha, P.K.3    Kojima, H.4    Li, L.5    Chang, B.H.6    Paul, A.7    Chan, L.8
  • 33
    • 33646346627 scopus 로고    scopus 로고
    • Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists
    • A.R. Nawrocki, M.W. Rajala, E. Tomas, U.B. Pajvani, A.K. Saha, M.E. Trumbauer, Z. Pang, A.S. Chen, N.B. Ruderman, and H. Chen Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists J. Biol. Chem. 281 2006 2654 2660
    • (2006) J. Biol. Chem. , vol.281 , pp. 2654-2660
    • Nawrocki, A.R.1    Rajala, M.W.2    Tomas, E.3    Pajvani, U.B.4    Saha, A.K.5    Trumbauer, M.E.6    Pang, Z.7    Chen, A.S.8    Ruderman, N.B.9    Chen, H.10
  • 35
    • 84857185764 scopus 로고    scopus 로고
    • Endocrine fibroblast growth factors 15/19 and 21: From feast to famine
    • M.J. Potthoff, S.A. Kliewer, and D.J. Mangelsdorf Endocrine fibroblast growth factors 15/19 and 21: from feast to famine Genes Dev. 26 2012 312 324
    • (2012) Genes Dev. , vol.26 , pp. 312-324
    • Potthoff, M.J.1    Kliewer, S.A.2    Mangelsdorf, D.J.3
  • 38
    • 33745222085 scopus 로고    scopus 로고
    • Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex
    • Y. Wang, K.S. Lam, L. Chan, K.W. Chan, J.B. Lam, M.C. Lam, R.C. Hoo, W.W. Mak, G.J. Cooper, and A. Xu Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex J. Biol. Chem. 281 2006 16391 16400
    • (2006) J. Biol. Chem. , vol.281 , pp. 16391-16400
    • Wang, Y.1    Lam, K.S.2    Chan, L.3    Chan, K.W.4    Lam, J.B.5    Lam, M.C.6    Hoo, R.C.7    Mak, W.W.8    Cooper, G.J.9    Xu, A.10
  • 39
    • 34248197560 scopus 로고    scopus 로고
    • Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention
    • Z.V. Wang, T.D. Schraw, J.Y. Kim, T. Khan, M.W. Rajala, A. Follenzi, and P.E. Scherer Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention Mol. Cell. Biol. 27 2007 3716 3731
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3716-3731
    • Wang, Z.V.1    Schraw, T.D.2    Kim, J.Y.3    Khan, T.4    Rajala, M.W.5    Follenzi, A.6    Scherer, P.E.7
  • 40
    • 38949125405 scopus 로고    scopus 로고
    • Post-translational modifications of adiponectin: Mechanisms and functional implications
    • Y. Wang, K.S. Lam, M.H. Yau, and A. Xu Post-translational modifications of adiponectin: mechanisms and functional implications Biochem. J. 409 2008 623 633
    • (2008) Biochem. J. , vol.409 , pp. 623-633
    • Wang, Y.1    Lam, K.S.2    Yau, M.H.3    Xu, A.4
  • 42
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • A. Xu, Y. Wang, H. Keshaw, L.Y. Xu, K.S. Lam, and G.J. Cooper The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice J. Clin. Invest. 112 2003 91 100
    • (2003) J. Clin. Invest. , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 43
    • 24044479055 scopus 로고    scopus 로고
    • Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
    • A. Xu, K.W. Chan, R.L. Hoo, Y. Wang, K.C. Tan, J. Zhang, B. Chen, M.C. Lam, C. Tse, G.J. Cooper, and K.S. Lam Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes J. Biol. Chem. 280 2005 18073 18080
    • (2005) J. Biol. Chem. , vol.280 , pp. 18073-18080
    • Xu, A.1    Chan, K.W.2    Hoo, R.L.3    Wang, Y.4    Tan, K.C.5    Zhang, J.6    Chen, B.7    Lam, M.C.8    Tse, C.9    Cooper, G.J.10    Lam, K.S.11
  • 44
    • 59649117072 scopus 로고    scopus 로고
    • Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice
    • A. Xu, H. Wang, R.L. Hoo, G. Sweeney, P.M. Vanhoutte, Y. Wang, D. Wu, W. Chu, G. Qin, and K.S. Lam Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice Endocrinology 150 2009 625 633
    • (2009) Endocrinology , vol.150 , pp. 625-633
    • Xu, A.1    Wang, H.2    Hoo, R.L.3    Sweeney, G.4    Vanhoutte, P.M.5    Wang, Y.6    Wu, D.7    Chu, W.8    Qin, G.9    Lam, K.S.10
  • 45
    • 61649127208 scopus 로고    scopus 로고
    • Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice
    • J. Xu, D.J. Lloyd, C. Hale, S. Stanislaus, M. Chen, G. Sivits, S. Vonderfecht, R. Hecht, Y.S. Li, and R.A. Lindberg Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice Diabetes 58 2009 250 259
    • (2009) Diabetes , vol.58 , pp. 250-259
    • Xu, J.1    Lloyd, D.J.2    Hale, C.3    Stanislaus, S.4    Chen, M.5    Sivits, G.6    Vonderfecht, S.7    Hecht, R.8    Li, Y.S.9    Lindberg, R.A.10
  • 47
    • 84863338708 scopus 로고    scopus 로고
    • Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB
    • C. Yang, C. Jin, X. Li, F. Wang, W.L. McKeehan, and Y. Luo Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB PLoS ONE 7 2012 e33870
    • (2012) PLoS ONE , vol.7 , pp. 33870
    • Yang, C.1    Jin, C.2    Li, X.3    Wang, F.4    McKeehan, W.L.5    Luo, Y.6
  • 48
    • 79956113302 scopus 로고    scopus 로고
    • Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans
    • H. Yu, F. Xia, K.S. Lam, Y. Wang, Y. Bao, J. Zhang, Y. Gu, P. Zhou, J. Lu, W. Jia, and A. Xu Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans Clin. Chem. 57 2011 691 700
    • (2011) Clin. Chem. , vol.57 , pp. 691-700
    • Yu, H.1    Xia, F.2    Lam, K.S.3    Wang, Y.4    Bao, Y.5    Zhang, J.6    Gu, Y.7    Zhou, P.8    Lu, J.9    Jia, W.10    Xu, A.11
  • 50
    • 54449085766 scopus 로고    scopus 로고
    • Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury
    • M. Zhou, A. Xu, P.K. Tam, K.S. Lam, L. Chan, R.L. Hoo, J. Liu, K.H. Chow, and Y. Wang Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury Hepatology 48 2008 1087 1096
    • (2008) Hepatology , vol.48 , pp. 1087-1096
    • Zhou, M.1    Xu, A.2    Tam, P.K.3    Lam, K.S.4    Chan, L.5    Hoo, R.L.6    Liu, J.7    Chow, K.H.8    Wang, Y.9


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