Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

Genes and Development

Volumn 14, Issue 22, 2000, Pages 2819-2830

  Repa, Joyce J ^a   Liang, Guosheng ^b   Ou, Jiafu ^b   Bashmakov, Yuriy ^a   Lobaccaro, Jean Marc A ^b   Shimomura, Iichiro ^c   Shan, Bei ^b   Brown, Michael S ^b   Goldstein, Joseph L ^b   Mangelsdorf, David J ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c AMGEN INC   (United States)

Author keywords

Cholesterol; Fatty acids; LXR; Nuclear receptor; RXR; SREBP 1

Indexed keywords

CELL NUCLEUS RECEPTOR; CHOLESTEROL; FATTY ACID; GENE PRODUCT; HELIX LOOP HELIX PROTEIN; HORMONE RECEPTOR; LEUCINE ZIPPER PROTEIN; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; MESSENGER RNA; OXYSTEROL; OXYSTEROL RECEPTOR; RETINOID X RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; DNA BINDING; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEINS; CHOLESTEROL; CHOLESTEROL, DIETARY; DIMERIZATION; DNA-BINDING PROTEINS; FATTY ACIDS; LIPID METABOLISM; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RECEPTORS, STEROID; RECEPTORS, THYROID HORMONE; RESPONSE ELEMENTS; RETINOID X RECEPTORS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROLS; TRANSCRIPTION FACTORS; UP-REGULATION;

ANIMALIA;

EID: 0034669025     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.844900     Document Type: Article

References (48)

1. Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene
2. Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells
3. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
4. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
5. Sterol-dependent transactivation of the ABC1 promoter by LXR/RXR
6. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
7. Influence of dietary cholesterol on desaturase enzymes of rat liver microsomes
8. Regulation of hepatic 7α-hydroxylase expression and response to dietary cholesterol in the rat and hamster
9. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
10. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
11. Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis
12. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13
13. An oxysterol signalling pathway mediated by the nuclear receptor LXRα
14. Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ
15. Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase
16. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver
17. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
18. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
19. Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N)
20. Dietary cholesterol and the activity of stearoyl CoA desaturase in rats: Evidence for an indirect regulatory effect
21. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
22. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element
23. Initial clinical trial of a selective retinoid X receptor ligand, LGD1069
24. The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase I
25. Sterol regulatory element binding proteins (SREBPs): Key regulators of nutritional homeostasis and insulin action
26. Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
27. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
28. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
29. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers
30. Oxysterols: Modulators of cholesterol metabolism and other processes
31. Role of LXRs in control of lipogenesis
32. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
33. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
34. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
35. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
36. Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
37. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
38. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver
39. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
40. Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2
41. OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoc acid receptor
42. ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
43. Human White/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages: A transcriptional role for specific oxysterols
44. Hepatocyte-specific mutation establishes retinoid X receptor α as a heterodimeric integrator of multiple physiological processes in the liver
45. Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR
46. LXR, a nuclear receptor that defines a distinct retinoid response pathway
47. A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids
48. SREBP-1, a basichelix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene