메뉴 건너뛰기




Volumn 13, Issue 6, 2011, Pages 729-738

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; FIBROBLAST GROWTH FACTOR 19; GLUCOSE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; UNCLASSIFIED DRUG;

EID: 79958066536     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2011.03.019     Document Type: Article
Times cited : (347)

References (50)
  • 1
    • 0033000161 scopus 로고    scopus 로고
    • Leptin increases circulating glucose, insulin and glucagon via sympathetic neural activation in fasted mice
    • Ahrén, B., and Havel, P.J. (1999). Leptin increases circulating glucose, insulin and glucagon via sympathetic neural activation in fasted mice. Int. J. Obes. Relat. Metab. Disord. 23, 660-665.
    • (1999) Int. J. Obes. Relat. Metab. Disord. , vol.23 , pp. 660-665
    • Ahrén, B.1    Havel, P.J.2
  • 2
    • 33644778829 scopus 로고    scopus 로고
    • Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse
    • DOI 10.2337/diabetes.55.02.06.db05-0686
    • Ayala, J.E., Bracy, D.P., McGuinness, O.P., and Wasserman, D.H. (2006). Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Diabetes 55, 390-397. (Pubitemid 43343268)
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 390-397
    • Ayala, J.E.1    Bracy, D.P.2    McGuinness, O.P.3    Wasserman, D.H.4
  • 3
    • 77956534963 scopus 로고    scopus 로고
    • Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice
    • NIH Mouse Metabolic Phenotyping Center Consortium.
    • Ayala, J.E., Samuel, V.T., Morton, G.J., Obici, S., Croniger, C.M., Shulman, G.I., Wasserman, D.H., and McGuinness, O.P.; NIH Mouse Metabolic Phenotyping Center Consortium. (2010). Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice. Dis Model Mech 3, 525-534.
    • (2010) Dis Model Mech , vol.3 , pp. 525-534
    • Ayala, J.E.1    Samuel, V.T.2    Morton, G.J.3    Obici, S.4    Croniger, C.M.5    Shulman, G.I.6    Wasserman, D.H.7    McGuinness, O.P.8
  • 4
    • 65649152582 scopus 로고    scopus 로고
    • Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis
    • Bhatnagar, S., Damron, H.A., and Hillgartner, F.B. (2009). Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. J. Biol. Chem. 284, 10023-10033.
    • (2009) J. Biol. Chem. , vol.284 , pp. 10023-10033
    • Bhatnagar, S.1    Damron, H.A.2    Hillgartner, F.B.3
  • 6
    • 33947580628 scopus 로고    scopus 로고
    • Cytosolic Phosphoenolpyruvate Carboxykinase Does Not Solely Control the Rate of Hepatic Gluconeogenesis in the Intact Mouse Liver
    • DOI 10.1016/j.cmet.2007.03.004, PII S1550413107000654
    • Burgess, S.C., He, T., Yan, Z., Lindner, J., Sherry, A.D., Malloy, C.R., Browning, J.D., and Magnuson, M.A. (2007). Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver. Cell Metab. 5, 313-320. (Pubitemid 46477858)
    • (2007) Cell Metabolism , vol.5 , Issue.4 , pp. 313-320
    • Burgess, S.C.1    He, T.2    Yan, Z.3    Lindner, J.4    Sherry, A.D.5    Malloy, C.R.6    Browning, J.D.7    Magnuson, M.A.8
  • 7
    • 33745865153 scopus 로고    scopus 로고
    • Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice
    • Burgess, S.C., Leone, T.C., Wende, A.R., Croce, M.A., Chen, Z., Sherry, A.D., Malloy, C.R., and Finck, B.N. (2006). Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator- activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. J. Biol. Chem. 281, 19000-19008.
    • (2006) J. Biol. Chem. , vol.281 , pp. 19000-19008
    • Burgess, S.C.1    Leone, T.C.2    Wende, A.R.3    Croce, M.A.4    Chen, Z.5    Sherry, A.D.6    Malloy, C.R.7    Finck, B.N.8
  • 10
    • 0027433708 scopus 로고
    • Phosphorylated CREB binds specifically to the nuclear protein CBP
    • DOI 10.1038/365855a0
    • Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, M.R., and Goodman, R.H. (1993). Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859. (Pubitemid 23341031)
    • (1993) Nature , vol.365 , Issue.6449 , pp. 855-859
    • Chrivia, J.C.1    Kwok, R.P.S.2    Lamb, N.3    Hagiwara, M.4    Montminy, M.R.5    Goodman, R.H.6
  • 11
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo, R.A., Tobin, J.D., and Andres, R. (1979). Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237, E214-E223.
    • (1979) Am. J. Physiol. , vol.237
    • DeFronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 12
    • 34548831102 scopus 로고    scopus 로고
    • Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
    • DOI 10.1038/nature06128, PII NATURE06128
    • Dentin, R., Liu, Y., Koo, S.H., Hedrick, S., Vargas, T., Heredia, J., Yates, J., 3rd, and Montminy, M. (2007). Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 449, 366-369. (Pubitemid 47443476)
    • (2007) Nature , vol.449 , Issue.7160 , pp. 366-369
    • Dentin, R.1    Liu, Y.2    Koo, S.-H.3    Hedrick, S.4    Vargas, T.5    Heredia, J.6    Yates III, J.7    Montminy, M.8
  • 13
    • 33644660537 scopus 로고    scopus 로고
    • PGC-1 coactivators: Inducible regulators of energy metabolism in health and disease
    • Finck, B.N., and Kelly, D.P. (2006). PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J. Clin. Invest. 116, 615-622.
    • (2006) J. Clin. Invest. , vol.116 , pp. 615-622
    • Finck, B.N.1    Kelly, D.P.2
  • 16
    • 0030625679 scopus 로고    scopus 로고
    • The multifunctional role of the co-activator CBP in transcriptional regulation
    • discussion 119-120
    • Goldman, P.S., Tran, V.K., and Goodman, R.H. (1997). The multifunctional role of the co-activator CBP in transcriptional regulation. Recent Prog. Horm. Res. 52, 103-119, discussion 119-120.
    • (1997) Recent Prog. Horm. Res. , vol.52 , pp. 103-119
    • Goldman, P.S.1    Tran, V.K.2    Goodman, R.H.3
  • 17
    • 0024445798 scopus 로고
    • Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
    • DOI 10.1016/0092-8674(89)90013-5
    • Gonzalez, G.A., and Montminy, M.R. (1989). Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59, 675-680. (Pubitemid 19282874)
    • (1989) Cell , vol.59 , Issue.4 , pp. 675-680
    • Gonzalez, G.A.1    Montminy, M.R.2
  • 19
    • 33845596500 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism
    • Handschin, C., and Spiegelman, B.M. (2006). Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr. Rev. 27, 728-735.
    • (2006) Endocr. Rev. , vol.27 , pp. 728-735
    • Handschin, C.1    Spiegelman, B.M.2
  • 21
    • 77952545895 scopus 로고    scopus 로고
    • Adenoviral targeting of gene expression to tumors
    • Hogg, R.T., Garcia, J.A., and Gerard, R.D. (2010). Adenoviral targeting of gene expression to tumors. Cancer Gene Ther. 17, 375-386.
    • (2010) Cancer Gene Ther. , vol.17 , pp. 375-386
    • Hogg, R.T.1    Garcia, J.A.2    Gerard, R.D.3
  • 23
    • 34948821192 scopus 로고    scopus 로고
    • FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet-induced fatty liver
    • DOI 10.2337/db07-0648
    • Huang, X., Yang, C., Luo, Y., Jin, C., Wang, F., and McKeehan, W.L. (2007). FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes 56, 2501-2510. (Pubitemid 47523257)
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2501-2510
    • Huang, X.1    Yang, C.2    Luo, Y.3    Jin, C.4    Wang, F.5    McKeehan, W.L.6
  • 26
    • 0036086509 scopus 로고    scopus 로고
    • Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis
    • DOI 10.1016/S1534-5807(02)00154-5
    • Kerr, T.A., Saeki, S., Schneider, M., Schaefer, K., Berdy, S., Redder, T., Shan, B., Russell, D.W., and Schwarz, M. (2002). Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis. Dev. Cell 2, 713-720. (Pubitemid 34650068)
    • (2002) Developmental Cell , vol.2 , Issue.6 , pp. 713-720
    • Kerr, T.A.1    Saeki, S.2    Schneider, M.3    Schaefer, K.4    Berdy, S.5    Redder, T.6    Shan, B.7    Russell, D.W.8    Schwarz, M.9
  • 29
    • 0021055596 scopus 로고
    • In vivo insulin sensitivity in the rat determined by euglycemic clamp
    • Kraegen, E.W., James, D.E., Bennett, S.P., and Chisholm, D.J. (1983). In vivo insulin sensitivity in the rat determined by euglycemic clamp. Am. J. Physiol. 245, E1-E7.
    • (1983) Am. J. Physiol. , vol.245
    • Kraegen, E.W.1    James, D.E.2    Bennett, S.P.3    Chisholm, D.J.4
  • 30
  • 32
    • 0033803048 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    • Lehman, J.J., Barger, P.M., Kovacs, A., Saffitz, J.E., Medeiros, D.M., and Kelly, D.P. (2000). Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J. Clin. Invest. 106, 847-856.
    • (2000) J. Clin. Invest. , vol.106 , pp. 847-856
    • Lehman, J.J.1    Barger, P.M.2    Kovacs, A.3    Saffitz, J.E.4    Medeiros, D.M.5    Kelly, D.P.6
  • 33
    • 34848866633 scopus 로고    scopus 로고
    • Liver-specific activities of FGF19 require Klotho beta
    • Lin, B.C., Wang, M., Blackmore, C., and Desnoyers, L.R. (2007). Liver-specific activities of FGF19 require Klotho beta. J. Biol. Chem. 282, 27277-27284.
    • (2007) J. Biol. Chem. , vol.282 , pp. 27277-27284
    • Lin, B.C.1    Wang, M.2    Blackmore, C.3    Desnoyers, L.R.4
  • 35
    • 33751115468 scopus 로고    scopus 로고
    • Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man
    • Lundåsen, T., Gälman, C., Angelin, B., and Rudling, M. (2006). Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man. J. Intern. Med. 260, 530-536.
    • (2006) J. Intern. Med. , vol.260 , pp. 530-536
    • Lundåsen, T.1    Gälman, C.2    Angelin, B.3    Rudling, M.4
  • 36
    • 0035430282 scopus 로고    scopus 로고
    • Transcriptional regulation by the phosphorylation- Dependent factor CREB
    • Mayr, B., and Montminy, M. (2001). Transcriptional regulation by the phosphorylation- dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2, 599-609.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 599-609
    • Mayr, B.1    Montminy, M.2
  • 37
    • 0033977889 scopus 로고    scopus 로고
    • The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism
    • Michael, L.F., Asahara, H., Shulman, A.I., Kraus, W.L., and Montminy, M. (2000). The phosphorylation status of a cyclic AMP-responsive activator is modulated via a chromatin-dependent mechanism. Mol. Cell. Biol. 20, 1596-1603.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1596-1603
    • Michael, L.F.1    Asahara, H.2    Shulman, A.I.3    Kraus, W.L.4    Montminy, M.5
  • 39
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): Transcriptional coactivator and metabolic regulator
    • Puigserver, P., and Spiegelman, B.M. (2003). Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 24, 78-90.
    • (2003) Endocr. Rev. , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 40
    • 77949279533 scopus 로고    scopus 로고
    • Fibroblast growth factor 19 serum levels: Relation to renal function and metabolic parameters
    • Reiche, M., Bachmann, A., Lössner, U., Blüher, M., Stumvoll, M., and Fasshauer, M. (2010). Fibroblast growth factor 19 serum levels: relation to renal function and metabolic parameters. Horm. Metab. Res. 42, 178-181.
    • (2010) Horm. Metab. Res. , vol.42 , pp. 178-181
    • Reiche, M.1    Bachmann, A.2    Lössner, U.3    Blüher, M.4    Stumvoll, M.5    Fasshauer, M.6
  • 42
    • 52949088575 scopus 로고    scopus 로고
    • Fibroblast growth factor-19: Development, analytical characterization and clinical evaluation of a new ELISA test
    • Stejskal, D., Karpísek, M., Hanulová, Z., and Stejskal, P. (2008). Fibroblast growth factor-19: development, analytical characterization and clinical evaluation of a new ELISA test. Scand. J. Clin. Lab. Invest. 68, 501-507.
    • (2008) Scand. J. Clin. Lab. Invest. , vol.68 , pp. 501-507
    • Stejskal, D.1    Karpísek, M.2    Hanulová, Z.3    Stejskal, P.4
  • 43
    • 77649114503 scopus 로고    scopus 로고
    • Gluconeogenesis differs in developing chick embryos derived from small compared with typical size broiler breeder eggs
    • Sunny, N.E., and Bequette, B.J. (2010). Gluconeogenesis differs in developing chick embryos derived from small compared with typical size broiler breeder eggs. J. Anim. Sci. 88, 912-921.
    • (2010) J. Anim. Sci. , vol.88 , pp. 912-921
    • Sunny, N.E.1    Bequette, B.J.2
  • 44
  • 45
    • 0027221605 scopus 로고
    • Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation
    • Wadzinski, B.E., Wheat, W.H., Jaspers, S., Peruski, L.F., Jr., Lickteig, R.L., Johnson, G.L., and Klemm, D.J. (1993). Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation. Mol. Cell. Biol. 13, 2822-2834.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 2822-2834
    • Wadzinski, B.E.1    Wheat, W.H.2    Jaspers, S.3    Peruski Jr., L.F.4    Lickteig, R.L.5    Johnson, G.L.6    Klemm, D.J.7
  • 47
    • 0037500306 scopus 로고    scopus 로고
    • Persistent ERK phosphorylation negatively regulates cAMP response element-binding protein (CREB) activity via recruitment of CREB-binding protein to pp90RSK
    • Wang, Z., Zhang, B., Wang, M., and Carr, B.I. (2003). Persistent ERK phosphorylation negatively regulates cAMP response element-binding protein (CREB) activity via recruitment of CREB-binding protein to pp90RSK. J. Biol. Chem. 278, 11138-11144.
    • (2003) J. Biol. Chem. , vol.278 , pp. 11138-11144
    • Wang, Z.1    Zhang, B.2    Wang, M.3    Carr, B.I.4
  • 48
    • 1842816370 scopus 로고    scopus 로고
    • Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction
    • Wright, T.J., Ladher, R., McWhirter, J., Murre, C., Schoenwolf, G.C., and Mansour, S.L. (2004). Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction. Dev. Biol. 269, 264-275.
    • (2004) Dev. Biol. , vol.269 , pp. 264-275
    • Wright, T.J.1    Ladher, R.2    McWhirter, J.3    Murre, C.4    Schoenwolf, G.C.5    Mansour, S.L.6
  • 50
    • 0034685916 scopus 로고    scopus 로고
    • Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
    • Yu, C., Wang, F., Kan, M., Jin, C., Jones, R.B., Weinstein, M., Deng, C.X., and McKeehan, W.L. (2000). Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J. Biol. Chem. 275, 15482-15489.
    • (2000) J. Biol. Chem. , vol.275 , pp. 15482-15489
    • Yu, C.1    Wang, F.2    Kan, M.3    Jin, C.4    Jones, R.B.5    Weinstein, M.6    Deng, C.X.7    McKeehan, W.L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.