HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor

Molecular Cell

Volumn 18, Issue 5, 2005, Pages 601-607

  Kovacs, Jeffrey J ^a   Murphy, Patrick J M ^b   Gaillard, Stéphanie ^a   Zhao, Xuan ^a   Wu, June Tai ^a   Nicchitta, Christopher V ^a   Yoshida, Minoru ^c,d   Toft, David O ^e   Pratt, William B ^b   Yao, Tso Pang ^a  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c RIKEN   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; GLUCOCORTICOID RECEPTOR; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE; HISTONE DEACETYLASE 6; PROTEIN P23; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEACETYLATION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; TRANSCRIPTION INITIATION;

ACETYLATION; ANIMALS; CELL LINE; DEXAMETHASONE; GLUCOCORTICOIDS; HISTONE DEACETYLASES; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MICE; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 21144444486     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2005.04.021     Document Type: Article

References (23)

1. F. Cadepond, G. Schweizer-Groyer, I. Segard-Maurel, N. Jibard, S.M. Hollenberg, V. Giguere, R.M. Evans, and E.E. Baulieu Heat shock protein 90 as a critical factor in maintaining glucocorticosteroid receptor in a nonfunctional state J. Biol. Chem. 266 1991 5834 5841
2. T. Cohen, and T.P. Yao AcK-knowledge reversible acetylation Sci. STKE 2004 2004 pe42
3. K.D. Dittmar, D.R. Demady, L.F. Stancato, P. Krishna, and W.B. Pratt Folding of the glucocorticoid receptor by the heat shock protein (hsp) 90-based chaperone machinery. The role of p23 is to stabilize receptor.hsp90 heterocomplexes formed by hsp90.p60.hsp70 J. Biol. Chem. 272 1997 21213 21220
4. R. Furumai, Y. Komatsu, N. Nishino, S. Khochbin, M. Yoshida, and S. Horinouchi Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin Proc. Natl. Acad. Sci. USA 98 2001 87 92
5. V. Giguere, S.M. Hollenberg, M.G. Rosenfeld, and R.M. Evans Functional domains of the human glucocorticoid receptor Cell 46 1986 645 652
6. S.J. Haggarty, K.M. Koeller, J.C. Wong, C.M. Grozinger, and S.L. Schreiber Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation Proc. Natl. Acad. Sci. USA 100 2003 4389 4394
7. C. Hubbert, A. Guardiola, R. Shao, Y. Kawaguchi, A. Ito, A. Nixon, M. Yoshida, X.F. Wang, and T.P. Yao HDAC6 is a microtubule-associated deacetylase Nature 417 2002 455 458
8. J.L. Johnson, and D.O. Toft A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23 J. Biol. Chem. 269 1994 24989 24993
9. A. Kamal, L. Thao, J. Sensintaffar, L. Zhang, M.F. Boehm, L.C. Fritz, and F.J. Burrows A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors Nature 425 2003 407 410
10. Y. Kawaguchi, J.J. Kovacs, A. McLaurin, J.M. Vance, A. Ito, and T.P. Yao The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress Cell 115 2003 727 738
11. Y. Komatsu, Y. Yukutake, and M. Yoshida Four different clones of mouse anti-acetyllysine monoclonal antibodies having different recognition properties share a common immunoglobulin framework structure J. Immunol. Methods 272 2003 161 175
12. A. Matsuyama, T. Shimazu, Y. Sumida, A. Saito, Y. Yoshimatsu, D. Seigneurin-Berny, H. Osada, Y. Komatsu, N. Nishino, and S. Khochbin In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation EMBO J. 21 2002 6820 6831
13. Y. Morishima, K.C. Kanelakis, P.J. Murphy, E.R. Lowe, G.J. Jenkins, Y. Osawa, R.K. Sunahara, and W.B. Pratt The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex J. Biol. Chem. 278 2003 48754 48763
14. L. Neckers Hsp90 inhibitors as novel cancer chemotherapeutic agents Trends Mol. Med. 8 2002 S55 S61
15. R. Nimmanapalli, L. Fuino, P. Bali, M. Gasparetto, M. Glozak, J. Tao, L. Moscinski, C. Smith, J. Wu, and R. Jove Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells Cancer Res. 63 2003 5126 5135
16. W.B. Pratt, and D.O. Toft Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery Exp. Biol. Med. (Maywood) 228 2003 111 133
17. K. Richter, and J. Buchner Hsp90: chaperoning signal transduction J. Cell. Physiol. 188 2001 281 290
18. C. Schneider, L. Sepp-Lorenzino, E. Nimmesgern, O. Ouerfelli, S. Danishefsky, N. Rosen, and F.U. Hartl Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90 Proc. Natl. Acad. Sci. USA 93 1996 14536 14541
19. A. Verdel, S. Curtet, M.P. Brocard, S. Rousseaux, C. Lemercier, M. Yoshida, and S. Khochbin Active maintenance of mHDA2/mHDAC6 histone-deacetylase in the cytoplasm Curr. Biol. 10 2000 747 749
20. L. Whitesell, and P. Cook Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells Mol. Endocrinol. 10 1996 705 712
21. W. Xu, E. Mimnaugh, M.F. Rosser, C. Nicchitta, M. Marcu, Y. Yarden, and L. Neckers Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90 J. Biol. Chem. 276 2001 3702 3708
22. X. Yu, Z.S. Guo, M.G. Marcu, L. Neckers, D.M. Nguyen, G.A. Chen, and D.S. Schrump Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228 J. Natl. Cancer Inst. 94 2002 504 513
23. Y. Zhang, N. Li, C. Caron, G. Matthias, D. Hess, S. Khochbin, and P. Matthias HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo EMBO J. 22 2003 1168 1179