Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program

Endocrinology

Volumn 152, Issue 6, 2011, Pages 2247-2255

  Ning, Jie ^a,b   Hong, Tao ^a,f   Ward, Adam ^a   Pi, Jingbo ^a   Liu, Zhenqi ^c   Liu, Hui Yu ^a   Cao, Wenhong ^d,e  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b The 2nd People's Hospital of Hunan Province   (China)

^c UNIVERSITY OF VIRGINIA   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e University of North Carolina   (United States)

^f UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID SYNTHASE; INSULIN; INSULIN DETEMIR; MAMMALIAN TARGET OF RAPAMYCIN; NUCLEIC ACID BINDING PROTEIN; NUCLEIC ACID BINDING PROTEIN SREBF1; PROTEIN IRE1; PROTEIN IRE1 ALPHA; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION; GENE OVEREXPRESSION; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID DIET; LIPOGENESIS; LIVER; LIVER CELL; MEDIATOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDORIBONUCLEASES; FATTY ACID SYNTHETASE COMPLEX; FEMALE; HEPATOCYTES; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; LIPOGENESIS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

EID: 79956292356     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1036     Document Type: Article

References (24)

1. Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, Schraw T, Durand JL, Li H, Li G, Jelicks LA, Mehler MF, Hui DY, Deshaies Y, Shulman GI, Schwartz GJ, Scherer PE 2007 Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 117:2621-2637 (Pubitemid 47494363)
2. Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L, Unger RH 2008 Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci USA 105:6139-6144 (Pubitemid 351758412)
3. Accili D 2004 Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic. Diabetes 53:1633-1642 (Pubitemid 38857019)
4. Burns JM, Donnelly JE, Anderson HS, Mayo MS, Spencer-Gardner L, Thomas G, Cronk BB, Haddad Z, Klima D, Hansen D, Brooks WM2007 Peripheral insulin and brain structure in early Alzheimer disease. Neurology 69:1094-1104
5. Cole GM, Frautschy SA 2007 The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer's disease. Exp Gerontol 42:10-21 (Pubitemid 44937832)
6. Crowell JA, Steele VE, Fay JR 2007 Targeting the AKT protein kinase for cancer chemoprevention. Mol Cancer Ther 6:2139-2148 (Pubitemid 47294742)
7. Moreira PI, Santos MS, Seiça R, Oliveira CR 2007 Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes. J Neurol Sci 257:206-214 (Pubitemid 46856489)
8. Al-Shawwa BA, Al-Huniti NH, DeMattia L, Gershan W 2007 Asthma and insulin resistance in morbidly obese children and adolescents. J Asthma 44:469-473 (Pubitemid 47123753)
9. Sterry W, Strober BE, Menter A 2007 Obesity in psoriasis: the metabolic, clinical and therapeutic implications. Report of an interdisciplinary conference and review. Br J Dermatol 157:649-655 (Pubitemid 47389868)
10. Popa C, Netea MG, van Riel PL, van der Meer JW, Stalenhoef AF 2007 The role of TNF-α in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. J Lipid Res 48:751-762
11. Okazaki R 2008 Links between osteoporosis and atherosclerosis; beyond insulin resistance. Clin Calcium 18:638-643
12. Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Ozdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil GS 2004 Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306:457-461 (Pubitemid 39372439)
13. Sriburi R, Jackowski S, Mori K, Brewer JW 2004 XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J Cell Biol 167:35-41
14. Basseri S, Austin RC 2008 ER stress and lipogenesis: a slippery slope toward hepatic steatosis. Dev Cell 15:795-796
15. Lee AH, Scapa EF, Cohen DE, Glimcher LH 2008 Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320:1492-1496 (Pubitemid 351929428)
16. Glimcher LH, Lee AH 2009 From sugar to fat: how the transcription factor XBP1 regulates hepatic lipogenesis. Ann NY Acad Sci 1173(Suppl 1):E2-E9
17. Liu H, Hong T, Wen GB, Han J, Zuo D, Liu Z, Cao W 2009 Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistance. Am J Physiol Endocrinol Metab 297:E898-E906
18. Liu HY, Cao SY, Hong T, Han J, Liu Z, Cao W 2009 Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM). J Biol Chem 284:27090-27100
19. Yoshida H 2007 Unconventional splicing of XBP-1 mRNA in the unfolded protein response. Antioxid Redox Signal 9:2323-2333 (Pubitemid 350059021)
20. Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F 2004 SREBP transcription factors: master regulators of lipid homeostasis. Biochimie 86:839-848 (Pubitemid 39602764)
21. Park SW, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U 2010 The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation. Nat Med 16:429-437
22. Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR 2010 A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat Med 16:438-445
23. Jastrzebski K, Hannan KM, Tchoubrieva EB, Hannan RD, Pearson RB 2007 Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors 25:209-226
24. Aoyama H, Daitoku H, Fukamizu A 2006 Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice. Int J Mol Med 18:433-439