Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance

Molecular and Cellular Biology

Volumn 24, Issue 17, 2004, Pages 7435-7443

  Duan, Chaojun ^a   Yang, Hongyan ^a   White, Morris F ^b   Rui, Liangyou ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SH2; PROTEIN SH2 B; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; ENZYME ACTIVATION; GENE DELETION; GENE DISRUPTION; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOSE TISSUE; AGING; ANIMALS; BLOOD GLUCOSE; CARRIER PROTEINS; CELL LINE; DIETARY FATS; GLUCOSE INTOLERANCE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; LIVER; MALE; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCLE, SKELETAL; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 4344581405     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.17.7435-7443.2004     Document Type: Article

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