메뉴 건너뛰기




Volumn 145-146, Issue , 2016, Pages 98-120

Insulin resistance and Parkinson's disease: A new target for disease modification?

Author keywords

Disease modification; Insulin resistance; Neurodegeneration; Parkinson's disease

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALPHA SYNUCLEIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; METFORMIN; PROTEIN KINASE B; ANTIDIABETIC AGENT;

EID: 84992383185     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2016.10.001     Document Type: Review
Times cited : (235)

References (359)
  • 1
    • 84928009282 scopus 로고    scopus 로고
    • Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NF(B and Nrf2-antioxidant signaling pathways
    • Abdelsalam, R.M., Safar, M.M., Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NF(B and Nrf2-antioxidant signaling pathways. J. Neurochem. 133 (2015), 700–707, 10.1111/jnc.13087.
    • (2015) J. Neurochem. , vol.133 , pp. 700-707
    • Abdelsalam, R.M.1    Safar, M.M.2
  • 5
    • 84934759512 scopus 로고    scopus 로고
    • Growth hormone, insulin-like growth factor-1 and the aging brain
    • Ashpole, N.M., Sanders, J.E., Hodges, E.L., Yan, H., Sonntag, W.E., Growth hormone, insulin-like growth factor-1 and the aging brain. Exp. Gerontol. 68 (2015), 76–81, 10.1016/j.exger.2014.10.002.
    • (2015) Exp. Gerontol. , vol.68 , pp. 76-81
    • Ashpole, N.M.1    Sanders, J.E.2    Hodges, E.L.3    Yan, H.4    Sonntag, W.E.5
  • 6
    • 84924042444 scopus 로고    scopus 로고
    • The ongoing pursuit of neuroprotective therapies in Parkinson disease
    • Athauda, D., Foltynie, T., The ongoing pursuit of neuroprotective therapies in Parkinson disease. Nat. Rev. Neurol. 11 (2014), 25–40, 10.1038/nrneurol.2014.226.
    • (2014) Nat. Rev. Neurol. , vol.11 , pp. 25-40
    • Athauda, D.1    Foltynie, T.2
  • 7
    • 84957388554 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
    • Athauda, D., Foltynie, T., The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action. Drug Discov. Today 21 (2016), 802–818, 10.1016/j.drudis.2016.01.013.
    • (2016) Drug Discov. Today , vol.21 , pp. 802-818
    • Athauda, D.1    Foltynie, T.2
  • 9
    • 84864855869 scopus 로고    scopus 로고
    • Parkinson's disease, insulin resistance and novel agents of neuroprotection
    • Aviles-Olmos, I., Limousin, P., Lees, A., Foltynie, T., Parkinson's disease, insulin resistance and novel agents of neuroprotection. Brain 136 (2013), 374–384, 10.1093/brain/aws009.
    • (2013) Brain , vol.136 , pp. 374-384
    • Aviles-Olmos, I.1    Limousin, P.2    Lees, A.3    Foltynie, T.4
  • 11
    • 84975263365 scopus 로고    scopus 로고
    • IGF-1 protects dopamine neurons against oxidative stress: association with changes in phosphokinases
    • El Zyadi, A., Zigmond, M.J., Smith, A.D., IGF-1 protects dopamine neurons against oxidative stress: association with changes in phosphokinases. Exp. Brain Res. 234 (2016), 1863–1873, 10.1007/s00221-016-4572-1.
    • (2016) Exp. Brain Res. , vol.234 , pp. 1863-1873
    • El Zyadi, A.1    Zigmond, M.J.2    Smith, A.D.3
  • 12
    • 84862684037 scopus 로고    scopus 로고
    • The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study
    • Azoulay, L., Yin, H., Filion, K.B., Assayag, J., Majdan, A., Pollak, M.N., Suissa, S., The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study. BMJ, 344, 2012, e3645.
    • (2012) BMJ , vol.344 , pp. e3645
    • Azoulay, L.1    Yin, H.2    Filion, K.B.3    Assayag, J.4    Majdan, A.5    Pollak, M.N.6    Suissa, S.7
  • 15
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio, L.L., Drucker, D.J., Biology of incretins: GLP-1 and GIP. Gastroenterology 132 (2007), 2131–2157, 10.1053/j.gastro.2007.03.054.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 16
    • 78651274000 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes
    • Baker, L.D., Cross, D.J., Minoshima, S., Belongia, D., Watson, G.S., Craft, S., Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes. Arch. Neurol. 68 (2011), 51–57, 10.1001/archneurol.2010.225.
    • (2011) Arch. Neurol. , vol.68 , pp. 51-57
    • Baker, L.D.1    Cross, D.J.2    Minoshima, S.3    Belongia, D.4    Watson, G.S.5    Craft, S.6
  • 17
    • 74149094597 scopus 로고    scopus 로고
    • [11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?
    • Bartels, A.L., Willemsen, A.T.M., Doorduin, J., de Vries, E.F.J., Dierckx, R.A., Leenders, K.L., [11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?. Parkinsonism Relat. Disord. 16 (2010), 57–59, 10.1016/j.parkreldis.2009.05.005.
    • (2010) Parkinsonism Relat. Disord. , vol.16 , pp. 57-59
    • Bartels, A.L.1    Willemsen, A.T.M.2    Doorduin, J.3    de Vries, E.F.J.4    Dierckx, R.A.5    Leenders, K.L.6
  • 19
    • 84901825835 scopus 로고    scopus 로고
    • W.G.T. for disease modifi, 2014. Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disocation?
    • Bassil, F., Fernagut, P.-O., Bezard, E., Meissner, W.G.T. for disease modifi, 2014. Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disocation?. Prog. Neurobiol., 2014, 10.1016/j.pneurobio.2014.02.005.
    • (2014) Prog. Neurobiol.
    • Bassil, F.1    Fernagut, P.-O.2    Bezard, E.3    Meissner4
  • 20
    • 85043802145 scopus 로고    scopus 로고
    • Brain insulin resistance in Parkinson's disease and Multiple System Atrophy
    • Submitted
    • Bassil, F., Canron, M., Vital, A., Bezard, E., Fernagut, P., Meissner, W., 2015. Brain insulin resistance in Parkinson's disease and Multiple System Atrophy. Submitted.
    • (2015)
    • Bassil, F.1    Canron, M.2    Vital, A.3    Bezard, E.4    Fernagut, P.5    Meissner, W.6
  • 21
    • 33847094700 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier
    • Bauer, B., Hartz, A.M.S., Miller, D.S., Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier. Mol. Pharmacol. 71 (2007), 667–675, 10.1124/mol.106.029512.
    • (2007) Mol. Pharmacol. , vol.71 , pp. 667-675
    • Bauer, B.1    Hartz, A.M.S.2    Miller, D.S.3
  • 22
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial
    • Bergenstal, R.M., Wysham, C., Macconell, L., Malloy, J., Walsh, B., Yan, P., Wilhelm, K., Malone, J., Porter, L.E., Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 376 (2010), 431–439, 10.1016/S0140-6736(10)60590-9.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    Macconell, L.3    Malloy, J.4    Walsh, B.5    Yan, P.6    Wilhelm, K.7    Malone, J.8    Porter, L.E.9
  • 24
    • 84944714835 scopus 로고    scopus 로고
    • Hippocampal insulin resistance and cognitive dysfunction
    • Biessels, G.J., Reagan, L.P., Hippocampal insulin resistance and cognitive dysfunction. Nat. Rev. Neurosci. 16 (2015), 660–671, 10.1038/nrn4019.
    • (2015) Nat. Rev. Neurosci. , vol.16 , pp. 660-671
    • Biessels, G.J.1    Reagan, L.P.2
  • 25
    • 84922693194 scopus 로고    scopus 로고
    • Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease
    • Blázquez, E., Velázquez, E., Hurtado-Carneiro, V., Ruiz-Albusac, J.M., Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease. Front. Endocrinol. (Lausanne)., 5, 2014, 161, 10.3389/fendo.2014.00161.
    • (2014) Front. Endocrinol. (Lausanne). , vol.5 , pp. 161
    • Blázquez, E.1    Velázquez, E.2    Hurtado-Carneiro, V.3    Ruiz-Albusac, J.M.4
  • 26
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Blüher, M., Kahn, B.B., Kahn, C.R., Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299 (2003), 572–574, 10.1126/science.1078223.
    • (2003) Science , vol.299 , pp. 572-574
    • Blüher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 27
    • 84874658819 scopus 로고    scopus 로고
    • Neural and immune mechanisms in the pathogenesis of Parkinson's disease
    • Blandini, F., Neural and immune mechanisms in the pathogenesis of Parkinson's disease. J. Neuroimmune Pharmacol. 8 (2013), 189–201, 10.1007/s11481-013-9435-y.
    • (2013) J. Neuroimmune Pharmacol. , vol.8 , pp. 189-201
    • Blandini, F.1
  • 29
  • 31
    • 43849090633 scopus 로고    scopus 로고
    • Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease
    • Bouchard, T.P., Malykhin, N., Martin, W.R.W., Hanstock, C.C., Emery, D.J., Fisher, N.J., Camicioli, R.M., Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease. Neurobiol. Aging 29 (2008), 1027–1039, 10.1016/j.neurobiolaging.2007.02.002.
    • (2008) Neurobiol. Aging , vol.29 , pp. 1027-1039
    • Bouchard, T.P.1    Malykhin, N.2    Martin, W.R.W.3    Hanstock, C.C.4    Emery, D.J.5    Fisher, N.J.6    Camicioli, R.M.7
  • 32
    • 65649098029 scopus 로고    scopus 로고
    • Phosphorylation of IRS proteins, insulin action, and insulin resistance
    • Boura-Halfon, S., Zick, Y., Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 296 (2009), E581–91, 10.1152/ajpendo.90437.2008.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.296 , pp. E581-91
    • Boura-Halfon, S.1    Zick, Y.2
  • 33
    • 84927942044 scopus 로고    scopus 로고
    • A mathematical model of insulin resistance in Parkinson's disease
    • Braatz, E.M., Coleman, R.A., A mathematical model of insulin resistance in Parkinson's disease. Comput. Biol. Chem. 56 (2015), 84–97, 10.1016/j.compbiolchem.2015.04.003.
    • (2015) Comput. Biol. Chem. , vol.56 , pp. 84-97
    • Braatz, E.M.1    Coleman, R.A.2
  • 34
    • 84938717912 scopus 로고    scopus 로고
    • Glitazone treatment and incidence of Parkinson's disease among people with diabetes: a retrospective cohort study
    • Brauer, R., Bhaskaran, K., Chaturvedi, N., Dexter, D.T., Smeeth, L., Douglas, I., Glitazone treatment and incidence of Parkinson's disease among people with diabetes: a retrospective cohort study. PLoS Med., 12, 2015, e1001854, 10.1371/journal.pmed.1001854.
    • (2015) PLoS Med. , vol.12 , pp. e1001854
    • Brauer, R.1    Bhaskaran, K.2    Chaturvedi, N.3    Dexter, D.T.4    Smeeth, L.5    Douglas, I.6
  • 36
    • 67649666737 scopus 로고    scopus 로고
    • LEAD-6 Study Group, 2009. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse, J.B., Rosenstock, J., Sesti, G., Schmidt, W.E., Montanya, E., Brett, J.H., Zychma, M., Blonde, L., LEAD-6 Study Group, 2009. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet (London, England) 374 (2009), 39–47, 10.1016/s0140-6736(09)60659-0.
    • (2009) Lancet (London, England) , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6    Zychma, M.7    Blonde, L.8
  • 37
    • 77951227122 scopus 로고    scopus 로고
    • Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments
    • Caccamo, A., Majumder, S., Richardson, A., Strong, R., Oddo, S., Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments. J. Biol. Chem. 285 (2010), 13107–13120, 10.1074/jbc.M110.100420.
    • (2010) J. Biol. Chem. , vol.285 , pp. 13107-13120
    • Caccamo, A.1    Majumder, S.2    Richardson, A.3    Strong, R.4    Oddo, S.5
  • 38
    • 84880383782 scopus 로고    scopus 로고
    • New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease
    • Calabresi, P., Castrioto, A., Di Filippo, M., Picconi, B., New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease. Lancet. Neurol. 12 (2013), 811–821, 10.1016/S1474-4422(13)70118-2.
    • (2013) Lancet. Neurol. , vol.12 , pp. 811-821
    • Calabresi, P.1    Castrioto, A.2    Di Filippo, M.3    Picconi, B.4
  • 40
    • 84959239661 scopus 로고    scopus 로고
    • A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson's disease by reducing chronic inflammation in the brain
    • Cao, L., Li, D., Feng, P., Li, L., Xue, G.-F., Li, G., Hölscher, C., A novel dual GLP-1 and GIP incretin receptor agonist is neuroprotective in a mouse model of Parkinson's disease by reducing chronic inflammation in the brain. Neuroreport 27 (2016), 384–391, 10.1097/WNR.0000000000000548.
    • (2016) Neuroreport , vol.27 , pp. 384-391
    • Cao, L.1    Li, D.2    Feng, P.3    Li, L.4    Xue, G.-F.5    Li, G.6    Hölscher, C.7
  • 41
    • 84863593338 scopus 로고    scopus 로고
    • Hippocampal abnormalities and memory deficits in Parkinson disease: a multimodal imaging study
    • Carlesimo, G.A., Piras, F., Assogna, F., Pontieri, F.E., Caltagirone, C., Spalletta, G., Hippocampal abnormalities and memory deficits in Parkinson disease: a multimodal imaging study. Neurology 78 (2012), 1939–1945, 10.1212/WNL.0b013e318259e1c5.
    • (2012) Neurology , vol.78 , pp. 1939-1945
    • Carlesimo, G.A.1    Piras, F.2    Assogna, F.3    Pontieri, F.E.4    Caltagirone, C.5    Spalletta, G.6
  • 42
    • 0036917631 scopus 로고    scopus 로고
    • Serum insulin-like growth factor I regulates brain amyloid-beta levels
    • Carro, E., Trejo, J.L., Gomez-Isla, T., LeRoith, D., Torres-Aleman, I., Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat. Med. 8 (2002), 1390–1397, 10.1038/nm793.
    • (2002) Nat. Med. , vol.8 , pp. 1390-1397
    • Carro, E.1    Trejo, J.L.2    Gomez-Isla, T.3    LeRoith, D.4    Torres-Aleman, I.5
  • 43
    • 0030597071 scopus 로고    scopus 로고
    • Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease
    • Castellani, R., Smith, M.A., Richey, P.L., Perry, G., Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease. Brain Res. 737 (1996), 195–200.
    • (1996) Brain Res. , vol.737 , pp. 195-200
    • Castellani, R.1    Smith, M.A.2    Richey, P.L.3    Perry, G.4
  • 44
    • 84863625218 scopus 로고    scopus 로고
    • Clinical features of Parkinson disease when onset of diabetes came first: a case-control study
    • Cereda, E., Barichella, M., Cassani, E., Caccialanza, R., Pezzoli, G., Clinical features of Parkinson disease when onset of diabetes came first: a case-control study. Neurology 78 (2012), 1507–1511, 10.1212/WNL.0b013e3182553cc9.
    • (2012) Neurology , vol.78 , pp. 1507-1511
    • Cereda, E.1    Barichella, M.2    Cassani, E.3    Caccialanza, R.4    Pezzoli, G.5
  • 45
    • 84907030397 scopus 로고    scopus 로고
    • DPP-4 inhibitors: pharmacological differences and their clinical implications
    • Ceriello, A., Sportiello, L., Rafaniello, C., Rossi, F., DPP-4 inhibitors: pharmacological differences and their clinical implications. Expert Opin. Drug Saf. 13:Suppl. 1 (2014), S57–68, 10.1517/14740338.2014.944862.
    • (2014) Expert Opin. Drug Saf. , vol.13 , pp. S57-68
    • Ceriello, A.1    Sportiello, L.2    Rafaniello, C.3    Rossi, F.4
  • 46
    • 85020061734 scopus 로고    scopus 로고
    • P-glycoprotein (P-gp) efflux limits brain penetration of pioglitazone and stereoisomer of pioglitazone is a better brain penetrant
    • Chang, K.L., Ho, P.C., P-glycoprotein (P-gp) efflux limits brain penetration of pioglitazone and stereoisomer of pioglitazone is a better brain penetrant. Alzheimer's Dement, 9, 2013, P892, 10.1016/j.jalz.2013.08.260.
    • (2013) Alzheimer's Dement , vol.9 , pp. P892
    • Chang, K.L.1    Ho, P.C.2
  • 47
    • 84924785693 scopus 로고    scopus 로고
    • Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease
    • Chang, K.L., Pee, H.N., Yang, S., Ho, P.C., Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease. Sci. Rep., 5, 2015, 9000, 10.1038/srep09000.
    • (2015) Sci. Rep. , vol.5 , pp. 9000
    • Chang, K.L.1    Pee, H.N.2    Yang, S.3    Ho, P.C.4
  • 49
    • 84895119109 scopus 로고    scopus 로고
    • Meta-analysis: overweight, obesity, and Parkinson's disease
    • Chen, J., Guan, Z., Wang, L., Song, G., Ma, B., Wang, Y., Meta-analysis: overweight, obesity, and Parkinson's disease. Int. J. Endocrinol., 2014, 2014, 203930, 10.1155/2014/203930.
    • (2014) Int. J. Endocrinol. , vol.2014 , pp. 203930
    • Chen, J.1    Guan, Z.2    Wang, L.3    Song, G.4    Ma, B.5    Wang, Y.6
  • 50
    • 27844537831 scopus 로고    scopus 로고
    • Tau is hyperphosphorylated in the insulin-like growth factor-I null brain
    • Cheng, C.M., Tseng, V., Wang, J., Wang, D., Matyakhina, L., Bondy, C.A., Tau is hyperphosphorylated in the insulin-like growth factor-I null brain. Endocrinology 146 (2005), 5086–5091, 10.1210/en.2005-0063.
    • (2005) Endocrinology , vol.146 , pp. 5086-5091
    • Cheng, C.M.1    Tseng, V.2    Wang, J.3    Wang, D.4    Matyakhina, L.5    Bondy, C.A.6
  • 51
    • 77957229010 scopus 로고    scopus 로고
    • Insulin signaling meets mitochondria in metabolism
    • Cheng, Z., Tseng, Y., White, M.F., Insulin signaling meets mitochondria in metabolism. Trends Endocrinol. Metab. 21 (2010), 589–598, 10.1016/j.tem.2010.06.005.
    • (2010) Trends Endocrinol. Metab. , vol.21 , pp. 589-598
    • Cheng, Z.1    Tseng, Y.2    White, M.F.3
  • 52
    • 44649198605 scopus 로고    scopus 로고
    • Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo
    • Chiu, S.-L., Chen, C.-M., Cline, H.T., Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 58 (2008), 708–719, 10.1016/j.neuron.2008.04.014.
    • (2008) Neuron , vol.58 , pp. 708-719
    • Chiu, S.-L.1    Chen, C.-M.2    Cline, H.T.3
  • 53
    • 13844275515 scopus 로고    scopus 로고
    • Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity
    • Choi, J.-Y., Jang, E.-H., Park, C.-S., Kang, J.-H., Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity. Free Radic. Biol. Med. 38 (2005), 806–816, 10.1016/j.freeradbiomed.2004.12.008.
    • (2005) Free Radic. Biol. Med. , vol.38 , pp. 806-816
    • Choi, J.-Y.1    Jang, E.-H.2    Park, C.-S.3    Kang, J.-H.4
  • 54
    • 72949122084 scopus 로고    scopus 로고
    • AMP-activated protein kinase is activated in Parkinson's disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Choi, J.-S., Park, C., Jeong, J.-W., AMP-activated protein kinase is activated in Parkinson's disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Biochem. Biophys. Res. Commun. 391 (2010), 147–151, 10.1016/j.bbrc.2009.11.022.
    • (2010) Biochem. Biophys. Res. Commun. , vol.391 , pp. 147-151
    • Choi, J.-S.1    Park, C.2    Jeong, J.-W.3
  • 55
    • 79955994007 scopus 로고    scopus 로고
    • Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease
    • Clark, J., Reddy, S., Zheng, K., Betensky, R.A., Simon, D.K., Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease. BMC Med. Genet., 12, 2011, 69, 10.1186/1471-2350-12-69.
    • (2011) BMC Med. Genet. , vol.12 , pp. 69
    • Clark, J.1    Reddy, S.2    Zheng, K.3    Betensky, R.A.4    Simon, D.K.5
  • 60
    • 84896840327 scopus 로고    scopus 로고
    • The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia
    • Compta, Y., Parkkinen, L., Kempster, P., Selikhova, M., Lashley, T., Holton, J.L., Lees, A.J., Revesz, T., The significance of α-synuclein, amyloid-β and tau pathologies in Parkinson's disease progression and related dementia. Neurodegener. Dis. 13 (2014), 154–156, 10.1159/000354670.
    • (2014) Neurodegener. Dis. , vol.13 , pp. 154-156
    • Compta, Y.1    Parkkinen, L.2    Kempster, P.3    Selikhova, M.4    Lashley, T.5    Holton, J.L.6    Lees, A.J.7    Revesz, T.8
  • 61
    • 84885309586 scopus 로고    scopus 로고
    • Do thiazolidinediones still have a role in treatment of type 2 diabetes mellitus?
    • Consoli, A., Formoso, G., Do thiazolidinediones still have a role in treatment of type 2 diabetes mellitus?. Diabetes. Obes. Metab. 15 (2013), 967–977, 10.1111/dom.12101.
    • (2013) Diabetes. Obes. Metab. , vol.15 , pp. 967-977
    • Consoli, A.1    Formoso, G.2
  • 62
    • 84921340542 scopus 로고    scopus 로고
    • Potential side effects to GLP-1 agonists: understanding their safety and tolerability
    • Consoli, A., Formoso, G., Potential side effects to GLP-1 agonists: understanding their safety and tolerability. Expert Opin. Drug Saf. 14 (2015), 207–218, 10.1517/14740338.2015.987122.
    • (2015) Expert Opin. Drug Saf. , vol.14 , pp. 207-218
    • Consoli, A.1    Formoso, G.2
  • 63
    • 84939883815 scopus 로고    scopus 로고
    • PPARγ and PGC-1α as therapeutic targets in Parkinson's
    • Corona, J.C., Duchen, M.R., PPARγ and PGC-1α as therapeutic targets in Parkinson's. Neurochem. Res. 40 (2015), 308–316, 10.1007/s11064-014-1377-0.
    • (2015) Neurochem. Res. , vol.40 , pp. 308-316
    • Corona, J.C.1    Duchen, M.R.2
  • 64
    • 84939883815 scopus 로고    scopus 로고
    • PPARγ and PGC-1α as therapeutic targets in Parkinson's
    • Corona, J.C., Duchen, M.R., PPARγ and PGC-1α as therapeutic targets in Parkinson's. Neurochem. Res. 40 (2015), 308–316, 10.1007/s11064-014-1377-0.
    • (2015) Neurochem. Res. , vol.40 , pp. 308-316
    • Corona, J.C.1    Duchen, M.R.2
  • 65
    • 84891915522 scopus 로고    scopus 로고
    • PPAR(activation rescues mitochondrial function from inhibition of complex I and loss of PINK1
    • Corona, J.C., de Souza, S.C., Duchen, M.R., PPAR(activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp. Neurol. 253 (2014), 16–27, 10.1016/j.expneurol.2013.12.012.
    • (2014) Exp. Neurol. , vol.253 , pp. 16-27
    • Corona, J.C.1    de Souza, S.C.2    Duchen, M.R.3
  • 68
    • 84925438105 scopus 로고    scopus 로고
    • Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research
    • Cunningham, C., Hennessy, E., Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research. Alzheimers. Res. Ther., 7, 2015, 33, 10.1186/s13195-015-0117-2.
    • (2015) Alzheimers. Res. Ther. , vol.7 , pp. 33
    • Cunningham, C.1    Hennessy, E.2
  • 72
    • 84960910536 scopus 로고    scopus 로고
    • Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor
    • Darsalia, V., Larsson, M., Lietzau, G., Nathanson, D., Nyström, T., Klein, T., Patrone, C., Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor. Diabetes, Obes. Metab. 18 (2016), 537–541, 10.1111/dom.12641.
    • (2016) Diabetes, Obes. Metab. , vol.18 , pp. 537-541
    • Darsalia, V.1    Larsson, M.2    Lietzau, G.3    Nathanson, D.4    Nyström, T.5    Klein, T.6    Patrone, C.7
  • 73
    • 84897907030 scopus 로고    scopus 로고
    • How does brain insulin resistance develop in Alzheimer's disease?
    • De Felice, F.G., Lourenco, M.V., Ferreira, S.T., How does brain insulin resistance develop in Alzheimer's disease?. Alzheimers. Dement. 10 (2014), S26–S32, 10.1016/j.jalz.2013.12.004.
    • (2014) Alzheimers. Dement. , vol.10 , pp. S26-S32
    • De Felice, F.G.1    Lourenco, M.V.2    Ferreira, S.T.3
  • 74
    • 0347087323 scopus 로고    scopus 로고
    • Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation
    • Dehmer, T., Heneka, M.T., Sastre, M., Dichgans, J., Schulz, J.B., Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J. Neurochem. 88 (2004), 494–501.
    • (2004) J. Neurochem. , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3    Dichgans, J.4    Schulz, J.B.5
  • 76
    • 84909606636 scopus 로고    scopus 로고
    • Insulin resistance in Alzheimer's disease
    • Dineley, K.T., Jahrling, J.B., Denner, L., Insulin resistance in Alzheimer's disease. Neurobiol. Dis. 72:Pt A (2014), 92–103, 10.1016/j.nbd.2014.09.001.
    • (2014) Neurobiol. Dis. , vol.72 , pp. 92-103
    • Dineley, K.T.1    Jahrling, J.B.2    Denner, L.3
  • 78
    • 56149110407 scopus 로고    scopus 로고
    • Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease
    • Driver, J.A., Smith, A., Buring, J.E., Gaziano, J.M., Kurth, T., Logroscino, G., Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease. Diabetes Care 31 (2008), 2003–2005, 10.2337/dc08-0688.
    • (2008) Diabetes Care , vol.31 , pp. 2003-2005
    • Driver, J.A.1    Smith, A.2    Buring, J.E.3    Gaziano, J.M.4    Kurth, T.5    Logroscino, G.6
  • 79
    • 75149128665 scopus 로고    scopus 로고
    • Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits
    • Drucker, D.J., Sherman, S.I., Gorelick, F.S., Bergenstal, R.M., Sherwin, R.S., Buse, J.B., Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits. Diabetes Care 33 (2010), 428–433, 10.2337/dc09-1499.
    • (2010) Diabetes Care , vol.33 , pp. 428-433
    • Drucker, D.J.1    Sherman, S.I.2    Gorelick, F.S.3    Bergenstal, R.M.4    Sherwin, R.S.5    Buse, J.B.6
  • 80
    • 0037234531 scopus 로고    scopus 로고
    • Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes
    • Drucker, D.J., Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes. Expert Opin. Investig. Drugs 12 (2003), 87–100, 10.1517/13543784.12.1.87.
    • (2003) Expert Opin. Investig. Drugs , vol.12 , pp. 87-100
    • Drucker, D.J.1
  • 81
    • 84868282388 scopus 로고    scopus 로고
    • 2012: Insulin in central nervous system: more than just a peripheral hormone
    • Duarte, A.I., Moreira, P.I., Oliveira, C.R., 2012: Insulin in central nervous system: more than just a peripheral hormone. J. Aging Res., 38401, 2012, 7, 10.1155/2012/384017.
    • (2012) J. Aging Res. , vol.38401 , pp. 7
    • Duarte, A.I.1    Moreira, P.I.2    Oliveira, C.R.3
  • 83
  • 84
    • 70349331692 scopus 로고    scopus 로고
    • Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models
    • Duka, T., Duka, V., Joyce, J.N., Sidhu, A., Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease models. FASEB J. 23 (2009), 2820–2830, 10.1096/fj.08-120410.
    • (2009) FASEB J. , vol.23 , pp. 2820-2830
    • Duka, T.1    Duka, V.2    Joyce, J.N.3    Sidhu, A.4
  • 86
    • 37549042851 scopus 로고    scopus 로고
    • Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease
    • Ebert, A.D., Beres, A.J., Barber, A.E., Svendsen, C.N., Human neural progenitor cells over-expressing IGF-1 protect dopamine neurons and restore function in a rat model of Parkinson's disease. Exp. Neurol. 209 (2008), 213–223, 10.1016/j.expneurol.2007.09.022.
    • (2008) Exp. Neurol. , vol.209 , pp. 213-223
    • Ebert, A.D.1    Beres, A.J.2    Barber, A.E.3    Svendsen, C.N.4
  • 87
    • 77949912389 scopus 로고    scopus 로고
    • Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein
    • Ebrahim, A.S., Ko, L.-W., Yen, S.-H., Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein. Neurosci. Lett. 473 (2010), 120–125, 10.1016/j.neulet.2010.02.034.
    • (2010) Neurosci. Lett. , vol.473 , pp. 120-125
    • Ebrahim, A.S.1    Ko, L.-W.2    Yen, S.-H.3
  • 88
    • 58149485983 scopus 로고    scopus 로고
    • Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model
    • Escribano, L., Simón, A.-M., Pérez-Mediavilla, A., Salazar-Colocho, P., Del Río, J., Frechilla, D., Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model. Biochem. Biophys. Res. Commun. 379 (2009), 406–410, 10.1016/j.bbrc.2008.12.071.
    • (2009) Biochem. Biophys. Res. Commun. , vol.379 , pp. 406-410
    • Escribano, L.1    Simón, A.-M.2    Pérez-Mediavilla, A.3    Salazar-Colocho, P.4    Del Río, J.5    Frechilla, D.6
  • 90
    • 33746278194 scopus 로고    scopus 로고
    • The selfish brain: competition for energy resources
    • Fehm, H.L., Kern, W., Peters, A., The selfish brain: competition for energy resources. Prog. Brain Res. 153 (2006), 129–140, 10.1016/S0079-6123(06)53007-9.
    • (2006) Prog. Brain Res. , vol.153 , pp. 129-140
    • Fehm, H.L.1    Kern, W.2    Peters, A.3
  • 91
    • 84897886749 scopus 로고    scopus 로고
    • Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
    • Ferreira, S.T., Clarke, J.R., Bomfim, T.R., De Felice, F.G., Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease. Alzheimer's Dement. 10 (2014), S76–S83, 10.1016/j.jalz.2013.12.010.
    • (2014) Alzheimer's Dement. , vol.10 , pp. S76-S83
    • Ferreira, S.T.1    Clarke, J.R.2    Bomfim, T.R.3    De Felice, F.G.4
  • 92
    • 84875166950 scopus 로고    scopus 로고
    • Pioglitazone and risk of bladder cancer: a meta-analysis of controlled studies
    • Ferwana, M., Firwana, B., Hasan, R., Al-Mallah, M.H., Kim, S., Montori, V.M., Murad, M.H., Pioglitazone and risk of bladder cancer: a meta-analysis of controlled studies. Diabet. Med. 30 (2013), 1026–1032, 10.1111/dme.12144.
    • (2013) Diabet. Med. , vol.30 , pp. 1026-1032
    • Ferwana, M.1    Firwana, B.2    Hasan, R.3    Al-Mallah, M.H.4    Kim, S.5    Montori, V.M.6    Murad, M.H.7
  • 95
    • 1542375990 scopus 로고    scopus 로고
    • The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study
    • Foltynie, T., Brayne, C.E.G., Robbins, T.W., Barker, R.A., The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study. Brain 127 (2004), 550–560, 10.1093/brain/awh067.
    • (2004) Brain , vol.127 , pp. 550-560
    • Foltynie, T.1    Brayne, C.E.G.2    Robbins, T.W.3    Barker, R.A.4
  • 98
    • 84924402070 scopus 로고    scopus 로고
    • Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
    • Gallegos, S., Pacheco, C., Peters, C., Opazo, C.M., Aguayo, L.G., Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease. Front. Neurosci., 9, 2015, 59, 10.3389/fnins.2015.00059.
    • (2015) Front. Neurosci. , vol.9 , pp. 59
    • Gallegos, S.1    Pacheco, C.2    Peters, C.3    Opazo, C.M.4    Aguayo, L.G.5
  • 99
    • 84898542999 scopus 로고    scopus 로고
    • Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model
    • Gao, C., Liu, Y., Jiang, Y., Ding, J., Li, L., Geniposide ameliorates learning memory deficits, reduces tau phosphorylation and decreases apoptosis via GSK3β pathway in streptozotocin-induced alzheimer rat model. Brain Pathol. 24 (2014), 261–269, 10.1111/bpa.12116.
    • (2014) Brain Pathol. , vol.24 , pp. 261-269
    • Gao, C.1    Liu, Y.2    Jiang, Y.3    Ding, J.4    Li, L.5
  • 100
    • 84926178115 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling
    • Gao, S., Duan, C., Gao, G., Wang, X., Yang, H., Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling. Int. J. Biochem. Cell Biol. 64 (2015), 25–33, 10.1016/j.biocel.2015.03.006.
    • (2015) Int. J. Biochem. Cell Biol. , vol.64 , pp. 25-33
    • Gao, S.1    Duan, C.2    Gao, G.3    Wang, X.4    Yang, H.5
  • 101
  • 102
    • 78651322583 scopus 로고    scopus 로고
    • A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease
    • Geldmacher, D.S., Fritsch, T., McClendon, M.J., Landreth, G., A randomized pilot clinical trial of the safety of pioglitazone in treatment of patients with Alzheimer disease. Arch. Neurol. 68 (2011), 45–50, 10.1001/archneurol.2010.229.
    • (2011) Arch. Neurol. , vol.68 , pp. 45-50
    • Geldmacher, D.S.1    Fritsch, T.2    McClendon, M.J.3    Landreth, G.4
  • 103
    • 82755176046 scopus 로고    scopus 로고
    • Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    • Gengler, S., McClean, P.L., McCurtin, R., Gault, V.A., Hölscher, C., Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol. Aging 33 (2012), 265–276, 10.1016/j.neurobiolaging.2010.02.014.
    • (2012) Neurobiol. Aging , vol.33 , pp. 265-276
    • Gengler, S.1    McClean, P.L.2    McCurtin, R.3    Gault, V.A.4    Hölscher, C.5
  • 104
    • 65549112678 scopus 로고    scopus 로고
    • Exenatide: a review from pharmacology to clinical practice
    • Gentilella, R., Bianchi, C., Rossi, A., Rotella, C.M., Exenatide: a review from pharmacology to clinical practice. Diabetes. Obes. Metab. 11 (2009), 544–556, 10.1111/j.1463-1326.2008.01018.x.
    • (2009) Diabetes. Obes. Metab. , vol.11 , pp. 544-556
    • Gentilella, R.1    Bianchi, C.2    Rossi, A.3    Rotella, C.M.4
  • 105
    • 84872501218 scopus 로고    scopus 로고
    • Insulin in the brain: sources, localization and functions
    • Ghasemi, R., Haeri, A., Dargahi, L., Mohamed, Z., Ahmadiani, A., Insulin in the brain: sources, localization and functions. Mol. Neurobiol. 47 (2013), 145–171, 10.1007/s12035-012-8339-9.
    • (2013) Mol. Neurobiol. , vol.47 , pp. 145-171
    • Ghasemi, R.1    Haeri, A.2    Dargahi, L.3    Mohamed, Z.4    Ahmadiani, A.5
  • 108
    • 79960189743 scopus 로고    scopus 로고
    • Serum insulinlike growth factor 1 as possible marker for risk and early diagnosis of Parkinson disease
    • Godau, J., Knauel, K., Weber, K., Brockmann, K., Maetzler, W., Binder, G., Berg, D., Serum insulinlike growth factor 1 as possible marker for risk and early diagnosis of Parkinson disease. Arch. Neurol. 68 (2011), 925–931, 10.1001/archneurol.2011.129.
    • (2011) Arch. Neurol. , vol.68 , pp. 925-931
    • Godau, J.1    Knauel, K.2    Weber, K.3    Brockmann, K.4    Maetzler, W.5    Binder, G.6    Berg, D.7
  • 110
    • 0038008186 scopus 로고    scopus 로고
    • Protein kinase C and ERK involvement in dendritic spine plasticity in cultured rodent hippocampal neurons [WWW Document]
    • URL (accessed 8.27.15)
    • Goldin, M., Protein kinase C and ERK involvement in dendritic spine plasticity in cultured rodent hippocampal neurons [WWW Document]. Eur. J. Neurosci., 2003 URL http://www.ncbi.nlm.nih.gov/pubmed/?term=Goldin,M.,+Segal,M.,+2003.+Protein+kinase+C+and+ERK+involvement+in+dendritic+spine+plas-+ticity (accessed 8.27.15).
    • (2003) Eur. J. Neurosci.
    • Goldin, M.1
  • 112
    • 84866330453 scopus 로고    scopus 로고
    • Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations
    • Gonzales, M.M., Tarumi, T., Eagan, D.E., Tanaka, H., Vaghasia, M., Haley, A.P., Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations. Psychosom. Med. 74 (2012), 691–698, 10.1097/PSY.0b013e31825ff1de.
    • (2012) Psychosom. Med. , vol.74 , pp. 691-698
    • Gonzales, M.M.1    Tarumi, T.2    Eagan, D.E.3    Tanaka, H.4    Vaghasia, M.5    Haley, A.P.6
  • 113
    • 84907994949 scopus 로고    scopus 로고
    • AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease
    • Grahame Hardie, D., AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease. J. Intern. Med. 276 (2014), 543–559, 10.1111/joim.12268.
    • (2014) J. Intern. Med. , vol.276 , pp. 543-559
    • Grahame Hardie, D.1
  • 114
    • 85027943896 scopus 로고    scopus 로고
    • Akt as a victim, villain and potential hero in Parkinson's disease pathophysiology and treatment
    • Greene, L.A., Levy, O., Malagelada, C., Akt as a victim, villain and potential hero in Parkinson's disease pathophysiology and treatment. Cell. Mol. Neurobiol. 31 (2011), 969–978, 10.1007/s10571-011-9671-8.
    • (2011) Cell. Mol. Neurobiol. , vol.31 , pp. 969-978
    • Greene, L.A.1    Levy, O.2    Malagelada, C.3
  • 115
    • 16244391770 scopus 로고    scopus 로고
    • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
    • Griffin, R.J., Moloney, A., Kelliher, M., Johnston, J.A., Ravid, R., Dockery, P., O'Connor, R., O'Neill, C., Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology. J. Neurochem. 93 (2005), 105–117, 10.1111/j.1471-4159.2004.02949.x.
    • (2005) J. Neurochem. , vol.93 , pp. 105-117
    • Griffin, R.J.1    Moloney, A.2    Kelliher, M.3    Johnston, J.A.4    Ravid, R.5    Dockery, P.6    O'Connor, R.7    O'Neill, C.8
  • 116
    • 79952439187 scopus 로고    scopus 로고
    • Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes
    • Gupta, A., Bisht, B., Dey, C.S., Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes. Neuropharmacology 60 (2011), 910–920, 10.1016/j.neuropharm.2011.01.033.
    • (2011) Neuropharmacology , vol.60 , pp. 910-920
    • Gupta, A.1    Bisht, B.2    Dey, C.S.3
  • 119
    • 84898830649 scopus 로고    scopus 로고
    • The neurobiological basis of cognitive impairment in Parkinson's disease
    • Halliday, G.M., Leverenz, J.B., Schneider, J.S., Adler, C.H., The neurobiological basis of cognitive impairment in Parkinson's disease. Mov. Disord. 29 (2014), 634–650, 10.1002/mds.25857.
    • (2014) Mov. Disord. , vol.29 , pp. 634-650
    • Halliday, G.M.1    Leverenz, J.B.2    Schneider, J.S.3    Adler, C.H.4
  • 120
    • 79751479118 scopus 로고    scopus 로고
    • Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain
    • Hamilton, A., Patterson, S., Porter, D., Gault, V.A., Holscher, C., Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain. J. Neurosci. Res. 89 (2011), 481–489, 10.1002/jnr.22565.
    • (2011) J. Neurosci. Res. , vol.89 , pp. 481-489
    • Hamilton, A.1    Patterson, S.2    Porter, D.3    Gault, V.A.4    Holscher, C.5
  • 122
    • 84869090452 scopus 로고    scopus 로고
    • Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats
    • Han, W.-N., Hölscher, C., Yuan, L., Yang, W., Wang, X.-H., Wu, M.-N., Qi, J.-S., Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats. Neurobiol. Aging 34 (2013), 576–588, 10.1016/j.neurobiolaging.2012.04.009.
    • (2013) Neurobiol. Aging , vol.34 , pp. 576-588
    • Han, W.-N.1    Hölscher, C.2    Yuan, L.3    Yang, W.4    Wang, X.-H.5    Wu, M.-N.6    Qi, J.-S.7
  • 123
    • 58149265311 scopus 로고    scopus 로고
    • Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus
    • Hanyu, H., Sato, T., Kiuchi, A., Sakurai, H., Iwamoto, T., Pioglitazone improved cognition in a pilot study on patients with Alzheimer's disease and mild cognitive impairment with diabetes mellitus. J. Am. Geriatr. Soc. 57 (2009), 177–179, 10.1111/j.1532-5415.2009.02067.x.
    • (2009) J. Am. Geriatr. Soc. , vol.57 , pp. 177-179
    • Hanyu, H.1    Sato, T.2    Kiuchi, A.3    Sakurai, H.4    Iwamoto, T.5
  • 124
    • 45549108268 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
    • Harkavyi, A., Abuirmeileh, A., Lever, R., Kingsbury, A.E., Biggs, C.S., Whitton, P.S., Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease. J. Neuroinflammation, 5, 2008, 19, 10.1186/1742-2094-5-19.
    • (2008) J. Neuroinflammation , vol.5 , pp. 19
    • Harkavyi, A.1    Abuirmeileh, A.2    Lever, R.3    Kingsbury, A.E.4    Biggs, C.S.5    Whitton, P.S.6
  • 126
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • Havrankova, J., Roth, J., Brownstein, M., Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272 (1978), 827–829.
    • (1978) Nature , vol.272 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 128
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years
    • Hely, M.A., Reid, W.G.J., Adena, M.A., Halliday, G.M., Morris, J.G.L., The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov. Disord. 23 (2008), 837–844, 10.1002/mds.21956.
    • (2008) Mov. Disord. , vol.23 , pp. 837-844
    • Hely, M.A.1    Reid, W.G.J.2    Adena, M.A.3    Halliday, G.M.4    Morris, J.G.L.5
  • 129
    • 85043826447 scopus 로고    scopus 로고
    • Effect of pioglitazone medication on the incidence of dementia − PubMed − NCBI [WWW Document]
    • URL (accessed 7.23.15)
    • Heneka, M.T., Fink, A., Effect of pioglitazone medication on the incidence of dementia − PubMed − NCBI [WWW Document]. Ann. Neurol., 2015 URL http://www.ncbi.nlm.nih.gov/pubmed/?term=Effect+of+pioglitazone+medication+on+the+incidence+of+dementi (accessed 7.23.15).
    • (2015) Ann. Neurol.
    • Heneka, M.T.1    Fink, A.2
  • 130
    • 84919725884 scopus 로고    scopus 로고
    • Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain
    • Heppner, K.M., Kirigiti, M., Secher, A., Paulsen, S.J., Buckingham, R., Pyke, C., Knudsen, L.B., Vrang, N., Grove, K.L., Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain. Endocrinology 156 (2015), 255–267, 10.1210/en.2014-1675.
    • (2015) Endocrinology , vol.156 , pp. 255-267
    • Heppner, K.M.1    Kirigiti, M.2    Secher, A.3    Paulsen, S.J.4    Buckingham, R.5    Pyke, C.6    Knudsen, L.B.7    Vrang, N.8    Grove, K.L.9
  • 131
    • 84907626815 scopus 로고    scopus 로고
    • The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
    • Heras-Sandoval, D., Pérez-Rojas, J.M., Hernández-Damián, J., Pedraza-Chaverri, J., The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell. Signal. 26 (2014), 2694–2701, 10.1016/j.cellsig.2014.08.019.
    • (2014) Cell. Signal. , vol.26 , pp. 2694-2701
    • Heras-Sandoval, D.1    Pérez-Rojas, J.M.2    Hernández-Damián, J.3    Pedraza-Chaverri, J.4
  • 132
    • 84881098355 scopus 로고    scopus 로고
    • Activation of GSK-3β and caspase-3 occurs in Nigral dopamine neurons during the development of apoptosis activated by a striatal injection of 6-hydroxydopamine
    • Hernandez-Baltazar, D., Mendoza-Garrido, M.E., Martinez-Fong, D., Activation of GSK-3β and caspase-3 occurs in Nigral dopamine neurons during the development of apoptosis activated by a striatal injection of 6-hydroxydopamine. PLoS One, 8, 2013, e70951, 10.1371/journal.pone.0070951.
    • (2013) PLoS One , vol.8 , pp. e70951
    • Hernandez-Baltazar, D.1    Mendoza-Garrido, M.E.2    Martinez-Fong, D.3
  • 133
    • 14844300111 scopus 로고    scopus 로고
    • Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity
    • Hilker, R., Schweitzer, K., Coburger, S., Ghaemi, M., Weisenbach, S., Jacobs, A.H., Rudolf, J., Herholz, K., Heiss, W.-D., Nonlinear progression of Parkinson disease as determined by serial positron emission tomographic imaging of striatal fluorodopa F 18 activity. Arch. Neurol. 62 (2005), 378–382, 10.1001/archneur.62.3.378.
    • (2005) Arch. Neurol. , vol.62 , pp. 378-382
    • Hilker, R.1    Schweitzer, K.2    Coburger, S.3    Ghaemi, M.4    Weisenbach, S.5    Jacobs, A.H.6    Rudolf, J.7    Herholz, K.8    Heiss, W.-D.9
  • 134
    • 0022510796 scopus 로고
    • Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas
    • Hill, J.M., Lesniak, M.A., Pert, C.B., Roth, J., Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas. Neuroscience 17 (1986), 1127–1138.
    • (1986) Neuroscience , vol.17 , pp. 1127-1138
    • Hill, J.M.1    Lesniak, M.A.2    Pert, C.B.3    Roth, J.4
  • 136
    • 84873427263 scopus 로고    scopus 로고
    • Pathogenesis of parkinson's disease
    • Hirsch, E.C., Jenner, P., Przedborski, S., Pathogenesis of parkinson's disease. Mov. Disord. 28 (2013), 24–30, 10.1002/mds.25032.
    • (2013) Mov. Disord. , vol.28 , pp. 24-30
    • Hirsch, E.C.1    Jenner, P.2    Przedborski, S.3
  • 138
    • 79951626557 scopus 로고    scopus 로고
    • Neuroprotective properties of GLP-1: theoretical and practical applications
    • Holst, J.J., Burcelin, R., Nathanson, E., Neuroprotective properties of GLP-1: theoretical and practical applications. Curr. Med. Res. Opin. 27 (2011), 547–558, 10.1185/03007995.2010.549466.
    • (2011) Curr. Med. Res. Opin. , vol.27 , pp. 547-558
    • Holst, J.J.1    Burcelin, R.2    Nathanson, E.3
  • 140
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil, G.S., Peraldi, P., Budavari, A., Ellis, R., White, M.F., Spiegelman, B.M., IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271 (1996), 665–668.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 142
    • 79956277464 scopus 로고    scopus 로고
    • Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin
    • Hsu, C.-C., Wahlqvist, M.L., Lee, M.-S., Tsai, H.-N., Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin. J. Alzheimers Dis. 24 (2011), 485–493, 10.3233/JAD-2011-101524.
    • (2011) J. Alzheimers Dis. , vol.24 , pp. 485-493
    • Hsu, C.-C.1    Wahlqvist, M.L.2    Lee, M.-S.3    Tsai, H.-N.4
  • 143
    • 84863875558 scopus 로고    scopus 로고
    • Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis
    • Hsuchou, H., Kastin, A.J., Pan, W., Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis. J. Mol. Neurosci. 47 (2012), 267–277, 10.1007/s12031-012-9734-4.
    • (2012) J. Mol. Neurosci. , vol.47 , pp. 267-277
    • Hsuchou, H.1    Kastin, A.J.2    Pan, W.3
  • 145
    • 0041765665 scopus 로고    scopus 로고
    • Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia
    • Huang, T.-J., Price, S.A., Chilton, L., Calcutt, N.A., Tomlinson, D.R., Verkhratsky, A., Fernyhough, P., Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia. Diabetes 52 (2003), 2129–2136.
    • (2003) Diabetes , vol.52 , pp. 2129-2136
    • Huang, T.-J.1    Price, S.A.2    Chilton, L.3    Calcutt, N.A.4    Tomlinson, D.R.5    Verkhratsky, A.6    Fernyhough, P.7
  • 146
    • 42049122792 scopus 로고    scopus 로고
    • Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease
    • Huang, C., Mattis, P., Perrine, K., Brown, N., Dhawan, V., Eidelberg, D., Metabolic abnormalities associated with mild cognitive impairment in Parkinson disease. Neurology 70 (2008), 1470–1477, 10.1212/01.wnl.0000304050.05332.9c.
    • (2008) Neurology , vol.70 , pp. 1470-1477
    • Huang, C.1    Mattis, P.2    Perrine, K.3    Brown, N.4    Dhawan, V.5    Eidelberg, D.6
  • 148
    • 84858713174 scopus 로고    scopus 로고
    • Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
    • Hunter, K., Hölscher, C., Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci., 13, 2012, 33, 10.1186/1471-2202-13-33.
    • (2012) BMC Neurosci. , vol.13 , pp. 33
    • Hunter, K.1    Hölscher, C.2
  • 149
    • 39149116014 scopus 로고    scopus 로고
    • Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats
    • Hunter, R.L., Choi, D.-Y., Ross, S.A., Bing, G., Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats. Neurosci. Lett. 432 (2008), 198–201, 10.1016/j.neulet.2007.12.019.
    • (2008) Neurosci. Lett. , vol.432 , pp. 198-201
    • Hunter, R.L.1    Choi, D.-Y.2    Ross, S.A.3    Bing, G.4
  • 151
    • 0344444234 scopus 로고    scopus 로고
    • Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains
    • Imamura, K., Hishikawa, N., Sawada, M., Nagatsu, T., Yoshida, M., Hashizume, Y., Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains. Acta Neuropathol. 106 (2003), 518–526, 10.1007/s00401-003-0766-2.
    • (2003) Acta Neuropathol. , vol.106 , pp. 518-526
    • Imamura, K.1    Hishikawa, N.2    Sawada, M.3    Nagatsu, T.4    Yoshida, M.5    Hashizume, Y.6
  • 152
    • 84861233877 scopus 로고    scopus 로고
    • Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study
    • Imfeld, P., Bodmer, M., Jick, S.S., Meier, C.R., Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study. J. Am. Geriatr. Soc. 60 (2012), 916–921, 10.1111/j.1532-5415.2012.03916.x.
    • (2012) J. Am. Geriatr. Soc. , vol.60 , pp. 916-921
    • Imfeld, P.1    Bodmer, M.2    Jick, S.S.3    Meier, C.R.4
  • 153
    • 84883174947 scopus 로고    scopus 로고
    • Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
    • Irwin, D.J., Lee, V.M.-Y., Trojanowski, J.Q., Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies. Nat. Rev. Neurosci. 14 (2013), 626–636, 10.1038/nrn3549.
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 626-636
    • Irwin, D.J.1    Lee, V.M.-Y.2    Trojanowski, J.Q.3
  • 154
    • 84983398492 scopus 로고    scopus 로고
    • Novel Incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells
    • Jalewa, J., Sharma, M.K., Hölscher, C., Novel Incretin analogues improve autophagy and protect from mitochondrial stress induced by rotenone in SH-SY5Y cells. J. Neurochem., 44, 2016, 10.1111/jnc.13736.
    • (2016) J. Neurochem. , vol.44
    • Jalewa, J.1    Sharma, M.K.2    Hölscher, C.3
  • 155
    • 0036202684 scopus 로고    scopus 로고
    • Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease
    • Jellinger, K.A., Seppi, K., Wenning, G.K., Poewe, W., Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease. J. Neural Transm. 109 (2002), 329–339.
    • (2002) J. Neural Transm. , vol.109 , pp. 329-339
    • Jellinger, K.A.1    Seppi, K.2    Wenning, G.K.3    Poewe, W.4
  • 157
    • 84962236691 scopus 로고    scopus 로고
    • A novel dual GLPand GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF
    • Ji, C., Xue, G.-F., Lijun, C., Feng, P., Li, D., Li, L., Li, G., Hölscher, C., A novel dual GLPand GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF. Brain Res., 2015, 10.1016/j.brainres.2015.09.035.
    • (2015) Brain Res.
    • Ji, C.1    Xue, G.-F.2    Lijun, C.3    Feng, P.4    Li, D.5    Li, L.6    Li, G.7    Hölscher, C.8
  • 158
    • 84965079907 scopus 로고    scopus 로고
    • Microglial phenotypes in Parkinson's disease and animal models of the disease
    • Joers, V., Tansey, M.G., Mulas, G., Carta, A.R., Microglial phenotypes in Parkinson's disease and animal models of the disease. Prog. Neurobiol., 2016, 10.1016/j.pneurobio.2016.04.006.
    • (2016) Prog. Neurobiol.
    • Joers, V.1    Tansey, M.G.2    Mulas, G.3    Carta, A.R.4
  • 159
    • 57049125529 scopus 로고    scopus 로고
    • Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin
    • Jolivalt, C.G., Lee, C.A., Beiswenger, K.K., Smith, J.L., Orlov, M., Torrance, M.A., Masliah, E., Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin. J. Neurosci. Res. 86 (2008), 3265–3274, 10.1002/jnr.21787.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 3265-3274
    • Jolivalt, C.G.1    Lee, C.A.2    Beiswenger, K.K.3    Smith, J.L.4    Orlov, M.5    Torrance, M.A.6    Masliah, E.7
  • 161
    • 84904113900 scopus 로고    scopus 로고
    • AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease
    • Ju, T.-C., Chen, H.-M., Chen, Y.-C., Chang, C.-P., Chang, C., Chern, Y., AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease. Biochim. Biophys. Acta 1842 (2014), 1668–1680, 10.1016/j.bbadis.2014.06.012.
    • (2014) Biochim. Biophys. Acta , vol.1842 , pp. 1668-1680
    • Ju, T.-C.1    Chen, H.-M.2    Chen, Y.-C.3    Chang, C.-P.4    Chang, C.5    Chern, Y.6
  • 162
    • 29244476043 scopus 로고    scopus 로고
    • Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity
    • Jung, T.W., Lee, J.Y., Shim, W.S., Kang, E.S., Kim, S.K., Ahn, C.W., Lee, H.C., Cha, B.S., Rosiglitazone protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity. Biochem. Biophys. Res. Commun. 340 (2006), 221–227, 10.1016/j.bbrc.2005.11.177.
    • (2006) Biochem. Biophys. Res. Commun. , vol.340 , pp. 221-227
    • Jung, T.W.1    Lee, J.Y.2    Shim, W.S.3    Kang, E.S.4    Kim, S.K.5    Ahn, C.W.6    Lee, H.C.7    Cha, B.S.8
  • 163
    • 77951977811 scopus 로고    scopus 로고
    • Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys
    • Kanaan, N.M., Kordower, J.H., Collier, T.J., Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. Neurobiol. Aging 31 (2010), 937–952, 10.1016/j.neurobiolaging.2008.07.006.
    • (2010) Neurobiol. Aging , vol.31 , pp. 937-952
    • Kanaan, N.M.1    Kordower, J.H.2    Collier, T.J.3
  • 164
    • 85043824440 scopus 로고    scopus 로고
    • Glucagon-Like peptide 1 increases mitochondrial biogenesis and function in INS-1 rat insulinoma cells
    • (Seoul, Korea)
    • Kang, M.Y., Oh, T.J., Cho, Y.M., Glucagon-Like peptide 1 increases mitochondrial biogenesis and function in INS-1 rat insulinoma cells. Endocrinol. Metab., 2014 (Seoul, Korea).
    • (2014) Endocrinol. Metab.
    • Kang, M.Y.1    Oh, T.J.2    Cho, Y.M.3
  • 165
    • 67349208526 scopus 로고    scopus 로고
    • Rescue of alpha-synuclein cytotoxicity by insulin-like growth factors
    • Kao, S.-Y., Rescue of alpha-synuclein cytotoxicity by insulin-like growth factors. Biochem. Biophys. Res. Commun. 385 (2009), 434–438, 10.1016/j.bbrc.2009.05.089.
    • (2009) Biochem. Biophys. Res. Commun. , vol.385 , pp. 434-438
    • Kao, S.-Y.1
  • 166
    • 84872569583 scopus 로고    scopus 로고
    • GLP-1 secretion by microglial cells and decreased CNS expression in obesity
    • Kappe, C., Tracy, L.M., Patrone, C., Iverfeldt, K., Sjöholm, Å., GLP-1 secretion by microglial cells and decreased CNS expression in obesity. J. Neuroinflammation, 9, 2012, 276, 10.1186/1742-2094-9-276.
    • (2012) J. Neuroinflammation , vol.9 , pp. 276
    • Kappe, C.1    Tracy, L.M.2    Patrone, C.3    Iverfeldt, K.4    Sjöholm, Å.5
  • 167
    • 0037349072 scopus 로고    scopus 로고
    • Entry of exendin-4 into brain is rapid but may be limited at high doses
    • Kastin, A.J., Akerstrom, V., Entry of exendin-4 into brain is rapid but may be limited at high doses. Int. J. Obes. Relat. Metab. Disord. 27 (2003), 313–318, 10.1038/sj.ijo.0802206.
    • (2003) Int. J. Obes. Relat. Metab. Disord. , vol.27 , pp. 313-318
    • Kastin, A.J.1    Akerstrom, V.2
  • 168
    • 84925803640 scopus 로고    scopus 로고
    • Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice
    • Khang, R., Park, C., Shin, J.-H., Dysregulation of parkin in the substantia nigra of db/db and high-fat diet mice. Neuroscience 294 (2015), 182–192, 10.1016/j.neuroscience.2015.03.017.
    • (2015) Neuroscience , vol.294 , pp. 182-192
    • Khang, R.1    Park, C.2    Shin, J.-H.3
  • 169
    • 84865489968 scopus 로고    scopus 로고
    • Suppression of nuclear factor-(B activation and inflammation in microglia by physically modified saline
    • Khasnavis, S., Jana, A., Roy, A., Mazumder, M., Bhushan, B., Wood, T., Ghosh, S., Watson, R., Pahan, K., Suppression of nuclear factor-(B activation and inflammation in microglia by physically modified saline. J. Biol. Chem. 287 (2012), 29529–29542, 10.1074/jbc.M111.338012.
    • (2012) J. Biol. Chem. , vol.287 , pp. 29529-29542
    • Khasnavis, S.1    Jana, A.2    Roy, A.3    Mazumder, M.4    Bhushan, B.5    Wood, T.6    Ghosh, S.7    Watson, R.8    Pahan, K.9
  • 170
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • Kieffer, T.J., McIntosh, C.H., Pederson, R.A., Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV. Endocrinology 136 (1995), 3585–3596, 10.1210/endo.136.8.7628397.
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1    McIntosh, C.H.2    Pederson, R.A.3
  • 171
    • 70349334516 scopus 로고    scopus 로고
    • Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease
    • Kim, S., Moon, M., Park, S., Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease. J. Endocrinol. 202 (2009), 431–439, 10.1677/JOE-09-0132.
    • (2009) J. Endocrinol. , vol.202 , pp. 431-439
    • Kim, S.1    Moon, M.2    Park, S.3
  • 172
    • 80052290624 scopus 로고    scopus 로고
    • Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling
    • Kim, S.R., Ries, V., Cheng, H.-C., Kareva, T., Oo, T.F., Yu, W.H., Duff, K., Kholodilov, N., Burke, R.E., Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. Neurobiol. Dis. 44 (2011), 215–222, 10.1016/j.nbd.2011.07.003.
    • (2011) Neurobiol. Dis. , vol.44 , pp. 215-222
    • Kim, S.R.1    Ries, V.2    Cheng, H.-C.3    Kareva, T.4    Oo, T.F.5    Yu, W.H.6    Duff, K.7    Kholodilov, N.8    Burke, R.E.9
  • 173
    • 84862799796 scopus 로고    scopus 로고
    • Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures
    • Kim, D.-H., Huh, J.-W., Jang, M., Suh, J.-H., Kim, T.-W., Park, J.-S., Yoon, S.-Y., Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures. Neurobiol. Dis. 46 (2012), 52–58, 10.1016/j.nbd.2011.12.043.
    • (2012) Neurobiol. Dis. , vol.46 , pp. 52-58
    • Kim, D.-H.1    Huh, J.-W.2    Jang, M.3    Suh, J.-H.4    Kim, T.-W.5    Park, J.-S.6    Yoon, S.-Y.7
  • 174
    • 84893058002 scopus 로고    scopus 로고
    • Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling
    • Kim, M.-H., Jee, J.-H., Park, S., Lee, M.-S., Kim, K.-W., Lee, M.-K., Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling. J. Endocrinol. 220 (2014), 117–128, 10.1530/JOE-13-0381.
    • (2014) J. Endocrinol. , vol.220 , pp. 117-128
    • Kim, M.-H.1    Jee, J.-H.2    Park, S.3    Lee, M.-S.4    Kim, K.-W.5    Lee, M.-K.6
  • 176
    • 80052964176 scopus 로고    scopus 로고
    • The PKB/FOXO switch in aging and cancer
    • Kloet, D.E.A., Burgering, B.M.T., The PKB/FOXO switch in aging and cancer. Biochim. Biophys. Acta 1813 (2011), 1926–1937, 10.1016/j.bbamcr.2011.04.003.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1926-1937
    • Kloet, D.E.A.1    Burgering, B.M.T.2
  • 179
    • 84865172032 scopus 로고    scopus 로고
    • Inappropriate metformin prescribing in elderly type 2 diabetes mellitus (T2DM) patients
    • Kosmalski, M., Drozdowska, A., Sliwinska, A., Drzewoski, J., Inappropriate metformin prescribing in elderly type 2 diabetes mellitus (T2DM) patients. Adv. Med. Sci. 57 (2012), 65–70, 10.2478/v10039-012-0017-7.
    • (2012) Adv. Med. Sci. , vol.57 , pp. 65-70
    • Kosmalski, M.1    Drozdowska, A.2    Sliwinska, A.3    Drzewoski, J.4
  • 180
  • 183
    • 0036791755 scopus 로고    scopus 로고
    • Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells
    • Kumar, N., Dey, C.S., Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells. Br. J. Pharmacol. 137 (2002), 329–336, 10.1038/sj.bjp.0704878.
    • (2002) Br. J. Pharmacol. , vol.137 , pp. 329-336
    • Kumar, N.1    Dey, C.S.2
  • 184
    • 84874638291 scopus 로고    scopus 로고
    • The role of aging upon β cell turnover
    • Kushner, J.A., The role of aging upon β cell turnover. J. Clin. Invest. 123 (2013), 990–995, 10.1172/JCI64095.
    • (2013) J. Clin. Invest. , vol.123 , pp. 990-995
    • Kushner, J.A.1
  • 186
    • 84859795927 scopus 로고    scopus 로고
    • Differential susceptibility to the PPAR-γ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease
    • Laloux, C., Petrault, M., Lecointe, C., Devos, D., Bordet, R., Differential susceptibility to the PPAR-γ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease. Pharmacol. Res. 65 (2012), 514–522, 10.1016/j.phrs.2012.02.008.
    • (2012) Pharmacol. Res. , vol.65 , pp. 514-522
    • Laloux, C.1    Petrault, M.2    Lecointe, C.3    Devos, D.4    Bordet, R.5
  • 187
    • 84906975441 scopus 로고    scopus 로고
    • Harnessing neurogenesis for the possible treatment of Parkinson's disease
    • Lamm, O., Ganz, J., Melamed, E., Offen, D., Harnessing neurogenesis for the possible treatment of Parkinson's disease. J. Comp. Neurol. 522 (2014), 2817–2830, 10.1002/cne.23607.
    • (2014) J. Comp. Neurol. , vol.522 , pp. 2817-2830
    • Lamm, O.1    Ganz, J.2    Melamed, E.3    Offen, D.4
  • 189
    • 70349567668 scopus 로고    scopus 로고
    • Cerebral proteolysis of amiloid-b peptide: relevance of insulin-degrading enzyme in Alzheimer's disease
    • Leal, M.C., Fernandez Gamba, A., Morelli, L., Castaño, E.M., Cerebral proteolysis of amiloid-b peptide: relevance of insulin-degrading enzyme in Alzheimer's disease. Med. (B. Aires). 69 (2009), 466–472.
    • (2009) Med. (B. Aires). , vol.69 , pp. 466-472
    • Leal, M.C.1    Fernandez Gamba, A.2    Morelli, L.3    Castaño, E.M.4
  • 190
    • 24044474689 scopus 로고    scopus 로고
    • Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway
    • Lee, C.-C., Huang, C.-C., Wu, M.-Y., Hsu, K.-S., Insulin stimulates postsynaptic density-95 protein translation via the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway. J. Biol. Chem. 280 (2005), 18543–18550, 10.1074/jbc.M414112200.
    • (2005) J. Biol. Chem. , vol.280 , pp. 18543-18550
    • Lee, C.-C.1    Huang, C.-C.2    Wu, M.-Y.3    Hsu, K.-S.4
  • 191
    • 84865320274 scopus 로고    scopus 로고
    • Rosiglitazone, a PPAR-γ agonist, protects against striatal dopaminergic neurodegeneration induced by 6-OHDA lesions in the substantia nigra of rats
    • Lee, E.Y., Lee, J.E., Park, J.H., Shin, I.C., Koh, H.C., Rosiglitazone, a PPAR-γ agonist, protects against striatal dopaminergic neurodegeneration induced by 6-OHDA lesions in the substantia nigra of rats. Toxicol. Lett. 213 (2012), 332–344, 10.1016/j.toxlet.2012.07.016.
    • (2012) Toxicol. Lett. , vol.213 , pp. 332-344
    • Lee, E.Y.1    Lee, J.E.2    Park, J.H.3    Shin, I.C.4    Koh, H.C.5
  • 192
    • 77749295756 scopus 로고    scopus 로고
    • Cross-talk between PPARgamma and insulin signaling and modulation of insulin sensitivity
    • Leonardini, A., Laviola, L., Perrini, S., Natalicchio, A., Giorgino, F., Cross-talk between PPARgamma and insulin signaling and modulation of insulin sensitivity. PPAR Res., 2009, 2009, 818945, 10.1155/2009/818945.
    • (2009) PPAR Res. , vol.2009 , pp. 818945
    • Leonardini, A.1    Laviola, L.2    Perrini, S.3    Natalicchio, A.4    Giorgino, F.5
  • 193
    • 0034714313 scopus 로고    scopus 로고
    • Glucose-regulated dopamine release from substantia nigra neurons
    • Levin, B.E., Glucose-regulated dopamine release from substantia nigra neurons. Brain Res. 874 (2000), 158–164.
    • (2000) Brain Res. , vol.874 , pp. 158-164
    • Levin, B.E.1
  • 196
    • 78149357102 scopus 로고    scopus 로고
    • Effects of metformin in experimental stroke
    • Li, J., Benashski, S.E., Venna, V.R., McCullough, L.D., Effects of metformin in experimental stroke. Stroke 41 (2010), 2645–2652, 10.1161/STROKEAHA.110.589697.
    • (2010) Stroke , vol.41 , pp. 2645-2652
    • Li, J.1    Benashski, S.E.2    Venna, V.R.3    McCullough, L.D.4
  • 198
    • 84859043569 scopus 로고    scopus 로고
    • Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice
    • Li, J., Deng, J., Sheng, W., Zuo, Z., Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice. Pharmacol. Biochem. Behav. 101 (2012), 564–574, 10.1016/j.pbb.2012.03.002.
    • (2012) Pharmacol. Biochem. Behav. , vol.101 , pp. 564-574
    • Li, J.1    Deng, J.2    Sheng, W.3    Zuo, Z.4
  • 199
    • 84862780458 scopus 로고    scopus 로고
    • Advanced glycation end products and neurodegenerative diseases: mechanisms and perspective
    • Li, J., Liu, D., Sun, L., Lu, Y., Zhang, Z., Advanced glycation end products and neurodegenerative diseases: mechanisms and perspective. J. Neurol. Sci. 317 (2012), 1–5, 10.1016/j.jns.2012.02.018.
    • (2012) J. Neurol. Sci. , vol.317 , pp. 1-5
    • Li, J.1    Liu, D.2    Sun, L.3    Lu, Y.4    Zhang, Z.5
  • 200
    • 84886242581 scopus 로고    scopus 로고
    • Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells
    • Li, Z., Zhou, Z., Huang, G., Hu, F., Xiang, Y., He, L., Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells. PLoS One, 8, 2013, e76172, 10.1371/journal.pone.0076172.
    • (2013) PLoS One , vol.8 , pp. e76172
    • Li, Z.1    Zhou, Z.2    Huang, G.3    Hu, F.4    Xiang, Y.5    He, L.6
  • 201
    • 69849106777 scopus 로고    scopus 로고
    • Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-[18F]FDG-PET
    • Liepelt, I., Reimold, M., Maetzler, W., Godau, J., Reischl, G., Gaenslen, A., Herbst, H., Berg, D., Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-[18F]FDG-PET. Mov. Disord. 24 (2009), 1504–1511, 10.1002/mds.22662.
    • (2009) Mov. Disord. , vol.24 , pp. 1504-1511
    • Liepelt, I.1    Reimold, M.2    Maetzler, W.3    Godau, J.4    Reischl, G.5    Gaenslen, A.6    Herbst, H.7    Berg, D.8
  • 202
    • 84947032830 scopus 로고    scopus 로고
    • AMPK-mediated regulation of neuronal metabolism and function in brain diseases
    • Liu, Y.-J., Chern, Y., AMPK-mediated regulation of neuronal metabolism and function in brain diseases. J. Neurogenet., 2015, 1–23, 10.3109/01677063.2015.1067203.
    • (2015) J. Neurogenet. , pp. 1-23
    • Liu, Y.-J.1    Chern, Y.2
  • 204
    • 84936871959 scopus 로고    scopus 로고
    • Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • Liu, W., Jalewa, J., Sharma, M., Li, G., Li, L., Hölscher, C., Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Neuroscience 303 (2015), 42–50, 10.1016/j.neuroscience.2015.06.054.
    • (2015) Neuroscience , vol.303 , pp. 42-50
    • Liu, W.1    Jalewa, J.2    Sharma, M.3    Li, G.4    Li, L.5    Hölscher, C.6
  • 205
    • 84940650550 scopus 로고    scopus 로고
    • Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease
    • Liu, W., Li, Y., Jalewa, J., Saunders-Wood, T., Li, L., Hölscher, C., Neuroprotective effects of an oxyntomodulin analogue in the MPTP mouse model of Parkinson's disease. Eur. J. Pharmacol. 765 (2015), 284–290, 10.1016/j.ejphar.2015.08.038.
    • (2015) Eur. J. Pharmacol. , vol.765 , pp. 284-290
    • Liu, W.1    Li, Y.2    Jalewa, J.3    Saunders-Wood, T.4    Li, L.5    Hölscher, C.6
  • 207
    • 84964266916 scopus 로고    scopus 로고
    • Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis
    • Liu, Y.-J., Lee, L.-M., Lai, H.-L., Chern, Y., Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis. FEBS Lett. 589 (2015), 432–439, 10.1016/j.febslet.2014.12.029.
    • (2015) FEBS Lett. , vol.589 , pp. 432-439
    • Liu, Y.-J.1    Lee, L.-M.2    Lai, H.-L.3    Chern, Y.4
  • 208
    • 84874722479 scopus 로고    scopus 로고
    • The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease
    • Long-Smith, C.M., Manning, S., McClean, P.L., Coakley, M.F., O'Halloran, D.J., Holscher, C., O'Neill, C., The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease. Neuromolecular Med. 15 (2013), 102–114, 10.1007/s12017-012-8199-5.
    • (2013) Neuromolecular Med. , vol.15 , pp. 102-114
    • Long-Smith, C.M.1    Manning, S.2    McClean, P.L.3    Coakley, M.F.4    O'Halloran, D.J.5    Holscher, C.6    O'Neill, C.7
  • 209
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • Lovshin, J.A., Drucker, D.J., Incretin-based therapies for type 2 diabetes mellitus. Nat. Rev. Endocrinol. 5 (2009), 262–269, 10.1038/nrendo.2009.48.
    • (2009) Nat. Rev. Endocrinol. , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 211
    • 84908160592 scopus 로고    scopus 로고
    • Diabetes and risk of Parkinson's disease: an updated meta-analysis of case-control studies
    • Lu, L., Fu, D.-L., Li, H.-Q., Liu, A.-J., Li, J.-H., Zheng, G.-Q., Diabetes and risk of Parkinson's disease: an updated meta-analysis of case-control studies. PLoS One, 9, 2014, e85781, 10.1371/journal.pone.0085781.
    • (2014) PLoS One , vol.9 , pp. e85781
    • Lu, L.1    Fu, D.-L.2    Li, H.-Q.3    Liu, A.-J.4    Li, J.-H.5    Zheng, G.-Q.6
  • 212
    • 84906910072 scopus 로고    scopus 로고
    • Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β
    • Ma, T., Chen, Y., Vingtdeux, V., Zhao, H., Viollet, B., Marambaud, P., Klann, E., Inhibition of AMP-activated protein kinase signaling alleviates impairments in hippocampal synaptic plasticity induced by amyloid β. J. Neurosci. 34 (2014), 12230–12238, 10.1523/JNEUROSCI.1694-14.2014.
    • (2014) J. Neurosci. , vol.34 , pp. 12230-12238
    • Ma, T.1    Chen, Y.2    Vingtdeux, V.3    Zhao, H.4    Viollet, B.5    Marambaud, P.6    Klann, E.7
  • 213
    • 84943580301 scopus 로고    scopus 로고
    • Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice
    • Ma, D.-L., Chen, F.-Q., Xu, W.-J., Yue, W.-Z., Yuan, G., Yang, Y., Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in diabetic db/db mice. J. Neurochem., 2015, 10.1111/jnc.13248.
    • (2015) J. Neurochem.
    • Ma, D.-L.1    Chen, F.-Q.2    Xu, W.-J.3    Yue, W.-Z.4    Yuan, G.5    Yang, Y.6
  • 215
    • 84876078566 scopus 로고    scopus 로고
    • The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation
    • Mairet-Coello, G., Courchet, J., Pieraut, S., Courchet, V., Maximov, A., Polleux, F., The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation. Neuron 78 (2013), 94–108, 10.1016/j.neuron.2013.02.003.
    • (2013) Neuron , vol.78 , pp. 94-108
    • Mairet-Coello, G.1    Courchet, J.2    Pieraut, S.3    Courchet, V.4    Maximov, A.5    Polleux, F.6
  • 216
    • 58149395816 scopus 로고    scopus 로고
    • RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation
    • Malagelada, C., Jin, Z.H., Greene, L.A., RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. J. Neurosci. 28 (2008), 14363–14371, 10.1523/JNEUROSCI.3928-08.2008.
    • (2008) J. Neurosci. , vol.28 , pp. 14363-14371
    • Malagelada, C.1    Jin, Z.H.2    Greene, L.A.3
  • 217
    • 84864249514 scopus 로고    scopus 로고
    • Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
    • Mandrekar-Colucci, S., Karlo, J.C., Landreth, G.E., Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J. Neurosci. 32 (2012), 10117–10128, 10.1523/JNEUROSCI.5268-11.2012.
    • (2012) J. Neurosci. , vol.32 , pp. 10117-10128
    • Mandrekar-Colucci, S.1    Karlo, J.C.2    Landreth, G.E.3
  • 218
    • 79959879208 scopus 로고    scopus 로고
    • Central insulin and leptin-mediated autonomic control of glucose homeostasis
    • Marino, J.S., Xu, Y., Hill, J.W., Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol. Metab. 22 (2011), 275–285, 10.1016/j.tem.2011.03.001.
    • (2011) Trends Endocrinol. Metab. , vol.22 , pp. 275-285
    • Marino, J.S.1    Xu, Y.2    Hill, J.W.3
  • 219
    • 0035834076 scopus 로고    scopus 로고
    • beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    • Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., Mucke, L., beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc. Natl. Acad. Sci. U. S. A 98 (2001), 12245–12250.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , pp. 12245-12250
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Sagara, Y.4    Mallory, M.5    Hashimoto, M.6    Mucke, L.7
  • 220
    • 77949912530 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor-1 and insulin-like growth factor binding proteins in the serum and cerebrospinal fluid of patients with Parkinson's disease
    • Mashayekhi, F., Mirzajani, E., Naji, M., Azari, M., Expression of insulin-like growth factor-1 and insulin-like growth factor binding proteins in the serum and cerebrospinal fluid of patients with Parkinson's disease. J. Clin. Neurosci. 17 (2010), 623–627, 10.1016/j.jocn.2009.08.013.
    • (2010) J. Clin. Neurosci. , vol.17 , pp. 623-627
    • Mashayekhi, F.1    Mirzajani, E.2    Naji, M.3    Azari, M.4
  • 222
    • 84931292010 scopus 로고    scopus 로고
    • Mechanisms of neurodegeration in type 2 diabetes and the neuroprotective potential of dipeptidyl peptidase 4 inhibitors
    • Matteucci, E., Giampietro, O., Mechanisms of neurodegeration in type 2 diabetes and the neuroprotective potential of dipeptidyl peptidase 4 inhibitors. Curr. Med. Chem. 22 (2015), 1573–1581.
    • (2015) Curr. Med. Chem. , vol.22 , pp. 1573-1581
    • Matteucci, E.1    Giampietro, O.2
  • 223
    • 77649187436 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease
    • McClean, P.L., Gault, V.A., Harriott, P., Hölscher, C., Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. Eur. J. Pharmacol. 630 (2010), 158–162, 10.1016/j.ejphar.2009.12.023.
    • (2010) Eur. J. Pharmacol. , vol.630 , pp. 158-162
    • McClean, P.L.1    Gault, V.A.2    Harriott, P.3    Hölscher, C.4
  • 224
    • 84865521108 scopus 로고    scopus 로고
    • Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain
    • McGovern, S.F.J., Hunter, K., Hölscher, C., Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain. Brain Res. 1473 (2012), 204–213, 10.1016/j.brainres.2012.07.029.
    • (2012) Brain Res. , vol.1473 , pp. 204-213
    • McGovern, S.F.J.1    Hunter, K.2    Hölscher, C.3
  • 225
    • 77952545095 scopus 로고    scopus 로고
    • Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance
    • McNay, E.C., Ong, C.T., McCrimmon, R.J., Cresswell, J., Bogan, J.S., Sherwin, R.S., Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance. Neurobiol. Learn. Mem. 93 (2010), 546–553, 10.1016/j.nlm.2010.02.002.
    • (2010) Neurobiol. Learn. Mem. , vol.93 , pp. 546-553
    • McNay, E.C.1    Ong, C.T.2    McCrimmon, R.J.3    Cresswell, J.4    Bogan, J.S.5    Sherwin, R.S.6
  • 226
    • 0028171374 scopus 로고
    • Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
    • Mogi, M., Harada, M., Kondo, T., Riederer, P., Inagaki, H., Minami, M., Nagatsu, T., Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci. Lett. 180 (1994), 147–150.
    • (1994) Neurosci. Lett. , vol.180 , pp. 147-150
    • Mogi, M.1    Harada, M.2    Kondo, T.3    Riederer, P.4    Inagaki, H.5    Minami, M.6    Nagatsu, T.7
  • 227
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • Moloney, A.M., Griffin, R.J., Timmons, S., O'Connor, R., Ravid, R., O'Neill, C., Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol. Aging 31 (2010), 224–243, 10.1016/j.neurobiolaging.2008.04.002.
    • (2010) Neurobiol. Aging , vol.31 , pp. 224-243
    • Moloney, A.M.1    Griffin, R.J.2    Timmons, S.3    O'Connor, R.4    Ravid, R.5    O'Neill, C.6
  • 229
    • 38649121744 scopus 로고    scopus 로고
    • Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation
    • Moran, L.B., Graeber, M.B., Towards a pathway definition of Parkinson's disease: a complex disorder with links to cancer, diabetes and inflammation. Neurogenetics 9 (2008), 1–13, 10.1007/s10048-007-0116-y.
    • (2008) Neurogenetics , vol.9 , pp. 1-13
    • Moran, L.B.1    Graeber, M.B.2
  • 230
    • 84948978519 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus and biomarkers of neurodegeneration
    • Moran, C., Beare, R., Phan, T.G., Bruce, D.G., Callisaya, M.L., Srikanth, V., Type 2 diabetes mellitus and biomarkers of neurodegeneration. Neurology 85 (2015), 1123–1130, 10.1212/WNL.0000000000001982.
    • (2015) Neurology , vol.85 , pp. 1123-1130
    • Moran, C.1    Beare, R.2    Phan, T.G.3    Bruce, D.G.4    Callisaya, M.L.5    Srikanth, V.6
  • 231
    • 33746153746 scopus 로고    scopus 로고
    • Insulin attenuates diabetes-related mitochondrial alterations: a comparative study
    • Moreira, P.I., Rolo, A.P., Sena, C., Seiça, R., Oliveira, C.R., Santos, M.S., Insulin attenuates diabetes-related mitochondrial alterations: a comparative study. Med. Chem. 2 (2006), 299–308.
    • (2006) Med. Chem. , vol.2 , pp. 299-308
    • Moreira, P.I.1    Rolo, A.P.2    Sena, C.3    Seiça, R.4    Oliveira, C.R.5    Santos, M.S.6
  • 232
    • 0028344810 scopus 로고
    • Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease
    • Moroo, I., Yamada, T., Makino, H., Tooyama, I., McGeer, P.L., McGeer, E.G., Hirayama, K., Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease. Acta Neuropathol. 87 (1994), 343–348.
    • (1994) Acta Neuropathol. , vol.87 , pp. 343-348
    • Moroo, I.1    Yamada, T.2    Makino, H.3    Tooyama, I.4    McGeer, P.L.5    McGeer, E.G.6    Hirayama, K.7
  • 233
    • 54549097933 scopus 로고    scopus 로고
    • Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease
    • Morris, J.K., Zhang, H., Gupte, A.A., Bomhoff, G.L., Stanford, J.A., Geiger, P.C., Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease. Brain Res. 1240 (2008), 185–195, 10.1016/j.brainres.2008.08.089.
    • (2008) Brain Res. , vol.1240 , pp. 185-195
    • Morris, J.K.1    Zhang, H.2    Gupte, A.A.3    Bomhoff, G.L.4    Stanford, J.A.5    Geiger, P.C.6
  • 234
    • 77957575432 scopus 로고    scopus 로고
    • Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet
    • Morris, J.K., Bomhoff, G.L., Stanford, J.A., Geiger, P.C., Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet. AJP Regul. Integr. Comp. Physiol. 299 (2010), R1082–R1090, 10.1152/ajpregu.00449.2010.
    • (2010) AJP Regul. Integr. Comp. Physiol. , vol.299 , pp. R1082-R1090
    • Morris, J.K.1    Bomhoff, G.L.2    Stanford, J.A.3    Geiger, P.C.4
  • 236
    • 82455175237 scopus 로고    scopus 로고
    • Effects of unilateral nigrostriatal dopamine depletion on peripheral glucose tolerance and insulin signaling in middle aged rats
    • Morris, J.K., Seim, N.B., Bomhoff, G.L., Geiger, P.C., Stanford, J.A., Effects of unilateral nigrostriatal dopamine depletion on peripheral glucose tolerance and insulin signaling in middle aged rats. Neurosci. Lett. 504 (2011), 219–222, 10.1016/j.neulet.2011.09.027.
    • (2011) Neurosci. Lett. , vol.504 , pp. 219-222
    • Morris, J.K.1    Seim, N.B.2    Bomhoff, G.L.3    Geiger, P.C.4    Stanford, J.A.5
  • 238
    • 84937520622 scopus 로고    scopus 로고
    • Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial
    • ENINDS Exploratory Trials in Parkinson Disease (NET-PD) FS-ZONE Investigators, Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial. Lancet. Neurol. 14 (2015), 795–803, 10.1016/S1474-4422(15)00144-1.
    • (2015) Lancet. Neurol. , vol.14 , pp. 795-803
    • ENINDS Exploratory Trials in Parkinson Disease (NET-PD) FS-ZONE Investigators1
  • 240
    • 67649196932 scopus 로고    scopus 로고
    • Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis
    • Nath, N., Khan, M., Paintlia, M.K., Singh, I., Hoda, M.N., Giri, S., Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis. J. Immunol. 182 (2009), 8005–8014, 10.4049/jimmunol.0803563.
    • (2009) J. Immunol. , vol.182 , pp. 8005-8014
    • Nath, N.1    Khan, M.2    Paintlia, M.K.3    Singh, I.4    Hoda, M.N.5    Giri, S.6
  • 241
    • 84867269951 scopus 로고    scopus 로고
    • AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease
    • Ng, C.-H., Guan, M.S.H., Koh, C., Ouyang, X., Yu, F., Tan, E.-K., O'Neill, S.P., Zhang, X., Chung, J., Lim, K.-L., AMP kinase activation mitigates dopaminergic dysfunction and mitochondrial abnormalities in Drosophila models of Parkinson's disease. J. Neurosci. 32 (2012), 14311–143117, 10.1523/JNEUROSCI.0499-12.2012.
    • (2012) J. Neurosci. , vol.32 , pp. 14311-143117
    • Ng, C.-H.1    Guan, M.S.H.2    Koh, C.3    Ouyang, X.4    Yu, F.5    Tan, E.-K.6    O'Neill, S.P.7    Zhang, X.8    Chung, J.9    Lim, K.-L.10
  • 242
    • 55249125525 scopus 로고    scopus 로고
    • Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist
    • Nicolakakis, N., Aboulkassim, T., Ongali, B., Lecrux, C., Fernandes, P., Rosa-Neto, P., Tong, X.-K., Hamel, E., Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. J. Neurosci. 28 (2008), 9287–9296, 10.1523/JNEUROSCI.3348-08.2008.
    • (2008) J. Neurosci. , vol.28 , pp. 9287-9296
    • Nicolakakis, N.1    Aboulkassim, T.2    Ongali, B.3    Lecrux, C.4    Fernandes, P.5    Rosa-Neto, P.6    Tong, X.-K.7    Hamel, E.8
  • 243
    • 66649120006 scopus 로고    scopus 로고
    • Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF
    • O'Keeffe, G.C., Tyers, P., Aarsland, D., Dalley, J.W., Barker, R.A., Caldwell, M.A., Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF. Proc. Natl. Acad. Sci. 106 (2009), 8754–8759, 10.1073/pnas.0803955106.
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , pp. 8754-8759
    • O'Keeffe, G.C.1    Tyers, P.2    Aarsland, D.3    Dalley, J.W.4    Barker, R.A.5    Caldwell, M.A.6
  • 244
    • 84879026548 scopus 로고    scopus 로고
    • PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease
    • O'Neill, C., PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease. Exp. Gerontol. 48 (2013), 647–653, 10.1016/j.exger.2013.02.025.
    • (2013) Exp. Gerontol. , vol.48 , pp. 647-653
    • O'Neill, C.1
  • 245
    • 80051987703 scopus 로고    scopus 로고
    • Crosstalk in NF-κB signaling pathways
    • Oeckinghaus, A., Hayden, M.S., Ghosh, S., Crosstalk in NF-κB signaling pathways. Nat. Immunol. 12 (2011), 695–708, 10.1038/ni.2065.
    • (2011) Nat. Immunol. , vol.12 , pp. 695-708
    • Oeckinghaus, A.1    Hayden, M.S.2    Ghosh, S.3
  • 246
  • 248
    • 84878016938 scopus 로고    scopus 로고
    • Gray matter atrophy in Parkinson's disease with dementia: evidence from meta-analysis of voxel-based morphometry studies
    • Pan, P.L., Shi, H.C., Zhong, J.G., Xiao, P.R., Shen, Y., Wu, L.J., Song, Y.Y., He, G.X., Li, H.L., Gray matter atrophy in Parkinson's disease with dementia: evidence from meta-analysis of voxel-based morphometry studies. Neurol. Sci. 34 (2013), 613–619, 10.1007/s10072-012-1250-3.
    • (2013) Neurol. Sci. , vol.34 , pp. 613-619
    • Pan, P.L.1    Shi, H.C.2    Zhong, J.G.3    Xiao, P.R.4    Shen, Y.5    Wu, L.J.6    Song, Y.Y.7    He, G.X.8    Li, H.L.9
  • 249
    • 84880399455 scopus 로고    scopus 로고
    • Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology
    • Papadopoulos, P., Rosa-Neto, P., Rochford, J., Hamel, E., Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-β and cerebrovascular pathology. PLoS One, 8, 2013, e68612, 10.1371/journal.pone.0068612.
    • (2013) PLoS One , vol.8 , pp. e68612
    • Papadopoulos, P.1    Rosa-Neto, P.2    Rochford, J.3    Hamel, E.4
  • 250
    • 0034012731 scopus 로고    scopus 로고
    • Intracerebroventricular insulin enhances memory in a passive-avoidance task
    • Park, C.R., Seeley, R.J., Craft, S., Woods, S.C., Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiol. Behav. 68 (2000), 509–514.
    • (2000) Physiol. Behav. , vol.68 , pp. 509-514
    • Park, C.R.1    Seeley, R.J.2    Craft, S.3    Woods, S.C.4
  • 251
    • 84907032242 scopus 로고    scopus 로고
    • Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice
    • Patil, S.P., Jain, P.D., Ghumatkar, P.J., Tambe, R., Sathaye, S., Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice. Neuroscience 277 (2014), 747–754, 10.1016/j.neuroscience.2014.07.046.
    • (2014) Neuroscience , vol.277 , pp. 747-754
    • Patil, S.P.1    Jain, P.D.2    Ghumatkar, P.J.3    Tambe, R.4    Sathaye, S.5
  • 254
    • 84905757105 scopus 로고    scopus 로고
    • Metformin–mode of action and clinical implications for diabetes and cancer
    • Pernicova, I., Korbonits, M., Metformin–mode of action and clinical implications for diabetes and cancer. Nat. Rev. Endocrinol. 10 (2014), 143–156, 10.1038/nrendo.2013.256.
    • (2014) Nat. Rev. Endocrinol. , vol.10 , pp. 143-156
    • Pernicova, I.1    Korbonits, M.2
  • 256
    • 0036182251 scopus 로고    scopus 로고
    • A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells
    • Perry, T., Lahiri, D.K., Chen, D., Zhou, J., Shaw, K.T.Y., Egan, J.M., Greig, N.H., A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J. Pharmacol. Exp. Ther. 300 (2002), 958–966.
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 958-966
    • Perry, T.1    Lahiri, D.K.2    Chen, D.3    Zhou, J.4    Shaw, K.T.Y.5    Egan, J.M.6    Greig, N.H.7
  • 257
    • 0038248960 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron
    • Perry, T., Lahiri, D.K., Sambamurti, K., Chen, D., Mattson, M.P., Egan, J.M., Greig, N.H., Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J. Neurosci. Res. 72 (2003), 603–612, 10.1002/jnr.10611.
    • (2003) J. Neurosci. Res. , vol.72 , pp. 603-612
    • Perry, T.1    Lahiri, D.K.2    Sambamurti, K.3    Chen, D.4    Mattson, M.P.5    Egan, J.M.6    Greig, N.H.7
  • 258
    • 33846585119 scopus 로고    scopus 로고
    • Systemic infections and inflammation affect chronic neurodegeneration
    • Perry, V.H., Cunningham, C., Holmes, C., Systemic infections and inflammation affect chronic neurodegeneration. Nat. Rev. Immunol. 7 (2007), 161–617, 10.1038/nri2015.
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 161-617
    • Perry, V.H.1    Cunningham, C.2    Holmes, C.3
  • 260
    • 84858121110 scopus 로고    scopus 로고
    • Synaptic dysfunction in Parkinson's disease
    • Picconi, B., Piccoli, G., Calabresi, P., Synaptic dysfunction in Parkinson's disease. Adv. Exp. Med. Biol. 970 (2012), 553–572, 10.1007/978-3-7091-0932-8_24.
    • (2012) Adv. Exp. Med. Biol. , vol.970 , pp. 553-572
    • Picconi, B.1    Piccoli, G.2    Calabresi, P.3
  • 261
    • 84872175094 scopus 로고    scopus 로고
    • Unraveling oxyntomodulin, GLP1’s enigmatic brother
    • Pocai, A., Unraveling oxyntomodulin, GLP1’s enigmatic brother. J. Endocrinol. 215 (2012), 335–346, 10.1530/JOE-12-0368.
    • (2012) J. Endocrinol. , vol.215 , pp. 335-346
    • Pocai, A.1
  • 262
    • 77956134398 scopus 로고    scopus 로고
    • Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance
    • Porter, D.W., Kerr, B.D., Flatt, P.R., Holscher, C., Gault, V.A., Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance. Diabetes. Obes. Metab. 12 (2010), 891–899, 10.1111/j.1463-1326.2010.01259.x.
    • (2010) Diabetes. Obes. Metab. , vol.12 , pp. 891-899
    • Porter, D.W.1    Kerr, B.D.2    Flatt, P.R.3    Holscher, C.4    Gault, V.A.5
  • 264
    • 84996939136 scopus 로고    scopus 로고
    • Aberrations in peripheral inflammatory cytokine levels in Parkinson disease: a systematic review and meta-analysis
    • Qin, X.-Y., Zhang, S.-P., Cao, C., Loh, Y.P., Cheng, Y., Aberrations in peripheral inflammatory cytokine levels in Parkinson disease: a systematic review and meta-analysis. JAMA Neurol., 2016, 10.1001/jamaneurol.2016.2742.
    • (2016) JAMA Neurol.
    • Qin, X.-Y.1    Zhang, S.-P.2    Cao, C.3    Loh, Y.P.4    Cheng, Y.5
  • 265
    • 29844432266 scopus 로고    scopus 로고
    • Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis
    • Qiu, W.Q., Folstein, M.F., Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol. Aging 27 (2006), 190–198, 10.1016/j.neurobiolaging.2005.01.004.
    • (2006) Neurobiol. Aging , vol.27 , pp. 190-198
    • Qiu, W.Q.1    Folstein, M.F.2
  • 266
    • 42949100802 scopus 로고    scopus 로고
    • The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B
    • Quinn, L.P., Crook, B., Hows, M.E., Vidgeon-Hart, M., Chapman, H., Upton, N., Medhurst, A.D., Virley, D.J., The PPARgamma agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B. Br. J. Pharmacol. 154 (2008), 226–233, 10.1038/bjp.2008.78.
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 226-233
    • Quinn, L.P.1    Crook, B.2    Hows, M.E.3    Vidgeon-Hart, M.4    Chapman, H.5    Upton, N.6    Medhurst, A.D.7    Virley, D.J.8
  • 268
    • 84867040244 scopus 로고    scopus 로고
    • Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions
    • Rampersaud, N., Harkavyi, A., Giordano, G., Lever, R., Whitton, J., Whitton, P.S., Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions. Neuropeptides 46 (2012), 183–193, 10.1016/j.npep.2012.07.004.
    • (2012) Neuropeptides , vol.46 , pp. 183-193
    • Rampersaud, N.1    Harkavyi, A.2    Giordano, G.3    Lever, R.4    Whitton, J.5    Whitton, P.S.6
  • 269
    • 84856196205 scopus 로고    scopus 로고
    • Diabetes as a chronic metabolic stressor: causes, consequences and clinical complications
    • Reagan, L.P., Diabetes as a chronic metabolic stressor: causes, consequences and clinical complications. Exp. Neurol. 233 (2012), 68–78, 10.1016/j.expneurol.2011.02.004.
    • (2012) Exp. Neurol. , vol.233 , pp. 68-78
    • Reagan, L.P.1
  • 270
    • 70450213422 scopus 로고    scopus 로고
    • Peripheral chemo-cytokine profiles in Alzheimer's and Parkinson's diseases
    • Reale, M., Greig, N.H., Kamal, M.A., Peripheral chemo-cytokine profiles in Alzheimer's and Parkinson's diseases. Mini Rev. Med. Chem. 9 (2009), 1229–1241.
    • (2009) Mini Rev. Med. Chem. , vol.9 , pp. 1229-1241
    • Reale, M.1    Greig, N.H.2    Kamal, M.A.3
  • 272
    • 84860813005 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies
    • CD008454. pub2
    • Rees, K., Stowe, R., Patel, S., Ives, N., Breen, K., Clarke, C.E., Ben-Shlomo, Y., Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies. Cochrane database Syst. Rev. CD008454., 2011, 10.1002/14651858 CD008454. pub2.
    • (2011) Cochrane database Syst. Rev. CD008454.
    • Rees, K.1    Stowe, R.2    Patel, S.3    Ives, N.4    Breen, K.5    Clarke, C.E.6    Ben-Shlomo, Y.7
  • 273
    • 84904689167 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity
    • Regensburger, M., Prots, I., Winner, B., Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity. Neural Plast., 2014, 2014, 454696, 10.1155/2014/454696.
    • (2014) Neural Plast. , vol.2014 , pp. 454696
    • Regensburger, M.1    Prots, I.2    Winner, B.3
  • 277
    • 33745266146 scopus 로고    scopus 로고
    • Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease. Pharmacogenomics J. 6, 246–54.
    • Risner, M.E., Saunders, A.M., Altman, J.F.B., Ormandy, G.C., Craft, S., Foley, I.M., Zvartau-Hind, M.E., Hosford, D.A., Roses, A.D., Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease. Pharmacogenomics J. 6, 246–54. http://dx.doi.org/10.1038/sj.tpj.6500369.
    • Risner, M.E.1    Saunders, A.M.2    Altman, J.F.B.3    Ormandy, G.C.4    Craft, S.5    Foley, I.M.6    Zvartau-Hind, M.E.7    Hosford, D.A.8    Roses, A.D.9
  • 278
    • 78149407291 scopus 로고    scopus 로고
    • Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status
    • Rodriguez-Rivera, J., Denner, L., Dineley, K.T., Rosiglitazone reversal of Tg2576 cognitive deficits is independent of peripheral gluco-regulatory status. Behav. Brain Res. 216 (2011), 255–261, 10.1016/j.bbr.2010.08.002.
    • (2011) Behav. Brain Res. , vol.216 , pp. 255-261
    • Rodriguez-Rivera, J.1    Denner, L.2    Dineley, K.T.3
  • 279
    • 77955072991 scopus 로고    scopus 로고
    • Association between cognition and function in patients with Parkinson disease with and without dementia
    • Rosenthal, E., Brennan, L., Xie, S., Hurtig, H., Milber, J., Weintraub, D., Karlawish, J., Siderowf, A., Association between cognition and function in patients with Parkinson disease with and without dementia. Mov. Disord. 25 (2010), 1170–1176, 10.1002/mds.23073.
    • (2010) Mov. Disord. , vol.25 , pp. 1170-1176
    • Rosenthal, E.1    Brennan, L.2    Xie, S.3    Hurtig, H.4    Milber, J.5    Weintraub, D.6    Karlawish, J.7    Siderowf, A.8
  • 280
    • 84879621442 scopus 로고    scopus 로고
    • AMPK, insulin resistance, and the metabolic syndrome
    • Ruderman, N.B., Carling, D., Prentki, M., Cacicedo, J.M., AMPK, insulin resistance, and the metabolic syndrome. J. Clin. Invest. 123 (2013), 2764–2772, 10.1172/JCI67227.
    • (2013) J. Clin. Invest. , vol.123 , pp. 2764-2772
    • Ruderman, N.B.1    Carling, D.2    Prentki, M.3    Cacicedo, J.M.4
  • 281
    • 84860123393 scopus 로고    scopus 로고
    • Full and partial peroxisome proliferation-activated receptor-(agonists, but not (agonist, rescue of dopaminergic neurons in the 6-OHDA parkinsonian model is associated with inhibition of microglial activation and MMP expression
    • Sadeghian, M., Marinova-Mutafchieva, L., Broom, L., Davis, J.B., Virley, D., Medhurst, A.D., Dexter, D.T., Full and partial peroxisome proliferation-activated receptor-(agonists, but not (agonist, rescue of dopaminergic neurons in the 6-OHDA parkinsonian model is associated with inhibition of microglial activation and MMP expression. J. Neuroimmunol. 246 (2012), 69–77, 10.1016/j.jneuroim.2012.03.010.
    • (2012) J. Neuroimmunol. , vol.246 , pp. 69-77
    • Sadeghian, M.1    Marinova-Mutafchieva, L.2    Broom, L.3    Davis, J.B.4    Virley, D.5    Medhurst, A.D.6    Dexter, D.T.7
  • 282
    • 84888235042 scopus 로고    scopus 로고
    • Effect of sitagliptin on the working memory and reference memory in type 2 diabetic Sprague-Dawley rats: possible role of adiponectin receptors 1
    • Sakr, H.F., Effect of sitagliptin on the working memory and reference memory in type 2 diabetic Sprague-Dawley rats: possible role of adiponectin receptors 1. J. Physiol. Pharmacol. 64 (2013), 613–623.
    • (2013) J. Physiol. Pharmacol. , vol.64 , pp. 613-623
    • Sakr, H.F.1
  • 283
    • 84855182851 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
    • Salminen, A., Kaarniranta, K., AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res. Rev. 11 (2012), 230–241, 10.1016/j.arr.2011.12.005.
    • (2012) Ageing Res. Rev. , vol.11 , pp. 230-241
    • Salminen, A.1    Kaarniranta, K.2
  • 284
    • 0027561888 scopus 로고
    • The relationship between diabetes mellitus and Parkinson's disease
    • Sandyk, R., The relationship between diabetes mellitus and Parkinson's disease. Int. J. Neurosci. 69 (1993), 125–130.
    • (1993) Int. J. Neurosci. , vol.69 , pp. 125-130
    • Sandyk, R.1
  • 285
    • 0037112093 scopus 로고    scopus 로고
    • Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain
    • Sankar, R., Thamotharan, S., Shin, D., Moley, K.H., Devaskar, S.U., Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain. Brain Res. Mol. Brain Res. 107 (2002), 157–165.
    • (2002) Brain Res. Mol. Brain Res. , vol.107 , pp. 157-165
    • Sankar, R.1    Thamotharan, S.2    Shin, D.3    Moley, K.H.4    Devaskar, S.U.5
  • 286
    • 84909590793 scopus 로고    scopus 로고
    • System-based approaches to decode the molecular links in Parkinson's disease and diabetes
    • Santiago, J.A., Potashkin, J.A., System-based approaches to decode the molecular links in Parkinson's disease and diabetes. Neurobiol. Dis, 2014, 10.1016/j.nbd.2014.03.019.
    • (2014) Neurobiol. Dis
    • Santiago, J.A.1    Potashkin, J.A.2
  • 287
    • 84869420795 scopus 로고    scopus 로고
    • Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle [WWW Document]
    • URL (accessed 4.21.15)
    • Santos, Fernando, R., Diamond-Stanic, H.E., Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle [WWW Document]. Arch. Physiol. Biochem., 2012 URL http://informahealthcare.com/doi/pdf/10.3109/13813455.2012.713366 (accessed 4.21.15).
    • (2012) Arch. Physiol. Biochem.
    • Santos1    Fernando, R.2    Diamond-Stanic, H.E.3
  • 288
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
    • Sastre, M., Dewachter, I., Landreth, G.E., Willson, T.M., Klockgether, T., van Leuven, F., Heneka, M.T., Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J. Neurosci. 23 (2003), 9796–9804.
    • (2003) J. Neurosci. , vol.23 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3    Willson, T.M.4    Klockgether, T.5    van Leuven, F.6    Heneka, M.T.7
  • 289
    • 79959479102 scopus 로고    scopus 로고
    • Efficacy of PPAR-(agonist pioglitazone in mild Alzheimer disease
    • Sato, T., Hanyu, H., Hirao, K., Kanetaka, H., Sakurai, H., Iwamoto, T., Efficacy of PPAR-(agonist pioglitazone in mild Alzheimer disease. Neurobiol. Aging 32 (2011), 1626–1633, 10.1016/j.neurobiolaging.2009.10.009.
    • (2011) Neurobiol. Aging , vol.32 , pp. 1626-1633
    • Sato, T.1    Hanyu, H.2    Hirao, K.3    Kanetaka, H.4    Sakurai, H.5    Iwamoto, T.6
  • 290
    • 84863991205 scopus 로고    scopus 로고
    • Metabolic markers or conditions preceding Parkinson's disease: a case-control study
    • Savica, R., Grossardt, B.R., Ahlskog, J.E., Rocca, W.A., Metabolic markers or conditions preceding Parkinson's disease: a case-control study. Mov. Disord. 27 (2012), 974–979, 10.1002/mds.25016.
    • (2012) Mov. Disord. , vol.27 , pp. 974-979
    • Savica, R.1    Grossardt, B.R.2    Ahlskog, J.E.3    Rocca, W.A.4
  • 291
    • 77954862456 scopus 로고    scopus 로고
    • Molecular and clinical prodrome of Parkinson disease: implications for treatment
    • Schapira, A.H.V., Tolosa, E., Molecular and clinical prodrome of Parkinson disease: implications for treatment. Nat. Rev. Neurol. 6 (2010), 309–317, 10.1038/nrneurol.2010.52.
    • (2010) Nat. Rev. Neurol. , vol.6 , pp. 309-317
    • Schapira, A.H.V.1    Tolosa, E.2
  • 292
    • 84906306620 scopus 로고    scopus 로고
    • Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives
    • Schapira, A.H.V., Olanow, C.W., Greenamyre, J.T., Bezard, E., Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives. Lancet, 6736, 2014, 10.1016/S0140-6736(14)61010-2.
    • (2014) Lancet , vol.6736
    • Schapira, A.H.V.1    Olanow, C.W.2    Greenamyre, J.T.3    Bezard, E.4
  • 293
    • 37049004489 scopus 로고    scopus 로고
    • Mitochondria in the aetiology and pathogenesis of Parkinson's disease
    • Schapira, A.H.V., Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol. 7 (2008), 97–109, 10.1016/S1474-4422(07)70327-7.
    • (2008) Lancet Neurol. , vol.7 , pp. 97-109
    • Schapira, A.H.V.1
  • 294
    • 79956139625 scopus 로고    scopus 로고
    • Diabetes and the risk of developing Parkinson's disease in Denmark
    • Schernhammer, E., Hansen, J., Rugbjerg, K., Wermuth, L., Ritz, B., Diabetes and the risk of developing Parkinson's disease in Denmark. Diabetes Care 34 (2011), 1102–1108, 10.2337/dc10-1333.
    • (2011) Diabetes Care , vol.34 , pp. 1102-1108
    • Schernhammer, E.1    Hansen, J.2    Rugbjerg, K.3    Wermuth, L.4    Ritz, B.5
  • 295
    • 61449237400 scopus 로고    scopus 로고
    • PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease− PubMed − NCBI [WWW Document]
    • URL (accessed 7.23.15)
    • Schintu, N., Frau, L., Ibba, M., Caboni, P., Garau, A., Carboni, E.C.A., PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease− PubMed − NCBI [WWW Document]. Eur. J. Neurosci., 2009 URL http://www.ncbi.nlm.nih.gov/pubmed/19245367?dopt=Abstract (accessed 7.23.15).
    • (2009) Eur. J. Neurosci.
    • Schintu, N.1    Frau, L.2    Ibba, M.3    Caboni, P.4    Garau, A.5    Carboni, E.C.A.6
  • 296
    • 84894048190 scopus 로고    scopus 로고
    • Dysfunctional and compensatory synaptic plasticity in Parkinson's disease
    • Schroll, H., Vitay, J., Hamker, F.H., Dysfunctional and compensatory synaptic plasticity in Parkinson's disease. Eur. J. Neurosci. 39 (2014), 688–702, 10.1111/ejn.12434.
    • (2014) Eur. J. Neurosci. , vol.39 , pp. 688-702
    • Schroll, H.1    Vitay, J.2    Hamker, F.H.3
  • 298
    • 84859761962 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease and related disorders: a lesson from genetically manipulated mouse models of α-synucleinopathies
    • Sekiyama, K., Sugama, S., Fujita, M., Sekigawa, A., Takamatsu, Y., Waragai, M., Takenouchi, T., Hashimoto, M., Neuroinflammation in Parkinson's disease and related disorders: a lesson from genetically manipulated mouse models of α-synucleinopathies. Parkinsons Dis., 271732, 2012, 10.1155/2012/271732.
    • (2012) Parkinsons Dis. , vol.27
    • Sekiyama, K.1    Sugama, S.2    Fujita, M.3    Sekigawa, A.4    Takamatsu, Y.5    Waragai, M.6    Takenouchi, T.7    Hashimoto, M.8
  • 300
    • 84875439056 scopus 로고    scopus 로고
    • DPP-4 inhibition and neuroprotection: do mechanisms matter?
    • Shannon, R.P., DPP-4 inhibition and neuroprotection: do mechanisms matter?. Diabetes 62 (2013), 1029–1031, 10.2337/db12-1794.
    • (2013) Diabetes , vol.62 , pp. 1029-1031
    • Shannon, R.P.1
  • 301
    • 84861822831 scopus 로고    scopus 로고
    • Rosiglitazone treatment reversed depression- but not psychosis-like behavior of db/db diabetic mice
    • Sharma, A.N., Elased, K.M., Lucot, J.B., Rosiglitazone treatment reversed depression- but not psychosis-like behavior of db/db diabetic mice. J. Psychopharmacol. 26 (2012), 724–732, 10.1177/0269881111434620.
    • (2012) J. Psychopharmacol. , vol.26 , pp. 724-732
    • Sharma, A.N.1    Elased, K.M.2    Lucot, J.B.3
  • 304
    • 77954829973 scopus 로고    scopus 로고
    • Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis
    • Shibata, N., Yamamoto, T., Hiroi, A., Omi, Y., Kato, Y., Kobayashi, M., Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis. Neuropathology 30 (2010), 353–360, 10.1111/j.1440-1789.2009.01078.x.
    • (2010) Neuropathology , vol.30 , pp. 353-360
    • Shibata, N.1    Yamamoto, T.2    Hiroi, A.3    Omi, Y.4    Kato, Y.5    Kobayashi, M.6
  • 305
    • 84907990392 scopus 로고    scopus 로고
    • Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes
    • Soccio, R.E., Chen, E.R., Lazar, M.A., Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. Cell Metab. 20 (2014), 573–591, 10.1016/j.cmet.2014.08.005.
    • (2014) Cell Metab. , vol.20 , pp. 573-591
    • Soccio, R.E.1    Chen, E.R.2    Lazar, M.A.3
  • 306
    • 84904104280 scopus 로고    scopus 로고
    • Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration
    • Spielman, L.J., Little, J.P., Klegeris, A., Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration. J. Neuroimmunol., 2014, 10.1016/j.jneuroim.2014.06.004.
    • (2014) J. Neuroimmunol.
    • Spielman, L.J.1    Little, J.P.2    Klegeris, A.3
  • 307
    • 84897909488 scopus 로고    scopus 로고
    • The paradox of neuronal insulin action and resistance in the development of aging-associated diseases
    • Steculorum, S.M., Solas, M., Brüning, J.C., The paradox of neuronal insulin action and resistance in the development of aging-associated diseases. Alzheimers Dement. 10 (2014), S3–S11, 10.1016/j.jalz.2013.12.008.
    • (2014) Alzheimers Dement. , vol.10 , pp. S3-S11
    • Steculorum, S.M.1    Solas, M.2    Brüning, J.C.3
  • 308
    • 84878253079 scopus 로고    scopus 로고
    • The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of α-synuclein levels in β-cells
    • Steneberg, P., Bernardo, L., Edfalk, S., Lundberg, L., Backlund, F., Ostenson, C.-G., Edlund, H., The type 2 diabetes-associated gene ide is required for insulin secretion and suppression of α-synuclein levels in β-cells. Diabetes 62 (2013), 2004–2014, 10.2337/db12-1045.
    • (2013) Diabetes , vol.62 , pp. 2004-2014
    • Steneberg, P.1    Bernardo, L.2    Edfalk, S.3    Lundberg, L.4    Backlund, F.5    Ostenson, C.-G.6    Edlund, H.7
  • 309
    • 79952763934 scopus 로고    scopus 로고
    • Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
    • Stoica, L., Zhu, P.J., Huang, W., Zhou, H., Kozma, S.C., Costa-Mattioli, M., Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage. Proc. Natl. Acad. Sci. U. S. A. 108 (2011), 3791–3796, 10.1073/pnas.1014715108.
    • (2011) Proc. Natl. Acad. Sci. U. S. A. , vol.108 , pp. 3791-3796
    • Stoica, L.1    Zhu, P.J.2    Huang, W.3    Zhou, H.4    Kozma, S.C.5    Costa-Mattioli, M.6
  • 310
    • 0037192120 scopus 로고    scopus 로고
    • Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and −insoluble pools in CHO-695 cells
    • Sudoh, S., Frosch, M.P., Wolf, B.A., Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and −insoluble pools in CHO-695 cells. Biochemistry 41 (2002), 1091–1099.
    • (2002) Biochemistry , vol.41 , pp. 1091-1099
    • Sudoh, S.1    Frosch, M.P.2    Wolf, B.A.3
  • 311
    • 77951296766 scopus 로고    scopus 로고
    • Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium-induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta
    • Sun, X., Huang, L., Zhang, M., Sun, S., Wu, Y., Insulin like growth factor-1 prevents 1-mentyl-4-phenylphyridinium-induced apoptosis in PC12 cells through activation of glycogen synthase kinase-3beta. Toxicology 271 (2010), 5–12, 10.1016/j.tox.2010.01.001.
    • (2010) Toxicology , vol.271 , pp. 5-12
    • Sun, X.1    Huang, L.2    Zhang, M.3    Sun, S.4    Wu, Y.5
  • 312
    • 84862110832 scopus 로고    scopus 로고
    • Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications
    • Sun, Y., Chang, Y.-H., Chen, H.-F., Su, Y.-H., Su, H.-F., Li, C.-Y., Risk of Parkinson disease onset in patients with diabetes: a 9-year population-based cohort study with age and sex stratifications. Diabetes Care 35 (2012), 1047–1049, 10.2337/dc11-1511.
    • (2012) Diabetes Care , vol.35 , pp. 1047-1049
    • Sun, Y.1    Chang, Y.-H.2    Chen, H.-F.3    Su, Y.-H.4    Su, H.-F.5    Li, C.-Y.6
  • 313
    • 75249084816 scopus 로고    scopus 로고
    • Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat
    • Suzuki, S., Arnold, L.L., Pennington, K.L., Kakiuchi-Kiyota, S., Wei, M., Wanibuchi, H., Cohen, S.M., Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat. Toxicol. Sci. 113 (2010), 349–357, 10.1093/toxsci/kfp256.
    • (2010) Toxicol. Sci. , vol.113 , pp. 349-357
    • Suzuki, S.1    Arnold, L.L.2    Pennington, K.L.3    Kakiuchi-Kiyota, S.4    Wei, M.5    Wanibuchi, H.6    Cohen, S.M.7
  • 314
    • 84985914579 scopus 로고    scopus 로고
    • Reduced incidence of Parkinson's disease after dipeptidyl peptidase-4 inhibitors-A nationwide case-control study
    • Svenningsson, P., Wirdefeldt, K., Yin, L., Fang, F., Markaki, I., Efendic, S., Ludvigsson, J.F., Reduced incidence of Parkinson's disease after dipeptidyl peptidase-4 inhibitors-A nationwide case-control study. Mov. Disord, 2016, 10.1002/mds.26734.
    • (2016) Mov. Disord
    • Svenningsson, P.1    Wirdefeldt, K.2    Yin, L.3    Fang, F.4    Markaki, I.5    Efendic, S.6    Ludvigsson, J.F.7
  • 315
    • 84902996320 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor-gamma in the substantia nigra of hemiparkinsonian nonhuman primates
    • Swanson, C., Emborg, M., Expression of peroxisome proliferator-activated receptor-gamma in the substantia nigra of hemiparkinsonian nonhuman primates. Neurol. Res. 36 (2014), 634–646, 10.1179/1743132813Y.0000000305.
    • (2014) Neurol. Res. , vol.36 , pp. 634-646
    • Swanson, C.1    Emborg, M.2
  • 317
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • Taguchi, A., Wartschow, L.M., White, M.F., Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 317 (2007), 369–372, 10.1126/science.1142179.
    • (2007) Science , vol.317 , pp. 369-372
    • Taguchi, A.1    Wartschow, L.M.2    White, M.F.3
  • 318
    • 69449084089 scopus 로고    scopus 로고
    • Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
    • Tain, L.S., Mortiboys, H., Tao, R.N., Ziviani, E., Bandmann, O., Whitworth, A.J., Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. Nat. Neurosci. 12 (2009), 1129–1135, 10.1038/nn.2372.
    • (2009) Nat. Neurosci. , vol.12 , pp. 1129-1135
    • Tain, L.S.1    Mortiboys, H.2    Tao, R.N.3    Ziviani, E.4    Bandmann, O.5    Whitworth, A.J.6
  • 320
    • 84897881837 scopus 로고    scopus 로고
    • The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease
    • Talbot, K., Wang, H.-Y., The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease. Alzheimers. Dement. 10 (2014), S12–S25, 10.1016/j.jalz.2013.12.007.
    • (2014) Alzheimers. Dement. , vol.10 , pp. S12-S25
    • Talbot, K.1    Wang, H.-Y.2
  • 322
    • 84935441397 scopus 로고    scopus 로고
    • Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection
    • Thouennon, E., Cheng, Y., Falahatian, V., Cawley, N.X., Loh, Y.P., Rosiglitazone-activated PPARγ induces neurotrophic factor-α1 transcription contributing to neuroprotection. J. Neurochem. 134 (2015), 463–470, 10.1111/jnc.13152.
    • (2015) J. Neurochem. , vol.134 , pp. 463-470
    • Thouennon, E.1    Cheng, Y.2    Falahatian, V.3    Cawley, N.X.4    Loh, Y.P.5
  • 323
    • 70350347175 scopus 로고    scopus 로고
    • Akt signal transduction dysfunction in Parkinson's disease
    • Timmons, S., Coakley, M.F., Moloney, A.M., O’ Neill, C., Akt signal transduction dysfunction in Parkinson's disease. Neurosci. Lett. 467 (2009), 30–35, 10.1016/j.neulet.2009.09.055.
    • (2009) Neurosci. Lett. , vol.467 , pp. 30-35
    • Timmons, S.1    Coakley, M.F.2    Moloney, A.M.3    O’ Neill, C.4
  • 324
    • 84867412992 scopus 로고    scopus 로고
    • Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway
    • Tokutake, T., Kasuga, K., Yajima, R., Sekine, Y., Tezuka, T., Nishizawa, M., Ikeuchi, T., Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway. J. Biol. Chem. 287 (2012), 35222–35233, 10.1074/jbc.M112.348300.
    • (2012) J. Biol. Chem. , vol.287 , pp. 35222-35233
    • Tokutake, T.1    Kasuga, K.2    Yajima, R.3    Sekine, Y.4    Tezuka, T.5    Nishizawa, M.6    Ikeuchi, T.7
  • 325
    • 61949235512 scopus 로고    scopus 로고
    • Diagnosis and the premotor phase of Parkinson disease
    • Tolosa, E., Gaig, C., Santamaría, J., Compta, Y., Diagnosis and the premotor phase of Parkinson disease. Neurology 72 (2009), S12–S20, 10.1212/WNL.0b013e318198db11.
    • (2009) Neurology , vol.72 , pp. S12-S20
    • Tolosa, E.1    Gaig, C.2    Santamaría, J.3    Compta, Y.4
  • 326
    • 65549103889 scopus 로고    scopus 로고
    • Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity
    • Tong, M., Dong, M., de la Monte, S.M., Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity. J. Alzheimers. Dis. 16 (2009), 585–599, 10.3233/JAD-2009-0995.
    • (2009) J. Alzheimers. Dis. , vol.16 , pp. 585-599
    • Tong, M.1    Dong, M.2    de la Monte, S.M.3
  • 327
    • 77949741721 scopus 로고    scopus 로고
    • Toward a comprehensive neurobiology of IGF-I
    • Torres-Aleman, I., Toward a comprehensive neurobiology of IGF-I. Dev. Neurobiol. 70 (2010), 384–396, 10.1002/dneu.20778.
    • (2010) Dev. Neurobiol. , vol.70 , pp. 384-396
    • Torres-Aleman, I.1
  • 328
    • 0034161516 scopus 로고    scopus 로고
    • Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
    • Vekrellis, K., Ye, Z., Qiu, W.Q., Walsh, D., Hartley, D., Chesneau, V., Rosner, M.R., Selkoe, D.J., Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. J. Neurosci. 20 (2000), 1657–1665.
    • (2000) J. Neurosci. , vol.20 , pp. 1657-1665
    • Vekrellis, K.1    Ye, Z.2    Qiu, W.Q.3    Walsh, D.4    Hartley, D.5    Chesneau, V.6    Rosner, M.R.7    Selkoe, D.J.8
  • 329
    • 84862199583 scopus 로고    scopus 로고
    • Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort
    • Wahlqvist, M.L., Lee, M.-S., Hsu, C.-C., Chuang, S.-Y., Lee, J.-T., Tsai, H.-N., Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort. Parkinsonism Relat. Disord. 18 (2012), 753–758, 10.1016/j.parkreldis.2012.03.010.
    • (2012) Parkinsonism Relat. Disord. , vol.18 , pp. 753-758
    • Wahlqvist, M.L.1    Lee, M.-S.2    Hsu, C.-C.3    Chuang, S.-Y.4    Lee, J.-T.5    Tsai, H.-N.6
  • 330
    • 77957126457 scopus 로고    scopus 로고
    • Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats
    • Wang, X.H., Li, L., Hölscher, C., Pan, Y.F., Chen, X.R., Qi, J.S., Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats. Neuroscience 170 (2010), 1239–1248, 10.1016/j.neuroscience.2010.08.028.
    • (2010) Neuroscience , vol.170 , pp. 1239-1248
    • Wang, X.H.1    Li, L.2    Hölscher, C.3    Pan, Y.F.4    Chen, X.R.5    Qi, J.S.6
  • 331
    • 79953247926 scopus 로고    scopus 로고
    • Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK
    • Wang, X.-J., Zhang, S., Yan, Z.-Q., Zhao, Y.-X., Zhou, H.-Y., Wang, Y., Lu, G.-Q., Zhang, J.-D., Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: roles of aging, superoxide, NADPH oxidase, and p38 MAPK. Free Radic. Biol. Med. 50 (2011), 1094–1106, 10.1016/j.freeradbiomed.2011.01.032.
    • (2011) Free Radic. Biol. Med. , vol.50 , pp. 1094-1106
    • Wang, X.-J.1    Zhang, S.2    Yan, Z.-Q.3    Zhao, Y.-X.4    Zhou, H.-Y.5    Wang, Y.6    Lu, G.-Q.7    Zhang, J.-D.8
  • 332
    • 84888062088 scopus 로고    scopus 로고
    • Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice
    • Wang, L., Zhai, Y.-Q., Xu, L.-L., Qiao, C., Sun, X.-L., Ding, J.-H., Lu, M., Hu, G., Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice. Exp. Neurol. 251 (2014), 22–29, 10.1016/j.expneurol.2013.11.001.
    • (2014) Exp. Neurol. , vol.251 , pp. 22-29
    • Wang, L.1    Zhai, Y.-Q.2    Xu, L.-L.3    Qiao, C.4    Sun, X.-L.5    Ding, J.-H.6    Lu, M.7    Hu, G.8
  • 333
    • 84898598303 scopus 로고    scopus 로고
    • Peripheral expression of MAPK pathways in Alzheimer's and Parkinson's diseases
    • Wang, S., Zhang, C., Sheng, X., Zhang, X., Wang, B., Zhang, G., Peripheral expression of MAPK pathways in Alzheimer's and Parkinson's diseases. J. Clin. Neurosci. 21 (2014), 810–814, 10.1016/j.jocn.2013.08.017.
    • (2014) J. Clin. Neurosci. , vol.21 , pp. 810-814
    • Wang, S.1    Zhang, C.2    Sheng, X.3    Zhang, X.4    Wang, B.5    Zhang, G.6
  • 341
    • 77955664249 scopus 로고    scopus 로고
    • Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia
    • Wills, J., Jones, J., Haggerty, T., Duka, V., Joyce, J.N., Sidhu, A., Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia. Exp. Neurol. 225 (2010), 210–218, 10.1016/j.expneurol.2010.06.017.
    • (2010) Exp. Neurol. , vol.225 , pp. 210-218
    • Wills, J.1    Jones, J.2    Haggerty, T.3    Duka, V.4    Joyce, J.N.5    Sidhu, A.6
  • 344
    • 84899984684 scopus 로고    scopus 로고
    • Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in vitro models of Parkinson's disease
    • Xu, Y., Liu, C., Chen, S., Ye, Y., Guo, M., Ren, Q., Liu, L., Zhang, H., Xu, C., Zhou, Q., Huang, S., Chen, L., Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in vitro models of Parkinson's disease. Cell. Signal. 26 (2014), 1680–1689, 10.1016/j.cellsig.2014.04.009.
    • (2014) Cell. Signal. , vol.26 , pp. 1680-1689
    • Xu, Y.1    Liu, C.2    Chen, S.3    Ye, Y.4    Guo, M.5    Ren, Q.6    Liu, L.7    Zhang, H.8    Xu, C.9    Zhou, Q.10    Huang, S.11    Chen, L.12
  • 345
    • 79959434134 scopus 로고    scopus 로고
    • Impaired CNS leptin action is implicated in depression associated with obesity
    • Yamada, N., Katsuura, G., Ochi, Y., Ebihara, K., Kusakabe, T., Hosoda, K., Nakao, K., Impaired CNS leptin action is implicated in depression associated with obesity. Endocrinology 152 (2011), 2634–2643, 10.1210/en.2011-0004.
    • (2011) Endocrinology , vol.152 , pp. 2634-2643
    • Yamada, N.1    Katsuura, G.2    Ochi, Y.3    Ebihara, K.4    Kusakabe, T.5    Hosoda, K.6    Nakao, K.7
  • 346
    • 84870226700 scopus 로고    scopus 로고
    • PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice
    • Yamanaka, M., Ishikawa, T., Griep, A., Axt, D., Kummer, M.P., Heneka, M.T., PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice. J. Neurosci. 32 (2012), 17321–17331, 10.1523/JNEUROSCI.1569-12.2012.
    • (2012) J. Neurosci. , vol.32 , pp. 17321-17331
    • Yamanaka, M.1    Ishikawa, T.2    Griep, A.3    Axt, D.4    Kummer, M.P.5    Heneka, M.T.6
  • 348
    • 36248979076 scopus 로고    scopus 로고
    • A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies
    • Yong, S.W., Yoon, J.K., An, Y.S., Lee, P.H., A comparison of cerebral glucose metabolism in Parkinson's disease, Parkinson's disease dementia and dementia with Lewy bodies. Eur. J. Neurol. 14 (2007), 1357–1362, 10.1111/j.1468-1331.2007.01977.x.
    • (2007) Eur. J. Neurol. , vol.14 , pp. 1357-1362
    • Yong, S.W.1    Yoon, J.K.2    An, Y.S.3    Lee, P.H.4
  • 349
    • 84922169955 scopus 로고    scopus 로고
    • The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway
    • Yuan, Y.-H., Yan, W.-F., Sun, J.-D., Huang, J.-Y., Mu, Z., Chen, N.-H., The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway. Toxicol. Lett. 233 (2015), 163–171, 10.1016/j.toxlet.2014.11.029.
    • (2015) Toxicol. Lett. , vol.233 , pp. 163-171
    • Yuan, Y.-H.1    Yan, W.-F.2    Sun, J.-D.3    Huang, J.-Y.4    Mu, Z.5    Chen, N.-H.6
  • 350
    • 77952411101 scopus 로고    scopus 로고
    • Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity
    • Zhang, F., Qian, L., Flood, P.M., Shi, J.-S., Hong, J.-S., Gao, H.-M., Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity. J. Pharmacol. Exp. Ther. 333 (2010), 822–833, 10.1124/jpet.110.165829.
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 822-833
    • Zhang, F.1    Qian, L.2    Flood, P.M.3    Shi, J.-S.4    Hong, J.-S.5    Gao, H.-M.6
  • 351
    • 84962114196 scopus 로고    scopus 로고
    • Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes
    • Zhang, H., Hao, Y., Manor, B., Novak, P., Milberg, W., Zhang, J., Fang, J., Novak, V., Intranasal insulin enhanced resting-state functional connectivity of hippocampal regions in type 2 diabetes. Diabetes 64 (2015), 1025–1034, 10.2337/db14-1000.
    • (2015) Diabetes , vol.64 , pp. 1025-1034
    • Zhang, H.1    Hao, Y.2    Manor, B.3    Novak, P.4    Milberg, W.5    Zhang, J.6    Fang, J.7    Novak, V.8
  • 352
    • 64249129005 scopus 로고    scopus 로고
    • Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease
    • Zhao, W.-Q., Townsend, M., Insulin resistance and amyloidogenesis as common molecular foundation for type 2 diabetes and Alzheimer's disease. Biochim. Biophys. Acta 1792 (2009), 482–496, 10.1016/j.bbadis.2008.10.014.
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 482-496
    • Zhao, W.-Q.1    Townsend, M.2
  • 353
    • 10944228564 scopus 로고    scopus 로고
    • Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention
    • Zhao, L., Teter, B., Morihara, T., Lim, G.P., Ambegaokar, S.S., Ubeda, O.J., Frautschy, S.A., Cole, G.M., Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J. Neurosci. 24 (2004), 11120–11126, 10.1523/JNEUROSCI.2860-04.2004.
    • (2004) J. Neurosci. , vol.24 , pp. 11120-11126
    • Zhao, L.1    Teter, B.2    Morihara, T.3    Lim, G.P.4    Ambegaokar, S.S.5    Ubeda, O.J.6    Frautschy, S.A.7    Cole, G.M.8
  • 354
    • 1842633872 scopus 로고    scopus 로고
    • Insulin and the insulin receptor in experimental models of learning and memory
    • Zhao, W.-Q., Chen, H., Quon, M.J., Alkon, D.L., Insulin and the insulin receptor in experimental models of learning and memory. Eur. J. Pharmacol. 490 (2004), 71–81, 10.1016/j.ejphar.2004.02.045.
    • (2004) Eur. J. Pharmacol. , vol.490 , pp. 71-81
    • Zhao, W.-Q.1    Chen, H.2    Quon, M.J.3    Alkon, D.L.4
  • 356
    • 0035500813 scopus 로고    scopus 로고
    • Insulin resistance: a phosphorylation-based uncoupling of insulin signaling
    • Zick, Y., Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. Trends Cell Biol. 11 (2001), 437–441.
    • (2001) Trends Cell Biol. , vol.11 , pp. 437-441
    • Zick, Y.1
  • 357
    • 33745919520 scopus 로고    scopus 로고
    • Epidemiology of Parkinson's disease
    • de Lau, L.M.L., Breteler, M.M.B., Epidemiology of Parkinson's disease. Lancet. Neurol. 5 (2006), 525–535, 10.1016/S1474-4422(06)70471-9.
    • (2006) Lancet. Neurol. , vol.5 , pp. 525-535
    • de Lau, L.M.L.1    Breteler, M.M.B.2
  • 359
    • 33748295795 scopus 로고    scopus 로고
    • Insulin signaling in the central nervous system: learning to survive
    • van der Heide, L.P., Ramakers, G.M.J., Smidt, M.P., Insulin signaling in the central nervous system: learning to survive. Prog. Neurobiol. 79 (2006), 205–221, 10.1016/j.pneurobio.2006.06.003.
    • (2006) Prog. Neurobiol. , vol.79 , pp. 205-221
    • van der Heide, L.P.1    Ramakers, G.M.J.2    Smidt, M.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.