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Volumn 287, Issue 42, 2012, Pages 35222-35233

Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; CELL CO-CULTURES; DONOR CELLS; EXTRACELLULAR; HYPERPHOSPHORYLATION; INSULIN SIGNALING; N2A CELLS; NANOMOLAR CONCENTRATION; NEUROFIBRILLARY TANGLES; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PRIMARY CULTURE; ROSIGLITAZONE; SENILE PLAQUES; SIGNALING PATHWAYS;

EID: 84867412992     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.348300     Document Type: Article
Times cited : (95)

References (45)
  • 1
    • 57649148788 scopus 로고    scopus 로고
    • Structural classification of toxic amyloid oligomers
    • Glabe, C. G. (2008) Structural classification of toxic amyloid oligomers. J. Biol. Chem. 283, 29639-29643
    • (2008) J. Biol. Chem. , vol.283 , pp. 29639-29643
    • Glabe, C.G.1
  • 2
    • 63849197629 scopus 로고    scopus 로고
    • Amyloid β-protein assembly and Alzheimer disease
    • Roychaudhuri, R., Yang, M., Hoshi, M. M., and Teplow, D. B. (2009) Amyloid β-protein assembly and Alzheimer disease. J. Biol. Chem. 284, 4749-4753
    • (2009) J. Biol. Chem. , vol.284 , pp. 4749-4753
    • Roychaudhuri, R.1    Yang, M.2    Hoshi, M.M.3    Teplow, D.B.4
  • 5
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • DOI 10.1523/JNEUROSCI.4970-06.2007
    • Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., and Sabatini, B. L. (2007) Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 27, 2866-2875 (Pubitemid 46438992)
    • (2007) Journal of Neuroscience , vol.27 , Issue.11 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3    Walsh, D.M.4    Selkoe, D.J.5    Sabatini, B.L.6
  • 6
    • 67650729973 scopus 로고    scopus 로고
    • β-Amyloid oligomers induce phosphorylation of Tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling. Suppression by ω-3 fatty acids and curcumin
    • Ma, Q. L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., Chen, P. P., Hudspeth, B., Chen, C., Zhao, Y., Vinters, H. V., Frautschy, S. A., and Cole, G. M. (2009) β-Amyloid oligomers induce phosphorylation of Tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling. Suppression by ω-3 fatty acids and curcumin. J. Neurosci. 29, 9078-9089
    • (2009) J. Neurosci. , vol.29 , pp. 9078-9089
    • Ma, Q.L.1    Yang, F.2    Rosario, E.R.3    Ubeda, O.J.4    Beech, W.5    Gant, D.J.6    Chen, P.P.7    Hudspeth, B.8    Chen, C.9    Zhao, Y.10    Vinters, H.V.11    Frautschy, S.A.12    Cole, G.M.13
  • 7
    • 77956587739 scopus 로고    scopus 로고
    • 2+ elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
    • 2+ elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines. J. Neurosci. 30, 11938-11950
    • (2010) J. Neurosci. , vol.30 , pp. 11938-11950
    • Zempel, H.1    Thies, E.2    Mandelkow, E.3    Mandelkow, E.M.4
  • 8
    • 79955044494 scopus 로고    scopus 로고
    • Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
    • Jin, M., Shepardson, N., Yang, T., Chen, G., Walsh, D., and Selkoe, D. J. (2011) Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc. Natl. Acad. Sci. U.S.A. 108, 5819-5824
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 5819-5824
    • Jin, M.1    Shepardson, N.2    Yang, T.3    Chen, G.4    Walsh, D.5    Selkoe, D.J.6
  • 9
    • 29044449855 scopus 로고    scopus 로고
    • Risk of dementia in diabetes mellitus: A systematic review
    • DOI 10.1016/S1474-4422(05)70284-2, PII S1474442205702842
    • Biessels, G. J., Staekenborg, S., Brunner, E., Brayne, C., and Scheltens, P. (2006) Risk of dementia in diabetes mellitus. A systematic review. Lancet Neurol. 5, 64-74 (Pubitemid 41790697)
    • (2006) Lancet Neurology , vol.5 , Issue.1 , pp. 64-74
    • Biessels, G.J.1    Staekenborg, S.2    Brunner, E.3    Brayne, C.4    Scheltens, P.5
  • 10
    • 76849101075 scopus 로고    scopus 로고
    • Meta-analysis of Alzheimer disease risk with obesity, diabetes, and related disorders
    • Profenno, L. A., Porsteinsson, A. P., and Faraone, S. V. (2010) Meta-analysis of Alzheimer disease risk with obesity, diabetes, and related disorders. Biol. Psychiat. 67, 505-512
    • (2010) Biol. Psychiat. , vol.67 , pp. 505-512
    • Profenno, L.A.1    Porsteinsson, A.P.2    Faraone, S.V.3
  • 11
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • DOI 10.1038/414799a
    • Saltiel, A. R., and Kahn, C. R. (2001) Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414, 799-806 (Pubitemid 34000783)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 12
    • 0022510796 scopus 로고
    • Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas
    • DOI 10.1016/0306-4522(86)90082-5
    • Hill, J. M., Lesniak, M. A., Pert, C. B., and Roth, J. (1986) Autoradiographic localization of insulin receptors in rat brain. Prominence in olfactory and limbic areas. Neuroscience 17, 1127-1138 (Pubitemid 16080101)
    • (1986) Neuroscience , vol.17 , Issue.4 , pp. 1127-1138
    • Hill, J.M.1    Lesniak, M.A.2    Pert, C.B.3    Roth, J.4
  • 13
    • 0033521130 scopus 로고    scopus 로고
    • Brain insulin receptors and spatial memory: Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats
    • Zhao, W., Chen, H., Xu, H., Moore, E., Meiri, N., Quon, M. J., and Alkon, D. L. (1999) Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze-trained rats. J. Biol. Chem. 274, 34893-34902 (Pubitemid 129509536)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.49 , pp. 34893-34902
    • Zhao, W.1    Chen, H.2    Xu, H.3    Moore, E.4    Meiri, N.5    Quon, M.J.6    Alkon, D.L.7
  • 14
    • 79951754336 scopus 로고    scopus 로고
    • Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus. A missing link to therapeutic potential
    • Sato, N., Takeda, S., Uchio-Yamada, K., Ueda, H., Fujisawa, T., Rakugi, H., and Morishita, R. (2011) Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus. A missing link to therapeutic potential. Curr. Aging Sci. 4, 118-127
    • (2011) Curr. Aging Sci. , vol.4 , pp. 118-127
    • Sato, N.1    Takeda, S.2    Uchio-Yamada, K.3    Ueda, H.4    Fujisawa, T.5    Rakugi, H.6    Morishita, R.7
  • 15
    • 0030044463 scopus 로고    scopus 로고
    • Exposure of rat hippocampal neurons to amyloid β peptide (25-35) induces the inactivation of phosphatidylinositol 3-kinase and the activation of Tau protein kinase I/glycogen synthase kinase-3β
    • Takashima, A., Noguchi, K., Michel, G., Mercken, M., Hoshi, M., Ishiguro, K., and Imahori, K. (1996) Exposure of rat hippocampal neurons to amyloid β peptide (25-35) induces the inactivation of phosphatidylinositol 3-kinase and the activation of Tau protein kinase I/glycogen synthase kinase-3β. Neurosci. Lett. 203, 33-36
    • (1996) Neurosci. Lett. , vol.203 , pp. 33-36
    • Takashima, A.1    Noguchi, K.2    Michel, G.3    Mercken, M.4    Hoshi, M.5    Ishiguro, K.6    Imahori, K.7
  • 16
    • 0037470192 scopus 로고    scopus 로고
    • Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Aβ1-40 and Aβ1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase"
    • DOI 10.1074/jbc.M209252200
    • Ikeuchi, T., Dolios, G., Kim, S. H., Wang, R., and Sisodia, S. S. (2003) Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Aβ 1-40 and Aβ 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "γ- secretase". J. Biol. Chem. 278, 7010-7018 (Pubitemid 36800696)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.9 , pp. 7010-7018
    • Ikeuchi, T.1    Dolios, G.2    Kim, S.-H.3    Wang, R.4    Sisodia, S.S.5
  • 17
    • 36849084633 scopus 로고    scopus 로고
    • Enhanced accumulation of phosphorylated α-synuclein and elevated β-amyloid 42/40 ratio caused by expression of the presenilin-1 ΔT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease
    • DOI 10.1523/JNEUROSCI.4244-07.2007
    • Kaneko, H., Kakita, A., Kasuga, K., Nozaki, H., Ishikawa, A., Miyashita, A., Kuwano, R., Ito, G., Iwatsubo, T., Takahashi, H., Nishizawa, M., Onodera, O., Sisodia, S. S., and Ikeuchi, T. (2007) Enhanced accumulation of phosphorylated α-synuclein and elevated β-amyloid 42/40 ratio caused by expression of the presenilin-1 ΔT440 mutant associated with familial Lewy body disease and variant Alzheimer disease. J. Neurosci. 27, 13092-13097 (Pubitemid 350225495)
    • (2007) Journal of Neuroscience , vol.27 , Issue.48 , pp. 13092-13097
    • Kaneko, H.1    Kakita, A.2    Kasuga, K.3    Nozaki, H.4    Ishikawa, A.5    Miyashita, A.6    Kuwano, R.7    Ito, G.8    Iwatsubo, T.9    Takahashi, H.10    Nishizawa, M.11    Onodera, O.12    Sisodia, S.S.13    Ikeuchi, T.14
  • 18
    • 34250874502 scopus 로고    scopus 로고
    • Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase
    • DOI 10.1016/j.bbrc.2007.06.022, PII S0006291X07012223
    • Kasuga, K., Kaneko, H., Nishizawa, M., Onodera, O., and Ikeuchi, T. (2007) Generation of intracellular domain of insulin receptor tyrosine kinase by γ-secretase. Biochem. Biophys. Res. Commun. 360, 90-96 (Pubitemid 46990327)
    • (2007) Biochemical and Biophysical Research Communications , vol.360 , Issue.1 , pp. 90-96
    • Kasuga, K.1    Kaneko, H.2    Nishizawa, M.3    Onodera, O.4    Ikeuchi, T.5
  • 20
    • 68349152224 scopus 로고    scopus 로고
    • Depression and psychiatric symptoms preceding onset of dementia in a family with early onset Alzheimer disease with a novel PSEN1 mutation
    • Kasuga, K., Ohno, T., Ishihara, T., Miyashita, A., Kuwano, R., Onodera, O., Nishizawa, M., and Ikeuchi, T. (2009) Depression and psychiatric symptoms preceding onset of dementia in a family with early onset Alzheimer disease with a novel PSEN1 mutation. J. Neurol. 256, 1351-1353
    • (2009) J. Neurol. , vol.256 , pp. 1351-1353
    • Kasuga, K.1    Ohno, T.2    Ishihara, T.3    Miyashita, A.4    Kuwano, R.5    Onodera, O.6    Nishizawa, M.7    Ikeuchi, T.8
  • 21
    • 60549107033 scopus 로고    scopus 로고
    • A specific enzyme-linked immunosorbent assay for measuring β-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease
    • Xia, W., Yang, T., Shankar, G., Smith, I. M., Shen, Y., Walsh, D. M., and Selkoe, D. J. (2009) A specific enzyme-linked immunosorbent assay for measuring β-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch. Neurol. 66, 190-199
    • (2009) Arch. Neurol. , vol.66 , pp. 190-199
    • Xia, W.1    Yang, T.2    Shankar, G.3    Smith, I.M.4    Shen, Y.5    Walsh, D.M.6    Selkoe, D.J.7
  • 23
    • 80555157642 scopus 로고    scopus 로고
    • Glucose tolerance status and risk of dementia in the community. The Hisayama study
    • Ohara, T., Doi, Y., Ninomiya, T., Hirakawa, Y., Hata, J., Iwaki, T., Kanba, S., and Kiyohara, Y. (2011) Glucose tolerance status and risk of dementia in the community. The Hisayama study. Neurology 77, 1126-1134
    • (2011) Neurology , vol.77 , pp. 1126-1134
    • Ohara, T.1    Doi, Y.2    Ninomiya, T.3    Hirakawa, Y.4    Hata, J.5    Iwaki, T.6    Kanba, S.7    Kiyohara, Y.8
  • 25
    • 0030748390 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
    • DOI 10.1074/jbc.272.31.19547
    • Hong, M., and Lee, V. M. (1997) Insulin and insulin-like growth factor-1 regulate Tau phosphorylation in cultured human neurons. J. Biol. Chem. 272, 19547-19553 (Pubitemid 27337756)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.31 , pp. 19547-19553
    • Hong, M.1    Lee, V.M.-Y.2
  • 26
    • 0034638270 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons
    • DOI 10.1016/S0306-4522(00)00200-1, PII S0306452200002001
    • Lesort, M., and Johnson, G. V. (2000) Insulin-like growth factor-1 and insulin mediate transient site-selective increases in Tau phosphorylation in primary cortical neurons. Neuroscience 99, 305-316 (Pubitemid 30628418)
    • (2000) Neuroscience , vol.99 , Issue.2 , pp. 305-316
    • Lesort, M.1    Johnson, G.V.W.2
  • 29
  • 30
    • 79960896430 scopus 로고    scopus 로고
    • Deficient brain insulin signaling pathway in Alzheimer disease and diabetes
    • Liu, Y., Liu, F., Grundke-Iqbal, I., Iqbal, K., and Gong, C. X. (2011) Deficient brain insulin signaling pathway in Alzheimer disease and diabetes. J. Pathol. 225, 54-62
    • (2011) J. Pathol. , vol.225 , pp. 54-62
    • Liu, Y.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4    Gong, C.X.5
  • 31
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Aβ inhibits specific signal transduction cascades common to the insulin receptor pathway
    • DOI 10.1074/jbc.M610390200
    • Townsend, M., Mehta, T., and Selkoe, D. J. (2007) Soluble Aβ inhibits specific signal transduction cascades common to the insulin receptor pathway. J. Biol. Chem. 282, 33305-33312 (Pubitemid 350159548)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.46 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 32
    • 65249113325 scopus 로고    scopus 로고
    • The insulin/Akt signaling pathway is targeted by intracellular β-amyloid
    • Lee, H. K., Kumar, P., Fu, Q., Rosen, K. M., and Querfurth, H. W. (2009) The insulin/Akt signaling pathway is targeted by intracellular β-amyloid. Mol. Biol. Cell 20, 1533-1544
    • (2009) Mol. Biol. Cell , vol.20 , pp. 1533-1544
    • Lee, H.K.1    Kumar, P.2    Fu, Q.3    Rosen, K.M.4    Querfurth, H.W.5
  • 36
    • 18544390506 scopus 로고    scopus 로고
    • Post-translational modifications of tau protein in Alzheimer's disease
    • DOI 10.1007/s00702-004-0221-0
    • Gong, C. X., Liu, F., Grundke-Iqbal, I., and Iqbal, K. (2005) Post-translational modifications of Tau protein in Alzheimer disease. J. Neural Transm. 112, 813-838 (Pubitemid 40655573)
    • (2005) Journal of Neural Transmission , vol.112 , Issue.6 , pp. 813-838
    • Gong, C.-X.1    Liu, F.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 37
    • 39849110726 scopus 로고    scopus 로고
    • The GSK3 hypothesis of Alzheimer disease
    • Hooper, C., Killick, R., and Lovestone, S. (2008) The GSK3 hypothesis of Alzheimer disease. J. Neurochem. 104, 1433-1439
    • (2008) J. Neurochem. , vol.104 , pp. 1433-1439
    • Hooper, C.1    Killick, R.2    Lovestone, S.3
  • 39
    • 13644271368 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents β-amyloid neurodegeneration: Role of Wnt signaling
    • DOI 10.1016/j.yexcr.2004.09.032
    • Inestrosa, N. C., Godoy, J. A., Quintanilla, R. A., Koenig, C. S., and Bronfman, M. (2005) Peroxisome proliferator-activated receptor γ is expressed in hippocampal neurons, and its activation prevents β-amyloid neurodegeneration. Role of Wnt signaling. Exp. Cell Res. 304, 91-104 (Pubitemid 40227422)
    • (2005) Experimental Cell Research , vol.304 , Issue.1 , pp. 91-104
    • Inestrosa, N.C.1    Godoy, J.A.2    Quintanilla, R.A.3    Koenig, C.S.4    Bronfman, M.5
  • 40
    • 78650236128 scopus 로고    scopus 로고
    • Microdialysis combined blood sampling technique for the determination of rosiglitazone and glucose in brain and blood of gerbils subjected to cerebral ischemia
    • Sheu, W. H., Chuang, H. C., Cheng, S. M., Lee, M. R., Chou, C. C., and Cheng, F. C. (2011) Microdialysis combined blood sampling technique for the determination of rosiglitazone and glucose in brain and blood of gerbils subjected to cerebral ischemia. J. Pharm. Biomed. Anal. 54, 759-764
    • (2011) J. Pharm. Biomed. Anal. , vol.54 , pp. 759-764
    • Sheu, W.H.1    Chuang, H.C.2    Cheng, S.M.3    Lee, M.R.4    Chou, C.C.5    Cheng, F.C.6
  • 41
    • 33745234766 scopus 로고    scopus 로고
    • Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
    • DOI 10.1016/j.expneurol.2006.01.018, PII S001448860600029X
    • Pedersen, W. A., McMillan, P. J., Kulstad, J. J., Leverenz, J. B., Craft, S., and Haynatzki, G. R. (2006) Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice. Exp. Neurol. 199, 265-273 (Pubitemid 43928978)
    • (2006) Experimental Neurology , vol.199 , Issue.2 , pp. 265-273
    • Pedersen, W.A.1    McMillan, P.J.2    Kulstad, J.J.3    Leverenz, J.B.4    Craft, S.5    Haynatzki, G.R.6


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