Reduced insulin/IGF-1 signalling and human longevity

Aging Cell

Volumn 4, Issue 2, 2005, Pages 79-85

  Van Heemst, Diana ^a   Beekman, Marian ^a   Mooijaart, Simon P ^a   Heijmans, Bastiaan T ^a   Brandt, Bernd W ^a   Zwaan, Bas J ^b   Slagboom, P Eline ^a   Westendorp, Rudi G J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Human; Insulin IGF 1 signalling; Longevity; Polymorphisms; Prospective analysis

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR RECEPTOR; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C; HORMONE RECEPTOR; HUMAN GROWTH HORMONE; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; NEUROPEPTIDE RECEPTOR; PHOSPHOPROTEIN; SOMATOTROPIN RELEASING HORMONE RECEPTOR;

AGED; ALLELE; ARTICLE; BODY HEIGHT; BODY SIZE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; HUMAN; HUMAN EXPERIMENT; LONGEVITY; MALE; MORTALITY; PRIORITY JOURNAL; SENESCENCE; WILD TYPE; GENE LINKAGE DISEQUILIBRIUM; GENETICS; MULTIVARIATE ANALYSIS; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER;

AGED; AGED, 80 AND OVER; BODY HEIGHT; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; LINKAGE DISEQUILIBRIUM; LONGEVITY; MALE; MULTIVARIATE ANALYSIS; PHOSPHOPROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, NEUROPEPTIDE; RECEPTORS, PITUITARY HORMONE-REGULATING HORMONE;

EID: 22144477243     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9728.2005.00148.x     Document Type: Article

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