Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling

International Journal of Biochemistry and Cell Biology

Volumn 64, Issue , 2015, Pages 25-33

  Gao, Shanshan ^a   Duan, Chunli ^a   Gao, Ge ^a   Wang, Xiaoming ^a   Yang, Hui ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Alpha synuclein ( Syn); Insulin receptor substrate 1 (IRS 1); Mammalian target of rapamycin complex 1 (mTORC1); p70 Ribosomal S6 kinase 1 (S6K1); Protein phosphatase 2A (PP2A)

Indexed keywords

ALPHA SYNUCLEIN; CERAMIDE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; P70 RIBOSOMAL S6 KINASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; RAPAMYCIN; RIBOSOME PROTEIN; SERINE; TYROSINE; UNCLASSIFIED DRUG; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PHOSPHOPROTEIN PHOSPHATASE 2; RIBOSOMAL PROTEIN S6 KINASE, 70KD, POLYPEPTIDE 1; S6 KINASE; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MALE; MOUSE; NEGATIVE FEEDBACK; NEUROPATHOLOGY; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ANIMAL; C3H MOUSE; C57BL MOUSE; CELL LINE; GENE EXPRESSION; GENETICS; METABOLISM; PROTEIN STABILITY;

MAMMALIA; MUS MUSCULUS;

ALPHA-SYNUCLEIN; ANIMALS; CELL LINE; GENE EXPRESSION; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; MULTIPROTEIN COMPLEXES; PROTEIN PHOSPHATASE 2; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; TOR SERINE-THREONINE KINASES;

EID: 84926178115     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2015.03.006     Document Type: Article

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