메뉴 건너뛰기




Volumn 123, Issue 7, 2013, Pages 2764-2772

AMPK, insulin resistance, and the metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 10; METFORMIN; RESVERATROL; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

EID: 84879621442     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI67227     Document Type: Review
Times cited : (685)

References (151)
  • 1
    • 0023642627 scopus 로고
    • A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis
    • Carling D, Zammit VA, Hardie DG. A common bicyclic protein kinase cascade inactivates the regulatory enzymes of fatty acid and cholesterol biosynthesis. FEBS Lett. 1987;223(2):217-222.
    • (1987) FEBS Lett. , vol.223 , Issue.2 , pp. 217-222
    • Carling, D.1    Zammit, V.A.2    Hardie, D.G.3
  • 2
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
    • Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 2005;1(1):15-25. (Pubitemid 43960587)
    • (2005) Cell Metabolism , vol.1 , Issue.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 3
    • 3843061592 scopus 로고    scopus 로고
    • AMP kinase and malonyl-CoA: Targets for therapy of the metabolic syndrome
    • Ruderman NB, Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov. 2004;3(4):340-351. (Pubitemid 38499761)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.4 , pp. 340-351
    • Ruderman, N.1    Prentki, M.2
  • 5
    • 79959956336 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits NF-κB signaling and inflammation: Impact on healthspan and lifespan
    • Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med. 2011;89(7):667-676.
    • (2011) J Mol Med , vol.89 , Issue.7 , pp. 667-676
    • Salminen, A.1    Hyttinen, J.M.2    Kaarniranta, K.3
  • 6
    • 67650914230 scopus 로고    scopus 로고
    • AMPK in health and disease
    • Steinberg GR, Kemp BE. AMPK in health and disease. Physiol Rev. 2009;89(3):1025-1078.
    • (2009) Physiol Rev , vol.89 , Issue.3 , pp. 1025-1078
    • Steinberg, G.R.1    Kemp, B.E.2
  • 7
    • 79955618001 scopus 로고    scopus 로고
    • AMP-activated protein kinase and metabolic control
    • Viollet B, Andreelli F. AMP-activated protein kinase and metabolic control. Handb Exp Pharmacol. 2011;(203):303-330.
    • (2011) Handb Exp Pharmacol , Issue.203 , pp. 303-330
    • Viollet, B.1    Andreelli, F.2
  • 9
    • 0029978799 scopus 로고    scopus 로고
    • Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
    • Winder WW, Hardie DG. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise. Am J Physiol. 1996;270(2 pt 1):E299-E304.
    • (1996) Am J Physiol , vol.270 , Issue.2 PART 1
    • Winder, W.W.1    Hardie, D.G.2
  • 11
    • 0014831170 scopus 로고
    • The effect of physical training on insulin production in obesity
    • Bjorntorp P, De Jounge K, Sjostrom L, Sullivan L. The effect of physical training on insulin production in obesity. Metabolism. 1970;19(8):631-638.
    • (1970) Metabolism , vol.19 , Issue.8 , pp. 631-638
    • Bjorntorp, P.1    De Jounge, K.2    Sjostrom, L.3    Sullivan, L.4
  • 12
    • 0015433806 scopus 로고
    • Carbohydrate and lipid metabolism in middle-aged, physically well-trained men
    • Bjorntorp P, Fahlen M, Grimby G. Carbohydrate and lipid metabolism in middle-aged, physically well-trained men. Metabolism. 1972;21(11):1037-1044.
    • (1972) Metabolism , vol.21 , Issue.11 , pp. 1037-1044
    • Bjorntorp, P.1    Fahlen, M.2    Grimby, G.3
  • 13
    • 77949817711 scopus 로고    scopus 로고
    • AMPK and SIRT1: A long-standing partnership?
    • Ruderman NB, et al. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010;298(4):E751-E760.
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , Issue.4
    • Ruderman, N.B.1
  • 14
    • 57349092160 scopus 로고    scopus 로고
    • Changes in adenosine 5′-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome
    • Kola B, et al. Changes in adenosine 5′-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome. J Clin Endocrinol Metab. 2008;93(12):4969-4973.
    • (2008) J Clin Endocrinol Metab , vol.93 , Issue.12 , pp. 4969-4973
    • Kola, B.1
  • 15
    • 78650964142 scopus 로고    scopus 로고
    • Decreased AMP-activated protein kinase activity is associated wtih increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans
    • Gauthier MS, et al. Decreased AMP-activated protein kinase activity is associated wtih increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun. 2011;404(1):382-387.
    • (2011) Biochem Biophys Res Commun , vol.404 , Issue.1 , pp. 382-387
    • Gauthier, M.S.1
  • 16
    • 84859412650 scopus 로고    scopus 로고
    • Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue
    • Xu XJ, et al. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012;53(4):792-801.
    • (2012) J Lipid Res , vol.53 , Issue.4 , pp. 792-801
    • Xu, X.J.1
  • 17
    • 67649344115 scopus 로고    scopus 로고
    • Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): A prospective, controlled intervention trial
    • Sjöström L, et al. Effects of bariatric surgery on cancer incidence in obese patients in Sweden (Swedish Obese Subjects Study): a prospective, controlled intervention trial. Lancet Oncol. 2009;10(7):653-662.
    • (2009) Lancet Oncol , vol.10 , Issue.7 , pp. 653-662
    • Sjöström, L.1
  • 18
    • 84855367738 scopus 로고    scopus 로고
    • Bariatric surgery and long-term cardiovascular events
    • Sjöström L, et al. Bariatric surgery and long-term cardiovascular events. JAMA. 2012;307(1):56-65.
    • (2012) JAMA , vol.307 , Issue.1 , pp. 56-65
    • Sjöström, L.1
  • 19
    • 84872836906 scopus 로고    scopus 로고
    • What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant?
    • Xu XJ, Pories WJ, Dohm LG, Ruderman NB. What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant? Curr Opin Lipidol. 2013;24(1):49-56.
    • (2013) Curr Opin Lipidol , vol.24 , Issue.1 , pp. 49-56
    • Xu, X.J.1    Pories, W.J.2    Dohm, L.G.3    Ruderman, N.B.4
  • 22
    • 61449106744 scopus 로고    scopus 로고
    • AMPK and the biochemistry of exercise: Implications for human health and disease
    • Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J. 2009;418(2):261-275.
    • (2009) Biochem J. , vol.418 , Issue.2 , pp. 261-275
    • Richter, E.A.1    Ruderman, N.B.2
  • 23
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595-1607. (Pubitemid 19004941)
    • (1988) Diabetes , vol.37 , Issue.12 , pp. 1595-1607
    • Reaven, G.M.1
  • 24
    • 85153818507 scopus 로고    scopus 로고
    • The metabolic syndrome
    • Jamieson JL, DeGroot LJ, eds. 6th ed. Philadelphia, Pennsylvania: Elsevier
    • Ruderman NB, Shulman GI. The metabolic syndrome. In: Jamieson JL, DeGroot LJ, eds. Textbook of Endocrinology. 6th ed. Philadelphia, Pennsylvania: Elsevier; 2010:822-839.
    • (2010) Textbook of Endocrinology , pp. 822-839
    • Ruderman, N.B.1    Shulman, G.I.2
  • 25
    • 79960202841 scopus 로고    scopus 로고
    • Type 2 diabetes across generations: From pathophysiology to prevention and management
    • Nolan CJ, Damm P, Prentki M. Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet. 2011;378(9786):169-181.
    • (2011) Lancet , vol.378 , Issue.9786 , pp. 169-181
    • Nolan, C.J.1    Damm, P.2    Prentki, M.3
  • 27
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • Alberti KG, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation. 2009;120(16):1640-1645.
    • (2009) Circulation , vol.120 , Issue.16 , pp. 1640-1645
    • Alberti, K.G.1
  • 28
    • 0031944785 scopus 로고    scopus 로고
    • The metabolically obese, normal-weight individual revisited
    • DOI 10.2337/diabetes.47.5.699
    • Ruderman NB, Chisholm D, Pi-Sunyer X, Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes. 1998;47(5):699-713. (Pubitemid 28201798)
    • (1998) Diabetes , vol.47 , Issue.5 , pp. 699-713
    • Ruderman, N.1    Chisholm, D.2    Pi-Sunyer, X.3    Schneider, S.4
  • 29
    • 1442275317 scopus 로고    scopus 로고
    • Inflammation and Activated Innate Immunity in the Pathogenesis of Type 2 Diabletes
    • DOI 10.2337/diacare.27.3.813
    • Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27(3):813-823. (Pubitemid 38280558)
    • (2004) Diabetes Care , vol.27 , Issue.3 , pp. 813-823
    • Pickup, J.C.1
  • 30
    • 79954517977 scopus 로고    scopus 로고
    • Structure of mammalian AMPK and its regulation by ADP
    • Xiao B, et al. Structure of mammalian AMPK and its regulation by ADP. Nature. 2011;472(7342):230-233.
    • (2011) Nature , vol.472 , Issue.7342 , pp. 230-233
    • Xiao, B.1
  • 31
    • 79959338922 scopus 로고    scopus 로고
    • AMPK is a direct adenylate charge-regulated protein kinase
    • Oakhill JS, et al. AMPK is a direct adenylate charge-regulated protein kinase. Science. 2011;332(6036):1433-1435.
    • (2011) Science , vol.332 , Issue.6036 , pp. 1433-1435
    • Oakhill, J.S.1
  • 32
    • 36348978499 scopus 로고    scopus 로고
    • Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family
    • DOI 10.1074/jbc.M706543200
    • Sanders MJ, Ali ZS, Hegarty BD, Heath R, Snowden MA, Carling D. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem. 2007;282(45):32539-32548. (Pubitemid 350159309)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.45 , pp. 32539-32548
    • Sanders, M.J.1    Ali, Z.S.2    Hegarty, B.D.3    Heath, R.4    Snowden, M.A.5    Carling, D.6
  • 33
    • 84866404225 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase kinase 2: Roles in signaling and pathophysiology
    • Racioppi L, Means AR. Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. J Biol Chem. 2012;287(38):31658- 31665.
    • (2012) J Biol Chem , vol.287 , Issue.38 , pp. 31658-31665
    • Racioppi, L.1    Means, A.R.2
  • 35
    • 16044369576 scopus 로고    scopus 로고
    • Surgeon General's report on physical activity and health. From the Centers for Disease Control and Prevention
    • No authors listed
    • [No authors listed]. Surgeon General's report on physical activity and health. From the Centers for Disease Control and Prevention. JAMA. 1996;276(7):522.
    • (1996) JAMA , vol.276 , Issue.7 , pp. 522
  • 37
    • 0023026240 scopus 로고
    • Lower prevalence of diabetes in female former college athletes compared with nonathletes
    • Frisch RE, Wyshak G, Albright TE, Albright NL, Schiff I. Lower prevalence of diabetes in female former college athletes compared with nonathletes. Diabetes. 1986;35(10):1101-1105. (Pubitemid 17176953)
    • (1986) Diabetes , vol.35 , Issue.10 , pp. 1101-1105
    • Frisch, R.E.1    Wyshak, G.2    Albright, T.E.3
  • 40
    • 0037031840 scopus 로고    scopus 로고
    • Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3- phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
    • DOI 10.1074/jbc.M201692200
    • Park H, et al. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem. 2002;277(36):32571-32577. (Pubitemid 34984761)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.36 , pp. 32571-32577
    • Park, H.1    Kaushik, V.K.2    Constant, S.3    Prentki, M.4    Przybytkowski, E.5    Ruderman, N.6    Saha, A.K.7
  • 42
    • 68149166789 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: Role of vascular signalling kinases
    • Zhang QJ, McMillin SL, Tanner JM, Palionyte M, Abel ED, Symons JD. Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases. J Physiol. 2009;587(pt 15):3911-3920.
    • (2009) J Physiol , vol.587 , Issue.PART 15 , pp. 3911-3920
    • Zhang, Q.J.1    McMillin, S.L.2    Tanner, J.M.3    Palionyte, M.4    Abel, E.D.5    Symons, J.D.6
  • 43
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res. 2000;87(10):840-844.
    • (2000) Circ Res , vol.87 , Issue.10 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 45
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • No authors listed UK Prospective Diabetes Study (UKPDS) Group
    • [No authors listed]. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998;352(9131):854- 865.
    • (1998) Lancet , vol.352 , Issue.9131 , pp. 854-865
  • 46
    • 84862848716 scopus 로고    scopus 로고
    • Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: A meta-analysis
    • Soranna D, et al. Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes: a meta-analysis. Oncologist. 2012;17(6):813-822.
    • (2012) Oncologist , vol.17 , Issue.6 , pp. 813-822
    • Soranna, D.1
  • 47
    • 84866138849 scopus 로고    scopus 로고
    • Cancer outcomes and all-cause mortality in adults allocated to metformin: Systematic review and collaborative meta-analysis of randomised clinical trials
    • Stevens RJ, et al. Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials. Diabetologia. 2012;55(10):2593-2603.
    • (2012) Diabetologia , vol.55 , Issue.10 , pp. 2593-2603
    • Stevens, R.J.1
  • 49
    • 84873707522 scopus 로고    scopus 로고
    • Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
    • Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature. 2013;494(7436):256-260.
    • (2013) Nature , vol.494 , Issue.7436 , pp. 256-260
    • Miller, R.A.1    Chu, Q.2    Xie, J.3    Foretz, M.4    Viollet, B.5    Birnbaum, M.J.6
  • 52
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • DOI 10.1210/er.2005-0005
    • Kadowaki T, Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev. 2005;26(3):439-451. (Pubitemid 40686653)
    • (2005) Endocrine Reviews , vol.26 , Issue.3 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 53
    • 33747356154 scopus 로고    scopus 로고
    • Adipose tissue: From lipid storage compartment to endocrine organ
    • DOI 10.2337/db06-0263
    • Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes. 2006;55(6):1537-1545. (Pubitemid 44324105)
    • (2006) Diabetes , vol.55 , Issue.6 , pp. 1537-1545
    • Scherer, P.E.1
  • 54
    • 84873404989 scopus 로고    scopus 로고
    • Adiponectin receptor as a key player in healthy longevity and obesity-related diseases
    • Yamauchi T, Kadowaki T. Adiponectin receptor as a key player in healthy longevity and obesity-related diseases. Cell Metab. 2013;17(2):185-196.
    • (2013) Cell Metab , vol.17 , Issue.2 , pp. 185-196
    • Yamauchi, T.1    Kadowaki, T.2
  • 55
    • 77951872309 scopus 로고    scopus 로고
    • 2+) and AMPK/SIRT1
    • 2+) and AMPK/SIRT1. Nature. 2010;464(7293):1313- 1319.
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1313-1319
    • Iwabu, M.1
  • 57
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • DOI 10.1074/jbc.M202489200
    • Fryer LG, Parbu-Patel A, Carling D. The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem. 2002;277(28):25226-25232. (Pubitemid 34951829)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.28 , pp. 25226-25232
    • Fryer, L.G.D.1    Parbu-Patel, A.2    Carling, D.3
  • 62
    • 79953232077 scopus 로고    scopus 로고
    • Pioglitazone for diabetes prevention in impaired glucose tolerance
    • DeFronzo RA, et al. Pioglitazone for diabetes prevention in impaired glucose tolerance. N Engl J Med. 2011;364(12):1104-1115.
    • (2011) N Engl J Med , vol.364 , Issue.12 , pp. 1104-1115
    • DeFronzo, R.A.1
  • 63
    • 84872327440 scopus 로고    scopus 로고
    • Pathophysiology of human visceral obesity: An update
    • Tchernof A, Despres JP. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013;93(1):359-404.
    • (2013) Physiol Rev , vol.93 , Issue.1 , pp. 359-404
    • Tchernof, A.1    Despres, J.P.2
  • 64
    • 84862493914 scopus 로고    scopus 로고
    • AMP-activated protein kinase: New regulation, new roles?
    • Carling D, Thornton C, Woods A, Sanders MJ. AMP-activated protein kinase: new regulation, new roles? Biochem J. 2012;445(1):11-27.
    • (2012) Biochem J , vol.445 , Issue.1 , pp. 11-27
    • Carling, D.1    Thornton, C.2    Woods, A.3    Sanders, M.J.4
  • 65
    • 80053035284 scopus 로고    scopus 로고
    • AMP-activated protein kinase: An energy sensor that regulates all aspects of cell function
    • Hardie DG. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. 2011;25(18):1895-1908.
    • (2011) Genes Dev , vol.25 , Issue.18 , pp. 1895-1908
    • Hardie, D.G.1
  • 66
    • 65349177200 scopus 로고    scopus 로고
    • AMPK: An emerging drug target for diabetes and the metabolic syndrome
    • Zhang BB, Zhou G, Li C. AMPK: an emerging drug target for diabetes and the metabolic syndrome. Cell Metab. 2009;9(5):407-416.
    • (2009) Cell Metab , vol.9 , Issue.5 , pp. 407-416
    • Zhang, B.B.1    Zhou, G.2    Li, C.3
  • 67
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012;13(4):251-262.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.4 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 68
    • 80052517174 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis
    • Svegliati-Baroni G, et al. Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis. Liver Int. 2011;31(9):1285-1297.
    • (2011) Liver Int , vol.31 , Issue.9 , pp. 1285-1297
    • Svegliati-Baroni, G.1
  • 69
    • 84861222690 scopus 로고    scopus 로고
    • The ancient drug salicylate directly activates AMP-activated protein kinase
    • Hawley SA, et al. The ancient drug salicylate directly activates AMP-activated protein kinase. Science. 2012;336(6083):918-922.
    • (2012) Science , vol.336 , Issue.6083 , pp. 918-922
    • Hawley, S.A.1
  • 70
    • 0036307179 scopus 로고    scopus 로고
    • Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome
    • Buhl ES, et al. Long-term AICAR administration reduces metabolic disturbances and lowers blood pressure in rats displaying features of the insulin resistance syndrome. Diabetes. 2002;51(7):2199-2206. (Pubitemid 34729025)
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2199-2206
    • Buhl, E.S.1    Jessen, N.2    Pold, R.3    Ledet, T.4    Flyvbjerg, A.5    Pedersen, S.B.6    Pedersen, O.7    Schmitz, O.8    Lund, S.9
  • 71
    • 0036289911 scopus 로고    scopus 로고
    • Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations
    • DOI 10.1016/S0006-291X(02)00557-0, PII S0006291X02005570
    • Halseth AE, Ensor NJ, White TA, Ross SA, Gulve EA. Acute and chronic treatment of ob/ob and db/db mice with AICAR decreases blood glucose concentrations. Biochem Biophys Res Commun. 2002;294(4):798-805. (Pubitemid 34687187)
    • (2002) Biochemical and Biophysical Research Communications , vol.294 , Issue.4 , pp. 798-805
    • Halseth, A.E.1    Ensor, N.J.2    White, T.A.3    Ross, S.A.4    Gulve, E.A.5
  • 74
    • 12144271041 scopus 로고    scopus 로고
    • Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: Prevention of diabetes and ectopic lipid deposition
    • DOI 10.1007/s00125-004-1570-9
    • Yu X, et al. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia. 2004;47(11):2012-2021. (Pubitemid 40110213)
    • (2004) Diabetologia , vol.47 , Issue.11 , pp. 2012-2021
    • Yu, X.1    McCorkle, S.2    Wang, M.3    Lee, Y.4    Li, J.5    Saha, A.K.6    Unger, R.H.7    Ruderman, N.B.8
  • 76
    • 0029133854 scopus 로고
    • Insulin secretory defect in Zucker fa/fa rats is improved by ameliorating insulin resistance
    • de Souza CJ, Yu JH, Robinson DD, Ulrich RG, Meglasson MD. Insulin secretory defect in Zucker fa/fa rats is improved by ameliorating insulin resistance. Diabetes. 1995;44(8):984-991.
    • (1995) Diabetes , vol.44 , Issue.8 , pp. 984-991
    • De Souza, C.J.1    Yu, J.H.2    Robinson, D.D.3    Ulrich, R.G.4    Meglasson, M.D.5
  • 77
    • 0027303172 scopus 로고
    • In vivo metformin treatment ameliorates insulin resistance: Evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes
    • DOI 10.1210/en.133.1.304
    • Matthaei S, et al. In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin-induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes. Endocrinology. 1993;133(1):304-311. (Pubitemid 23206408)
    • (1993) Endocrinology , vol.133 , Issue.1 , pp. 304-311
    • Matthaei, S.1    Reibold, J.P.2    Hamann, A.3    Benecke, H.4    Haring, H.U.5    Greten, H.6    Klein, H.H.7
  • 78
    • 80052385397 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Also regulated by ADP?
    • Hardie DG, Carling D, Gamblin SJ. AMP-activated protein kinase: also regulated by ADP? Trends Biochem Sci. 2011;36(9):470-477.
    • (2011) Trends Biochem Sci , vol.36 , Issue.9 , pp. 470-477
    • Hardie, D.G.1    Carling, D.2    Gamblin, S.J.3
  • 79
    • 84874993428 scopus 로고    scopus 로고
    • AMPK and exercise: Glucose uptake and insulin sensitivity
    • O'Neill HM. AMPK and exercise: glucose uptake and insulin sensitivity. Diabetes Metab J. 2013;37(1):1-21.
    • (2013) Diabetes Metab J , vol.37 , Issue.1 , pp. 1-21
    • O'Neill, H.M.1
  • 80
    • 84864001222 scopus 로고    scopus 로고
    • The AMPK beta2 subunit is required for energy homeostasis during metabolic stress
    • Dasgupta B, et al. The AMPK beta2 subunit is required for energy homeostasis during metabolic stress. Mol Cell Biol. 2012;32(14):2837-2848.
    • (2012) Mol Cell Biol , vol.32 , Issue.14 , pp. 2837-2848
    • Dasgupta, B.1
  • 81
    • 58149348480 scopus 로고    scopus 로고
    • Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice
    • Fujii N, et al. Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice. Diabetes. 2008;57(11):2958-2966.
    • (2008) Diabetes , vol.57 , Issue.11 , pp. 2958-2966
    • Fujii, N.1
  • 82
    • 77950348878 scopus 로고    scopus 로고
    • AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    • Um JH, et al. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes. 2010;59(3):554-563.
    • (2010) Diabetes , vol.59 , Issue.3 , pp. 554-563
    • Um, J.H.1
  • 83
    • 78049278390 scopus 로고    scopus 로고
    • AMP-activated protein kinase alpha2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids
    • Jelenik T, et al. AMP-activated protein kinase alpha2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids. Diabetes. 2010;59(11):2737-2746.
    • (2010) Diabetes , vol.59 , Issue.11 , pp. 2737-2746
    • Jelenik, T.1
  • 84
    • 33644755871 scopus 로고    scopus 로고
    • Unlocking the secrets of longevity genes
    • Sinclair DA, Guarente L. Unlocking the secrets of longevity genes. Sci Am. 2006;294(3):48-51.
    • (2006) Sci Am , vol.294 , Issue.3 , pp. 48-51
    • Sinclair, D.A.1    Guarente, L.2
  • 85
    • 84874594425 scopus 로고    scopus 로고
    • The sirtuin family's role in aging and age-associated pathologies
    • Hall JA, Dominy JE, Lee Y, Puigserver P. The sirtuin family's role in aging and age-associated pathologies. J Clin Invest. 2013;123(3):973-979.
    • (2013) J Clin Invest , vol.123 , Issue.3 , pp. 973-979
    • Hall, J.A.1    Dominy, J.E.2    Lee, Y.3    Puigserver, P.4
  • 86
    • 55549096745 scopus 로고    scopus 로고
    • SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
    • Lan F, Cacicedo J, Ruderman N, Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem. 2008;283(41):27628-27635.
    • (2008) J Biol Chem , vol.283 , Issue.41 , pp. 27628-27635
    • Lan, F.1    Cacicedo, J.2    Ruderman, N.3    Ido, Y.4
  • 87
    • 50649112638 scopus 로고    scopus 로고
    • SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
    • Hou X, et al. SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem. 2008;283(29):20015-20026.
    • (2008) J Biol Chem , vol.283 , Issue.29 , pp. 20015-20026
    • Hou, X.1
  • 88
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • Price NL, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 2012;15(5):675-690.
    • (2012) Cell Metab , vol.15 , Issue.5 , pp. 675-690
    • Price, N.L.1
  • 89
    • 67349276169 scopus 로고    scopus 로고
    • + metabolism and SIRT1 activity
    • + metabolism and SIRT1 activity. Nature. 2009;458(7241):1056-1060.
    • (2009) Nature , vol.458 , Issue.7241 , pp. 1056-1060
    • Canto, C.1
  • 90
    • 33749349202 scopus 로고    scopus 로고
    • Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
    • DOI 10.2337/db05-1188
    • Zang M, et al. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006;55(8):2180-2191. (Pubitemid 44743614)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2180-2191
    • Zang, M.1    Xu, S.2    Maitland-Toolan, K.A.3    Zuccollo, A.4    Hou, X.5    Jiang, B.6    Wierzbicki, M.7    Verbeuren, T.J.8    Cohen, R.A.9
  • 91
    • 84857788916 scopus 로고    scopus 로고
    • Glycerolipid/free fatty acid cycle and islet beta-cell function in health, obesity and diabetes
    • Prentki M, Madiraju SR. Glycerolipid/free fatty acid cycle and islet beta-cell function in health, obesity and diabetes. Mol Cell Endocrinol. 2012;353(1-2):88-100.
    • (2012) Mol Cell Endocrinol , vol.353 , Issue.1-2 , pp. 88-100
    • Prentki, M.1    Madiraju, S.R.2
  • 92
    • 0036095269 scopus 로고    scopus 로고
    • Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: Inhibition by the AMP-activated protein kinase activation
    • Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 2002;51(1):159-167. (Pubitemid 34517993)
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 159-167
    • Ido, Y.1    Carling, D.2    Ruderman, N.3
  • 93
    • 33744976813 scopus 로고    scopus 로고
    • Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells
    • DOI 10.1161/01.HYP.0000221429.94591.72, PII 0000426820060600000025
    • Hattori Y, Suzuki K, Hattori S, Kasai K. Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells. Hypertension. 2006;47(6):1183-1188. (Pubitemid 44289177)
    • (2006) Hypertension , vol.47 , Issue.6 , pp. 1183-1188
    • Hattori, Y.1    Suzuki, K.2    Hattori, S.3    Kasai, K.4
  • 94
    • 33644749330 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
    • DOI 10.2337/diabetes.55.1.120
    • Kukidome D, et al. Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes. 2006;55(1):120-127. (Pubitemid 43343306)
    • (2006) Diabetes , vol.55 , Issue.1 , pp. 120-127
    • Kukidome, D.1    Nishikawa, T.2    Sonoda, K.3    Imoto, K.4    Fujisawa, K.5    Yano, M.6    Motoshima, H.7    Taguchi, T.8    Matsumura, T.9    Araki, E.10
  • 95
    • 14344257169 scopus 로고    scopus 로고
    • AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells
    • DOI 10.1016/j.bbrc.2004.09.177
    • Cacicedo JM, Yagihashi N, Keaney JF, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2004;324(4):1204-1209. (Pubitemid 40292150)
    • (2004) Biochemical and Biophysical Research Communications , vol.324 , Issue.4 , pp. 1204-1209
    • Cacicedo, J.M.1    Yagihashi, N.2    Keaney Jr., J.F.3    Ruderman, N.B.4    Ido, Y.5
  • 97
    • 0033036636 scopus 로고    scopus 로고
    • AMP-activated protein kinase phosphorylation of endothelial NO synthase
    • Chen ZP, et al. AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett. 1999;443(3):285-289.
    • (1999) FEBS Lett , vol.443 , Issue.3 , pp. 285-289
    • Chen, Z.P.1
  • 98
    • 33845707278 scopus 로고    scopus 로고
    • Statins activate AMP-activated protein kinase in vitro and in vivo
    • DOI 10.1161/CIRCULATIONAHA.106.630194, PII 0000301720061212000015
    • Sun W, et al. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation. 2006;114(24):2655-2662. (Pubitemid 44967349)
    • (2006) Circulation , vol.114 , Issue.24 , pp. 2655-2662
    • Sun, W.1    Lee, T.-S.2    Zhu, M.3    Gu, C.4    Wang, Y.5    Zhu, Y.6    Shyy, J.Y.-J.7
  • 99
    • 79956319051 scopus 로고    scopus 로고
    • Progress and challenges in translating the biology of atherosclerosis
    • Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473(7347):317-325.
    • (2011) Nature , vol.473 , Issue.7347 , pp. 317-325
    • Libby, P.1    Ridker, P.M.2    Hansson, G.K.3
  • 100
    • 77149134285 scopus 로고    scopus 로고
    • Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo
    • Dong Y, et al. Reduction of AMP-activated protein kinase alpha2 increases endoplasmic reticulum stress and atherosclerosis in vivo. Circulation. 2010;121(6):792-803.
    • (2010) Circulation , vol.121 , Issue.6 , pp. 792-803
    • Dong, Y.1
  • 101
    • 80053196866 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: The role of uncoupling protein 2
    • Wang Q, Zhang M, Liang B, Shirwany N, Zhu Y, Zou MH. Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. PLoS One. 2011;6(9):e25436.
    • (2011) PLoS One , vol.6 , Issue.9
    • Wang, Q.1    Zhang, M.2    Liang, B.3    Shirwany, N.4    Zhu, Y.5    Zou, M.H.6
  • 104
    • 84860441011 scopus 로고    scopus 로고
    • Inflammation and lipid signaling in the etiology of insulin resistance
    • Glass CK, Olefsky JM. Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 2012;15(5):635-645.
    • (2012) Cell Metab , vol.15 , Issue.5 , pp. 635-645
    • Glass, C.K.1    Olefsky, J.M.2
  • 105
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11(2):98-107.
    • (2011) Nat Rev Immunol , vol.11 , Issue.2 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 106
    • 2442713803 scopus 로고    scopus 로고
    • Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: A new mechanism of action of insulin-sensitizing drugs
    • DOI 10.1074/jbc.M401390200
    • Pilon G, Dallaire P, Marette A. Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs. J Biol Chem. 2004;279(20):20767-20774. (Pubitemid 38656473)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.20 , pp. 20767-20774
    • Pilon, G.1    Dallaire, P.2    Marette, A.3
  • 107
    • 58849115949 scopus 로고    scopus 로고
    • Adenosine 5′-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    • Sag D, Carling D, Stout RD, Suttles J. Adenosine 5′-monophosphate- activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype. J Immunol. 2008;181(12):8633-8641.
    • (2008) J Immunol , vol.181 , Issue.12 , pp. 8633-8641
    • Sag, D.1    Carling, D.2    Stout, R.D.3    Suttles, J.4
  • 108
    • 77953517927 scopus 로고    scopus 로고
    • Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1
    • Yang Z, Kahn BB, Shi H, Xue BZ. Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1. J Biol Chem. 2010;285(25):19051-19059.
    • (2010) J Biol Chem , vol.285 , Issue.25 , pp. 19051-19059
    • Yang, Z.1    Kahn, B.B.2    Shi, H.3    Xue, B.Z.4
  • 109
    • 84055190798 scopus 로고    scopus 로고
    • Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
    • Galic S, et al. Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest. 2011;121(12):4903-4915.
    • (2011) J Clin Invest , vol.121 , Issue.12 , pp. 4903-4915
    • Galic, S.1
  • 110
    • 84872576236 scopus 로고    scopus 로고
    • Metabolism of inflammation limited by AMPK and pseudo-starvation
    • O'Neill LA, Hardie DG. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature. 2013;493(7432):346-355.
    • (2013) Nature , vol.493 , Issue.7432 , pp. 346-355
    • O'Neill, L.A.1    Hardie, D.G.2
  • 111
    • 84857364150 scopus 로고    scopus 로고
    • Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans
    • Goossens GH, et al. Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans. Mol Immunol. 2012;50(3):142-149.
    • (2012) Mol Immunol , vol.50 , Issue.3 , pp. 142-149
    • Goossens, G.H.1
  • 113
    • 79955006431 scopus 로고    scopus 로고
    • Dampening insulin signaling by an NLRP3 'meta-flammasome'
    • Choi AMK, Nakahira K. Dampening insulin signaling by an NLRP3 'meta-flammasome'. Nat Immunol. 2011;12(5):379-380.
    • (2011) Nat Immunol , vol.12 , Issue.5 , pp. 379-380
    • Choi, A.M.K.1    Nakahira, K.2
  • 114
    • 84865643438 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress activate inflammasomes: Impact on the aging process and age-related diseases
    • Salminen A, Ojala J, Kaarniranta K, Kauppinen A. Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell Mol Life Sci. 2012;69(18):2999-3013.
    • (2012) Cell Mol Life Sci , vol.69 , Issue.18 , pp. 2999-3013
    • Salminen, A.1    Ojala, J.2    Kaarniranta, K.3    Kauppinen, A.4
  • 115
    • 84872018875 scopus 로고    scopus 로고
    • Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes
    • Lee HM, Kim JJ, Kim HJ, Shong M, Ku BJ, Jo EK. Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes. 2013;62(1):194-204.
    • (2013) Diabetes , vol.62 , Issue.1 , pp. 194-204
    • Lee, H.M.1    Kim, J.J.2    Kim, H.J.3    Shong, M.4    Ku, B.J.5    Jo, E.K.6
  • 117
    • 84864062918 scopus 로고    scopus 로고
    • Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism
    • Nogueiras R, et al. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev. 2012;92(3):1479-1514.
    • (2012) Physiol Rev , vol.92 , Issue.3 , pp. 1479-1514
    • Nogueiras, R.1
  • 120
    • 80053902834 scopus 로고    scopus 로고
    • Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats
    • da Luz G, et al. Endurance exercise training ameliorates insulin resistance and reticulum stress in adipose and hepatic tissue in obese rats. Eur J Appl Physiol. 2011;111(9):2015-2023.
    • (2011) Eur J Appl Physiol , vol.111 , Issue.9 , pp. 2015-2023
    • Da Luz, G.1
  • 121
    • 84866164347 scopus 로고    scopus 로고
    • Regular physical exercise as a strategy to improve antioxidant and anti-inflammatory status: Benefits in type 2 diabetes mellitus
    • de Lemos ET, Oliveira J, Pinheiro JP, Reis F. Regular physical exercise as a strategy to improve antioxidant and anti-inflammatory status: benefits in type 2 diabetes mellitus. Oxid Med Cell Longev. 2012;2012:741545.
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 741545
    • De Lemos, E.T.1    Oliveira, J.2    Pinheiro, J.P.3    Reis, F.4
  • 122
    • 79551510124 scopus 로고    scopus 로고
    • The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1alpha/ATF6alpha complex
    • Wu J, et al. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1alpha/ATF6alpha complex. Cell Metab. 2011;13(2):160-169.
    • (2011) Cell Metab , vol.13 , Issue.2 , pp. 160-169
    • Wu, J.1
  • 124
    • 84855182851 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
    • Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev. 2012;11(2):230-241.
    • (2012) Ageing Res Rev , vol.11 , Issue.2 , pp. 230-241
    • Salminen, A.1    Kaarniranta, K.2
  • 125
    • 84855459760 scopus 로고    scopus 로고
    • Obesity is associated with hypothalamic injury in rodents and humans
    • Thaler JP, et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest. 2012;122(1):153-162.
    • (2012) J Clin Invest , vol.122 , Issue.1 , pp. 153-162
    • Thaler, J.P.1
  • 128
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED, Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature. 2006;440(7086):944-948.
    • (2006) Nature , vol.440 , Issue.7086 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 129
    • 38449098785 scopus 로고    scopus 로고
    • Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients
    • Uzun H, Konukoglu D, Gelisgen R, Zengin K, Taskin M. Plasma protein carbonyl and thiol stress before and after laparoscopic gastric banding in morbidly obese patients. Obes Surg. 2007;17(10):1367-1373.
    • (2007) Obes Surg , vol.17 , Issue.10 , pp. 1367-1373
    • Uzun, H.1    Konukoglu, D.2    Gelisgen, R.3    Zengin, K.4    Taskin, M.5
  • 130
    • 58849100321 scopus 로고    scopus 로고
    • Oxidative stress in severely obese persons is greater in those with insulin resistance
    • Tinahones FJ, et al. Oxidative stress in severely obese persons is greater in those with insulin resistance. Obesity (Silver Spring). 2009;17(2):240-246.
    • (2009) Obesity (Silver Spring) , vol.17 , Issue.2 , pp. 240-246
    • Tinahones, F.J.1
  • 131
    • 77955494890 scopus 로고    scopus 로고
    • The obese healthy paradox: is inflammation the answer?
    • Barbarrosa N, et al. The obese healthy paradox: is inflammation the answer? Biochem J. 2010;430(1):141-149.
    • (2010) Biochem J , vol.430 , Issue.1 , pp. 141-149
    • Barbarrosa, N.1
  • 132
    • 78751649211 scopus 로고    scopus 로고
    • Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity
    • Hardy OT, et al. Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Surg Obes Relat Dis. 2011;7(1):60-67.
    • (2011) Surg Obes Relat Dis , vol.7 , Issue.1 , pp. 60-67
    • Hardy, O.T.1
  • 133
  • 134
    • 84874410516 scopus 로고    scopus 로고
    • Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients
    • Qatanani M, et al. Inverse regulation of inflammation and mitochondrial function in adipose tissue defines extreme insulin sensitivity in morbidly obese patients. Diabetes. 2013;62(3):855-863.
    • (2013) Diabetes , vol.62 , Issue.3 , pp. 855-863
    • Qatanani, M.1
  • 135
    • 85152807468 scopus 로고    scopus 로고
    • Bariatric surgery and reversal of metabolic disorders
    • Bagchi B, Preuss HG, eds. Boca Raton, Florida, USA: CRC Press
    • Manco M. Bariatric surgery and reversal of metabolic disorders. In: Bagchi B, Preuss HG, eds. Obesity: Epidemiology, Pathophysiology, and Prevention. Boca Raton, Florida, USA: CRC Press; 2012:931-940.
    • (2012) Obesity: Epidemiology, Pathophysiology, and Prevention , pp. 931-940
    • Manco, M.1
  • 136
    • 78751618979 scopus 로고    scopus 로고
    • Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity
    • Gealekman O, et al. Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity. Circulation. 2011;123(2):186-194.
    • (2011) Circulation , vol.123 , Issue.2 , pp. 186-194
    • Gealekman, O.1
  • 137
    • 79960359853 scopus 로고    scopus 로고
    • Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation
    • Goossens GH, et al. Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation. Circulation. 2011;124(1):67-76.
    • (2011) Circulation , vol.124 , Issue.1 , pp. 67-76
    • Goossens, G.H.1
  • 138
    • 33947710793 scopus 로고    scopus 로고
    • Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    • Civitarese AE, et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 2007;4(3):e76.
    • (2007) PLoS Med , vol.4 , Issue.3
    • Civitarese, A.E.1
  • 139
    • 73249117062 scopus 로고    scopus 로고
    • Adipose tissue collagen VI in obesity
    • Pasarica M, et al. Adipose tissue collagen VI in obesity. J Clin Endocrinol Metab. 2009;94(12):5155-5162.
    • (2009) J Clin Endocrinol Metab , vol.94 , Issue.12 , pp. 5155-5162
    • Pasarica, M.1
  • 140
    • 79957902145 scopus 로고    scopus 로고
    • Gut microbiome, obesity, and metabolic dysfunction
    • Tilg H, Kaser A. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest. 2011;121(6):2126-2132.
    • (2011) J Clin Invest , vol.121 , Issue.6 , pp. 2126-2132
    • Tilg, H.1    Kaser, A.2
  • 141
    • 84874045511 scopus 로고    scopus 로고
    • The origins and drivers of insulin resistance
    • Johnson AM, Olefsky JM. The origins and drivers of insulin resistance. Cell. 2013;152(4):673-684.
    • (2013) Cell , vol.152 , Issue.4 , pp. 673-684
    • Johnson, A.M.1    Olefsky, J.M.2
  • 142
    • 84857058546 scopus 로고    scopus 로고
    • Immuno-microbiota cross and talk: The new paradigm of metabolic diseases
    • Burcelin R, Garidou L, Pomie C. Immuno-microbiota cross and talk: the new paradigm of metabolic diseases. Semin Immunol. 2012;24(1):67-74.
    • (2012) Semin Immunol , vol.24 , Issue.1 , pp. 67-74
    • Burcelin, R.1    Garidou, L.2    Pomie, C.3
  • 144
    • 84865161315 scopus 로고    scopus 로고
    • Transgenic mouse models resistant to diet-induced metabolic disease: Is energy balance the key?
    • Gilliam LA, Neufer PD. Transgenic mouse models resistant to diet-induced metabolic disease: is energy balance the key? J Pharmacol Exp Ther. 2012;342(3):631-636.
    • (2012) J Pharmacol Exp Ther , vol.342 , Issue.3 , pp. 631-636
    • Gilliam, L.A.1    Neufer, P.D.2
  • 146
    • 84866141702 scopus 로고    scopus 로고
    • Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice
    • Carvalho BM, et al. Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice. Diabetologia. 2012;55(10):2823-2834.
    • (2012) Diabetologia , vol.55 , Issue.10 , pp. 2823-2834
    • Carvalho, B.M.1
  • 147
    • 62749178966 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss
    • Gregor MF, et al. Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes. 2009;58(3):639-700.
    • (2009) Diabetes , vol.58 , Issue.3 , pp. 639-700
    • Gregor, M.F.1
  • 148
    • 33749370466 scopus 로고    scopus 로고
    • Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
    • DOI 10.2337/db06-0062
    • Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes. 2006;55(8):2277-2285. (Pubitemid 44743625)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2277-2285
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 151
    • 70450231612 scopus 로고    scopus 로고
    • Energetics, epigenetics, mitochondrial genetics
    • Wallace DC, Fan W. Energetics, epigenetics, mitochondrial genetics. Mitochondrion. 2010;10(1):12-31.
    • (2010) Mitochondrion , vol.10 , Issue.1 , pp. 12-31
    • Wallace, D.C.1    Fan, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.