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Volumn 21, Issue 5, 2016, Pages 802-818

The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: Mechanisms of action

Author keywords

[No Author keywords available]

Indexed keywords

DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 DERIVATIVE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; LINAGLIPTIN; LIRAGLUTIDE; LIXISENATIDE; SAXAGLIPTIN; SITAGLIPTIN; VILDAGLIPTIN; GLUCAGON LIKE PEPTIDE 1; PROTEIN KINASE B;

EID: 84957388554     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2016.01.013     Document Type: Review
Times cited : (261)

References (255)
  • 1
    • 84883174947 scopus 로고    scopus 로고
    • Parkinson's disease dementia: Convergence of α-synuclein, tau and amyloid-β pathologies
    • D.J. Irwin, and et al. Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies Nat. Rev. Neurosci. 14 2013 626 636
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 626-636
    • Irwin, D.J.1
  • 2
    • 67651173077 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus
    • J.A. Lovshin, and D.J. Drucker Incretin-based therapies for type 2 diabetes mellitus Nat. Rev. Endocrinol. 5 2009 262 269
    • (2009) Nat. Rev. Endocrinol. , vol.5 , pp. 262-269
    • Lovshin, J.A.1    Drucker, D.J.2
  • 3
    • 75149128665 scopus 로고    scopus 로고
    • Incretin-based therapies for the treatment of type 2 diabetes: Evaluation of the risks and benefits
    • D.J. Drucker, and et al. Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits Diabetes Care 33 2010 428 433
    • (2010) Diabetes Care , vol.33 , pp. 428-433
    • Drucker, D.J.1
  • 4
    • 84919725884 scopus 로고    scopus 로고
    • Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain
    • K.M. Heppner, and et al. Expression and distribution of glucagon-like peptide-1 receptor mRNA, protein and binding in the male nonhuman primate (Macaca mulatta) brain Endocrinology 156 2015 255 267
    • (2015) Endocrinology , vol.156 , pp. 255-267
    • Heppner, K.M.1
  • 5
    • 13644268431 scopus 로고    scopus 로고
    • The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem
    • E. Alvarez, and et al. The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem J. Neurochem. 92 2005 798 806
    • (2005) J. Neurochem. , vol.92 , pp. 798-806
    • Alvarez, E.1
  • 6
    • 84942198303 scopus 로고    scopus 로고
    • Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain
    • S.C. Cork, and et al. Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain Mol. Metab. 4 2015 718 731
    • (2015) Mol. Metab. , vol.4 , pp. 718-731
    • Cork, S.C.1
  • 8
    • 84872569583 scopus 로고    scopus 로고
    • GLP-1 secretion by microglial cells and decreased CNS expression in obesity
    • C. Kappe, and et al. GLP-1 secretion by microglial cells and decreased CNS expression in obesity J. Neuroinflammation 9 2012 276
    • (2012) J. Neuroinflammation , vol.9 , pp. 276
    • Kappe, C.1
  • 9
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • L.L. Baggio, and D.J. Drucker Biology of incretins: GLP-1 and GIP Gastroenterology 132 2007 2131 2157
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 10
    • 0029118049 scopus 로고
    • Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV
    • T.J. Kieffer, and et al. Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV Endocrinology 136 1995 3585 3596
    • (1995) Endocrinology , vol.136 , pp. 3585-3596
    • Kieffer, T.J.1
  • 11
    • 0037234531 scopus 로고    scopus 로고
    • Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes
    • D.J. Drucker Therapeutic potential of dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes Expert Opin. Investig. Drugs 12 2003 87 100
    • (2003) Expert Opin. Investig. Drugs , vol.12 , pp. 87-100
    • Drucker, D.J.1
  • 12
    • 79951626557 scopus 로고    scopus 로고
    • Neuroprotective properties of GLP-1: Theoretical and practical applications
    • J.J. Holst, and et al. Neuroprotective properties of GLP-1: theoretical and practical applications Curr. Med. Res. Opin. 27 2011 547 558
    • (2011) Curr. Med. Res. Opin. , vol.27 , pp. 547-558
    • Holst, J.J.1
  • 13
    • 84872700382 scopus 로고    scopus 로고
    • Discovery and development of exenatide: The first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1
    • D.G. Parkes, and et al. Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1 Expert Opin. Drug Discov. 8 2013 219 244
    • (2013) Expert Opin. Drug Discov. , vol.8 , pp. 219-244
    • Parkes, D.G.1
  • 14
    • 65549112678 scopus 로고    scopus 로고
    • Exenatide: A review from pharmacology to clinical practice
    • R. Gentilella, and et al. Exenatide: a review from pharmacology to clinical practice Diabetes Obes. Metab. 11 2009 544 556
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 544-556
    • Gentilella, R.1
  • 15
    • 0037349072 scopus 로고    scopus 로고
    • Entry of exendin-4 into brain is rapid but may be limited at high doses
    • A.J. Kastin, and V. Akerstrom Entry of exendin-4 into brain is rapid but may be limited at high doses Int. J. Obes. Relat. Metab. Disord. 27 2003 313 318
    • (2003) Int. J. Obes. Relat. Metab. Disord. , vol.27 , pp. 313-318
    • Kastin, A.J.1    Akerstrom, V.2
  • 16
    • 84858713174 scopus 로고    scopus 로고
    • Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
    • K. Hunter, and C. Hölscher Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis BMC Neurosci. 13 2012 33
    • (2012) BMC Neurosci. , vol.13 , pp. 33
    • Hunter, K.1    Hölscher, C.2
  • 17
    • 45549108268 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
    • A. Harkavyi, and et al. Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease J. Neuroinflammation 5 2008 19
    • (2008) J. Neuroinflammation , vol.5 , pp. 19
    • Harkavyi, A.1
  • 18
    • 59049087723 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
    • Y. Li, and et al. GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism Proc. Natl. Acad. Sci. U. S. A. 106 2009 1285 1290
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 1285-1290
    • Li, Y.1
  • 19
    • 38849196303 scopus 로고    scopus 로고
    • Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease
    • G. Bertilsson, and et al. Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease J. Neurosci. Res. 86 2008 326 338
    • (2008) J. Neurosci. Res. , vol.86 , pp. 326-338
    • Bertilsson, G.1
  • 20
    • 70349334516 scopus 로고    scopus 로고
    • Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease
    • S. Kim, and et al. Exendin-4 protects dopaminergic neurons by inhibition of microglial activation and matrix metalloproteinase-3 expression in an animal model of Parkinson's disease J. Endocrinol. 202 2009 431 439
    • (2009) J. Endocrinol. , vol.202 , pp. 431-439
    • Kim, S.1
  • 21
    • 84867040244 scopus 로고    scopus 로고
    • Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions
    • N. Rampersaud, and et al. Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions Neuropeptides 46 2012 183 193
    • (2012) Neuropeptides , vol.46 , pp. 183-193
    • Rampersaud, N.1
  • 22
    • 84936871959 scopus 로고    scopus 로고
    • Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • W. Liu, and et al. Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease Neuroscience 303 2015 42 50
    • (2015) Neuroscience , vol.303 , pp. 42-50
    • Liu, W.1
  • 23
    • 84908344678 scopus 로고    scopus 로고
    • Saxagliptin: A novel antiparkinsonian approach
    • N.N. Nassar, and et al. Saxagliptin: a novel antiparkinsonian approach Neuropharmacology 89 2015 308 317
    • (2015) Neuropharmacology , vol.89 , pp. 308-317
    • Nassar, N.N.1
  • 24
    • 84969634782 scopus 로고    scopus 로고
    • Sitagliptin does not protect against MPTP-induced dopaminergic striatal toxicity
    • abst185P
    • 2 Online 10 2012 abst185P
    • (2012) 2 Online , vol.10
    • Ribeiro, C.A.1
  • 25
    • 84865521108 scopus 로고    scopus 로고
    • Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain
    • S.F.J. McGovern, and et al. Effects of the glucagon-like polypeptide-1 analogue (Val8)GLP-1 on learning, progenitor cell proliferation and neurogenesis in the C57B/16 mouse brain Brain Res. 1473 2012 204 213
    • (2012) Brain Res. , vol.1473 , pp. 204-213
    • McGovern, S.F.J.1
  • 26
    • 82755176046 scopus 로고    scopus 로고
    • Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    • S. Gengler, and et al. Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice Neurobiol. Aging 33 2012 265 276
    • (2012) Neurobiol. Aging , vol.33 , pp. 265-276
    • Gengler, S.1
  • 27
    • 77957126457 scopus 로고    scopus 로고
    • Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats
    • X.H. Wang, and et al. Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats Neuroscience 170 2010 1239 1248
    • (2010) Neuroscience , vol.170 , pp. 1239-1248
    • Wang, X.H.1
  • 28
    • 84869090452 scopus 로고    scopus 로고
    • Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats
    • W-N. Han, and et al. Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats Neurobiol. Aging 34 2013 576 588
    • (2013) Neurobiol. Aging , vol.34 , pp. 576-588
    • Han, W.-N.1
  • 29
    • 77649187436 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease
    • P.L. McClean, and et al. Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease Eur. J. Pharmacol. 630 2010 158 162
    • (2010) Eur. J. Pharmacol. , vol.630 , pp. 158-162
    • McClean, P.L.1
  • 30
    • 0038248960 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron
    • T. Perry, and et al. Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron J. Neurosci. Res. 72 2003 603 612
    • (2003) J. Neurosci. Res. , vol.72 , pp. 603-612
    • Perry, T.1
  • 31
    • 77950352189 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease
    • Y. Li, and et al. GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease J. Alzheimers Dis. 19 2010 1205 1219
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 1205-1219
    • Li, Y.1
  • 32
    • 77956134398 scopus 로고    scopus 로고
    • Four weeks administration of liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance
    • D.W. Porter, and et al. Four weeks administration of liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance Diabetes Obes. Metab. 12 2010 891 899
    • (2010) Diabetes Obes. Metab. , vol.12 , pp. 891-899
    • Porter, D.W.1
  • 33
    • 79751479118 scopus 로고    scopus 로고
    • Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain
    • A. Hamilton, and et al. Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain J. Neurosci. Res. 89 2011 481 489
    • (2011) J. Neurosci. Res. , vol.89 , pp. 481-489
    • Hamilton, A.1
  • 34
    • 84884829726 scopus 로고    scopus 로고
    • Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease
    • J. Kosaraju, and et al. Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease Neuropharmacology 72 2013 291 300
    • (2013) Neuropharmacology , vol.72 , pp. 291-300
    • Kosaraju, J.1
  • 35
    • 76749116176 scopus 로고    scopus 로고
    • Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice
    • M. D'Amico, and et al. Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice Exp. Gerontol. 45 2010 202 207
    • (2010) Exp. Gerontol. , vol.45 , pp. 202-207
    • D'Amico, M.1
  • 36
    • 84862799796 scopus 로고    scopus 로고
    • Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures
    • D-H. Kim, and et al. Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures Neurobiol. Dis. 46 2012 52 58
    • (2012) Neurobiol. Dis. , vol.46 , pp. 52-58
    • Kim, D.-H.1
  • 37
    • 84860813005 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: Evidence from observational studies
    • K. Rees, and et al. Non-steroidal anti-inflammatory drugs as disease-modifying agents for Parkinson's disease: evidence from observational studies Cochrane Database Syst. Rev. 11 2011 CD008454
    • (2011) Cochrane Database Syst. Rev. , vol.11 , pp. CD008454
    • Rees, K.1
  • 38
    • 74149094597 scopus 로고    scopus 로고
    • 11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?
    • 11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease? Parkinsonism Relat. Disord. 16 2010 57 59
    • (2010) Parkinsonism Relat. Disord. , vol.16 , pp. 57-59
    • Bartels, A.L.1
  • 39
    • 84931577112 scopus 로고    scopus 로고
    • Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia
    • Z. Fan, and et al. Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia Alzheimers Dement. 11 2015 608 621
    • (2015) Alzheimers Dement. , vol.11 , pp. 608-621
    • Fan, Z.1
  • 40
    • 84876183295 scopus 로고    scopus 로고
    • Interleukin-1β and tumor necrosis factor-α: Reliable targets for protective therapies in Parkinson's Disease?
    • M.C. Leal, and et al. Interleukin-1β and tumor necrosis factor-α: reliable targets for protective therapies in Parkinson's Disease? Front. Cell. Neurosci. 7 2013 53
    • (2013) Front. Cell. Neurosci. , vol.7 , pp. 53
    • Leal, M.C.1
  • 41
    • 0344444234 scopus 로고    scopus 로고
    • Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains
    • K. Imamura, and et al. Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains Acta Neuropathol. 106 2003 518 526
    • (2003) Acta Neuropathol. , vol.106 , pp. 518-526
    • Imamura, K.1
  • 42
    • 84876326189 scopus 로고    scopus 로고
    • Antipsychotic-like effect of GLP-1 agonist liraglutide but not DPP-IV inhibitor sitagliptin in mouse model for psychosis
    • T.S. Dixit, and et al. Antipsychotic-like effect of GLP-1 agonist liraglutide but not DPP-IV inhibitor sitagliptin in mouse model for psychosis Physiol. Behav. 114-115 2013 38 41
    • (2013) Physiol. Behav. , vol.114-115 , pp. 38-41
    • Dixit, T.S.1
  • 43
    • 84919448750 scopus 로고    scopus 로고
    • Exenatide treatment exerts anxiolytic- and antidepressant-like effects and reverses neuropathy in a mouse model of type-2 diabetes
    • I. Komsuoglu Celikyurt, and et al. Exenatide treatment exerts anxiolytic- and antidepressant-like effects and reverses neuropathy in a mouse model of type-2 diabetes Med. Sci. Monit. Basic Res. 20 2014 112 117
    • (2014) Med. Sci. Monit. Basic Res. , vol.20 , pp. 112-117
    • Komsuoglu Celikyurt, I.1
  • 44
    • 84924148527 scopus 로고    scopus 로고
    • GLP-1 receptor agonist liraglutide reverses long-term atypical antipsychotic treatment associated behavioral depression and metabolic abnormalities in rats
    • A.N. Sharma, and et al. GLP-1 receptor agonist liraglutide reverses long-term atypical antipsychotic treatment associated behavioral depression and metabolic abnormalities in rats Metab. Brain Dis. 30 2015 519 527
    • (2015) Metab. Brain Dis. , vol.30 , pp. 519-527
    • Sharma, A.N.1
  • 45
    • 84927940916 scopus 로고    scopus 로고
    • Depression and cognitive impairment in Parkinson's disease: A role for inflammation and immunomodulation?
    • N. Pessoa Rocha, and et al. Depression and cognitive impairment in Parkinson's disease: a role for inflammation and immunomodulation? Neuroimmunomodulation 21 2014 88 94
    • (2014) Neuroimmunomodulation , vol.21 , pp. 88-94
    • Pessoa Rocha, N.1
  • 46
    • 84874654334 scopus 로고    scopus 로고
    • Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein
    • D. Béraud, and et al. Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein J. Neuroimmune Pharmacol. 8 2013 94 117
    • (2013) J. Neuroimmune Pharmacol. , vol.8 , pp. 94-117
    • Béraud, D.1
  • 47
    • 84874658819 scopus 로고    scopus 로고
    • Neural and immune mechanisms in the pathogenesis of Parkinson's disease
    • F. Blandini Neural and immune mechanisms in the pathogenesis of Parkinson's disease J. Neuroimmune Pharmacol. 8 2013 189 201
    • (2013) J. Neuroimmune Pharmacol. , vol.8 , pp. 189-201
    • Blandini, F.1
  • 48
    • 84924402070 scopus 로고    scopus 로고
    • Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease
    • S. Gallegos, and et al. Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease Front. Neurosci. 9 2015 59
    • (2015) Front. Neurosci. , vol.9 , pp. 59
    • Gallegos, S.1
  • 49
    • 84938292218 scopus 로고    scopus 로고
    • M1 and M2 immune activation in Parkinson's Disease: Foe and ally?
    • M.S. Moehle, and A.B. West M1 and M2 immune activation in Parkinson's Disease: foe and ally? Neuroscience 27 2014 59 73
    • (2014) Neuroscience , vol.27 , pp. 59-73
    • Moehle, M.S.1    West, A.B.2
  • 50
    • 84859761962 scopus 로고    scopus 로고
    • Neuroinflammation in Parkinson's disease and related disorders: A lesson from genetically manipulated mouse models of α-synucleinopathies
    • K. Sekiyama, and et al. Neuroinflammation in Parkinson's disease and related disorders: a lesson from genetically manipulated mouse models of α-synucleinopathies Parkinsons Dis. 2012 2012 271732
    • (2012) Parkinsons Dis. , vol.2012 , pp. 271732
    • Sekiyama, K.1
  • 51
    • 13144258735 scopus 로고    scopus 로고
    • Microglial activation and dopamine terminal loss in early Parkinson's disease
    • Y. Ouchi, and et al. Microglial activation and dopamine terminal loss in early Parkinson's disease Ann. Neurol. 57 2005 168 175
    • (2005) Ann. Neurol. , vol.57 , pp. 168-175
    • Ouchi, Y.1
  • 52
    • 84871529499 scopus 로고    scopus 로고
    • In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease
    • S. Iannaccone, and et al. In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease Parkinsonism Relat. Disord. 19 2013 47 52
    • (2013) Parkinsonism Relat. Disord. , vol.19 , pp. 47-52
    • Iannaccone, S.1
  • 53
    • 84875795989 scopus 로고    scopus 로고
    • Effect of human interleukin-10 on the expression of nitric oxide synthases in the MPTP-based model of Parkinson's disease
    • J. Schwenkgrub, and et al. Effect of human interleukin-10 on the expression of nitric oxide synthases in the MPTP-based model of Parkinson's disease Pharmacol. Rep. 65 2013 44 49
    • (2013) Pharmacol. Rep. , vol.65 , pp. 44-49
    • Schwenkgrub, J.1
  • 54
    • 84902476451 scopus 로고    scopus 로고
    • The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease
    • I. Joniec-Maciejak, and et al. The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease Pharmacol. Rep. 66 2014 660 669
    • (2014) Pharmacol. Rep. , vol.66 , pp. 660-669
    • Joniec-Maciejak, I.1
  • 55
    • 79955608846 scopus 로고    scopus 로고
    • Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia
    • C.H. Lee, and et al. Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia J. Neurosci. Res. 89 2011 1103 1113
    • (2011) J. Neurosci. Res. , vol.89 , pp. 1103-1113
    • Lee, C.H.1
  • 56
    • 79960996273 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia
    • S. Teramoto, and et al. Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia J. Cereb. Blood Flow Metab. 31 2011 1696 1705
    • (2011) J. Cereb. Blood Flow Metab. , vol.31 , pp. 1696-1705
    • Teramoto, S.1
  • 57
    • 82955195404 scopus 로고    scopus 로고
    • Repeated administration of exendin-4 reduces focal cerebral ischemia-induced infarction in rats
    • S. Briyal, and et al. Repeated administration of exendin-4 reduces focal cerebral ischemia-induced infarction in rats Brain Res. 1427 2012 23 34
    • (2012) Brain Res. , vol.1427 , pp. 23-34
    • Briyal, S.1
  • 58
    • 84905493033 scopus 로고    scopus 로고
    • Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization
    • V. Darsalia, and et al. Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization PLOS ONE 9 2014 e103114
    • (2014) PLOS ONE , vol.9 , pp. e103114
    • Darsalia, V.1
  • 59
    • 84858722980 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in type 2 diabetic rats
    • V. Darsalia, and et al. Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in type 2 diabetic rats Clin. Sci. (Lond.) 122 2012 473 483
    • (2012) Clin. Sci. (Lond.) , vol.122 , pp. 473-483
    • Darsalia, V.1
  • 60
    • 84891464127 scopus 로고    scopus 로고
    • Exendin-4 ameliorates traumatic brain injury-induced cognitive impairment in rats
    • K. Eakin, and et al. Exendin-4 ameliorates traumatic brain injury-induced cognitive impairment in rats PLOS ONE 8 2013 e82016
    • (2013) PLOS ONE , vol.8 , pp. e82016
    • Eakin, K.1
  • 61
    • 84897845269 scopus 로고    scopus 로고
    • Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury
    • N.H. Greig, and et al. Incretin mimetics as pharmacologic tools to elucidate and as a new drug strategy to treat traumatic brain injury Alzheimers Dement. 10 2014 S62 S75
    • (2014) Alzheimers Dement. , vol.10 , pp. S62-S75
    • Greig, N.H.1
  • 62
    • 84868458245 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice
    • D. Tweedie, and et al. Exendin-4, a glucagon-like peptide-1 receptor agonist prevents mTBI-induced changes in hippocampus gene expression and memory deficits in mice Exp. Neurol. 239 2013 170 182
    • (2013) Exp. Neurol. , vol.239 , pp. 170-182
    • Tweedie, D.1
  • 63
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • P.L. McClean, and et al. The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease J. Neurosci. 31 2011 6587 6594
    • (2011) J. Neurosci. , vol.31 , pp. 6587-6594
    • McClean, P.L.1
  • 64
    • 84942435321 scopus 로고    scopus 로고
    • Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats
    • V. Solmaz, and et al. Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats Eur. J. Pharmacol. 765 2015 482 487
    • (2015) Eur. J. Pharmacol. , vol.765 , pp. 482-487
    • Solmaz, V.1
  • 65
    • 84884699311 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogue therapy for psoriasis patients with obesity and type 2 diabetes: A prospective cohort study
    • T. Ahern, and et al. Glucagon-like peptide-1 analogue therapy for psoriasis patients with obesity and type 2 diabetes: a prospective cohort study J. Eur. Acad. Dermatol. Venereol. 27 2013 1440 1443
    • (2013) J. Eur. Acad. Dermatol. Venereol. , vol.27 , pp. 1440-1443
    • Ahern, T.1
  • 66
    • 84902375846 scopus 로고    scopus 로고
    • Anti-inflammatory effect of exendin-4 postconditioning during myocardial ischemia and reperfusion
    • X. Du, and et al. Anti-inflammatory effect of exendin-4 postconditioning during myocardial ischemia and reperfusion Mol. Biol. Rep. 41 2014 3853 3857
    • (2014) Mol. Biol. Rep. , vol.41 , pp. 3853-3857
    • Du, X.1
  • 67
    • 77951151612 scopus 로고    scopus 로고
    • Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4
    • M. Arakawa, and et al. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4 Diabetes 59 2010 1030 1037
    • (2010) Diabetes , vol.59 , pp. 1030-1037
    • Arakawa, M.1
  • 68
    • 0030842085 scopus 로고    scopus 로고
    • Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson disease
    • S. Hunot, and et al. Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease Proc. Natl. Acad. Sci. U. S. A. 94 1997 7531 7536
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 7531-7536
    • Hunot, S.1
  • 69
    • 36749015082 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease
    • A. Ghosh, and et al. Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease Proc. Natl. Acad. Sci. U. S. A. 104 2007 18754 18759
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 18754-18759
    • Ghosh, A.1
  • 70
    • 77952411101 scopus 로고    scopus 로고
    • Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity
    • F. Zhang, and et al. Inhibition of IkappaB kinase-beta protects dopamine neurons against lipopolysaccharide-induced neurotoxicity J. Pharmacol. Exp. Ther. 333 2010 822 833
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , pp. 822-833
    • Zhang, F.1
  • 71
    • 84877734347 scopus 로고    scopus 로고
    • Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
    • G. Zhang, and et al. Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH Nature 497 2013 211 216
    • (2013) Nature , vol.497 , pp. 211-216
    • Zhang, G.1
  • 72
    • 84928009282 scopus 로고    scopus 로고
    • Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: Role of RAGE-NFκB and Nrf2-antioxidant signaling pathways
    • R.M. Abdelsalam, and M.M. Safar Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways J. Neurochem. 133 2015 700 707
    • (2015) J. Neurochem. , vol.133 , pp. 700-707
    • Abdelsalam, R.M.1    Safar, M.M.2
  • 73
    • 84866546292 scopus 로고    scopus 로고
    • Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways
    • L. Han, and et al. Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways Diabetes Res. Clin. Pract. 97 2012 453 460
    • (2012) Diabetes Res. Clin. Pract. , vol.97 , pp. 453-460
    • Han, L.1
  • 74
    • 84866055251 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes
    • Y-S. Lee, and et al. Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes Diabetologia 55 2012 2456 2468
    • (2012) Diabetologia , vol.55 , pp. 2456-2468
    • Lee, Y.-S.1
  • 75
    • 84886165527 scopus 로고    scopus 로고
    • Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction
    • Y-T. Chen, and et al. Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction J. Transl. Med. 11 2013 270
    • (2013) J. Transl. Med. , vol.11 , pp. 270
    • Chen, Y.-T.1
  • 76
    • 79953826349 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes
    • R. Kodera, and et al. Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes Diabetologia 54 2011 965 978
    • (2011) Diabetologia , vol.54 , pp. 965-978
    • Kodera, R.1
  • 77
    • 80051987703 scopus 로고    scopus 로고
    • Crosstalk in NF-κB signaling pathways
    • A. Oeckinghaus, and et al. Crosstalk in NF-κB signaling pathways Nat. Immunol. 12 2011 695 708
    • (2011) Nat. Immunol. , vol.12 , pp. 695-708
    • Oeckinghaus, A.1
  • 78
    • 84865489968 scopus 로고    scopus 로고
    • Suppression of nuclear factor-κB activation and inflammation in microglia by physically modified saline
    • S. Khasnavis, and et al. Suppression of nuclear factor-κB activation and inflammation in microglia by physically modified saline J. Biol. Chem. 287 2012 29529 29542
    • (2012) J. Biol. Chem. , vol.287 , pp. 29529-29542
    • Khasnavis, S.1
  • 79
    • 84858704659 scopus 로고    scopus 로고
    • Selective autophagy in the maintenance of cellular homeostasis in aging organisms
    • V.M. Hubbard, and et al. Selective autophagy in the maintenance of cellular homeostasis in aging organisms Biogerontology 13 2012 21 35
    • (2012) Biogerontology , vol.13 , pp. 21-35
    • Hubbard, V.M.1
  • 80
    • 37049004489 scopus 로고    scopus 로고
    • Mitochondria in the aetiology and pathogenesis of Parkinson's disease
    • A.H.V. Schapira Mitochondria in the aetiology and pathogenesis of Parkinson's disease Lancet Neurol. 7 2008 97 109
    • (2008) Lancet Neurol. , vol.7 , pp. 97-109
    • Schapira, A.H.V.1
  • 81
    • 84947574098 scopus 로고    scopus 로고
    • Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease
    • Y. Chen, and et al. Neuroprotective effects of geniposide in the MPTP mouse model of Parkinson's disease Eur. J. Pharmacol. 768 2015 21 27
    • (2015) Eur. J. Pharmacol. , vol.768 , pp. 21-27
    • Chen, Y.1
  • 82
    • 84955455721 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 increases mitochondrial biogenesis and function in INS-1 Rat insulinoma cells
    • M.Y. Kang, and et al. Glucagon-like peptide-1 increases mitochondrial biogenesis and function in INS-1 Rat insulinoma cells Endocrinol. Metab. (Seoul, Korea) 30 2015 216 220
    • (2015) Endocrinol. Metab. (Seoul, Korea) , vol.30 , pp. 216-220
    • Kang, M.Y.1
  • 83
    • 84937895712 scopus 로고    scopus 로고
    • Neuroprotective effects of exendin-4 in rat model of spinal cord injury via inhibiting mitochondrial apoptotic pathway
    • H. Li, and et al. Neuroprotective effects of exendin-4 in rat model of spinal cord injury via inhibiting mitochondrial apoptotic pathway Int. J. Clin. Exp. Pathol. 8 2015 4837 4843
    • (2015) Int. J. Clin. Exp. Pathol. , vol.8 , pp. 4837-4843
    • Li, H.1
  • 84
    • 84908703140 scopus 로고    scopus 로고
    • Exendin-4 protects retinal cells from early diabetes in Goto-Kakizaki rats by increasing the Bcl-2/Bax and Bcl-xL/Bax ratios and reducing reactive gliosis
    • Y. Fan, and et al. Exendin-4 protects retinal cells from early diabetes in Goto-Kakizaki rats by increasing the Bcl-2/Bax and Bcl-xL/Bax ratios and reducing reactive gliosis Mol. Vis. 20 2014 1557 1568
    • (2014) Mol. Vis. , vol.20 , pp. 1557-1568
    • Fan, Y.1
  • 85
    • 84908042187 scopus 로고    scopus 로고
    • Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium
    • M. DeNicola, and et al. Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium Am. J. Physiol. Endocrinol. Metab. 307 2014 E630 E643
    • (2014) Am. J. Physiol. Endocrinol. Metab. , vol.307 , pp. E630-E643
    • DeNicola, M.1
  • 86
    • 84876680630 scopus 로고    scopus 로고
    • Therapeutic potential of N-acetyl-glucagon-like peptide-1 in primary motor neuron cultures derived from non-transgenic and SOD1-G93A ALS mice
    • H. Sun, and et al. Therapeutic potential of N-acetyl-glucagon-like peptide-1 in primary motor neuron cultures derived from non-transgenic and SOD1-G93A ALS mice Cell. Mol. Neurobiol. 33 2013 347 357
    • (2013) Cell. Mol. Neurobiol. , vol.33 , pp. 347-357
    • Sun, H.1
  • 87
    • 44949196953 scopus 로고    scopus 로고
    • Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell
    • A. Wiederkehr, and C.B. Wollheim Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell Cell Calcium 44 2008 64 76
    • (2008) Cell Calcium , vol.44 , pp. 64-76
    • Wiederkehr, A.1    Wollheim, C.B.2
  • 88
    • 84897979984 scopus 로고    scopus 로고
    • GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum-mitochondria coupling
    • P.E. Morales, and et al. GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum-mitochondria coupling Biochem. Biophys. Res. Commun. 446 2014 410 416
    • (2014) Biochem. Biophys. Res. Commun. , vol.446 , pp. 410-416
    • Morales, P.E.1
  • 89
    • 84891410019 scopus 로고    scopus 로고
    • α-Synuclein is localized to mitochondria-associated ER membranes
    • C. Guardia-Laguarta, and et al. α-Synuclein is localized to mitochondria-associated ER membranes J. Neurosci. 34 2014 249 259
    • (2014) J. Neurosci. , vol.34 , pp. 249-259
    • Guardia-Laguarta, C.1
  • 90
    • 84938868077 scopus 로고    scopus 로고
    • Effects of Exendin-4 on bone marrow mesenchymal stem cell proliferation, migration and apoptosis in vitro
    • H. Zhou, and et al. Effects of Exendin-4 on bone marrow mesenchymal stem cell proliferation, migration and apoptosis in vitro Sci. Rep. 5 2015 12898
    • (2015) Sci. Rep. , vol.5 , pp. 12898
    • Zhou, H.1
  • 91
    • 84863787414 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (GLP-1) protects vascular endothelial cells against advanced glycation end products (AGEs)-induced apoptosis
    • Y. Zhan, and et al. Glucagon-like peptide-1 (GLP-1) protects vascular endothelial cells against advanced glycation end products (AGEs)-induced apoptosis Med. Sci. Monit. 18 2012 BR286 BR291
    • (2012) Med. Sci. Monit. , vol.18 , pp. BR286-BR291
    • Zhan, Y.1
  • 92
    • 65649095207 scopus 로고    scopus 로고
    • Anti-apoptotic action of exendin-4 in INS-1 beta cells: Comparative protein pattern analysis of isolated mitochondria
    • D. Tews, and et al. Anti-apoptotic action of exendin-4 in INS-1 beta cells: comparative protein pattern analysis of isolated mitochondria Horm. Metab. Res. 41 2009 294 301
    • (2009) Horm. Metab. Res. , vol.41 , pp. 294-301
    • Tews, D.1
  • 93
    • 84886242581 scopus 로고    scopus 로고
    • Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells
    • Z. Li, and et al. Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells PLOS ONE 8 2013 e76172
    • (2013) PLOS ONE , vol.8 , pp. e76172
    • Li, Z.1
  • 94
    • 77958072667 scopus 로고    scopus 로고
    • PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease
    • B. Zheng, and et al. PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease Sci. Transl. Med. 2 2010 52ra73
    • (2010) Sci. Transl. Med. , vol.2 , pp. 52ra73
    • Zheng, B.1
  • 95
    • 79955994007 scopus 로고    scopus 로고
    • Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease
    • J. Clark, and et al. Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease BMC Med. Genet. 12 2011 69
    • (2011) BMC Med. Genet. , vol.12 , pp. 69
    • Clark, J.1
  • 96
    • 77949912389 scopus 로고    scopus 로고
    • Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein
    • A.S. Ebrahim, and et al. Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1alpha enhances alpha-synuclein oligomerization and down regulates AKT/GSK3beta signaling pathway in human neuronal cells that inducibly express alpha-synuclein Neurosci. Lett. 473 2010 120 125
    • (2010) Neurosci. Lett. , vol.473 , pp. 120-125
    • Ebrahim, A.S.1
  • 97
    • 84895127938 scopus 로고    scopus 로고
    • SIRT1 metabolic actions: Integrating recent advances from mouse models
    • M. Boutant, and C. Cantó SIRT1 metabolic actions: integrating recent advances from mouse models Mol. Metab. 3 2014 5 18
    • (2014) Mol. Metab. , vol.3 , pp. 5-18
    • Boutant, M.1    Cantó, C.2
  • 98
    • 64549127790 scopus 로고    scopus 로고
    • PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
    • C. Cantó, and J. Auwerx PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure Curr. Opin. Lipidol. 20 2009 98 105
    • (2009) Curr. Opin. Lipidol. , vol.20 , pp. 98-105
    • Cantó, C.1    Auwerx, J.2
  • 99
    • 84908632327 scopus 로고    scopus 로고
    • SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis
    • F. Xu, and et al. SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosis Diabetes 63 2014 3637 3646
    • (2014) Diabetes , vol.63 , pp. 3637-3646
    • Xu, F.1
  • 100
    • 85027921730 scopus 로고    scopus 로고
    • Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism
    • J. Lee, and et al. Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism Cell Stress Chaperones 19 2014 649 656
    • (2014) Cell Stress Chaperones , vol.19 , pp. 649-656
    • Lee, J.1
  • 101
    • 84904303364 scopus 로고    scopus 로고
    • Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice
    • R. Lennox, and et al. Comparison of the independent and combined effects of sub-chronic therapy with metformin and a stable GLP-1 receptor agonist on cognitive function, hippocampal synaptic plasticity and metabolic control in high-fat fed mice Neuropharmacology 86 2014 22 30
    • (2014) Neuropharmacology , vol.86 , pp. 22-30
    • Lennox, R.1
  • 102
    • 84893459319 scopus 로고    scopus 로고
    • SIRT1 in neurodevelopment and brain senescence
    • A.Z. Herskovits, and L. Guarente SIRT1 in neurodevelopment and brain senescence Neuron 81 2014 471 483
    • (2014) Neuron , vol.81 , pp. 471-483
    • Herskovits, A.Z.1    Guarente, L.2
  • 103
    • 33748310632 scopus 로고    scopus 로고
    • Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: Possible neuroprotective mechanisms
    • P. Kumar, and et al. Effect of resveratrol on 3-nitropropionic acid-induced biochemical and behavioural changes: possible neuroprotective mechanisms Behav. Pharmacol. 17 2006 485 492
    • (2006) Behav. Pharmacol. , vol.17 , pp. 485-492
    • Kumar, P.1
  • 104
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • M. Lagouge, and et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha Cell 127 2006 1109 1122
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1
  • 105
    • 84957428404 scopus 로고    scopus 로고
    • CSF β-amyloid 1-42 predicts progression to cognitive impairment in newly diagnosed Parkinson disease
    • M. Terrelonge, and et al. CSF β-amyloid 1-42 predicts progression to cognitive impairment in newly diagnosed Parkinson disease J. Mol. Neurosci. 58 2015 88 92
    • (2015) J. Mol. Neurosci. , vol.58 , pp. 88-92
    • Terrelonge, M.1
  • 106
    • 0035834076 scopus 로고    scopus 로고
    • Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    • E. Masliah, and et al. Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease Proc. Natl. Acad. Sci. U. S. A. 98 2001 12245 12250
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 12245-12250
    • Masliah, E.1
  • 107
    • 0036202684 scopus 로고    scopus 로고
    • Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease
    • K.A. Jellinger, and et al. Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease J. Neural Transm. 109 2002 329 339
    • (2002) J. Neural Transm. , vol.109 , pp. 329-339
    • Jellinger, K.A.1
  • 108
    • 84867390597 scopus 로고    scopus 로고
    • Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia
    • P.T. Kotzbauer, and et al. Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia Arch. Neurol. 69 2012 1326 1331
    • (2012) Arch. Neurol. , vol.69 , pp. 1326-1331
    • Kotzbauer, P.T.1
  • 109
    • 79957453213 scopus 로고    scopus 로고
    • Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: Which is more important?
    • Y. Compta, and et al. Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important? Brain 134 2011 1493 1505
    • (2011) Brain , vol.134 , pp. 1493-1505
    • Compta, Y.1
  • 110
    • 52249112474 scopus 로고    scopus 로고
    • Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42)
    • Z. Qin, and et al. Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42) Neurosci. Lett. 444 2008 217 221
    • (2008) Neurosci. Lett. , vol.444 , pp. 217-221
    • Qin, Z.1
  • 111
    • 77957915935 scopus 로고    scopus 로고
    • Chronic treatment of exendin-4 affects cell proliferation and neuroblast differentiation in the adult mouse hippocampal dentate gyrus
    • H. Li, and et al. Chronic treatment of exendin-4 affects cell proliferation and neuroblast differentiation in the adult mouse hippocampal dentate gyrus Neurosci. Lett. 486 2010 38 42
    • (2010) Neurosci. Lett. , vol.486 , pp. 38-42
    • Li, H.1
  • 112
    • 84929302567 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes
    • W. Xu, and et al. Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes J. Investig. Med. 63 2015 267 272
    • (2015) J. Investig. Med. , vol.63 , pp. 267-272
    • Xu, W.1
  • 113
    • 84867577041 scopus 로고    scopus 로고
    • Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4
    • S. Chen, and et al. Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4 Age (Dordr.) 34 2012 1211 1224
    • (2012) Age (Dordr.) , vol.34 , pp. 1211-1224
    • Chen, S.1
  • 114
    • 84888008405 scopus 로고    scopus 로고
    • Vildagliptin: An anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease
    • J. Kosaraju, and et al. Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease J. Pharm. Pharmacol. 65 2013 1773 1784
    • (2013) J. Pharm. Pharmacol. , vol.65 , pp. 1773-1784
    • Kosaraju, J.1
  • 115
    • 84888058168 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation
    • S. Chen, and et al. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation Neuroscience 256 2014 137 146
    • (2014) Neuroscience , vol.256 , pp. 137-146
    • Chen, S.1
  • 116
    • 84943580301 scopus 로고    scopus 로고
    • Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation in DIABETIC db/db mice
    • D-L. Ma, and et al. Early intervention with glucagon-like peptide 1 analog liraglutide prevents tau hyperphosphorylation IN DIABETIC db/db mice J. Neurochem. 135 2015 301 308
    • (2015) J. Neurochem. , vol.135 , pp. 301-308
    • Ma, D.-L.1
  • 117
    • 84890808796 scopus 로고    scopus 로고
    • Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes
    • Y. Yang, and et al. Subcutaneous administration of liraglutide ameliorates Alzheimer-associated tau hyperphosphorylation in rats with type 2 diabetes J. Alzheimers Dis. 37 2013 637 648
    • (2013) J. Alzheimers Dis. , vol.37 , pp. 637-648
    • Yang, Y.1
  • 118
    • 84890392083 scopus 로고    scopus 로고
    • New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease
    • M. Medina, and J. Avila New insights into the role of glycogen synthase kinase-3 in Alzheimer's disease Expert Opin. Ther. Targets 18 2014 69 77
    • (2014) Expert Opin. Ther. Targets , vol.18 , pp. 69-77
    • Medina, M.1    Avila, J.2
  • 119
    • 84928608814 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease
    • M. Golpich, and et al. Glycogen synthase kinase-3 beta (GSK-3β) signaling: implications for Parkinson's disease Pharmacol. Res. 97 2015 16 26
    • (2015) Pharmacol. Res. , vol.97 , pp. 16-26
    • Golpich, M.1
  • 120
    • 70349331692 scopus 로고    scopus 로고
    • Alpha-synuclein contributes to GSK-3beta-catalysed Tau phosphorylation in Parkinson's disease models
    • T. Duka, and et al. Alpha-synuclein contributes to GSK-3beta-catalysed Tau phosphorylation in Parkinson's disease models FASEB J. 23 2009 2820 2830
    • (2009) FASEB J. , vol.23 , pp. 2820-2830
    • Duka, T.1
  • 121
    • 84922169955 scopus 로고    scopus 로고
    • The molecular mechanism of rotenone-induced α-synuclein aggregation: Emphasizing the role of the calcium/GSK3β pathway
    • Y-H. Yuan, and et al. The molecular mechanism of rotenone-induced α-synuclein aggregation: emphasizing the role of the calcium/GSK3β pathway Toxicol. Lett. 233 2015 163 171
    • (2015) Toxicol. Lett. , vol.233 , pp. 163-171
    • Yuan, Y.-H.1
  • 122
    • 84874709843 scopus 로고    scopus 로고
    • SIRT1 and SIRT2: Emerging targets in neurodegeneration
    • G. Donmez, and T.F. Outeiro SIRT1 and SIRT2: emerging targets in neurodegeneration EMBO Mol. Med. 5 2013 344 352
    • (2013) EMBO Mol. Med. , vol.5 , pp. 344-352
    • Donmez, G.1    Outeiro, T.F.2
  • 123
    • 84855929223 scopus 로고    scopus 로고
    • SIRT1 protects against α-synuclein aggregation by activating molecular chaperones
    • G. Donmez, and et al. SIRT1 protects against α-synuclein aggregation by activating molecular chaperones J. Neurosci. 32 2012 124 132
    • (2012) J. Neurosci. , vol.32 , pp. 124-132
    • Donmez, G.1
  • 125
    • 84883244791 scopus 로고    scopus 로고
    • Geniposide decreases the level of Aβ1-42 in the hippocampus of streptozotocin-induced diabetic rats
    • J. Liu, and et al. Geniposide decreases the level of Aβ1-42 in the hippocampus of streptozotocin-induced diabetic rats Acta Biochim. Biophys. Sin. (Shanghai) 45 2013 787 791
    • (2013) Acta Biochim. Biophys. Sin. (Shanghai) , vol.45 , pp. 787-791
    • Liu, J.1
  • 126
    • 84938236564 scopus 로고    scopus 로고
    • Neuroprotective effects of geniposide on Alzheimer's disease pathology
    • W. Liu, and et al. Neuroprotective effects of geniposide on Alzheimer's disease pathology Rev. Neurosci. 26 2015 371 383
    • (2015) Rev. Neurosci. , vol.26 , pp. 371-383
    • Liu, W.1
  • 127
    • 84938523810 scopus 로고    scopus 로고
    • Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner
    • S.K. Sharma, and et al. Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner Sci. Rep. 5 2015 12531
    • (2015) Sci. Rep. , vol.5 , pp. 12531
    • Sharma, S.K.1
  • 128
    • 29844432266 scopus 로고    scopus 로고
    • Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: Review and hypothesis
    • W.Q. Qiu, and M.F. Folstein Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis Neurobiol. Aging 27 2006 190 198
    • (2006) Neurobiol. Aging , vol.27 , pp. 190-198
    • Qiu, W.Q.1    Folstein, M.F.2
  • 129
    • 0034161516 scopus 로고    scopus 로고
    • Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme
    • K. Vekrellis, and et al. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme J. Neurosci. 20 2000 1657 1665
    • (2000) J. Neurosci. , vol.20 , pp. 1657-1665
    • Vekrellis, K.1
  • 130
    • 0037192120 scopus 로고    scopus 로고
    • Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells
    • S. Sudoh, and et al. Differential effects of proteases involved in intracellular degradation of amyloid beta-protein between detergent-soluble and -insoluble pools in CHO-695 cells Biochemistry 41 2002 1091 1099
    • (2002) Biochemistry , vol.41 , pp. 1091-1099
    • Sudoh, S.1
  • 131
    • 84900333085 scopus 로고    scopus 로고
    • Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex
    • N. Ohtake, and et al. Exendin-4 promotes the membrane trafficking of the AMPA receptor GluR1 subunit and ADAM10 in the mouse neocortex Regul. Pept. 190-191 2014 1 11
    • (2014) Regul. Pept. , vol.190-191 , pp. 1-11
    • Ohtake, N.1
  • 132
    • 30644474606 scopus 로고    scopus 로고
    • Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
    • C. Zhao, and et al. Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus J. Neurosci. 26 2006 3 11
    • (2006) J. Neurosci. , vol.26 , pp. 3-11
    • Zhao, C.1
  • 133
    • 3042822087 scopus 로고    scopus 로고
    • Dopamine depletion impairs precursor cell proliferation in Parkinson disease
    • G.U. Höglinger, and et al. Dopamine depletion impairs precursor cell proliferation in Parkinson disease Nat. Neurosci. 7 2004 726 735
    • (2004) Nat. Neurosci. , vol.7 , pp. 726-735
    • Höglinger, G.U.1
  • 134
    • 66649120006 scopus 로고    scopus 로고
    • Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF
    • G.C. O'Keeffe, and et al. Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF Proc. Natl. Acad. Sci. U. S. A. 106 2009 8754 8759
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 8754-8759
    • O'Keeffe, G.C.1
  • 135
    • 84904689167 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis in Parkinson's disease: Impact on neuronal survival and plasticity
    • M. Regensburger, and et al. Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity Neural Plast. 2014 2014 454696
    • (2014) Neural Plast. , vol.2014 , pp. 454696
    • Regensburger, M.1
  • 136
    • 84906975441 scopus 로고    scopus 로고
    • Harnessing neurogenesis for the possible treatment of Parkinson's disease
    • O. Lamm, and et al. Harnessing neurogenesis for the possible treatment of Parkinson's disease J. Comp. Neurol. 522 2014 2817 2830
    • (2014) J. Comp. Neurol. , vol.522 , pp. 2817-2830
    • Lamm, O.1
  • 137
    • 84863593338 scopus 로고    scopus 로고
    • Hippocampal abnormalities and memory deficits in Parkinson disease: A multimodal imaging study
    • G.A. Carlesimo, and et al. Hippocampal abnormalities and memory deficits in Parkinson disease: a multimodal imaging study Neurology 78 2012 1939 1945
    • (2012) Neurology , vol.78 , pp. 1939-1945
    • Carlesimo, G.A.1
  • 138
    • 78149466370 scopus 로고    scopus 로고
    • Differentiating effects of the glucagon-like peptide-1 analogue exendin-4 in a human neuronal cell model
    • P. Luciani, and et al. Differentiating effects of the glucagon-like peptide-1 analogue exendin-4 in a human neuronal cell model Cell. Mol. Life Sci. 67 2010 3711 3723
    • (2010) Cell. Mol. Life Sci. , vol.67 , pp. 3711-3723
    • Luciani, P.1
  • 139
    • 84862748768 scopus 로고    scopus 로고
    • Neuroprotective and neurotrophic actions of glucagon-like peptide-1: An emerging opportunity to treat neurodegenerative and cerebrovascular disorders
    • I. Salcedo, and et al. Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders Br. J. Pharmacol. 166 2012 1586 1599
    • (2012) Br. J. Pharmacol. , vol.166 , pp. 1586-1599
    • Salcedo, I.1
  • 140
    • 72749091486 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons
    • D.D. Belsham, and et al. Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons FASEB J. 23 2009 4256 4565
    • (2009) FASEB J. , vol.23 , pp. 4256-4565
    • Belsham, D.D.1
  • 141
    • 78649745810 scopus 로고    scopus 로고
    • The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test
    • R. Isacson, and et al. The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test Eur. J. Pharmacol. 650 2011 249 255
    • (2011) Eur. J. Pharmacol. , vol.650 , pp. 249-255
    • Isacson, R.1
  • 142
    • 84877575636 scopus 로고    scopus 로고
    • Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice
    • W.D. Porter, and et al. Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice Int. J. Obes. (Lond.) 37 2013 678 684
    • (2013) Int. J. Obes. (Lond.) , vol.37 , pp. 678-684
    • Porter, W.D.1
  • 143
    • 84936990507 scopus 로고    scopus 로고
    • The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer's disease
    • H.H. Hansen, and et al. The GLP-1 receptor agonist liraglutide improves memory function and increases hippocampal CA1 neuronal numbers in a senescence-accelerated mouse model of Alzheimer's disease J. Alzheimers Dis. 46 2015 877 888
    • (2015) J. Alzheimers Dis. , vol.46 , pp. 877-888
    • Hansen, H.H.1
  • 144
    • 44149122563 scopus 로고    scopus 로고
    • GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid
    • V.A. Gault, and C. Hölscher GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid Eur. J. Pharmacol. 587 2008 112 117
    • (2008) Eur. J. Pharmacol. , vol.587 , pp. 112-117
    • Gault, V.A.1    Hölscher, C.2
  • 145
    • 69949167076 scopus 로고    scopus 로고
    • Involvement of Akt in neurite outgrowth
    • D.E. Read, and A.M. Gorman Involvement of Akt in neurite outgrowth Cell. Mol. Life Sci. 66 2009 2975 2984
    • (2009) Cell. Mol. Life Sci. , vol.66 , pp. 2975-2984
    • Read, D.E.1    Gorman, A.M.2
  • 146
    • 70449473508 scopus 로고    scopus 로고
    • Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively
    • M.H. Grider, and et al. Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively J. Neurosci. Res. 87 2009 3033 3042
    • (2009) J. Neurosci. Res. , vol.87 , pp. 3033-3042
    • Grider, M.H.1
  • 147
    • 67449161796 scopus 로고    scopus 로고
    • Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B
    • V. Ries, and et al. Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B J. Neurochem. 110 2009 23 33
    • (2009) J. Neurochem. , vol.110 , pp. 23-33
    • Ries, V.1
  • 148
    • 84875278767 scopus 로고    scopus 로고
    • Impaired basal and running-induced hippocampal neurogenesis coincides with reduced Akt signaling in adult R6/1 HD mice
    • M.I. Ransome, and A.J. Hannan Impaired basal and running-induced hippocampal neurogenesis coincides with reduced Akt signaling in adult R6/1 HD mice Mol. Cell. Neurosci. 54 2013 93 107
    • (2013) Mol. Cell. Neurosci. , vol.54 , pp. 93-107
    • Ransome, M.I.1    Hannan, A.J.2
  • 149
    • 0033027914 scopus 로고    scopus 로고
    • Mash1 regulates neurogenesis in the ventral telencephalon
    • S. Casarosa, and et al. Mash1 regulates neurogenesis in the ventral telencephalon Development 126 1999 525 534
    • (1999) Development , vol.126 , pp. 525-534
    • Casarosa, S.1
  • 150
    • 69149097811 scopus 로고    scopus 로고
    • Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1
    • K. Oishi, and et al. Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1 Proc. Natl. Acad. Sci. U. S. A. 106 2009 13064 13069
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 13064-13069
    • Oishi, K.1
  • 151
    • 84879028474 scopus 로고    scopus 로고
    • Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease
    • G.M. Petzinger, and et al. Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease Lancet Neurol. 12 2013 716 726
    • (2013) Lancet Neurol. , vol.12 , pp. 716-726
    • Petzinger, G.M.1
  • 152
    • 84855278236 scopus 로고    scopus 로고
    • Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model
    • Z. Kohl, and et al. Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model Eur. J. Neurosci. 35 2012 10 19
    • (2012) Eur. J. Neurosci. , vol.35 , pp. 10-19
    • Kohl, Z.1
  • 153
    • 17044382151 scopus 로고    scopus 로고
    • Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions
    • P. Mohapel, and et al. Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions Neuroscience 132 2005 767 776
    • (2005) Neuroscience , vol.132 , pp. 767-776
    • Mohapel, P.1
  • 154
    • 84895882964 scopus 로고    scopus 로고
    • Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models
    • J.J. Ramos-Rodriguez, and et al. Central proliferation and neurogenesis is impaired in type 2 diabetes and prediabetes animal models PLOS ONE 9 2014 e89229
    • (2014) PLOS ONE , vol.9 , pp. e89229
    • Ramos-Rodriguez, J.J.1
  • 155
    • 0344737625 scopus 로고    scopus 로고
    • Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells
    • T. Ben-Hur, and et al. Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells Mol. Cell. Neurosci. 24 2003 623 631
    • (2003) Mol. Cell. Neurosci. , vol.24 , pp. 623-631
    • Ben-Hur, T.1
  • 156
    • 77949535527 scopus 로고    scopus 로고
    • Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats: Reversal by fluoxetine
    • K. Suzuki, and et al. Destruction of dopaminergic neurons in the midbrain by 6-hydroxydopamine decreases hippocampal cell proliferation in rats: reversal by fluoxetine PLoS ONE 5 2010 e9260
    • (2010) PLoS ONE , vol.5 , pp. e9260
    • Suzuki, K.1
  • 157
    • 77957233908 scopus 로고    scopus 로고
    • Neurotrophic factor therapy for Parkinson's disease
    • S.B. Rangasamy, and et al. Neurotrophic factor therapy for Parkinson's disease Prog. Brain Res. 184 2010 237 264
    • (2010) Prog. Brain Res. , vol.184 , pp. 237-264
    • Rangasamy, S.B.1
  • 158
    • 84942430232 scopus 로고    scopus 로고
    • Viral vector delivery of neurotrophic factors for Parkinson's disease therapy
    • M.J. Kelly, and et al. Viral vector delivery of neurotrophic factors for Parkinson's disease therapy Expert Rev. Mol. Med. 17 2015 e8
    • (2015) Expert Rev. Mol. Med. , vol.17 , pp. e8
    • Kelly, M.J.1
  • 159
    • 84938099480 scopus 로고    scopus 로고
    • Intranasal administration of glial-derived neurotrophic factor (GDNF) rapidly and significantly increases whole-brain GDNF level in rats
    • T.S. Bender, and et al. Intranasal administration of glial-derived neurotrophic factor (GDNF) rapidly and significantly increases whole-brain GDNF level in rats Neuroscience 303 2015 569 576
    • (2015) Neuroscience , vol.303 , pp. 569-576
    • Bender, T.S.1
  • 160
    • 62049083420 scopus 로고    scopus 로고
    • Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
    • A.H. Nagahara, and et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease Nat. Med. 15 2009 331 337
    • (2009) Nat. Med. , vol.15 , pp. 331-337
    • Nagahara, A.H.1
  • 161
    • 0036182251 scopus 로고    scopus 로고
    • A novel neurotrophic property of glucagon-like peptide 1: A promoter of nerve growth factor-mediated differentiation in PC12 cells
    • T. Perry, and et al. A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells J. Pharmacol. Exp. Ther. 300 2002 958 966
    • (2002) J. Pharmacol. Exp. Ther. , vol.300 , pp. 958-966
    • Perry, T.1
  • 162
    • 80052882537 scopus 로고    scopus 로고
    • Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice
    • T. Himeno, and et al. Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice Diabetes 60 2011 2397 2406
    • (2011) Diabetes , vol.60 , pp. 2397-2406
    • Himeno, T.1
  • 163
    • 84861460226 scopus 로고    scopus 로고
    • Glucagon-like peptide 1, insulin, sensory neurons, and diabetic neuropathy
    • M. Kan, and et al. Glucagon-like peptide 1, insulin, sensory neurons, and diabetic neuropathy J. Neuropathol. Exp. Neurol. 71 2012 494 510
    • (2012) J. Neuropathol. Exp. Neurol. , vol.71 , pp. 494-510
    • Kan, M.1
  • 164
    • 0036721026 scopus 로고    scopus 로고
    • Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4
    • T. Perry, and et al. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4 J. Pharmacol. Exp. Ther. 302 2002 881 888
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 881-888
    • Perry, T.1
  • 165
    • 84863115597 scopus 로고    scopus 로고
    • Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis
    • Y. Li, and et al. Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis PLoS ONE 7 2012 e32008
    • (2012) PLoS ONE , vol.7 , pp. e32008
    • Li, Y.1
  • 166
    • 84924716479 scopus 로고    scopus 로고
    • Exendin-4 enhances the migration of adipose-derived stem cells to neonatal rat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide 3-kinase/Akt-stromal cell-derived factor-1α/CXC chemokine receptor 4 pathway
    • H. Zhou, and et al. Exendin-4 enhances the migration of adipose-derived stem cells to neonatal rat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide 3-kinase/Akt-stromal cell-derived factor-1α/CXC chemokine receptor 4 pathway Mol. Med. Rep. 11 2015 4063 4072
    • (2015) Mol. Med. Rep. , vol.11 , pp. 4063-4072
    • Zhou, H.1
  • 167
    • 84902595146 scopus 로고    scopus 로고
    • Exendin-4 pretreated adipose derived stem cells are resistant to oxidative stress and improve cardiac performance via enhanced adhesion in the infarcted heart
    • J. Liu, and et al. Exendin-4 pretreated adipose derived stem cells are resistant to oxidative stress and improve cardiac performance via enhanced adhesion in the infarcted heart PLOS ONE 9 2014 e99756
    • (2014) PLOS ONE , vol.9 , pp. e99756
    • Liu, J.1
  • 168
    • 84904916519 scopus 로고    scopus 로고
    • The stem cell adjuvant with Exendin-4 repairs the heart after myocardial infarction via STAT3 activation
    • J. Liu, and et al. The stem cell adjuvant with Exendin-4 repairs the heart after myocardial infarction via STAT3 activation J. Cell. Mol. Med. 18 2014 1381 1391
    • (2014) J. Cell. Mol. Med. , vol.18 , pp. 1381-1391
    • Liu, J.1
  • 169
    • 84891727675 scopus 로고    scopus 로고
    • Exenatide pretreatment improved graft function in nonhuman primate islet recipients compared to treatment after transplant only
    • J.L. Buss, and et al. Exenatide pretreatment improved graft function in nonhuman primate islet recipients compared to treatment after transplant only J. Transplant. 2012 2012 382518
    • (2012) J. Transplant. , vol.2012 , pp. 382518
    • Buss, J.L.1
  • 170
    • 84942193062 scopus 로고    scopus 로고
    • Liraglutide promotes cortical neurite outgrowth via the MEK-ERK pathway
    • M. Li, and et al. Liraglutide promotes cortical neurite outgrowth via the MEK-ERK pathway Cell. Mol. Neurobiol. 35 2015 987 993
    • (2015) Cell. Mol. Neurobiol. , vol.35 , pp. 987-993
    • Li, M.1
  • 171
    • 84894048190 scopus 로고    scopus 로고
    • Dysfunctional and compensatory synaptic plasticity in Parkinson's disease
    • H. Schroll, and et al. Dysfunctional and compensatory synaptic plasticity in Parkinson's disease Eur. J. Neurosci. 39 2014 688 702
    • (2014) Eur. J. Neurosci. , vol.39 , pp. 688-702
    • Schroll, H.1
  • 172
    • 84858121110 scopus 로고    scopus 로고
    • Synaptic dysfunction in Parkinson's disease
    • B. Picconi, and et al. Synaptic dysfunction in Parkinson's disease Adv. Exp. Med. Biol. 970 2012 553 572
    • (2012) Adv. Exp. Med. Biol. , vol.970 , pp. 553-572
    • Picconi, B.1
  • 173
    • 84880383782 scopus 로고    scopus 로고
    • New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease
    • P. Calabresi, and et al. New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease Lancet Neurol. 12 2013 811 821
    • (2013) Lancet Neurol. , vol.12 , pp. 811-821
    • Calabresi, P.1
  • 174
    • 41149173996 scopus 로고    scopus 로고
    • The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years
    • M.A. Hely, and et al. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years Mov. Disord. 23 2008 837 844
    • (2008) Mov. Disord. , vol.23 , pp. 837-844
    • Hely, M.A.1
  • 175
    • 84885666304 scopus 로고    scopus 로고
    • The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort
    • C.H. Williams-Gray, and et al. The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort J. Neurol. Neurosurg. Psychiatry 84 2013 1258 1264
    • (2013) J. Neurol. Neurosurg. Psychiatry , vol.84 , pp. 1258-1264
    • Williams-Gray, C.H.1
  • 176
    • 70350641659 scopus 로고    scopus 로고
    • The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
    • C.H. Williams-Gray, and et al. The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort Brain 132 2009 2958 2969
    • (2009) Brain , vol.132 , pp. 2958-2969
    • Williams-Gray, C.H.1
  • 177
    • 84861536116 scopus 로고    scopus 로고
    • Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease
    • C. Costa, and et al. Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease Brain 135 2012 1884 1899
    • (2012) Brain , vol.135 , pp. 1884-1899
    • Costa, C.1
  • 178
    • 43849090633 scopus 로고    scopus 로고
    • Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease
    • T.P. Bouchard, and et al. Age and dementia-associated atrophy predominates in the hippocampal head and amygdala in Parkinson's disease Neurobiol. Aging 29 2008 1027 1039
    • (2008) Neurobiol. Aging , vol.29 , pp. 1027-1039
    • Bouchard, T.P.1
  • 179
    • 55149101333 scopus 로고    scopus 로고
    • Hippocampal head atrophy predominance in Parkinson's disease with hallucinations and with dementia
    • N. Ibarretxe-Bilbao, and et al. Hippocampal head atrophy predominance in Parkinson's disease with hallucinations and with dementia J. Neurol. 255 2008 1324 1331
    • (2008) J. Neurol. , vol.255 , pp. 1324-1331
    • Ibarretxe-Bilbao, N.1
  • 180
    • 84878016938 scopus 로고    scopus 로고
    • Gray matter atrophy in Parkinson's disease with dementia: Evidence from meta-analysis of voxel-based morphometry studies
    • P.L. Pan, and et al. Gray matter atrophy in Parkinson's disease with dementia: evidence from meta-analysis of voxel-based morphometry studies Neurol. Sci. 34 2013 613 619
    • (2013) Neurol. Sci. , vol.34 , pp. 613-619
    • Pan, P.L.1
  • 181
    • 0033545166 scopus 로고    scopus 로고
    • Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system
    • I. Merchenthaler, and et al. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system J. Comp. Neurol. 403 1999 261 280
    • (1999) J. Comp. Neurol. , vol.403 , pp. 261-280
    • Merchenthaler, I.1
  • 182
    • 69549138878 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
    • T. Abbas, and et al. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: interaction between type 2 diabetes and Alzheimer's disease Behav. Brain Res. 205 2009 265 271
    • (2009) Behav. Brain Res. , vol.205 , pp. 265-271
    • Abbas, T.1
  • 183
    • 0141461415 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
    • M.J. During, and et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection Nat. Med. 9 2003 1173 1179
    • (2003) Nat. Med. , vol.9 , pp. 1173-1179
    • During, M.J.1
  • 184
    • 33645078446 scopus 로고    scopus 로고
    • Dementia in Parkinson disease: Functional imaging of cholinergic and dopaminergic pathways
    • R. Hilker, and et al. Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways Neurology 65 2005 1716 1722
    • (2005) Neurology , vol.65 , pp. 1716-1722
    • Hilker, R.1
  • 185
    • 0021837595 scopus 로고
    • Cholinergic correlates of cognitive impairment in Parkinson's disease: Comparisons with Alzheimer's disease
    • E.K. Perry, and et al. Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease J. Neurol. Neurosurg. Psychiatry 48 1985 413 421
    • (1985) J. Neurol. Neurosurg. Psychiatry , vol.48 , pp. 413-421
    • Perry, E.K.1
  • 186
    • 0020632128 scopus 로고
    • Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases
    • J.M. Candy, and et al. Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases J. Neurol. Sci. 59 1983 277 289
    • (1983) J. Neurol. Sci. , vol.59 , pp. 277-289
    • Candy, J.M.1
  • 187
    • 0347385143 scopus 로고    scopus 로고
    • Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: An in vivo positron emission tomographic study
    • N.I. Bohnen, and et al. Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study Arch. Neurol. 60 2003 1745 1748
    • (2003) Arch. Neurol. , vol.60 , pp. 1745-1748
    • Bohnen, N.I.1
  • 188
    • 32844471835 scopus 로고    scopus 로고
    • Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia
    • N.I. Bohnen, and et al. Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia J. Neurol. 253 2006 242 247
    • (2006) J. Neurol. , vol.253 , pp. 242-247
    • Bohnen, N.I.1
  • 189
    • 84861191579 scopus 로고    scopus 로고
    • Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status
    • S.H. Choi, and et al. Volumetric analysis of the substantia innominata in patients with Parkinson's disease according to cognitive status Neurobiol. Aging 33 2012 1265 1272
    • (2012) Neurobiol. Aging , vol.33 , pp. 1265-1272
    • Choi, S.H.1
  • 190
    • 27144549543 scopus 로고    scopus 로고
    • Cognitive profile of patients with newly diagnosed Parkinson disease
    • D. Muslimovic, and et al. Cognitive profile of patients with newly diagnosed Parkinson disease Neurology 65 2005 1239 1245
    • (2005) Neurology , vol.65 , pp. 1239-1245
    • Muslimovic, D.1
  • 191
    • 84875235515 scopus 로고    scopus 로고
    • Shared dysregulated pathways lead to Parkinson's disease and diabetes
    • J. Santiago, and J. Potashkin Shared dysregulated pathways lead to Parkinson's disease and diabetes Trends Mol. Med. 19 2013 176 186
    • (2013) Trends Mol. Med. , vol.19 , pp. 176-186
    • Santiago, J.1    Potashkin, J.2
  • 192
    • 84899689416 scopus 로고    scopus 로고
    • Insulin resistance and gray matter volume in neurodegenerative disease
    • J.K. Morris, and et al. Insulin resistance and gray matter volume in neurodegenerative disease Neuroscience 270 2014 139 147
    • (2014) Neuroscience , vol.270 , pp. 139-147
    • Morris, J.K.1
  • 193
    • 0030047594 scopus 로고    scopus 로고
    • Insulin receptor mRNA in the substantia nigra in Parkinson's disease
    • M. Takahashi, and et al. Insulin receptor mRNA in the substantia nigra in Parkinson's disease Neurosci. Lett. 204 1996 201 204
    • (1996) Neurosci. Lett. , vol.204 , pp. 201-204
    • Takahashi, M.1
  • 194
    • 84868282388 scopus 로고    scopus 로고
    • Insulin in central nervous system: More than just a peripheral hormone
    • A.I. Duarte, and et al. Insulin in central nervous system: more than just a peripheral hormone J. Aging Res. 2012 2012 384017
    • (2012) J. Aging Res. , vol.2012 , pp. 384017
    • Duarte, A.I.1
  • 195
    • 65549103889 scopus 로고    scopus 로고
    • Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: Potential role of manganese neurotoxicity
    • M. Tong, and et al. Brain insulin-like growth factor and neurotrophin resistance in Parkinson's disease and dementia with Lewy bodies: potential role of manganese neurotoxicity J. Alzheimers Dis. 16 2009 585 599
    • (2009) J. Alzheimers Dis. , vol.16 , pp. 585-599
    • Tong, M.1
  • 196
    • 84873427263 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease
    • E.C. Hirsch, and et al. Pathogenesis of Parkinson's disease Mov. Disord. 28 2013 24 30
    • (2013) Mov. Disord. , vol.28 , pp. 24-30
    • Hirsch, E.C.1
  • 197
    • 84888062088 scopus 로고    scopus 로고
    • Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice
    • L. Wang, and et al. Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice Exp. Neurol. 251 2014 22 29
    • (2014) Exp. Neurol. , vol.251 , pp. 22-29
    • Wang, L.1
  • 198
    • 77957575432 scopus 로고    scopus 로고
    • Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet
    • J.K. Morris, and et al. Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet AJP Regul. Integr. Comp. Physiol. 299 2010 R1082 R1090
    • (2010) AJP Regul. Integr. Comp. Physiol. , vol.299 , pp. R1082-R1090
    • Morris, J.K.1
  • 199
    • 79961030579 scopus 로고    scopus 로고
    • Insulin resistance impairs nigrostriatal dopamine function
    • J.K. Morris, and et al. Insulin resistance impairs nigrostriatal dopamine function Exp. Neurol. 231 2011 171 180
    • (2011) Exp. Neurol. , vol.231 , pp. 171-180
    • Morris, J.K.1
  • 200
    • 13844275515 scopus 로고    scopus 로고
    • Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity
    • J-Y. Choi, and et al. Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity Free Radic. Biol. Med. 38 2005 806 816
    • (2005) Free Radic. Biol. Med. , vol.38 , pp. 806-816
    • Choi, J.-Y.1
  • 201
    • 84925307917 scopus 로고    scopus 로고
    • Insulin resistance in brain alters dopamine turnover and causes behavioral disorders
    • A. Kleinridders, and et al. Insulin resistance in brain alters dopamine turnover and causes behavioral disorders Proc. Natl. Acad. Sci. U. S. A. 112 2015 3463 3468
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 3463-3468
    • Kleinridders, A.1
  • 202
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • J. Hirosumi, and et al. A central role for JNK in obesity and insulin resistance Nature 420 2002 333 336
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1
  • 203
    • 84869420795 scopus 로고    scopus 로고
    • Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle
    • F.R. Santos, and H.E. Diamond-Stanic Contribution of the serine kinase c-Jun N-terminal kinase (JNK) to oxidant-induced insulin resistance in isolated rat skeletal muscle Arch. Physiol. Biochem. 118 2012 231 236
    • (2012) Arch. Physiol. Biochem. , vol.118 , pp. 231-236
    • Santos, F.R.1    Diamond-Stanic, H.E.2
  • 204
    • 84897907030 scopus 로고    scopus 로고
    • How does brain insulin resistance develop in Alzheimer's disease?
    • F.G. De Felice, and et al. How does brain insulin resistance develop in Alzheimer's disease? Alzheimers Dement. 10 2014 S26 S32
    • (2014) Alzheimers Dement. , vol.10 , pp. S26-S32
    • De Felice, F.G.1
  • 205
    • 84897886749 scopus 로고    scopus 로고
    • Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
    • S.T. Ferreira, and et al. Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease Alzheimers Dement. 10 2014 S76 S83
    • (2014) Alzheimers Dement. , vol.10 , pp. S76-S83
    • Ferreira, S.T.1
  • 206
    • 84926178115 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling
    • S. Gao, and et al. Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling Int. J. Biochem. Cell Biol. 64 2015 25 33
    • (2015) Int. J. Biochem. Cell Biol. , vol.64 , pp. 25-33
    • Gao, S.1
  • 207
    • 84859726053 scopus 로고    scopus 로고
    • An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers
    • T.R. Bomfim, and et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease-associated Aβ oligomers J. Clin. Invest. 122 2012 1339 1353
    • (2012) J. Clin. Invest. , vol.122 , pp. 1339-1353
    • Bomfim, T.R.1
  • 208
    • 84874722479 scopus 로고    scopus 로고
    • The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease
    • C.M. Long-Smith, and et al. The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease Neuromol. Med. 15 2013 102 114
    • (2013) Neuromol. Med. , vol.15 , pp. 102-114
    • Long-Smith, C.M.1
  • 209
    • 84942296710 scopus 로고    scopus 로고
    • Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS1 transgenic model of Alzheimer's disease
    • Y. Zhang, and et al. Geniposide attenuates insulin-deficiency-induced acceleration of β-amyloidosis in an APP/PS1 transgenic model of Alzheimer's disease Neurochem. Int. 89 2015 7 16
    • (2015) Neurochem. Int. , vol.89 , pp. 7-16
    • Zhang, Y.1
  • 210
    • 84863875558 scopus 로고    scopus 로고
    • Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis
    • H. Hsuchou, and et al. Blood-borne metabolic factors in obesity exacerbate injury-induced gliosis J. Mol. Neurosci. 47 2012 267 277
    • (2012) J. Mol. Neurosci. , vol.47 , pp. 267-277
    • Hsuchou, H.1
  • 211
    • 84866330453 scopus 로고    scopus 로고
    • Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations
    • M.M. Gonzales, and et al. Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations Psychosom. Med. 74 2012 691 698
    • (2012) Psychosom. Med. , vol.74 , pp. 691-698
    • Gonzales, M.M.1
  • 212
    • 79952119299 scopus 로고    scopus 로고
    • Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation
    • M.R. Hayes, and et al. Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation Cell Metab. 13 2011 320 330
    • (2011) Cell Metab. , vol.13 , pp. 320-330
    • Hayes, M.R.1
  • 213
    • 75749139750 scopus 로고    scopus 로고
    • Exenatide and weight loss
    • D.P. Bradley, and et al. Exenatide and weight loss Nutrition 26 2010 243 249
    • (2010) Nutrition , vol.26 , pp. 243-249
    • Bradley, D.P.1
  • 214
    • 84907495079 scopus 로고    scopus 로고
    • GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK
    • D. Beiroa, and et al. GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK Diabetes 63 2014 3346 3358
    • (2014) Diabetes , vol.63 , pp. 3346-3358
    • Beiroa, D.1
  • 215
    • 47649114057 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus
    • L. Brunetti, and et al. Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus Peptides 29 2008 1377 1381
    • (2008) Peptides , vol.29 , pp. 1377-1381
    • Brunetti, L.1
  • 216
    • 80054855642 scopus 로고    scopus 로고
    • Is the GLP-1 system a viable therapeutic target for weight reduction?
    • J. Tong, and D.A. Sandoval Is the GLP-1 system a viable therapeutic target for weight reduction? Rev. Endocr. Metab. Disord. 12 2011 187 195
    • (2011) Rev. Endocr. Metab. Disord. , vol.12 , pp. 187-195
    • Tong, J.1    Sandoval, D.A.2
  • 217
    • 84924598594 scopus 로고    scopus 로고
    • Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses
    • H.S. Sallam, and et al. Peripheral adipose tissue insulin resistance alters lipid composition and function of hippocampal synapses J. Neurochem. 133 2015 125 133
    • (2015) J. Neurochem. , vol.133 , pp. 125-133
    • Sallam, H.S.1
  • 218
    • 84876362365 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 regulates adipogenesis in 3T3-L1 preadipocytes
    • J. Yang, and et al. Glucagon-like peptide 1 regulates adipogenesis in 3T3-L1 preadipocytes Int. J. Mol. Med. 31 2013 1429 1435
    • (2013) Int. J. Mol. Med. , vol.31 , pp. 1429-1435
    • Yang, J.1
  • 219
    • 84857461922 scopus 로고    scopus 로고
    • Regulation of adipocyte formation by GLP-1/GLP-1R signaling
    • T.D. Challa, and et al. Regulation of adipocyte formation by GLP-1/GLP-1R signaling J. Biol. Chem. 287 2012 6421 6430
    • (2012) J. Biol. Chem. , vol.287 , pp. 6421-6430
    • Challa, T.D.1
  • 220
    • 84898057274 scopus 로고    scopus 로고
    • Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease
    • S.K. Abbott, and et al. Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson's disease Mov. Disord. 29 2014 518 526
    • (2014) Mov. Disord. , vol.29 , pp. 518-526
    • Abbott, S.K.1
  • 221
    • 84884264199 scopus 로고    scopus 로고
    • Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: A pilot study
    • M.M. Mielke, and et al. Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study PLOS ONE 8 2013 e73094
    • (2013) PLOS ONE , vol.8 , pp. e73094
    • Mielke, M.M.1
  • 222
    • 84862849621 scopus 로고    scopus 로고
    • A role for sphingolipids in the pathophysiology of obesity-induced inflammation
    • B.T. Bikman A role for sphingolipids in the pathophysiology of obesity-induced inflammation Cell. Mol. Life Sci. 69 2012 2135 2146
    • (2012) Cell. Mol. Life Sci. , vol.69 , pp. 2135-2146
    • Bikman, B.T.1
  • 223
    • 67649687040 scopus 로고    scopus 로고
    • Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis
    • L.E. Lyn-Cook, and et al. Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis J. Alzheimers Dis. 16 2009 715 729
    • (2009) J. Alzheimers Dis. , vol.16 , pp. 715-729
    • Lyn-Cook, L.E.1
  • 224
    • 12444296116 scopus 로고    scopus 로고
    • Gaucher disease with parkinsonian manifestations: Does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism?
    • N. Tayebi, and et al. Gaucher disease with parkinsonian manifestations: does glucocerebrosidase deficiency contribute to a vulnerability to parkinsonism? Mol. Genet. Metab. 79 2003 104 109
    • (2003) Mol. Genet. Metab. , vol.79 , pp. 104-109
    • Tayebi, N.1
  • 225
    • 84923569616 scopus 로고    scopus 로고
    • Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy
    • O. Erbaş, and et al. Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy Kaohsiung J. Med. Sci. 30 2014 447 452
    • (2014) Kaohsiung J. Med. Sci. , vol.30 , pp. 447-452
    • Erbaş, O.1
  • 226
    • 1842855402 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells
    • Q. Wang, and et al. Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells Diabetologia 47 2004 478 487
    • (2004) Diabetologia , vol.47 , pp. 478-487
    • Wang, Q.1
  • 227
    • 84922559426 scopus 로고    scopus 로고
    • Pro-GLP-1, a Pro-drug of GLP-1, is neuroprotective in cerebral ischemia
    • H. Zhang, and et al. Pro-GLP-1, a Pro-drug of GLP-1, is neuroprotective in cerebral ischemia Eur. J. Pharm. Sci. 70 2015 82 91
    • (2015) Eur. J. Pharm. Sci. , vol.70 , pp. 82-91
    • Zhang, H.1
  • 228
    • 84867407469 scopus 로고    scopus 로고
    • Exendin-4 improved rat cortical neuron survival under oxygen/glucose deprivation through PKA pathway
    • M-D. Wang, and et al. Exendin-4 improved rat cortical neuron survival under oxygen/glucose deprivation through PKA pathway Neuroscience 226 2012 388 396
    • (2012) Neuroscience , vol.226 , pp. 388-396
    • Wang, M.-D.1
  • 229
    • 85027943896 scopus 로고    scopus 로고
    • Akt as a victim, villain and potential hero in Parkinson's disease pathophysiology and treatment
    • L.A. Greene, and et al. Akt as a victim, villain and potential hero in Parkinson's disease pathophysiology and treatment Cell. Mol. Neurobiol. 31 2011 969 978
    • (2011) Cell. Mol. Neurobiol. , vol.31 , pp. 969-978
    • Greene, L.A.1
  • 230
    • 70350347175 scopus 로고    scopus 로고
    • Akt signal transduction dysfunction in Parkinson's disease
    • S. Timmons, and et al. Akt signal transduction dysfunction in Parkinson's disease Neurosci. Lett. 467 2009 30 35
    • (2009) Neurosci. Lett. , vol.467 , pp. 30-35
    • Timmons, S.1
  • 231
    • 79959602140 scopus 로고    scopus 로고
    • Expression analysis of dopaminergic neurons in Parkinson's disease and aging links transcriptional dysregulation of energy metabolism to cell death
    • M. Elstner, and et al. Expression analysis of dopaminergic neurons in Parkinson's disease and aging links transcriptional dysregulation of energy metabolism to cell death Acta Neuropathol. 122 2011 75 86
    • (2011) Acta Neuropathol. , vol.122 , pp. 75-86
    • Elstner, M.1
  • 232
    • 16244391770 scopus 로고    scopus 로고
    • Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology
    • R.J. Griffin, and et al. Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology J. Neurochem. 93 2005 105 117
    • (2005) J. Neurochem. , vol.93 , pp. 105-117
    • Griffin, R.J.1
  • 233
    • 80052290624 scopus 로고    scopus 로고
    • Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling
    • S.R. Kim, and et al. Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling Neurobiol. Dis. 44 2011 215 222
    • (2011) Neurobiol. Dis. , vol.44 , pp. 215-222
    • Kim, S.R.1
  • 234
    • 58149395816 scopus 로고    scopus 로고
    • RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation
    • C. Malagelada, and et al. RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation J. Neurosci. 28 2008 14363 14371
    • (2008) J. Neurosci. , vol.28 , pp. 14363-14371
    • Malagelada, C.1
  • 235
    • 42049096551 scopus 로고    scopus 로고
    • Association between AKT1 gene and Parkinson's disease: A protective haplotype
    • G. Xiromerisiou, and et al. Association between AKT1 gene and Parkinson's disease: a protective haplotype Neurosci. Lett. 436 2008 232 234
    • (2008) Neurosci. Lett. , vol.436 , pp. 232-234
    • Xiromerisiou, G.1
  • 236
    • 84899984684 scopus 로고    scopus 로고
    • Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
    • Y. Xu, and et al. Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease Cell. Signal. 26 2014 1680 1689
    • (2014) Cell. Signal. , vol.26 , pp. 1680-1689
    • Xu, Y.1
  • 237
    • 84908267031 scopus 로고    scopus 로고
    • RTP801/REDD1: A stress coping regulator that turns into a troublemaker in neurodegenerative disorders
    • M. Canal, and et al. RTP801/REDD1: a stress coping regulator that turns into a troublemaker in neurodegenerative disorders Front. Cell. Neurosci. 8 2014 313
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 313
    • Canal, M.1
  • 238
    • 77957760057 scopus 로고    scopus 로고
    • Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase
    • M. Perrinjaquet, and et al. Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase J. Biol. Chem. 285 2010 31867 31875
    • (2010) J. Biol. Chem. , vol.285 , pp. 31867-31875
    • Perrinjaquet, M.1
  • 239
    • 77953218677 scopus 로고    scopus 로고
    • Use of growth factors for the treatment of Parkinson's disease
    • T. Yasuda, and H. Mochizuki Use of growth factors for the treatment of Parkinson's disease Expert Rev. Neurother. 10 2010 915 924
    • (2010) Expert Rev. Neurother. , vol.10 , pp. 915-924
    • Yasuda, T.1    Mochizuki, H.2
  • 240
    • 65949113601 scopus 로고    scopus 로고
    • Targeting mTOR with rapamycin: One dose does not fit all
    • D.A. Foster, and A. Toschi Targeting mTOR with rapamycin: one dose does not fit all Cell Cycle 8 2009 1026 1029
    • (2009) Cell Cycle , vol.8 , pp. 1026-1029
    • Foster, D.A.1    Toschi, A.2
  • 241
    • 84879026548 scopus 로고    scopus 로고
    • PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
    • C. O' Neill PI3-kinase/Akt/mTOR signaling: impaired on/off switches in aging, cognitive decline and Alzheimer's disease Exp. Gerontol. 48 2013 647 653
    • (2013) Exp. Gerontol. , vol.48 , pp. 647-653
    • Neill, O.C.1
  • 243
    • 77949653254 scopus 로고    scopus 로고
    • Striatal Akt/GSK3 signaling pathway in the development of l-Dopa-induced dyskinesias in MPTP monkeys
    • M. Morissette, and et al. Striatal Akt/GSK3 signaling pathway in the development of l-Dopa-induced dyskinesias in MPTP monkeys Prog. Neuropsychopharmacol. Biol. Psychiatry 34 2010 446 454
    • (2010) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.34 , pp. 446-454
    • Morissette, M.1
  • 244
    • 84898964381 scopus 로고    scopus 로고
    • GLP-1 receptor agonists vs. DPP-4 inhibitors for type 2 diabetes: Is one approach more successful or preferable than the other?
    • S. Brunton GLP-1 receptor agonists vs. DPP-4 inhibitors for type 2 diabetes: is one approach more successful or preferable than the other? Int. J. Clin. Pract. 68 2014 557 567
    • (2014) Int. J. Clin. Pract. , vol.68 , pp. 557-567
    • Brunton, S.1
  • 245
    • 84872084453 scopus 로고    scopus 로고
    • Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): A randomised, open-label study
    • J.B. Buse, and et al. Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study Lancet 381 2013 117 124
    • (2013) Lancet , vol.381 , pp. 117-124
    • Buse, J.B.1
  • 246
    • 84878542289 scopus 로고    scopus 로고
    • Exenatide and the treatment of patients with Parkinson's disease
    • I. Aviles-Olmos, and et al. Exenatide and the treatment of patients with Parkinson's disease J. Clin. Invest. 123 2013 2730 2736
    • (2013) J. Clin. Invest. , vol.123 , pp. 2730-2736
    • Aviles-Olmos, I.1
  • 247
    • 84904126994 scopus 로고    scopus 로고
    • Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson's disease
    • I. Aviles-Olmos, and et al. Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson's disease J. Parkinsons. Dis. 4 2014 337 344
    • (2014) J. Parkinsons. Dis. , vol.4 , pp. 337-344
    • Aviles-Olmos, I.1
  • 248
    • 84938138719 scopus 로고    scopus 로고
    • No decline of brain glucose metabolism in Alzheimer's disease patients treated with liraglutide
    • Boston, USA, June 5-9, 2015, abstr1309-P
    • M. Gejl, and et al. No decline of brain glucose metabolism in Alzheimer's disease patients treated with liraglutide American Diabetes Association, 75th Annual Meeting Boston, USA, June 5-9, 2015, abstr1309-P 2015
    • (2015) American Diabetes Association, 75th Annual Meeting
    • Gejl, M.1
  • 249
    • 84925282923 scopus 로고    scopus 로고
    • A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
    • B. Finan, and et al. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents Nat. Med. 21 2015 27 36
    • (2015) Nat. Med. , vol.21 , pp. 27-36
    • Finan, B.1
  • 250
    • 84890043525 scopus 로고    scopus 로고
    • Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans
    • B. Finan, and et al. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans Sci. Transl. Med. 5 2013 209ra151
    • (2013) Sci. Transl. Med. , vol.5 , pp. 209ra151
    • Finan, B.1
  • 251
    • 84961984876 scopus 로고    scopus 로고
    • A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF
    • S0006-8993
    • C. Ji, and et al. A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson's disease by increasing expression of BNDF Brain Res. 2015 S0006-8993
    • (2015) Brain Res.
    • Ji, C.1
  • 252
    • 84987781385 scopus 로고    scopus 로고
    • Systems-level G protein-coupled receptor therapy across a neurodegenerative continuum by the GLP-1 receptor system
    • J. Janssens, and et al. Systems-level G protein-coupled receptor therapy across a neurodegenerative continuum by the GLP-1 receptor system Front. Endocrinol. (Lausanne) 5 2014 142
    • (2014) Front. Endocrinol. (Lausanne) , vol.5 , pp. 142
    • Janssens, J.1
  • 253
    • 84904388473 scopus 로고    scopus 로고
    • The extra-pancreatic effects of GLP-1 receptor agonists: A focus on the cardiovascular, gastrointestinal and central nervous systems
    • J. Seufert, and B. Gallwitz The extra-pancreatic effects of GLP-1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems Diabetes Obes. Metab. 16 2014 673 688
    • (2014) Diabetes Obes. Metab. , vol.16 , pp. 673-688
    • Seufert, J.1    Gallwitz, B.2
  • 254
    • 78650038239 scopus 로고    scopus 로고
    • Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets
    • K.W. Sloop, and et al. Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets Diabetes 59 2010 3099 3107
    • (2010) Diabetes , vol.59 , pp. 3099-3107
    • Sloop, K.W.1
  • 255
    • 77956249652 scopus 로고    scopus 로고
    • Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: Implications for drug screening
    • C. Koole, and et al. Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening Mol. Pharmacol. 78 2010 456 465
    • (2010) Mol. Pharmacol. , vol.78 , pp. 456-465
    • Koole, C.1


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