-
1
-
-
0034108646
-
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once-daily administration.
-
Knudsen LB, Nielsen PF, Huusfeldt PO. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once-daily administration. J Med Chem 2001, 43:1664-1669..
-
(2001)
J Med Chem
, vol.43
-
-
Knudsen, L.B.1
Nielsen, P.F.2
Huusfeldt, P.O.3
-
2
-
-
0037844361
-
Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative.
-
Agersø H, Vicini P. Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative. Eur J Pharmacol 2003, 19:141-150..
-
(2003)
Eur J Pharmacol
, vol.19
-
-
Agersø, H.1
Vicini, P.2
-
3
-
-
3843121153
-
Glucagon-like peptide-1: the basis of a new class of treatment for type 2 diabetes.
-
Knudsen LB. Glucagon-like peptide-1: the basis of a new class of treatment for type 2 diabetes. J Med Chem 2004, 47:4128-4134..
-
(2004)
J Med Chem
, vol.47
-
-
Knudsen, L.B.1
-
4
-
-
73349106529
-
The effects of glucagon-like peptide-1 on the beta cell.
-
Vilsbøll T. The effects of glucagon-like peptide-1 on the beta cell. Diabetes Obes Metab 2009, 11:11-18..
-
(2009)
Diabetes Obes Metab
, vol.11
-
-
Vilsbøll, T.1
-
5
-
-
67651173077
-
Incretin-based therapies for type 2 diabetes mellitus.
-
Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol 2009, 5:262-269..
-
(2009)
Nat Rev Endocrinol
, vol.5
-
-
Lovshin, J.A.1
Drucker, D.J.2
-
6
-
-
0036784675
-
The long-acting GLP-1 derivative NN2211 ameliorates glycaemia and increases beta-cell mass in diabetic mice.
-
Rolin B, Larsen MO, Gotfredsen CF. The long-acting GLP-1 derivative NN2211 ameliorates glycaemia and increases beta-cell mass in diabetic mice. Am J Physiol Endocrinol Metab 2002, 283:745-752..
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
Rolin, B.1
Larsen, M.O.2
Gotfredsen, C.F.3
-
7
-
-
15744381238
-
The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro.
-
Bregenholt S, Møldrup A, Blume N. The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro. Biochem Biophys Res Commun 2005, 330:577-584..
-
(2005)
Biochem Biophys Res Commun
, vol.330
-
-
Bregenholt, S.1
Møldrup, A.2
Blume, N.3
-
8
-
-
65549144889
-
Recent advances in antidiabetic drug therapies targeting the enteroinsular axis.
-
Flatt PR, Bailey CJ, Green BD. Recent advances in antidiabetic drug therapies targeting the enteroinsular axis. Curr Drug Metab 2009, 10:125-137..
-
(2009)
Curr Drug Metab
, vol.10
-
-
Flatt, P.R.1
Bailey, C.J.2
Green, B.D.3
-
9
-
-
0036198285
-
Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain-barrier.
-
Kastin AJ, Akerstrom V, Pan W. Interactions of glucagon-like peptide-1 (GLP-1) with the blood-brain-barrier. J Mol Neurosci 2002, 18:7-14..
-
(2002)
J Mol Neurosci
, vol.18
-
-
Kastin, A.J.1
Akerstrom, V.2
Pan, W.3
-
10
-
-
0037349072
-
Entry of exendin-4 into brain is rapid but may be limited at high doses.
-
Kastin AJ, Akerstrom V. Entry of exendin-4 into brain is rapid but may be limited at high doses. Int J Obes Relat Metab Disord 2003, 27:313-318..
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
-
-
Kastin, A.J.1
Akerstrom, V.2
-
11
-
-
77649187436
-
Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease.
-
McClean PL, Gault VA, Harriott P, Hölscher C. Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease. Eur J Pharmacol 2010, 630:158-162..
-
(2010)
Eur J Pharmacol
, vol.630
-
-
McClean, P.L.1
Gault, V.A.2
Harriott, P.3
Hölscher, C.4
-
12
-
-
0141461415
-
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection.
-
During MJ, Cao L, Zuzga DS. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med 2003, 9:1173-1179..
-
(2003)
Nat Med
, vol.9
-
-
During, M.J.1
Cao, L.2
Zuzga, D.S.3
-
13
-
-
69549128161
-
Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system.
-
Hamilton A, Hölscher C. Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. Neuroreport 2009, 20:1161-1166..
-
(2009)
Neuroreport
, vol.20
-
-
Hamilton, A.1
Hölscher, C.2
-
14
-
-
13644268431
-
The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem.
-
Alvarez E, Martínez MD, Roncero I. The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem. J Neurochem 2005, 92:798-806..
-
(2005)
J Neurochem
, vol.92
-
-
Alvarez, E.1
Martínez, M.D.2
Roncero, I.3
-
15
-
-
69549138878
-
Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: interaction between type 2 diabetes and Alzheimer's disease.
-
Abbas T, Faivre E, Hölscher C. Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: interaction between type 2 diabetes and Alzheimer's disease. Behav Brain Res 2009, 205:265-271..
-
(2009)
Behav Brain Res
, vol.205
-
-
Abbas, T.1
Faivre, E.2
Hölscher, C.3
-
16
-
-
44149122563
-
GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid.
-
Gault VA, Hölscher C. GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid. Eur J Pharmacol 2008, 587:112-117..
-
(2008)
Eur J Pharmacol
, vol.587
-
-
Gault, V.A.1
Hölscher, C.2
-
17
-
-
0027476024
-
A synaptic model of memory: long-term potentiation in the hippocampus.
-
Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993, 361:31-39..
-
(1993)
Nature
, vol.361
-
-
Bliss, T.V.1
Collingridge, G.L.2
-
18
-
-
33745685529
-
Plasticity in the human central nervous system.
-
Cooke SF, Bliss TV. Plasticity in the human central nervous system. Brain 2006, 129:1659-1673..
-
(2006)
Brain
, vol.129
-
-
Cooke, S.F.1
Bliss, T.V.2
-
19
-
-
33947262557
-
Soluble beta-amyoid [25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning.
-
Hölscher C, Gengler S, Gault VA, Harriott P, Mallot HA. Soluble beta-amyoid [25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning. Eur J Pharmacol 2007, 56:85-90..
-
(2007)
Eur J Pharmacol
, vol.56
-
-
Hölscher, C.1
Gengler, S.2
Gault, V.A.3
Harriott, P.4
Mallot, H.A.5
-
20
-
-
34249024370
-
Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid [25-35] are dependent on stimulation-protocol and genetic background.
-
Gengler S, Gault VA, Harriott P, Hölscher C. Impairments of hippocampal synaptic plasticity induced by aggregated beta-amyloid [25-35] are dependent on stimulation-protocol and genetic background. Exp Brain Res 2007, 179:621-630..
-
(2007)
Exp Brain Res
, vol.179
-
-
Gengler, S.1
Gault, V.A.2
Harriott, P.3
Hölscher, C.4
-
21
-
-
0015038855
-
Determination of glucose by an automated analyser.
-
Stevens JF. Determination of glucose by an automated analyser. Clin Chem Acta 1971, 32:199-201..
-
(1971)
Clin Chem Acta
, vol.32
-
-
Stevens, J.F.1
-
22
-
-
0019471997
-
Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice.
-
Flatt PR, Bailey CJ. Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 1981, 20:573-577..
-
(1981)
Diabetologia
, vol.20
-
-
Flatt, P.R.1
Bailey, C.J.2
-
23
-
-
34247574175
-
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents.
-
Dere E, Huston JP, De Souza Silva MA. The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents. Neurosci Biobehav Rev 2007, 31:673-704..
-
(2007)
Neurosci Biobehav Rev
, vol.31
-
-
Dere, E.1
Huston, J.P.2
De Souza Silva, M.A.3
-
24
-
-
0343742511
-
Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation which can be depotentiated by stimulation on the negative phase in area CA1 in vivo.
-
Hölscher C, Anwyl R, Rowan MJ. Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation which can be depotentiated by stimulation on the negative phase in area CA1 in vivo. J Neurosci 1997, 17:6470-6477..
-
(1997)
J Neurosci
, vol.17
-
-
Hölscher, C.1
Anwyl, R.2
Rowan, M.J.3
-
26
-
-
66749102158
-
Clinical review: the extrapancreatic effects of glucagon-like peptide-1 and related peptides.
-
Abu-Hamdah R, Rabiee A, Meneilly GS, Shannon RP, Andersen DK, Elahi D. Clinical review: the extrapancreatic effects of glucagon-like peptide-1 and related peptides. J Clin Endocrinol Metab 2009, 94:1843-1852..
-
(2009)
J Clin Endocrinol Metab
, vol.94
-
-
Abu-Hamdah, R.1
Rabiee, A.2
Meneilly, G.S.3
Shannon, R.P.4
Andersen, D.K.5
Elahi, D.6
-
27
-
-
34447127048
-
Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose tolerance and associated disturbances in mice fed high-fat and cafeteria diets.
-
Gault VA, McClean PL, Cassidy RS, Irwin N, Flatt PR. Chemical gastric inhibitory polypeptide receptor antagonism protects against obesity, insulin resistance, glucose tolerance and associated disturbances in mice fed high-fat and cafeteria diets. Diabetologia 2007, 50:1752-1762..
-
(2007)
Diabetologia
, vol.50
-
-
Gault, V.A.1
McClean, P.L.2
Cassidy, R.S.3
Irwin, N.4
Flatt, P.R.5
-
28
-
-
0032010997
-
Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats.
-
Davis HR, Mullins DE, Pines JM. Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats. Obes Res 1998, 6:147-156..
-
(1998)
Obes Res
, vol.6
-
-
Davis, H.R.1
Mullins, D.E.2
Pines, J.M.3
-
29
-
-
0035516188
-
Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats.
-
Larsen PJ, Fledelius C, Knudsen LB, Tang-Christensen M. Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats. Diabetes 2001, 50:2530-2539..
-
(2001)
Diabetes
, vol.50
-
-
Larsen, P.J.1
Fledelius, C.2
Knudsen, L.B.3
Tang-Christensen, M.4
-
30
-
-
70349151817
-
Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signalling in obesity.
-
Ernst MB, Wunderlich CM, Hess S. Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signalling in obesity. J Neurosci 2009, 29:11582-11593..
-
(2009)
J Neurosci
, vol.29
-
-
Ernst, M.B.1
Wunderlich, C.M.2
Hess, S.3
-
31
-
-
0034333018
-
Cognition and synaptic plasticity in diabetes mellitus.
-
Gispen WH, Biessels GJ. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 2000, 23:542-549..
-
(2000)
Trends Neurosci
, vol.23
-
-
Gispen, W.H.1
Biessels, G.J.2
-
32
-
-
1842785174
-
Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus.
-
Trudeau F, Gagnon S, Massicotte G. Hippocampal synaptic plasticity and glutamate receptor regulation: influences of diabetes mellitus. Eur J Pharmacol 2004, 490:177-186..
-
(2004)
Eur J Pharmacol
, vol.490
-
-
Trudeau, F.1
Gagnon, S.2
Massicotte, G.3
-
33
-
-
1842734649
-
Modulation of memory by insulin and glucose: neuropsychologial observations in Alzheimer's disease.
-
Watson GS, Craft S. Modulation of memory by insulin and glucose: neuropsychologial observations in Alzheimer's disease. Eur J Pharmacol 2004, 490:97-113..
-
(2004)
Eur J Pharmacol
, vol.490
-
-
Watson, G.S.1
Craft, S.2
-
34
-
-
27844578300
-
Insulin and cognitive function in humans: experimental data and therapeutic considerations.
-
Strachan MW. Insulin and cognitive function in humans: experimental data and therapeutic considerations. Biochem Soc Trans 2005, 33:1037-1040..
-
(2005)
Biochem Soc Trans
, vol.33
-
-
Strachan, M.W.1
-
35
-
-
64249126355
-
The influences of juvenile diabetes on memory and hippocampal plasticity in rats: improving effects of glucagon-like peptide-1.
-
Iwai T, Suzuki M, Kobayashi K, Mori K, Mogi Y, Oka JI. The influences of juvenile diabetes on memory and hippocampal plasticity in rats: improving effects of glucagon-like peptide-1. Neurosci Res 2009, 64:67-74..
-
(2009)
Neurosci Res
, vol.64
-
-
Iwai, T.1
Suzuki, M.2
Kobayashi, K.3
Mori, K.4
Mogi, Y.5
Oka, J.I.6
-
36
-
-
23844470857
-
Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner.
-
van der Heide LP, Kamal A, Artola A, Gispen WH, Ramakers GM. Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner. J Neurosci 2005, 94:1158-1166..
-
(2005)
J Neurosci
, vol.94
-
-
van der Heide, L.P.1
Kamal, A.2
Artola, A.3
Gispen, W.H.4
Ramakers, G.M.5
-
38
-
-
36448936053
-
Common pathological processes in Alzheimer's disease and type 2 diabetes: a review.
-
Li L, Hölscher C. Common pathological processes in Alzheimer's disease and type 2 diabetes: a review. Brain Res Rev 2007, 56:384-402..
-
(2007)
Brain Res Rev
, vol.56
-
-
Li, L.1
Hölscher, C.2
-
39
-
-
76749116176
-
Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice.
-
D'Amico M, Di Filippo C, Marfella R. Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer's prone mice. Exp Gerontol 2010, 45:202-207..
-
(2010)
Exp Gerontol
, vol.45
-
-
D'Amico, M.1
Di Filippo, C.2
Marfella, R.3
-
40
-
-
77955470617
-
-
Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet., (Lond)
-
Gault VA, Porter WD, Flatt PR, Holscher C. Int J Obes 2010, 34:1341-1344. Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet., (Lond)
-
(2010)
Int J Obes
, vol.34
, pp. 1341-1344
-
-
Gault, V.A.1
Porter, W.D.2
Flatt, P.R.3
Holscher, C.4
-
41
-
-
84878636551
-
Restitution of brain responses to food stimuli and feeding in Type 2 diabetes by GLP-1 receptor agonist exenatide.
-
Nathan Y, Lee S, Ashoor G. Restitution of brain responses to food stimuli and feeding in Type 2 diabetes by GLP-1 receptor agonist exenatide. Diabetic Med 2010, 27(Suppl. 1):2..
-
(2010)
Diabetic Med
, vol.27
, Issue.SUPPL. 1
-
-
Nathan, Y.1
Lee, S.2
Ashoor, G.3
|