Impaired CD200-CD200R-mediated microglia silencing enhances midbrain dopaminergic neurodegeneration: Roles of aging, superoxide, NADPH oxidase, and p38 MAPK

Free Radical Biology and Medicine

Volumn 50, Issue 9, 2011, Pages 1094-1106

  Wang, Xi Jin ^a   Zhang, Shi ^a   Yan, Zhi Qiang ^b   Zhao, Yan Xin ^a   Zhou, Hai Yan ^a   Wang, Ying ^a   Lu, Guo Qiang ^a   Zhang, Jing Dong ^c  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Aging; CD200 CD200R; Dopaminergic neurons; Free radicals; Microglia; NADPH oxidase; p38 MAPK; Parkinson disease; Superoxide

Indexed keywords

BLOCKING ANTIBODY; CD200 ANTIGEN; CD200 RECEPTOR; CD200R BLOCKING ANTIBODY; INTERCELLULAR ADHESION MOLECULE 1; IRON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE; SUPEROXIDE; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; GENE EXPRESSION; GLIA; MESENCEPHALON; MICROGLIA; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA;

AGING; ANIMALS; ANTIBODIES, BLOCKING; ANTIGENS, CD; CELL CULTURE TECHNIQUES; CELLS, CULTURED; DOPAMINE; GENE EXPRESSION; INTERCELLULAR ADHESION MOLECULE-1; IRON; MESENCEPHALON; MICROGLIA; NADPH OXIDASE; NEURONS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, IMMUNOLOGIC; ROTENONE; SUPEROXIDES;

RATTUS;

EID: 79953247926     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.01.032     Document Type: Article

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