Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

Pharmacology Biochemistry and Behavior

Volumn 101, Issue 4, 2012, Pages 564-574

  Li, Jiejie ^a,b   Deng, Jiao ^a,c   Sheng, Wenli ^b   Zuo, Zhiyi ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b SUN YAT SEN UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

A ; Alzheimer disease; Diabetes; Metformin; Mice; Tau phosphorylation

Indexed keywords

AMYLOID BETA PROTEIN; METFORMIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; CONTROLLED STUDY; FEAR; HIPPOCAMPUS; HYPERGLYCEMIA; LEARNING; MALE; MAZE TEST; MEMORY; MOUSE; NEUROPATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CONDITIONING (PSYCHOLOGY); DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DRUG RESISTANCE; FEAR; HIPPOCAMPUS; HYPOGLYCEMIC AGENTS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEPTIN; MALE; MAZE LEARNING; MEMORY; METFORMIN; MICE; MICE, OBESE; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION; PLAQUE, AMYLOID; PROTEIN PHOSPHATASE 2; TAU PROTEINS; VESICULAR TRANSPORT PROTEINS;

MUS;

EID: 84859043569     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.03.002     Document Type: Article

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