-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
5344277556
-
Deciphering the molecular basis of memory failure in Alzheimer's disease
-
Walsh D.M., and Selkoe D.J. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 44 (2004) 181-193
-
(2004)
Neuron
, vol.44
, pp. 181-193
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
3
-
-
27844472159
-
Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?
-
Biessels G.J., and Kappelle L.J. Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?. Biochem. Soc. Trans. 33 (2005) 1041-1044
-
(2005)
Biochem. Soc. Trans.
, vol.33
, pp. 1041-1044
-
-
Biessels, G.J.1
Kappelle, L.J.2
-
4
-
-
0029016829
-
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
-
Lehmann J.M., Moore L.B., Smith-Oliver T.A., Wilkison W.O., Willson T.M., and Kliewer S.A. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem. 270 (1995) 12953-12956
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12953-12956
-
-
Lehmann, J.M.1
Moore, L.B.2
Smith-Oliver, T.A.3
Wilkison, W.O.4
Willson, T.M.5
Kliewer, S.A.6
-
5
-
-
20444499367
-
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta 1-42 levels in APPV717I transgenic mice
-
Heneka M.T., Sastre M., Dumitrescu-Ozimek L., Hanke A., Dewachter I., Kuiperi C., O'Banion K., Klockgether T., Van Leuven F., and Landreth G.E. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta 1-42 levels in APPV717I transgenic mice. Brain 128 (2005) 1442-1453
-
(2005)
Brain
, vol.128
, pp. 1442-1453
-
-
Heneka, M.T.1
Sastre, M.2
Dumitrescu-Ozimek, L.3
Hanke, A.4
Dewachter, I.5
Kuiperi, C.6
O'Banion, K.7
Klockgether, T.8
Van Leuven, F.9
Landreth, G.E.10
-
6
-
-
33745234766
-
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
-
Pedersen W.A., McMillan P.J., Kulstad J.J., Leverenz J.B., Craft S., and Haynatzki G.R. Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice. Exp. Neurol. 199 (2006) 265-273
-
(2006)
Exp. Neurol.
, vol.199
, pp. 265-273
-
-
Pedersen, W.A.1
McMillan, P.J.2
Kulstad, J.J.3
Leverenz, J.B.4
Craft, S.5
Haynatzki, G.R.6
-
7
-
-
31044445398
-
Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
-
Sastre M., Dewachter I., Rossner S., Bogdanovic N., Rosen E., Borghgraef P., Evert B.O., Dumitrescu-Ozimek L., Thal D.R., Landreth G.E., Walter J., Klockgether T., van Leuven F., and Heneka M.T. Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma. Proc. Natl. Acad. Sci. USA 103 (2006) 443-448
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 443-448
-
-
Sastre, M.1
Dewachter, I.2
Rossner, S.3
Bogdanovic, N.4
Rosen, E.5
Borghgraef, P.6
Evert, B.O.7
Dumitrescu-Ozimek, L.8
Thal, D.R.9
Landreth, G.E.10
Walter, J.11
Klockgether, T.12
van Leuven, F.13
Heneka, M.T.14
-
8
-
-
55249125525
-
Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist
-
Nicolakakis N., Aboulkassim T., Ongali B., Lecrux C., Fernandes P., Rosa-Neto P., Tong X.K., and Hamel E. Complete rescue of cerebrovascular function in aged Alzheimer's disease transgenic mice by antioxidants and pioglitazone, a peroxisome proliferator-activated receptor gamma agonist. J. Neurosci. 28 (2008) 9287-9296
-
(2008)
J. Neurosci.
, vol.28
, pp. 9287-9296
-
-
Nicolakakis, N.1
Aboulkassim, T.2
Ongali, B.3
Lecrux, C.4
Fernandes, P.5
Rosa-Neto, P.6
Tong, X.K.7
Hamel, E.8
-
9
-
-
33745266146
-
Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease
-
Risner M.E., Saunders A.M., Altman J.F., Ormandy G.C., Craft S., Foley I.M., Zvartau-Hind M.E., Hosford D.A., and Roses A.D. Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease. Pharmacogenomics J. 6 (2006) 246-254
-
(2006)
Pharmacogenomics J.
, vol.6
, pp. 246-254
-
-
Risner, M.E.1
Saunders, A.M.2
Altman, J.F.3
Ormandy, G.C.4
Craft, S.5
Foley, I.M.6
Zvartau-Hind, M.E.7
Hosford, D.A.8
Roses, A.D.9
-
10
-
-
33644592598
-
Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study
-
Watson G.S., Cholerton B.A., Reger M.A., Baker L.D., Plymate S.R., Asthana S., Fishel M.A., Kulstad J.J., Green P.S., Cook D.G., Kahn S.E., Keeling M.L., and Craft S. Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study. Am. J. Geriatr. Psychiatry 13 (2005) 950-958
-
(2005)
Am. J. Geriatr. Psychiatry
, vol.13
, pp. 950-958
-
-
Watson, G.S.1
Cholerton, B.A.2
Reger, M.A.3
Baker, L.D.4
Plymate, S.R.5
Asthana, S.6
Fishel, M.A.7
Kulstad, J.J.8
Green, P.S.9
Cook, D.G.10
Kahn, S.E.11
Keeling, M.L.12
Craft, S.13
-
11
-
-
0242609178
-
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
-
Sastre M., Dewachter I., Landreth G.E., Willson T.M., Klockgether T., van Leuven F., and Heneka M.T. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J. Neurosci. 23 (2003) 9796-9804
-
(2003)
J. Neurosci.
, vol.23
, pp. 9796-9804
-
-
Sastre, M.1
Dewachter, I.2
Landreth, G.E.3
Willson, T.M.4
Klockgether, T.5
van Leuven, F.6
Heneka, M.T.7
-
12
-
-
10044225937
-
Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide
-
Camacho I.E., Serneels L., Spittaels K., Merchiers P., Dominguez D., and De Strooper B. Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. J. Neurosci. 24 (2004) 10908-10917
-
(2004)
J. Neurosci.
, vol.24
, pp. 10908-10917
-
-
Camacho, I.E.1
Serneels, L.2
Spittaels, K.3
Merchiers, P.4
Dominguez, D.5
De Strooper, B.6
-
13
-
-
27744510142
-
Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death
-
d'Abramo C., Massone S., Zingg J.M., Pizzuti A., Marambaud P., Dalla Piccola B., Azzi A., Marinari U.M., Pronzato M.A., and Ricciarelli R. Role of peroxisome proliferator-activated receptor gamma in amyloid precursor protein processing and amyloid beta-mediated cell death. Biochem. J. 391 (2005) 693-698
-
(2005)
Biochem. J.
, vol.391
, pp. 693-698
-
-
d'Abramo, C.1
Massone, S.2
Zingg, J.M.3
Pizzuti, A.4
Marambaud, P.5
Dalla Piccola, B.6
Azzi, A.7
Marinari, U.M.8
Pronzato, M.A.9
Ricciarelli, R.10
-
14
-
-
33847698158
-
Rosiglitazone induces mitochondrial biogenesis in mouse brain
-
Strum J.C., Shehee R., Virley D., Richardson J., Mattie M., Selley P., Ghosh S., Nock C., Saunders A., and Roses A. Rosiglitazone induces mitochondrial biogenesis in mouse brain. J. Alzheimers Dis. 11 (2007) 45-51
-
(2007)
J. Alzheimers Dis.
, vol.11
, pp. 45-51
-
-
Strum, J.C.1
Shehee, R.2
Virley, D.3
Richardson, J.4
Mattie, M.5
Selley, P.6
Ghosh, S.7
Nock, C.8
Saunders, A.9
Roses, A.10
-
15
-
-
30944457675
-
Cognitive dysfunction, hippocampal atrophy and glucocorticoid feedback in Alzheimer's disease
-
Elgh E., Lindqvist Astot A., Fagerlund M., Eriksson S., Olsson T., and Nasman B. Cognitive dysfunction, hippocampal atrophy and glucocorticoid feedback in Alzheimer's disease. Biol. Psychiatry 59 (2006) 155-161
-
(2006)
Biol. Psychiatry
, vol.59
, pp. 155-161
-
-
Elgh, E.1
Lindqvist Astot, A.2
Fagerlund, M.3
Eriksson, S.4
Olsson, T.5
Nasman, B.6
-
16
-
-
0026352497
-
Inhibition of glucocorticoid secretion by the hippocampal formation in the primate
-
Sapolsky R.M., Zola-Morgan S., and Squire L.R. Inhibition of glucocorticoid secretion by the hippocampal formation in the primate. J. Neurosci. 11 (1991) 3695-3704
-
(1991)
J. Neurosci.
, vol.11
, pp. 3695-3704
-
-
Sapolsky, R.M.1
Zola-Morgan, S.2
Squire, L.R.3
-
17
-
-
17844371033
-
Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway
-
Ialenti A., Grassia G., Di Meglio P., Maffia P., Di Rosa M., and Ianaro A. Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway. Mol. Pharmacol. 67 (2005) 1620-1628
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 1620-1628
-
-
Ialenti, A.1
Grassia, G.2
Di Meglio, P.3
Maffia, P.4
Di Rosa, M.5
Ianaro, A.6
-
18
-
-
58149461547
-
-
L. Matthews, A. Berry, M. Tersigni, F. D'Acquisto, A. Ianaro, D. Ray, Thiazolidinediones are partial agonists for the glucocorticoid receptor, Endocrinology, (2008). [Epub ahead of print, doi: 10.1210/en.2008-0196].
-
L. Matthews, A. Berry, M. Tersigni, F. D'Acquisto, A. Ianaro, D. Ray, Thiazolidinediones are partial agonists for the glucocorticoid receptor, Endocrinology, (2008). [Epub ahead of print, doi: 10.1210/en.2008-0196].
-
-
-
-
19
-
-
0034213718
-
High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation
-
Mucke L., Masliah E., Yu G.Q., Mallory M., Rockenstein E.M., Tatsuno G., Hu K., Kholodenko D., Johnson-Wood K., and McConlogue L. High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 20 (2000) 4050-4058
-
(2000)
J. Neurosci.
, vol.20
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.Q.3
Mallory, M.4
Rockenstein, E.M.5
Tatsuno, G.6
Hu, K.7
Kholodenko, D.8
Johnson-Wood, K.9
McConlogue, L.10
-
20
-
-
33646677275
-
Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: correlation with AMPA receptor subunit expression in rat hippocampus
-
Schiapparelli L., Simón A., Del Río J., and Frechilla D. Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: correlation with AMPA receptor subunit expression in rat hippocampus. Neuropharmacology 50 (2006) 897-907
-
(2006)
Neuropharmacology
, vol.50
, pp. 897-907
-
-
Schiapparelli, L.1
Simón, A.2
Del Río, J.3
Frechilla, D.4
-
21
-
-
0030661790
-
Cortisol secretion and Alzheimer's disease progression
-
Weiner M.F., Vobach S., Olsson K., Svetlik D., and Risser R.C. Cortisol secretion and Alzheimer's disease progression. Biol. Psychiatry 42 (1997) 1030-1038
-
(1997)
Biol. Psychiatry
, vol.42
, pp. 1030-1038
-
-
Weiner, M.F.1
Vobach, S.2
Olsson, K.3
Svetlik, D.4
Risser, R.C.5
-
22
-
-
0035666488
-
Do glucocorticoids contribute to brain aging?
-
Nichols N.R., Zieba M., and Bye N. Do glucocorticoids contribute to brain aging?. Brain Res. Rev. 37 (2001) 273-286
-
(2001)
Brain Res. Rev.
, vol.37
, pp. 273-286
-
-
Nichols, N.R.1
Zieba, M.2
Bye, N.3
-
23
-
-
33748253471
-
Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease
-
Green K.N., Billings L.M., Roozendaal B., McGaugh J.L., and LaFerla F.M. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease. J. Neurosci. 26 (2006) 9047-9056
-
(2006)
J. Neurosci.
, vol.26
, pp. 9047-9056
-
-
Green, K.N.1
Billings, L.M.2
Roozendaal, B.3
McGaugh, J.L.4
LaFerla, F.M.5
-
24
-
-
33646227916
-
Chronic stress accelerates learning memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model
-
Jeong Y.H., Park C.H., Yoo J., Shin K.Y., Ahn S.M., Kim H.S., Lee S.H., Emson P.C., and Suh Y.H. Chronic stress accelerates learning memory impairments and increases amyloid deposition in APPV717I-CT100 transgenic mice, an Alzheimer's disease model. FASEB J. 20 (2006) 729-731
-
(2006)
FASEB J.
, vol.20
, pp. 729-731
-
-
Jeong, Y.H.1
Park, C.H.2
Yoo, J.3
Shin, K.Y.4
Ahn, S.M.5
Kim, H.S.6
Lee, S.H.7
Emson, P.C.8
Suh, Y.H.9
-
25
-
-
53149150976
-
Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau
-
Sotiropoulos I., Catania C., Riedemann T., Fry J.P., Breen K.C., Michaelidis T.M., and Almeida O.F. Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau. J. Neurochem. 107 (2008) 385-397
-
(2008)
J. Neurochem.
, vol.107
, pp. 385-397
-
-
Sotiropoulos, I.1
Catania, C.2
Riedemann, T.3
Fry, J.P.4
Breen, K.C.5
Michaelidis, T.M.6
Almeida, O.F.7
-
26
-
-
36949038203
-
The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications
-
Jiang Q., Heneka M., and Landreth G.E. The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications. CNS Drugs 22 (2008) 1-14
-
(2008)
CNS Drugs
, vol.22
, pp. 1-14
-
-
Jiang, Q.1
Heneka, M.2
Landreth, G.E.3
-
27
-
-
0031437277
-
Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption
-
Oitzl M.S., de Kloet E.R., Joels M., Schmid W., and Cole T.J. Spatial learning deficits in mice with a targeted glucocorticoid receptor gene disruption. Eur. J. Neurosci. 9 (1997) 2284-2296
-
(1997)
Eur. J. Neurosci.
, vol.9
, pp. 2284-2296
-
-
Oitzl, M.S.1
de Kloet, E.R.2
Joels, M.3
Schmid, W.4
Cole, T.J.5
-
28
-
-
0023870756
-
Antiglucocorticoid RU 38486 attenuates retention of a behaviour and disinhibits the hypothalamic-pituitary adrenal axis at different brain sites
-
De Kloet E.R., De Kock S., Schild V., and Veldhuis H.D. Antiglucocorticoid RU 38486 attenuates retention of a behaviour and disinhibits the hypothalamic-pituitary adrenal axis at different brain sites. Neuroendocrinology 47 (1988) 109-115
-
(1988)
Neuroendocrinology
, vol.47
, pp. 109-115
-
-
De Kloet, E.R.1
De Kock, S.2
Schild, V.3
Veldhuis, H.D.4
-
29
-
-
0036019156
-
Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease
-
Woulfe J.M., Hammond R., Richardson B., Sooriabalan D., Parks W., Rippstein P., and Muñoz D.G. Reduction of neuronal intranuclear rodlets immunoreactive for tubulin and glucocorticoid receptor in Alzheimer's disease. Brain Pathol. 12 (2002) 300-307
-
(2002)
Brain Pathol.
, vol.12
, pp. 300-307
-
-
Woulfe, J.M.1
Hammond, R.2
Richardson, B.3
Sooriabalan, D.4
Parks, W.5
Rippstein, P.6
Muñoz, D.G.7
-
30
-
-
0036218016
-
Decrements in nuclear glucocorticoid receptor (GR) protein levels and DNA binding in aged rat hippocampus
-
Murphy E.K., Spencer R.L., Sipe K.J., and Herman J.P. Decrements in nuclear glucocorticoid receptor (GR) protein levels and DNA binding in aged rat hippocampus. Endocrinology 143 (2002) 1362-1370
-
(2002)
Endocrinology
, vol.143
, pp. 1362-1370
-
-
Murphy, E.K.1
Spencer, R.L.2
Sipe, K.J.3
Herman, J.P.4
|