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Volumn 68, Issue , 2015, Pages 76-81

Growth hormone, insulin-like growth factor-1 and the aging brain

Author keywords

Aging; Brain; GH; IGF 1; Neuroendocrine

Indexed keywords

GROWTH HORMONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; SOMATOMEDIN C; HUMAN GROWTH HORMONE;

EID: 84934759512     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.10.002     Document Type: Review
Times cited : (161)

References (86)
  • 2
    • 70350335299 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor I and cognitive function: neuromodulation throughout the lifespan
    • Aleman A., Torres-Aleman I. Circulating insulin-like growth factor I and cognitive function: neuromodulation throughout the lifespan. Prog. Neurobiol. 2009, 89:256-265.
    • (2009) Prog. Neurobiol. , vol.89 , pp. 256-265
    • Aleman, A.1    Torres-Aleman, I.2
  • 3
    • 0034088789 scopus 로고    scopus 로고
    • Uptake of circulating insulin-like growth factor-I into the cerebrospinal fluid of normal and diabetic rats and normalization of IGF-II mRNA content in diabetic rat brain
    • Armstrong C.S., Wuarin L., Ishii D.N. Uptake of circulating insulin-like growth factor-I into the cerebrospinal fluid of normal and diabetic rats and normalization of IGF-II mRNA content in diabetic rat brain. J. Neurosci. Res. 2000, 59:649-660.
    • (2000) J. Neurosci. Res. , vol.59 , pp. 649-660
    • Armstrong, C.S.1    Wuarin, L.2    Ishii, D.N.3
  • 4
    • 33745016644 scopus 로고    scopus 로고
    • Effects of growth hormone substitution therapy on cognitive functioning in growth hormone deficient patients: a functional MRI study
    • Arwert L.I., Veltman D.J., Deijen J.B., van Dam P.S., Drent M.L. Effects of growth hormone substitution therapy on cognitive functioning in growth hormone deficient patients: a functional MRI study. Neuroendocrinology 2006, 83:12-19.
    • (2006) Neuroendocrinology , vol.83 , pp. 12-19
    • Arwert, L.I.1    Veltman, D.J.2    Deijen, J.B.3    van Dam, P.S.4    Drent, M.L.5
  • 5
    • 0026016403 scopus 로고
    • Impaired secretion of growth hormone-releasing hormone, growth hormone and IGF-I in elderly men
    • Bando H., Zhang C., Takada Y., Yamasaki R., Saito S. Impaired secretion of growth hormone-releasing hormone, growth hormone and IGF-I in elderly men. Acta Endocrinol. (Copenh) 1991, 124:31-36.
    • (1991) Acta Endocrinol. (Copenh) , vol.124 , pp. 31-36
    • Bando, H.1    Zhang, C.2    Takada, Y.3    Yamasaki, R.4    Saito, S.5
  • 6
    • 0028941681 scopus 로고
    • Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons
    • Beck K.D., Powell-Braxton L., Widmer H.R., Valverde J., Hefti F. Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons. Neuron 1995, 14:717-730.
    • (1995) Neuron , vol.14 , pp. 717-730
    • Beck, K.D.1    Powell-Braxton, L.2    Widmer, H.R.3    Valverde, J.4    Hefti, F.5
  • 7
    • 1642544606 scopus 로고    scopus 로고
    • A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency
    • Bonapace G., Concolino D., Formicola S., Strisciuglio P. A novel mutation in a patient with insulin-like growth factor 1 (IGF1) deficiency. J. Med. Genet. 2003, 40:913-917.
    • (2003) J. Med. Genet. , vol.40 , pp. 913-917
    • Bonapace, G.1    Concolino, D.2    Formicola, S.3    Strisciuglio, P.4
  • 8
    • 0026556829 scopus 로고
    • Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II
    • Bondy C., Werner H., Roberts C.T., LeRoith D. Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II. Neuroscience 1992, 46:909-923.
    • (1992) Neuroscience , vol.46 , pp. 909-923
    • Bondy, C.1    Werner, H.2    Roberts, C.T.3    LeRoith, D.4
  • 9
    • 84877331677 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay
    • Bozdagi O., Tavassoli T., Buxbaum J.D. Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay. Mol. Autism 2013, 4:9.
    • (2013) Mol. Autism , vol.4 , pp. 9
    • Bozdagi, O.1    Tavassoli, T.2    Buxbaum, J.D.3
  • 12
    • 18144446836 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor I mediates effects of exercise on the brain
    • Carro E., Nunez A., Busiguina S., Torres-Aleman I. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J. Neurosci. 2000, 20:2926-2933.
    • (2000) J. Neurosci. , vol.20 , pp. 2926-2933
    • Carro, E.1    Nunez, A.2    Busiguina, S.3    Torres-Aleman, I.4
  • 13
    • 28044466172 scopus 로고    scopus 로고
    • Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I
    • Carro E., Spuch C., Trejo J.L., Antequera D., Torres-Aleman I. Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I. J. Neurosci. 2005, 25:10884-10893.
    • (2005) J. Neurosci. , vol.25 , pp. 10884-10893
    • Carro, E.1    Spuch, C.2    Trejo, J.L.3    Antequera, D.4    Torres-Aleman, I.5
  • 15
    • 33644936605 scopus 로고    scopus 로고
    • Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness
    • Cediel R., Riquelme R., Contreras J., Diaz A., Varela-Nieto I. Sensorineural hearing loss in insulin-like growth factor I-null mice: a new model of human deafness. Eur. J. Neurosci. 2006, 23:587-590.
    • (2006) Eur. J. Neurosci. , vol.23 , pp. 587-590
    • Cediel, R.1    Riquelme, R.2    Contreras, J.3    Diaz, A.4    Varela-Nieto, I.5
  • 17
    • 0020647470 scopus 로고
    • Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus
    • Collingridge G.L., Kehl S.J., McLennan H. Excitatory amino acids in synaptic transmission in the Schaffer collateral-commissural pathway of the rat hippocampus. J. Physiol. 1983, 334:33-46.
    • (1983) J. Physiol. , vol.334 , pp. 33-46
    • Collingridge, G.L.1    Kehl, S.J.2    McLennan, H.3
  • 18
    • 0027473333 scopus 로고
    • Continuous subcutaneous infusions of growth hormone (GH) releasing hormone 1-44 for 14days increase GH and insulin-like growth factor-I levels in old men
    • Corpas E., Harman S.M., Pineyro M.A., Roberson R., Blackman M.R. Continuous subcutaneous infusions of growth hormone (GH) releasing hormone 1-44 for 14days increase GH and insulin-like growth factor-I levels in old men. J. Clin. Endocrinol. Metab. 1993, 76:134-138.
    • (1993) J. Clin. Endocrinol. Metab. , vol.76 , pp. 134-138
    • Corpas, E.1    Harman, S.M.2    Pineyro, M.A.3    Roberson, R.4    Blackman, M.R.5
  • 19
    • 0041419437 scopus 로고    scopus 로고
    • Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span
    • Coschigano K.T., Holland A.N., Riders M.E., List E.O., Flyvbjerg A., Kopchick J.J. Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span. Endocrinology 2003, 144:3799-3810.
    • (2003) Endocrinology , vol.144 , pp. 3799-3810
    • Coschigano, K.T.1    Holland, A.N.2    Riders, M.E.3    List, E.O.4    Flyvbjerg, A.5    Kopchick, J.J.6
  • 20
    • 0027142906 scopus 로고
    • Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency
    • Cuneo R.C., Salomon F., Watts G.F., Hesp R., Sonksen P.H. Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metab. Clin. Exp. 1993, 42:1519-1523.
    • (1993) Metab. Clin. Exp. , vol.42 , pp. 1519-1523
    • Cuneo, R.C.1    Salomon, F.2    Watts, G.F.3    Hesp, R.4    Sonksen, P.H.5
  • 24
    • 84868589263 scopus 로고    scopus 로고
    • The GH/IGF-I axis and cognitive changes across a 4-year period in healthy adults
    • 249421
    • Deijen J.B., Arwert L.I., Drent M.L. The GH/IGF-I axis and cognitive changes across a 4-year period in healthy adults. ISRN Endocrinol. 2011, 249421:2011.
    • (2011) ISRN Endocrinol. , pp. 2011
    • Deijen, J.B.1    Arwert, L.I.2    Drent, M.L.3
  • 26
    • 84886099768 scopus 로고    scopus 로고
    • Baseline characteristics and effects of ten years of growth hormone (GH) replacement therapy in adults previously treated with pituitary irradiation
    • Elbornsson M., Gotherstrom G., Bengtsson B.A., Johannsson G., Svensson J. Baseline characteristics and effects of ten years of growth hormone (GH) replacement therapy in adults previously treated with pituitary irradiation. Growth Horm. IGF Res. 2013, 23:249-255.
    • (2013) Growth Horm. IGF Res. , vol.23 , pp. 249-255
    • Elbornsson, M.1    Gotherstrom, G.2    Bengtsson, B.A.3    Johannsson, G.4    Svensson, J.5
  • 27
    • 0021985053 scopus 로고
    • Somatomedin-C levels in healthy young and old men: relationship to peak and 24-hour integrated levels of growth hormone
    • Florini J.R., Prinz P.N., Vitiello M.V., Hintz R.L. Somatomedin-C levels in healthy young and old men: relationship to peak and 24-hour integrated levels of growth hormone. J. Gerontol. 1985, 40:2-7.
    • (1985) J. Gerontol. , vol.40 , pp. 2-7
    • Florini, J.R.1    Prinz, P.N.2    Vitiello, M.V.3    Hintz, R.L.4
  • 30
    • 77953058601 scopus 로고    scopus 로고
    • Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampus
    • Glasper E.R., Llorens-Martin M.V., Leuner B., Gould E., Trejo J.L. Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampus. Hippocampus 2010, 20:706-712.
    • (2010) Hippocampus , vol.20 , pp. 706-712
    • Glasper, E.R.1    Llorens-Martin, M.V.2    Leuner, B.3    Gould, E.4    Trejo, J.L.5
  • 31
    • 0019826097 scopus 로고
    • Low somatomedin-C levels in older men rise in response to growth hormone administration
    • Johanson A.J., Blizzard R.M. Low somatomedin-C levels in older men rise in response to growth hormone administration. Johns Hopkins Med. J. 1981, 149:115-117.
    • (1981) Johns Hopkins Med. J. , vol.149 , pp. 115-117
    • Johanson, A.J.1    Blizzard, R.M.2
  • 35
    • 0023677162 scopus 로고
    • NMDA application potentiates synaptic transmission in the hippocampus
    • Kauer J.A., Malenka R.C., Nicoll R.A. NMDA application potentiates synaptic transmission in the hippocampus. Nature 1988, 334:250-252.
    • (1988) Nature , vol.334 , pp. 250-252
    • Kauer, J.A.1    Malenka, R.C.2    Nicoll, R.A.3
  • 36
    • 0035051811 scopus 로고    scopus 로고
    • Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice
    • Kinney B.A., Coschigano K.T., Kopchick J.J., Steger R.W., Bartke A. Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice. Physiol. Behav. 2001, 72:653-660.
    • (2001) Physiol. Behav. , vol.72 , pp. 653-660
    • Kinney, B.A.1    Coschigano, K.T.2    Kopchick, J.J.3    Steger, R.W.4    Bartke, A.5
  • 37
    • 0034966342 scopus 로고    scopus 로고
    • Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters
    • Kinney B.A., Meliska C.J., Steger R.W., Bartke A. Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm. Behav. 2001, 39:277-284.
    • (2001) Horm. Behav. , vol.39 , pp. 277-284
    • Kinney, B.A.1    Meliska, C.J.2    Steger, R.W.3    Bartke, A.4
  • 39
    • 0037076291 scopus 로고    scopus 로고
    • Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-d-aspartate receptor subunits gene transcripts in male rats
    • Le Greves M., Steensland P., Le Greves P., Nyberg F. Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-d-aspartate receptor subunits gene transcripts in male rats. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:7119-7123.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 7119-7123
    • Le Greves, M.1    Steensland, P.2    Le Greves, P.3    Nyberg, F.4
  • 40
    • 17044420428 scopus 로고    scopus 로고
    • Age-related effects of IGF-1 on the NMDA-, GH- and IGF-1-receptor mRNA transcripts in the rat hippocampus
    • Le Greves M., Le Greves P., Nyberg F. Age-related effects of IGF-1 on the NMDA-, GH- and IGF-1-receptor mRNA transcripts in the rat hippocampus. Brain Res. Bull. 2005, 65:369-374.
    • (2005) Brain Res. Bull. , vol.65 , pp. 369-374
    • Le Greves, M.1    Le Greves, P.2    Nyberg, F.3
  • 41
    • 33747588120 scopus 로고    scopus 로고
    • Growth hormone replacement in hypophysectomized rats affects spatial performance and hippocampal levels of NMDA receptor subunit and PSD-95 gene transcript levels
    • Le Greves M., Zhou Q., Berg M., Le Greves P., Fholenhag K., Meyerson B., Nyberg F. Growth hormone replacement in hypophysectomized rats affects spatial performance and hippocampal levels of NMDA receptor subunit and PSD-95 gene transcript levels. Exp. Brain Res. 2006, 173:267-273.
    • (2006) Exp. Brain Res. , vol.173 , pp. 267-273
    • Le Greves, M.1    Zhou, Q.2    Berg, M.3    Le Greves, P.4    Fholenhag, K.5    Meyerson, B.6    Nyberg, F.7
  • 42
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu J.P., Baker J., Perkins A.S., Robertson E.J., Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993, 75:59-72.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 43
    • 0032160227 scopus 로고    scopus 로고
    • Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice
    • Liu J.L., Grinberg A., Westphal H., Sauer B., Accili D., Karas M., LeRoith D. Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: manipulation using the Cre/loxP system in transgenic mice. Mol. Endocrinol. 1998, 12:1452-1462.
    • (1998) Mol. Endocrinol. , vol.12 , pp. 1452-1462
    • Liu, J.L.1    Grinberg, A.2    Westphal, H.3    Sauer, B.4    Accili, D.5    Karas, M.6    LeRoith, D.7
  • 45
    • 84866311426 scopus 로고    scopus 로고
    • Aging of the NMDA receptor: from a mouse's point of view
    • Magnusson K.R. Aging of the NMDA receptor: from a mouse's point of view. Future Neurol. 2012, 7:627-637.
    • (2012) Future Neurol. , vol.7 , pp. 627-637
    • Magnusson, K.R.1
  • 46
    • 0037186456 scopus 로고    scopus 로고
    • Age-related changes in the protein expression of subunits of the NMDA receptor
    • Magnusson K.R., Nelson S.E., Young A.B. Age-related changes in the protein expression of subunits of the NMDA receptor. Brain Res. Mol. Brain Res. 2002, 99:40-45.
    • (2002) Brain Res. Mol. Brain Res. , vol.99 , pp. 40-45
    • Magnusson, K.R.1    Nelson, S.E.2    Young, A.B.3
  • 47
    • 78049493731 scopus 로고    scopus 로고
    • Selective vulnerabilities of N-methyl-d-aspartate (NMDA) receptors during brain aging
    • Magnusson K.R., Brim B.L., Das S.R. Selective vulnerabilities of N-methyl-d-aspartate (NMDA) receptors during brain aging. Front. Aging Neurosci. 2010, 2:11.
    • (2010) Front. Aging Neurosci. , vol.2 , pp. 11
    • Magnusson, K.R.1    Brim, B.L.2    Das, S.R.3
  • 48
    • 33644788171 scopus 로고    scopus 로고
    • Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation
    • Maher F.O., Clarke R.M., Kelly A., Nally R.E., Lynch M.A. Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation. J. Neurochem. 2006, 96:1560-1571.
    • (2006) J. Neurochem. , vol.96 , pp. 1560-1571
    • Maher, F.O.1    Clarke, R.M.2    Kelly, A.3    Nally, R.E.4    Lynch, M.A.5
  • 49
    • 33646184567 scopus 로고    scopus 로고
    • Growth hormone enhances excitatory synaptic transmission in area CA1 of rat hippocampus
    • Mahmoud G.S., Grover L.M. Growth hormone enhances excitatory synaptic transmission in area CA1 of rat hippocampus. J. Neurophysiol. 2006, 95:2962-2974.
    • (2006) J. Neurophysiol. , vol.95 , pp. 2962-2974
    • Mahmoud, G.S.1    Grover, L.M.2
  • 50
    • 0032483062 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 ameliorates age-related behavioral deficits
    • Markowska A.L., Mooney M., Sonntag W.E. Insulin-like growth factor-1 ameliorates age-related behavioral deficits. Neuroscience 1998, 87:559-569.
    • (1998) Neuroscience , vol.87 , pp. 559-569
    • Markowska, A.L.1    Mooney, M.2    Sonntag, W.E.3
  • 51
    • 84886099931 scopus 로고    scopus 로고
    • Growth hormone replacement normalizes impaired fibrinolysis: new insights into endothelial dysfunction in patients with hypopituitarism and growth hormone deficiency
    • Miljic D., Miljic P., Doknic M., Pekic S., Stojanovic M., Cvijovic G., Micic D., Popovic V. Growth hormone replacement normalizes impaired fibrinolysis: new insights into endothelial dysfunction in patients with hypopituitarism and growth hormone deficiency. Growth Horm. IGF Res. 2013, 23:243-248.
    • (2013) Growth Horm. IGF Res. , vol.23 , pp. 243-248
    • Miljic, D.1    Miljic, P.2    Doknic, M.3    Pekic, S.4    Stojanovic, M.5    Cvijovic, G.6    Micic, D.7    Popovic, V.8
  • 54
    • 84892587857 scopus 로고    scopus 로고
    • Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats
    • Molina D.P., Ariwodola O.J., Weiner J.L., Brunso-Bechtold J.K., Adams M.M. Growth hormone and insulin-like growth factor-I alter hippocampal excitatory synaptic transmission in young and old rats. Age 2013, 35:1575-1587.
    • (2013) Age , vol.35 , pp. 1575-1587
    • Molina, D.P.1    Ariwodola, O.J.2    Weiner, J.L.3    Brunso-Bechtold, J.K.4    Adams, M.M.5
  • 55
    • 0028343648 scopus 로고
    • Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
    • Monyer H., Burnashev N., Laurie D.J., Sakmann B., Seeburg P.H. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 1994, 12:529-540.
    • (1994) Neuron , vol.12 , pp. 529-540
    • Monyer, H.1    Burnashev, N.2    Laurie, D.J.3    Sakmann, B.4    Seeburg, P.H.5
  • 56
    • 0022650213 scopus 로고
    • Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist, AP5
    • Morris R.G., Anderson E., Lynch G.S., Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist, AP5. Nature 1986, 319:774-776.
    • (1986) Nature , vol.319 , pp. 774-776
    • Morris, R.G.1    Anderson, E.2    Lynch, G.S.3    Baudry, M.4
  • 59
    • 0032584997 scopus 로고    scopus 로고
    • Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway×Fischer 344 rat brain
    • Niblock M.M., Brunso-Bechtold J.K., Lynch C.D., Ingram R.L., McShane T., Sonntag W.E. Distribution and levels of insulin-like growth factor I mRNA across the life span in the Brown Norway×Fischer 344 rat brain. Brain Res. 1998, 804:79-86.
    • (1998) Brain Res. , vol.804 , pp. 79-86
    • Niblock, M.M.1    Brunso-Bechtold, J.K.2    Lynch, C.D.3    Ingram, R.L.4    McShane, T.5    Sonntag, W.E.6
  • 66
    • 2342634470 scopus 로고    scopus 로고
    • Comparative analysis of CNS populations in knockout mice with altered growth hormone responsiveness
    • Ransome M.I., Goldshmit Y., Bartlett P.F., Waters M.J., Turnley A.M. Comparative analysis of CNS populations in knockout mice with altered growth hormone responsiveness. Eur. J. Neurosci. 2004, 19:2069-2079.
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 2069-2079
    • Ransome, M.I.1    Goldshmit, Y.2    Bartlett, P.F.3    Waters, M.J.4    Turnley, A.M.5
  • 67
    • 0027984463 scopus 로고
    • Insulin-like growth factors cross the blood-brain barrier
    • Reinhardt R.R., Bondy C.A. Insulin-like growth factors cross the blood-brain barrier. Endocrinology 1994, 135:1753-1761.
    • (1994) Endocrinology , vol.135 , pp. 1753-1761
    • Reinhardt, R.R.1    Bondy, C.A.2
  • 68
    • 0019423888 scopus 로고
    • Impaired growth hormone secretion in the adult population: relation to age and adiposity
    • Rudman D., Kutner M.H., Rogers C.M., Lubin M.F., Fleming G.A., Bain R.P. Impaired growth hormone secretion in the adult population: relation to age and adiposity. J. Clin. Invest. 1981, 67:1361-1369.
    • (1981) J. Clin. Invest. , vol.67 , pp. 1361-1369
    • Rudman, D.1    Kutner, M.H.2    Rogers, C.M.3    Lubin, M.F.4    Fleming, G.A.5    Bain, R.P.6
  • 70
    • 29744468658 scopus 로고    scopus 로고
    • The intellectual capacity of patients with Laron syndrome (LS) differs with various molecular defects of the growth hormone receptor gene. Correlation with CNS abnormalities
    • Shevah O., Kornreich L., Galatzer A., Laron Z. The intellectual capacity of patients with Laron syndrome (LS) differs with various molecular defects of the growth hormone receptor gene. Correlation with CNS abnormalities. Horm. Metab. Res. 2005, 37:757-760.
    • (2005) Horm. Metab. Res. , vol.37 , pp. 757-760
    • Shevah, O.1    Kornreich, L.2    Galatzer, A.3    Laron, Z.4
  • 71
    • 14244251413 scopus 로고    scopus 로고
    • Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus
    • Shi L., Linville M.C., Tucker E.W., Sonntag W.E., Brunso-Bechtold J.K. Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus. Cereb. Cortex 2005, 15:571-577.
    • (2005) Cereb. Cortex , vol.15 , pp. 571-577
    • Shi, L.1    Linville, M.C.2    Tucker, E.W.3    Sonntag, W.E.4    Brunso-Bechtold, J.K.5
  • 72
    • 0024477682 scopus 로고
    • Relationship between insulin, insulin-like growth factor I, and dehydroepiandrosterone sulfate concentrations during childhood, puberty, and adult life
    • Smith C.P., Dunger D.B., Williams A.J., Taylor A.M., Perry L.A., Gale E.A., Preece M.A., Savage M.O. Relationship between insulin, insulin-like growth factor I, and dehydroepiandrosterone sulfate concentrations during childhood, puberty, and adult life. J. Clin. Endocrinol. Metab. 1989, 68:932-937.
    • (1989) J. Clin. Endocrinol. Metab. , vol.68 , pp. 932-937
    • Smith, C.P.1    Dunger, D.B.2    Williams, A.J.3    Taylor, A.M.4    Perry, L.A.5    Gale, E.A.6    Preece, M.A.7    Savage, M.O.8
  • 73
    • 0025073534 scopus 로고
    • Somatostatin gene expression in hypothalamus and cortex of aging male rats
    • Sonntag W.E., Boyd R.L., Booze R.M. Somatostatin gene expression in hypothalamus and cortex of aging male rats. Neurobiol. Aging 1990, 11:409-416.
    • (1990) Neurobiol. Aging , vol.11 , pp. 409-416
    • Sonntag, W.E.1    Boyd, R.L.2    Booze, R.M.3
  • 75
    • 0034523517 scopus 로고    scopus 로고
    • The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing
    • Sonntag W.E., Lynch C., Thornton P., Khan A., Bennett S., Ingram R. The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. J. Anat. 2000, 197(Pt 4):575-585.
    • (2000) J. Anat. , vol.197 , pp. 575-585
    • Sonntag, W.E.1    Lynch, C.2    Thornton, P.3    Khan, A.4    Bennett, S.5    Ingram, R.6
  • 77
    • 23444432499 scopus 로고    scopus 로고
    • Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging
    • Sonntag W.E., Ramsey M., Carter C.S. Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing Res. Rev. 2005, 4:195-212.
    • (2005) Ageing Res. Rev. , vol.4 , pp. 195-212
    • Sonntag, W.E.1    Ramsey, M.2    Carter, C.S.3
  • 79
    • 13844277026 scopus 로고    scopus 로고
    • Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice
    • Sun L.Y., Al-Regaiey K., Masternak M.M., Wang J., Bartke A. Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiol. Aging 2005, 26:929-937.
    • (2005) Neurobiol. Aging , vol.26 , pp. 929-937
    • Sun, L.Y.1    Al-Regaiey, K.2    Masternak, M.M.3    Wang, J.4    Bartke, A.5
  • 80
    • 0034133296 scopus 로고    scopus 로고
    • Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory
    • Thornton P.L., Ingram R.L., Sonntag W.E. Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory. J. Gerontol. A Biol. Sci. Med. Sci. 2000, 55:B106-B112.
    • (2000) J. Gerontol. A Biol. Sci. Med. Sci. , vol.55 , pp. B106-B112
    • Thornton, P.L.1    Ingram, R.L.2    Sonntag, W.E.3
  • 84
    • 0029805072 scopus 로고    scopus 로고
    • Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene
    • Woods K.A., Camacho-Hubner C., Savage M.O., Clark A.J. Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene. N. Engl. J. Med. 1996, 335:1363-1367.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1363-1367
    • Woods, K.A.1    Camacho-Hubner, C.2    Savage, M.O.3    Clark, A.J.4
  • 86
    • 33646793301 scopus 로고    scopus 로고
    • Pmid. Reciprocal interactions of insulin and insulin-like growth factor I in receptor-mediated transport across the blood-brain barrier
    • Yu Y., Kastin A.J., Pan W.C.I.N.E.J. Pmid. Reciprocal interactions of insulin and insulin-like growth factor I in receptor-mediated transport across the blood-brain barrier. Endocrinology 2006, 147:2611-2615.
    • (2006) Endocrinology , vol.147 , pp. 2611-2615
    • Yu, Y.1    Kastin, A.J.2    Pan, W.C.I.N.E.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.